CN100566739C - The compositions that contains Radix Notoginseng, the Cortex Eucommiae and Radix Panacis Quinquefolii - Google Patents
The compositions that contains Radix Notoginseng, the Cortex Eucommiae and Radix Panacis Quinquefolii Download PDFInfo
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Abstract
A kind of compositions that contains Radix Notoginseng, the Cortex Eucommiae and Radix Panacis Quinquefolii.
Description
Background of invention
(1) invention field
The present invention relates to contain the compositions of " Denhichi " (Radix Notoginseng), " Tochu " (Cortex Eucommiae (Cortex Eucommiae)) and " SeiyoNinjin " (Radix Panacis Quinquefolii), if necessary, it can further contain " Osei " (Rhizoma Polygonati rhizome or analog) and/or contain medicinal herbs extract and/or " Kanzo " (licorice) of gallic acid.The present invention also provides its manufacture method.
Compositions of the present invention can be used as conventional medicine or replaces medicine and food supplement, it is not only for safeguarding human health and promote healthy and improve nutriture and immune system is useful, and also is effective for treatment or prevention hepatitis and infectious disease.
In addition, compositions of the present invention also can be used as food supplement, it not only can be used to prevent hypertension and the diabetes of animal (as Canis familiaris L., cat, pig, cattle, horse and other animal), can also be used to safeguard the healthy of these animals (comprising birds and fish) and improve their nutriture and immune system.
(2) description of association area
A nationwide result of study explanation, owing to environmental aspect, lack the diet of motion and high heat, the number of overweight, hypertension and diabetic individual has significant increase.In addition, the ability of opposing hepatitis, infectious disease and immunological diseases also obviously reduces.
These observed results in animal environment, have also been observed.In fact, the house pet of raising among a small circle, as, support in the room, also run into the disease of nutriture, hypertension, mental pressure and the overweight aspect relevant with higher fatty acid material.
On the other hand, the increase of suffering from patient's quantity of HBV and HCV also is serious problems that need to be resolved hurrily.
Usually, with disturbing treatment usually to suffer from the patient of HBV and HCV, although known disturbances have serious disadvantageous side effect.
Brief summary of the invention
An object of the present invention is to provide the hypercholesterolemia that is significantly improved, hypertension, diabetes and some cancer symptoms and the food supplement of the effect of the state of keeping fit and replacement medicine.
Another object of the present invention provide a kind of and interferon therapy mutually specific energy significantly improve the replacement medicine of HBV and HCV symptom.
" Radix Notoginseng ", " Cortex Eucommiae " and " Radix Panacis Quinquefolii " have been provided by providing first purpose of the present invention, if necessary, also contain " Rhizoma Polygonati rhizome " and/or contain the medicinal herbs extract of gallic acid and/or the food supplement of " licorice (Glycyrrhiza glabra) " and Related product and replace medicine and be achieved.
Another object of the present invention provides and contains " Radix Notoginseng ", " Cortex Eucommiae " and " Radix Panacis Quinquefolii ", if necessary, also contain " Rhizoma Polygonati rhizome " and/or contain the medicinal herbs extract of gallic acid and/or the replacement medicine of " licorice ", it can effectively treat the symptom of various hepatopathys.
Here also provide the medicinal herbs extract that contains " Radix Notoginseng ", " Cortex Eucommiae ", " Radix Panacis Quinquefolii ", contain gallic acid and, if necessary, also contain licorice (Glycyrrhiza glabra) " compositions; they are replaced medicine as the food supplement of health care and realize, it can be effectively as the complex food of replacement medicine, tonic, beverage, animal feed and animal, birds and the Fish of the food supplement of maintaining healthy, treatment hepatopathy.
Simultaneously, also provide the compositions that contains " Radix Notoginseng ", " Cortex Eucommiae ", " Radix Panacis Quinquefolii ", " Rhizoma Polygonati rhizome " and if necessary, also contain " licorice " here.
The invention provides the method for making above-mentioned composition, this method comprises the extract that concentrates through the hot water (60-100 ℃) of doing " Radix Notoginseng ", " Cortex Eucommiae " and " Radix Panacis Quinquefolii " of chopping or ethanol (room temperature-100 ℃) extract spissated to obtain " Radix Notoginseng ", " Cortex Eucommiae " and " Radix Panacis Quinquefolii ", can obtain the product of its pulverizing in case of necessity by heat drying; Concentrate through the hot water (60-100 ℃) of the medicinal herbs extract of doing that contains gallic acid of chopping or ethanol (room temperature-100 ℃) extract to obtain the spissated medicinal herbs extract that contains gallic acid, in case of necessity, can obtain the product of its pulverizing by heat drying; They are mixed, then the extract of the milling product of dry " Radix Notoginseng ", " Cortex Eucommiae " and " Radix Panacis Quinquefolii ", contain extract and the extract of " licorice " chosen wantonly or the product of pulverizing of milling product of the medicinal herbs extract of gallic acid.
The invention provides the method for making above-mentioned composition, this method comprises the extract that concentrates through the hot water (60-100 ℃) of doing " Radix Notoginseng ", " Cortex Eucommiae " and " Radix Panacis Quinquefolii " of chopping or ethanol (room temperature-100 ℃) extract spissated to obtain " Radix Notoginseng ", " Cortex Eucommiae " and " Radix Panacis Quinquefolii ", in case of necessity, can obtain the product of its pulverizing by heat drying; Concentrate extract, in case of necessity, can obtain the product of its pulverizing by heat drying through the hot water (60-100 ℃) of doing " Rhizoma Polygonati rhizome " of chopping or ethanol (room temperature-100 ℃) extract spissated to obtain " Rhizoma Polygonati rhizome "; They are mixed, then the extract of the product of product, " Rhizoma Polygonati rhizome " extract or the pulverizing of the extract of dry " Radix Notoginseng ", " Cortex Eucommiae " and " Radix Panacis Quinquefolii " or pulverizing and " licorice " chosen wantonly or the product of pulverizing.
Food effectively blood sugar lowering and the cholesterol and the enhance immunity system of replacement medicine, food supplement, beverage products and maintaining healthy that contains the humans and animals of above-mentioned composition.
In addition, compositions display of the present invention reduce the GOT raise and the effect of GTP level.Especially, alpha-fetoprotein and albumin that Orally administered containing " Rhizoma Polygonati rhizome " and/or the compositions that contains the medicinal herbs extract of gallic acid can make the people raise reduce, this illustrates that compositions of the present invention can effectively prevent or alleviate the symptom relevant with high blood cholesterol levels, hypertension and diabetes, and can effectively prevent chronic hepatitis.Although known " Rhizoma Polygonati rhizome " and/or the medicinal herbs extract that contains gallic acid itself are difficult to be absorbed by human body or animal body, the compositions that the present invention contains " Rhizoma Polygonati rhizome " and/or contains the medicinal herbs extract of gallic acid can be absorbed by human body or animal body easily.
Compositions of the present invention can effectively be improved hepatopathy, as various hepatitis, but curiously, and its blood pressure that can not raise.
The accompanying drawing summary
Fig. 1 has shown the effect of compositions Youjo-Hensikoh of the present invention in the acute hepatitis patient.
Fig. 2 has shown the effect of Youjo-Hensikoh in HCV patient.
Fig. 3 has shown the effect of Youjo-Hensikoh in HAV and HBV patient.
Fig. 4 has shown the effect of Youjo-Hensikoh in the alcoholic hepatitis patient.
Fig. 5 has shown the effect of Youjo-Hensikoh in the toxic hepatitis patient.
Fig. 6 has shown the effect of Youjo-Hensikoh in fatty degeneration of liver disease patient.
Fig. 7 has shown the effect of Youjo-Hensikoh in the rat of handling through galactosamine.
Fig. 8 has shown that compositions K-17.22 is to the effect of rat body weight and liver wet weights as described in the present invention.
Fig. 9 has shown the effect of K-17.22 to rat Y-albumen liver content.
Figure 10 has shown the effect of K-17.22 to rat liver GSH content.
Figure 11 has shown the effect of K-17.22 to the GSH S-transferase active of the Y-part measured with selective substrate.
Figure 12 has shown the effect of K-17.22 to transaminase's blood plasma level.
Figure 13 has shown the effect of K-17.22 to the blood plasma level of cholestasis parameter.
Figure 14 has shown the effect (necrosis+inflammatory infiltration) of K-17.22 to the liver histological score.
Figure 15 has shown the change of GPT among the HCV patient.
Figure 16 has shown the change of GPT among 20 HCV patients.
The description of preferred embodiment
The present invention has used the root of Radix Notoginseng [Panax pseudoginseng (Wall)], and it is called as " Denhichi ", and this Chinese medicine is known can be improved lipid metabolism depletion and control hypertension and ease the pain.
The Eucommia bark is the dried bark of the Cortex Eucommiae (Eucommiae ulmoides) normally, and it is called as " Tochu ".This Chinese medicine is known can to reduce hypertension and high blood lipid level.
Yet the Cortex Eucommiae among the present invention or " Tochu " not only refer to " eucommia bark ", and it also comprises the leaf and the fruit of the Cortex Eucommiae.
" Denhichi-Tochu-Sei " is a kind of new Chinese medicine composition that contains Radix Notoginseng and Cortex Eucommiae, and it is invented by the present inventor." Denhichi-Tochu-Sei " makes with the root of hot water extraction Radix Notoginseng and the Cortex Eucommiae.Compositions " Denhichi-Tochu-Sei " can contain Mel and Radix Ginseng (Chinese Radix Ginseng) as additive.
" Denhichi-Tochu-Sei " of the present invention speech refers to contain the compositions of the dry extract of Chinese medicine (mainly resembling the Radix Notoginseng and the Cortex Eucommiae).
In " Denhichi-Tochu-Sei " of the present invention, the compositions of Chinese medicine is the heavy Radix Notoginseng (Denhichi) of 10-90%, it is heavy to be preferably 30-90%, the Cortex Eucommiae (Tochu) that 10-90% is heavy, it is heavy to be preferably 10-70% weight or 40-90%, the Radix Ginseng (Chinese Radix Ginseng) that 0-20% is heavy, it is heavy to be preferably 5-20%, and the heavy Mel of 0-30%.Preferred " Denhichi-Tochu-Sei " compositions of the present invention contains 30% heavy Radix Notoginseng, the 40% heavy Cortex Eucommiae, 20% heavy Radix Ginseng (Chinese Radix Ginseng) and 10% heavy Mel, or contains 30% heavy Radix Notoginseng, the 40% heavy Cortex Eucommiae, 10% heavy Radix Ginseng (Chinese Radix Ginseng) and 10% heavy Mel and 10% other material that weighs.
Among the present invention, although Radix Notoginseng and the most preferred ratio of the Cortex Eucommiae are 3: 4 in the compositions, even if with 1: 0.1-1: 9 ratio, it still has and brings high blood pressure down and the biological agent of blood cholesterol levels and enhancing immunity and so on.
Radix Panacis Quinquefolii is root, leaf or the stem done of the Radix Panacis Quinquefolii (Panax quinguefolium L.) that belongs to Araliaceae, and it is also referred to as " Seiyo Ninjin ".Plant in China in the former North America of being longer than of this medical herbs.This medical herbs to have obvious xerostomia and by diabetes cause in the flue; Cardio-pulmonary function a little less than; And the low patient of immune function who causes owing to the side effect of anticarcinogen or radiation therapy is effective.Radix Panacis Quinquefolii uses with the heavy amount of 4-50%.Known Radix Panacis Quinquefolii can be used as tonic in this field.Yet, do not know also in this field that Radix Panacis Quinquefolii can reduce patient's blood pressure.
Gallic acid is 3,4, the 5-trihydroxybenzoic acid, and it is contained in " Gallae halepensis ", " Gallaerhois ", " Gallae chinensis " and other is used as in the medical herbs of Chinese medicine.The medicinal herbs extract that contains gallic acid comprises these Chinese medicine.It is by optional weighing with 0-20%, and it is heavy to be preferably 4-20%, preferably uses with the heavy amount of 6-12%.
Rhizoma Polygonati rhizome, Siberian Solomonseal rhizome etc. are called as " Osei ", and it is to obtain from Polygonatumfalcatum A.Gray, other plant that belongs to this genus or similar plant rhizome.The original plant of " Osei " comprises Polygonatum falcatum; Polygonatum cyrtonema Hua (Polygonatum multiflorum); Polygonatum odoratum; Rhizoma Polygonati Odorati; Polygonatum cyrtonema Hua; Polygonatum sibiricum Redoute; Rhizoma Polygonati; the Yunnan Rhizoma Polygonati; Polygonatum stenophyllum Maxim.; two luxuriant Rhizoma Polygonatis; hot river Rhizoma Polygonati; polygonatum cirrhifolium Royle; Polygonatum prattii Baker; the brightly yellowish essence of point; polygonatum ran-lanscianensepamp; the leaf Rhizoma Polygonati hangs down; lattice arteries and veins Rhizoma Polygonati; the Xinjiang Rhizoma Polygonati; the wheel blade Rhizoma Polygonati; the leaf Rhizoma Polygonati hangs down; Polygonatumerythrocarpum Hua; Polygonatum filipes Merr. Ex C. Jeffrey et McEwan; Polygonatum lasianthum Maxim. etc.In this description, term " Rhizoma Polygonati rhizome " refers to all " Osei " as Chinese medicine." Osei " is known and is used as Chinese medicine, and it is for improving nutriture and promoting that health is effective." Osei " is optional to be used with the heavy amount of 0-20%, and it is heavy to be preferably 4-20%, and preferably 6-12% is heavy.
Licorice is to obtain from root of G1ycyrrhiza glabra (Glycyrrhiza glabra Linn) etc. or kernel, is also referred to as " glycyrrhiza ", " licorice ", " liquorice ", " Glycyrrhiza radix " or " Kanzo ".Licorice uses with the heavy amount of 0-15%, and it is heavy to be preferably 4-15%, and preferably 6-11% is heavy.
By double-blind trial, the main component Glycyrricine of known licorice can improve some symptom relevant with hepar damnification and can improve serum transaminase.In addition, the glycyrricine demonstration can prevent CCl
4Inductive hepatic injury (Y.Ishii, Japan J.Pharmaco, 120,71,1971).
Denhichi-Tochu-Sei among the present invention can be dissolved in the water with the compositions that contains Denhichi-Tochu-Sei, root of Rhizoma Polygonati stem extract and/or Gallae rhois and licorice and can be absorbed by live body easily, finds that simultaneously they can provide effect continuously.
Especially; by dry, heating contain the Rhizoma Polygonati rhizome and/ effect that granule that the compositions of Gallae rhois, licorice, " Denhichi-Tochu-Sei " and Radix Panacis Quinquefolii and emulsifying agent obtains or tablet have not only shown Rhizoma Polygonati rhizome and/or Gallae rhois and Radix Glycyrrhizae; also show the synergism of " Denhichi-Tochu-Sei " and Radix Panacis Quinquefolii, can improve blood cholesterol levels and blood sugar level and liver function.
Compositions of the present invention preferably contains " Rhizoma Polygonati rhizome " (or Siberian Solomonseal rhizome etc.) Chinese medicine of this being called as " Osei ".
The present inventor has invented another kind of Chinese medicine, and it contains hot water or ethanol extraction and the Mel of Denhichi (Radix Notoginseng), Tochu (Cortex Eucommiae), Osei (such as Polygonatum falcatum, Rhizoma Polygonati rhizome, Siberian Solomonseal rhizome), Kanzo (licorice).This Chinese medicine can contain Radix Ginseng (Radix Ginseng) to prepare as following examples XUI-XIX described " Youjyo-Hensikoh ".Yet Radix Ginseng can improve the patient's who accepts medicine blood pressure usually.In this case, can and Radix Ginseng (Radix Ginseng) further use Radix Panacis Quinquefolii together or replace Radix Ginseng with it.Radix Panacis Quinquefolii and above-mentioned Chinese medicine, especially " Youjyo Hensikoh " use together and can make do not raise patient's blood pressure of the latter.
A kind of exemplary method of the preparation present composition is below described.
At first,, extracted 0.5-2 hour with the mixture of 60-100 ℃ hot water with chopping with the chopping of the exsiccant Cortex Eucommiae (leaf, fruit, bark) and exsiccant Radix Notoginseng, or with the ethanol of room temperature-100 ℃ or the mixed solution extraction (extraction step) of second alcohol and water.Then, through filtering and concentration step, the extract of gained is thus mixed (blend step) with the Chinese Radix Ginseng (Radix Ginseng) and the Mel of form of extract or other suitable form.Further by under hot-air, handling " Denhichi-Tochu-Sei " that can obtain powdered.
Similarly, if necessary, with the chopping of exsiccant Radix Panacis Quinquefolii and with 60-100 ℃ hot water extraction 0.5-2 hour, or with or with the ethanol of room temperature-100 ℃ or the mixed solution extraction (extraction step) of second alcohol and water.Through filtration and concentration step, can obtain extract, handle down in hot-air then.Can obtain the Radix Panacis Quinquefolii of powdered thus.
Use similar method, can obtain the root of Rhizoma Polygonati stem extract and/or contain the medicinal herbs extract of gallic acid through the dried Rhizoma Polygonati rhizome of chopping and/or through the Chinese herbal medicine that contains gallic acid of chopping, then extracting solution is concentrated with hot water or ethanol extraction.Can obtain the Rhizoma Polygonati rhizome and/or contain the powder of the medicinal herbs extract of gallic acid by the heat drying extract.
Among the present invention, can be with 60-100 ℃ hot water, or with the ethanol or 100 of room temperature-100 ℃: 0-0: the mixed solution of 100 second alcohol and water extracts.The extract that obtains with the mixed solution of ethanol or second alcohol and water is called as alcoholic extract in this manual.
In said mixture, add emulsifying agent to make tablet by heat drying.
Rhizoma Polygonati rhizome (extract) be can contain in above-mentioned " Denhichi-Tochu-Sei " and/or the Radix Panacis Quinquefolii and/or the medical herbs (medicinal herbs extract) and the Radix Glycyrrhizae extract of gallic acid contained.
In the mixture of making tablet, add emulsifying agent.Make powder, tablet, liquor and food supplement by handling above-mentioned composition.Mel, vegetable oil, xylitol etc. can be used as emulsifying agent.The percentage by weight of emulsifying agent is 0-20% preferably.
In the scope that blending ratio is heavy at 10-80% respectively, 4-50% is heavy, 0-20% is heavy and 0-15% is heavy of " Denhichi-Tochu-Sei ", Radix Panacis Quinquefolii, Rhizoma Polygonati rhizome (extract) medical herbs (medicinal herbs extract) of gallic acid (and/or contain) and licorice.For Rhizoma Polygonati rhizome (extract) and/or contain the medical herbs (medicinal herbs extract) of gallic acid, clearer and more definite blending ratio is that 0-20% is heavy, and it is heavy to be preferably 4-20%, and it is heavy to be more preferably 6-12%.For Radix Glycyrrhizae, clearer and more definite blending ratio is that 0-15% is heavy, and it is heavy to be preferably 4-15%, and it is heavy to be more preferably 6-11%, and this will decide according to each patient's situation.
Especially, with the Emulsion of the Radix Glycyrrhizae of the Radix Panacis Quinquefolii of " Denhichi-Tochu-Sei " of pulverous Radix Notoginseng that accounts for 60% weight, 20% weight, 4-50% weight, the Rhizoma Polygonati rhizome of 8% weight the medicinal herbs extract of gallic acid (and/or contain), 8% weight and 4% weight mixed compositions all be suitable for making various forms of food supplements.
Compositions of the present invention can be made into to be fit to do to replace powder, granule, tablet and the dry syrup of medicine, food supplement etc.The content of the present composition is every 0.1-0.5g, or accounts for the 0.1-30% that replaces medicine or food supplement weight, is preferably the 1-5% that accounts for weight.
For by heat drying " Denhichi powder ", " Denhichi-Tochu-Sei ", Radix Panacis Quinquefolii, Rhizoma Polygonati rhizome and/or contain the medicinal herbs extract of gallic acid and the tablet of the mixture gained of Radix Glycyrrhizae, the content of the present composition should be 0.25g/ sheet or still less.
The daily intake of suitable above-mentioned " Denhichi-Tochu-Sei " is 0.1-2g/kg, is preferably 0.1-0.25g/kg.
In the present invention, house pet comprise can be by the animal of artificial rearing, bird and fish (Canis familiaris L., cat, monkey, rabbit, chicken, duck, Carassius auratus).
In addition, in pig, cattle and horse (comprising horse racing) are also included within.
In addition, compositions of the present invention can be added in the food of cake, confection, bread, wine, Chinese liquor, curry and any maintaining healthy.
Explanation and the embodiment detailed have been write out below to the present invention.
Example I: to the analysis of " Denhichi-Tochu-Sei " (granule):
Table (i) has been listed the analytical data of " Denhichi-Tochu-Sei " (granule), and it contains 30% heavy Radix Notoginseng, 40% heavy Cortex Eucommiae, 20% heavy Radix Ginseng and 10% heavy Mel.
In following examples, the compositions of example I is used as " Denhichi-Tochu-Sei " (granule).
Table (i): the analytical table of " Denhichi-Tochu-Sei " (granule)
| Protein content | 8.28％(w/w) |
| Sugar content | 25.30％(w/w) |
| The elementary analysis value | C：40.95％ H：6.68％ N：0.29％ |
| Free amino acid: mg/100g granule | Asp：2.18 Ser：2.74 Gly：0.34 Ala：0.28 Gln：6.41 Ile：0.65 Lys：1.79 |
Table has (ii) shown the content of elements with above-mentioned " Denhichi-Tochu-Sei " (granule) of aas determination.
Show (ii): the result who above-mentioned " Denhichi-Tochu-Sei " (granule) is carried out the trace element test
| Element | μg/g | Element | μg/g |
| Na | 25.0 | Fe | 7.63 |
| K | 51.0 | Ca | 304 |
| Si | 0.181 | Water | 8.88％ |
| Sn | ＜0.413 | Ash | 0.42％ |
| Mg | 526 | ||
| Zn | 4.39 |
Example II: " Denhichi-Tochu-Sei " (granule) is to the effect of the serum cholesterol of the rat that suffers from hyperlipemia
Rat (180-200g heavy) and mice (18-20g weight) are divided into four groups (every groups 10 rats and mice).These four groups is A) normal group, B) hyperlipemia group (obtaining) with the high fat diet nursing, C) hyperlipemia group (using " Denhichi-Tochu-Sei " (granule) of high dose) and D) hyperlipemia group (using " Denhichi-Tochu-Sei " (granule) of low dosage).In C group and D group, in stomach, use " Denhichi-Tochu-Sei " and high-fat feedstuff by gastric intubation always, carried out like this 30 days.After using 1 hour for the last time, from the vena ophthalmica of rat, take out blood sample, therefrom isolate serum.Detect the level of cholesterol, triglyceride, low-molecular-weight lipoprotein, LDL and the high molecular lipoprotein of serum with the serum biochemical analyzing equipment CX5 of Beckman.The result be presented at table (iii) in.
Show (iii) clear the demonstration and in high fat diet, add the appearance that " Denhichi-Tochu-Sei " (granule) can prevent hyperlipemia.That is, reduction and the high molecular lipoprotein of having observed serum cholesterol and low-molecular-weight lipoprotein in C group and D group have raising slightly, and the reduction of triglyceride.In fact, by normal group (A) or the value that only adopts the group (B) of high fat diet to obtain, and between the value that obtains by the group that adopts high dose " Denhichi-Tochu-Sei " statistically-significant difference (reference table (iii)) is arranged.
EXAMPLE III: " Denhichi-Tochu-Sei " (granule) is to the effect of the mice of compromised immune
Mice is divided into three groups, that is, and normal group as a comparison, the group of compromised immune and give the group of the compromised immune of " Denhichi-Tochu-Sei " (granule).This immune system of three groups is compared.As from visible showing (iv), as if be improved in the immune system of using each mice of " Denhichi-Tochu-Sei " (granule) back.
Show (iv): " Denhichi-Tochu-Sei " (granule) is to immune effect
| Group | The animal number | Dosage (g/kg) | The K value |
| Normal group (contrast) | 10 | 0.079±0.098 | |
| The model group of compromised immune | 10 | 0.034±0.015 | |
| Compromised immune is also used the model group of " Denhichi-Tochu-Sei " (granule) | 10 | 2 | 0.060±0.024 |
* compare P＜0.01 with the model group of compromised immune
EXAMPLE IV: anti-fatigue test:
(heavy 18-20g) is divided into two groups with mice.One group is normal group, and another kind is to use 20 days group of " Denhichi-Tochu-Sei " (granule).Table (result who has v) shown anti-fatigue test, use the last time after 1 hour and carry out by this test.In test, on the tail of mice, enclose the iron block that is equivalent to its body weight 10%, and allow mice 40cm length * 28cm wide * 30cm is dark, water temperature is to swim in 20 ℃ the temperature bath.The time (second) of record swimming.The result is presented at table (v).
Table (v): the swimming time of using the heavy burden mice of " Denhichi-Tochu-Sei " (granule)
| Group | The animal number | Dosage (g/kg) | Swimming time (second) |
| |
10 | 60.42±18.81 | |
| Use the group of " Denhichi-Tochu-Sei " (granule) | 10 | 2 | 100.72±31.91 |
P＜0.01
Table (use the swimming time of the group of " Denhichi-Tochu-Sei " (granule) and obviously be longer than normal group by v) clear the demonstration.The result shows that " Denhichi-Tochu-Sei " (granule) can promote the antifatigue ability.
EXAMPLE V: to the effect of the mice that suffers from hyperglycemia
Used blood sugar level to surpass the mice of 180mg/dl in this test.Mice (21-23g heavy) is divided into three groups, and group that the group of normal mouse, blood sugar level are high and blood sugar level are high and use the group of " Denhichi-Tochu-Sei " (granule).Detect their blood sugar level.The result is presented at table (vi).After the hyperglycemia mice was accepted " Denhichi-Tochu-Sei " (granule), the higher blood sugar level of mice reduced to normal level.The result shows, " Denhichi-Tochu-Sei " (granule) has the ability of blood sugar level that effective control suffers from the mice of diabetes.
Example VI: " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " (mixed extract) are to the effect of the rat blood cholesterol of suffering from hyperlipemia
Rat and mice are divided into following four groups (every group of 10 rats and 10 mices).They are A) normal group, B) hyperlipemia group (obtaining) with the high fat diet nursing, C) hyperlipemia group (using " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " (being also referred to as mixed extract later on) of high dose), D) hyperlipemia group (using the mixed extract of a small amount of " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice ").
The composition of mixed extraction compositions is 20% heavy " Denhichi-Tochu-Sei ", 8% " the Gallae rhois " that weighs and 8% heavy " licorice " in present embodiment and following examples.In C group and D group, use mixed extract and high-fat feedstuff by gastric intubation always, carried out like this 30 days.After using 1 hour for the last time, from the vena ophthalmica of rat, take blood sample, therefrom isolate serum.Detect the level of cholesterol, triglyceride, low-molecular-weight lipoprotein, LDL and the high molecular lipoprotein of serum with the serum biochemical analyzing equipment CX5 of Beckman.The result is presented at table (vii).
(result vii) as can be seen, the mixed extract that adds " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " in high fat diet can prevent the appearance of hyperlipemia from table.That is, observed the reduction of serum cholesterol and low-molecular-weight lipoprotein in C group and D group, the high molecular lipoprotein has raising slightly, and the reduction of triglyceride.By normal group (A) or the value of obtaining only for the group (B) of high fat diet, with by the group C that gives mixed extract) and the value that D) obtains between statistically-significant difference is arranged.
Example VII A: the mixed extract of " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " is to the effect of hepatopathy
Table (Viii) has shown that the mixed extract of " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " is to suffering from the effect by the rat (n=8) of the inductive hepatopathy of D-glycosamine (800mg/kg).
(viii): the mixed extract (2000mg/kg) of " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " is to suffering from the effect by the rat (n=8) of the inductive hepatopathy of D-glycosamine (800mg/kg) for table
| Normal group | Use the group of doses mixed extract | |
| GPT(μ％±S.D) | 1012±220 | 730±17 |
| GOT(μ％±S.D) | 1696±130 | 1252±35 |
Example VII A I: the mixed extract of " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " to by the lipid peroxidation of tetrachloro-methane induction, lipid and
14CCl
4The influence of generation, NADPH oxidation and oxygen consumption of combination, CO
Table (ix) shown to by the lipid peroxidation of tetrachloro-methane induction, lipid and
14CCl
4The influence of generation, NADPH oxidation and oxygen consumption of combination, CO
Embodiment X: to the effect of the high mice of blood sugar level
When every day by vein when mice (body weight 21-23g) is used streptozotocin solution (90mg/kg), mice just has hyperglycemia, loses weight and has the situation that amount of drinking water and voided volume increase.
This embodiment has used blood sugar level to be 180mg/dl or higher mice.Mice (body weight 21-23g) is divided into three groups, and group that the group of normal mouse, blood sugar level are high and blood sugar level are high and use the group of mixed extract (granule).Detect their blood sugar level.The result is presented in the table (x).After the hyperglycemia mice was accepted mixed extract (granule), the higher blood sugar level of mice became near normal level.Mixed extract of the present invention (granule) can effectively be controlled the mouse blood sugar level of suffering from diabetes and raise.
Can know from above-mentioned animal experiment and to draw to draw a conclusion.
1) mixed extract that use " Denhichi-Tochu-Sei " and " Denhichi-Tochu-Sei ", contains the medicinal herbs extract of gallic acid and " licorice " has the effect that reduces the rat hyperlipidemia, simultaneously can reduce serum cholesterol and the low-molecular-weight lipoprotein of mice, improve the high molecular lipoprotein slightly, and triglyceride reducing.
2) use the mononuclear phagocyte of " Denhichi-Tochu-Sei " can activating immune system impaired mice.
3) chronic administration " Denhichi-Tochu-Sei " is effective to the anti-fatigue ability that improves mice.
4) serum GTP, GOT level that the mixed extract that use " Denhichi-Tochu-Sei ", contains the medicinal herbs extract of gallic acid and " licorice " suffers from by the rising of the rat of the inductive hepatopathy of D-glycosamine reduction are effective.
5) mixed extract that use " Denhichi-Tochu-Sei ", contains the medicinal herbs extract of gallic acid and " licorice " to by the rat MDA generation of tetrachloro-methane induction, lipid and
14CCl
4Combination, generation, NADPH oxidation and the oxygen consumption of CO inhibitory action is arranged.
6) use " Denhichi-Tochu-Sei " and use " Denhichi-Tochu-Sei ", the mixed extract that contains the extract of medicinal herbs of gallic acid and " licorice " has and reduces the effect of suffering from by the rat blood sugar level of the inductive hyperglycemia of streptozotocin.
The above results has shown that " Denhichi-Tochu-Sei " has preventive effect to hyperlipemia, and the mixed extract of " Denhichi-Tochu-Sei " and " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice ", or they are added in the food and with the obvious blood sugar lowering level of the forage feed that has added them.Mixed extract has the effect that improves liver function simultaneously.These results prove that the present invention can effectively promote human and animal's health.
And, what deserves to be mentioned is, in any animal experiment, all do not observe the side effect that comprises acute toxic and side effects.
Embodiment 11: the mixed extract of " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " is to the therapeutic effect of the symptom of chronic viral hepatitis C patients
Treated HCV patient (male, 50 years old) about 3.5 months with interferon (IFN), the GOP and the GTP that do not observe him have any improvement.On the other hand, the mixed extract treatment patient by using " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " is after 10 days, and the GOP level has dropped to 89 from 159, and GTP has dropped to 48 from 204.The result is presented in the table (xi).
Embodiment XII: the mixed extract of " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " is to the therapeutic effect of non-viral hepatitis:
Treat women's non-viral hepatitis after 10 days with " Denhichi-Tochu-Sei " of doses, the mixed extract of " Gallae rhois " and " licorice ", the GOP level has dropped to 39 from 53, and GTP has reduced by 35 from 58.The result is presented in the table (xii).
Embodiment XIII: the mixed extract of " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " is to the effect of hepatitis B patient:
Treat the patient (male, 70 years old) 10 days of a HBs antibody positive with the mixed extract of " Denhichi-Tochu-Sei " of doses, " Gallae rhois " and " licorice ".Behind the acceptable dose the 4th day, his GOP level have dropped to 23 from 28, and GTP is reduced to 28 from 60.The result is presented in the table (xiii).
Table (xiii)
| 99/199/2 | |
| Mixed extraction (the 4th day) (the 8th day) thing (first day) is used in prescription on individual diagnosis | |
| AST(GOT) ALT(GTP) γ-GTP | 55-115 82 23 27 56-123 60 28 15 33-51 35 27 24 |
Embodiment XIV: the mixed extract of " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " is to drug induced hepatitis patient's effect:
Treated a drug induced hepatitis patient (male, 30 years old) 10 days with " Denhichi-Tochu-Sei " of doses, the mixed extract of " Gallae rhois " and " licorice ".After discontinuing medication the 5th day, GOP level have dropped to 32 from 43, and GTP has reduced by 27 from 121.The result is presented in the table (xiv).
Table (xiv)
| ’98/11 ’99/1 | |
| Leaving hospital began to use the 17th day that mixes the 5th day of stopping to use the back extract after stopping to use | |
| AST(GOT) ALT(GTP) | 66 43 32 38 200 121 27 88 |
Embodiment XV: the mixed extract of " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice " is to the effect of chronic active hepatitis C patients symptom:
The patient of an abnormal liver function (GOT 80, and GTP 102, and γ-GTP 68) treats weekly three times with the interferon of doses, treats for two weeks altogether.Treatment side effect appearred on the 11st day.Therefore use " Denhichi-Tochu-Sei " of 6g dosage every day to replace interferon therapy 6 days.Side effect has disappeared, and liver function has been improved (GOT60, GTP 47, γ-GTP 17).Yet the amount of virus still remains unchanged.After leaving hospital, the patient has accepted inferior on every Wendesdays interferon, after about two weeks, treats a week with " Denhichi-Tochu-Sei " of 3g dosage every day, the mixed extract of " Gallae rhois " and " licorice ".The amount of virus has dropped to 0.5Meq/ml or lower.Liver function recovery is to normal level (GOT 31, and GPT 8, and γ-GTP 14).Use the mixed extract of " Denhichi-Tochu-Sei ", " Gallaerhois " and " licorice " and observed normal liver function (GOT 25, and GTP 9, and γ-GTP 12) after two months.The result is presented in the table (xv).
Table (xv)
| 7/29 | 8/18 | 8/19*1 | 8/25 | 9/11*2 | 9/18 | 11/24 | |
| AST(GOT) ALT(GTP) γ- |
80 102 68 | 50 58 83 | 60 47 17 | 31 8 14 | 25 9 12 |
* 1 begins to use interferon and " Denhichi-Tochu-Sei "
* the mixed extract of 2 " Denhichi-Tochu-Sei ", " Gallae rhois " and " licorice "
As mentioned above, the mixed extract of " Denhichi-Tochu-Sei " of the present invention and " Denhichi-Tochu-Sei ", the extract of medicinal herbs that contains gallic acid and " licorice " can be used as the food supplement (feed additive) of maintaining healthy.Compositions of the present invention is proved to be effectively prophylaxis of hypertension and hepatopathy.Prove that also they are to maintaining healthy with improve nutriture and immune system is effective.Especially, if contain the extract and " licorice " mix preparation with " Denhichi-Tochu-Sei " of the medicinal herbs of gallic acid, these two kinds of compositions can be absorbed by the human and animal easily.In addition, observing above-mentioned preparation can tell on rapidly.
Embodiment XVI:Youjyo-Hensikoh is to various hepatopaths' effect
Made the Chinese herb drugs prescription that is called as " Youjyo-Hensikoh " from the hot water extract of Radix Notoginseng (" Denhichi ") (55% weight), the Cortex Eucommiae (" Tochu ") (25% weight), Rhizoma Polygonati rhizome (Polygonatumfalcatum) (" Osei ") (10% weight), licorice (Glycyrrhiza licorice) (" Kanzo ") (5% weight), Ginseng root (Radix Ginseng) (3% weight) and Mel (2% weight).
Under doctor's guidance, allow the patient (n=20) who suffers from the various hepatopathys that comprise HCV oral 1 restrain above-mentioned prescription, every day three times after the meal.Detect the serum levels of patient ALT, AST and γ-GTP.
With " Youjyo-Hensikoh " treatment 10 days after these serum levels significantly reduced (ALT has on average reduced by 18%, and AST has on average reduced by 59%).For the normal person, Serum ALT and AST level almost do not change.When treatment, do not observe any side effect.
The result is presented among Fig. 1-6.
Embodiment XVII:Youjyo-Hensikoh is to the effect of the rat of handling through the D-glycosamine
Rat (n=9) 2 milliliters of Youjyo-Hensikoh of orally give (50mg/ml) of the 3rd group, and to the rat skin lower injection 1ml D-glycosamine solution (800mg/kg) of the 2nd group (n=9) and the 3rd group.The 1st group (n=8) in contrast.After 24 hours, stop feed.Use Youjyo-Hensikoh and gather blood after 48 hours, measure ALT and AST then.The result is presented among Fig. 7, and result wherein represents that with the form of meansigma methods ± SD * represents p＜0.01 when comparing with group 1 (contrast), and * * represented p＜0.01 when group 2 (D-glycosamines) compared.
Embodiment XVIII:Youjyo-Hensikoh is to CCl
4The effect of glutathione metabolism during inductive liver cirrhosis
From Radix Notoginseng (" Denhichi ") (55% weight), the Cortex Eucommiae (" Tochu ") (25% weight), Rhizoma Polygonati rhizome (Polygonatumfalcatum or Siberian Solomonseal rhizome) (" Osei ") (10% weight), licorice (Glycyrrhizalicorice or Glycyrrhiza glabra Linn) (" Kanzo ") (5% weight), made among the hot water extract of Ginseng root (Radix Ginseng) (3% weight) and Mel (2% weight) and be called as " Youjyo-Hensikoh " herbal composite (k-17.22).
The female albefaction Wistar rat (in 3 ages in week, body weight is 60-75g) that to raise in isolated cage (be placed on can free food sanitation standard food and the ecological feed lot that controls environment of deionized water in) is divided into three groups:
A) subcutaneous injection 0.1ml/100g body weight is dissolved in the CCl of olive oil
4(1: 1v/v), twice, 5 week weekly;
B) as A, and CCl
4The injection while, oral again 50mg/kg was dissolved in the K-17.22 of 5% glucose;
C), inject CCl for the first time as A
4Oral again 50mg/kg is dissolved in the K-17.22 of 5% glucose after one week.
Organize in contrast with independent subcutaneous injection olive oil.
(the last injection is after 3 days) put to death rat when conceptual phase finishes, and obtain blood and liver sample.The supernatant part of preparation liver
Method with (Biochem Pharmacol, 1977) such as Iga prepares 50% tissue homogenate.A part of tissue homogenate is used for GSH to be measured.Remaining with the 65p-7 of Hitachi supercentrifuge 4 ℃ with 150, centrifugal 120 minutes of 000g.Immediately the supernatant partial gel is filtered after the measurement volumes.
The eluting of supernatant
The 3ml supernatant is added to Sephadex G-75 post (on 2.5 * 100cm).Under 4 ℃, drive with pump and to flow downward (2ml/40 minute/test tube), carry out eluting with the phosphate buffer (pH7.4) of 0.01M.With 1-chloro-2,4-dinitro benzene (CDNB) is as substrate, measure from the GST activity of a liquid of 200 μ l of corresponding all test tubes of Y-part.With all show the active test tube of GST merge ,-80 ℃ of following lyophilizing and be kept at-40 ℃ up to measuring.
Analytic process
With exsiccant Y-protein dissolution in phosphate buffer (pH 7.4), and with (J.Biol.Chem. such as Habig, 1951) method of Miao Shuing is with CDNB and 1,2-two chloro-4-Nitrobenzol (DCNB) are measured the activity of GST as substrate, measure the concentration of Y-albumen and GSH in the liver tissue homogenate respectively with Lowry-Folin and Ellman method.Measure plasma A LT and AST with E.C. 1.2.3.3-parachlorophenol method.
Independently cut into slices under the unwitting situation of examiner with 3 downright bad and inflammatory infiltration are carried out the evaluation (1+: there is a focus in each visual field, 2+: there are two or more focuses in each visual field) of liver histological.
Statistical analysis
Listed standard error (meansigma methods ± S.E.) together with meansigma methods.The t check is used to determine contrast and CCl
4-or CCl
4The significance of difference between the+K-17.22 processed group.
The results are shown among Fig. 8-14.
These figure have shown that compositions K-17.22 is to the effect (Fig. 8) of body weight and the liver wet weights of rat as described in the present invention, K-17.22 is to the effect (Fig. 9) of rat Y-albumen liver content, K-17.22 is to the effect (Figure 10) of rat liver GSH content, adopt selected substrate to measure, K-17.22 is to the effect (Figure 11) of GSH S-transaminase activity in the Y-part, K-17.22 is to the effect (Figure 12) of the blood plasma level of transferring enzyme, K-17.22 is to the effect (Figure 13) of the blood plasma level of cholestasis parameter, and K-17.22 to the effect (necrosis+inflammatory infiltration) of liver histological score (Figure 14).These data declarations:
1) K-17.22 is at CCl
4In the inductive hepatic injury GSH and the proteic reduction of Y-there are remarkable inhibitory action, and can obviously improve relevant hepatic necrosis and cholestatic blood parameters;
2) the obvious reduction that necrosis-inflammation and fibre modification change in this variation and the liver is parallel;
3) what is interesting is, even if at CCl
4Poisoning, the beginning back is this unusually also to improve to some extent;
4) because antioxidation may take place in the inherent useful mechanism of K-17.22.
The effect that embodiment XIX:Youjyo-Hensikoh changes hepatitis C patients GPT
From the water extract of Radix Notoginseng (55% weight), the Cortex Eucommiae (25% weight), Rhizoma Polygonati rhizome (Polygonatum falcatum) (10% weight), licorice (Glycyrrhiza licorice) (5% weight), Ginseng root (Radix Ginseng) (3% weight) and Mel (2% weight), made Youjyo-Hensikoh.Made every tablet of tablet that contains 250mg Youjyo-Hensikoh.
Allow 20 hepatitis C patients after regular meal, take two, every day three times.Table (xvi) and Figure 15 and 16 have shown the change of patient GPT.
This embodiment be for show when and Radix Panacis Quinquefolii use " Youjyo-Hensikoh " when being made into compositions of the present invention together, the rising of patient's blood pressure has been suppressed.
With the leaf and the stem of water rinse Radix Panacis Quinquefolii, drying is also cut into slices.With the part of these sheets bubble in the water of 8 times of amounts and be heated to 40 ℃ or higher temperature 30 minutes, 2.5 hours after-filtration.Then, with the above-mentioned section of water logging bubble another part of 6 times of amounts, 1.5 hours after-filtration.Be concentrated to primary volume with the mixing of two parts filtrate and by heating.With concentrated solution and 60 parts of " Youjyo-Hensikoh " mixing that weight prepares in embodiment XVI of 40 parts of weight, dry then and granulating.The granule that obtains is wrapped in the capsule, make this capsule contain each composition of 150mg.
Allow two patients that suffer from different hepatopathys use the capsule that contains the present composition that makes thus, 56 years old male of the first (patient A), another is male's (patient B) of 61 years old.Allow each patient regular meal the back oral two capsules, every day three times.Measure patient's blood pressure every day before the breakfast.
Table 1 has shown in the variation of using compositions of the present invention front and back patient's blood pressure.The blood pressure of patient A month before medication is 152-168/93-107 (maximum/minimum), but it is lower to accept his blood pressure in that middle of the month of the present composition continuously at him, is 144-158/82-96 (maximum/minimum).The blood pressure of patient B month before medication is 157-170/99-110 (maximum/minimum), but it is lower to accept his blood pressure in that middle of the month of the present composition continuously at him, is 140-175/89-102 (maximum/minimum).
The method of the routine that usually adopts with this field is extracted flavonoid (being called the Radix Panacis Quinquefolii flavone later on) from the leaf of Radix Panacis Quinquefolii, and studies influence to cat and rat blood circulation with it.If this research determines whether blood circulation is had new effect, and whether the Radix Panacis Quinquefolii flavone can be used for food, food supplement, medicine etc.
Cat (heavy 1.2-1.7kg, the male and female number equates) and Wister rat (heavy 220-270g, the male and female number is identical) are used in this research.
24 cats are divided into four groups.(concentration 30g/l is 3.0mg/kg) with they anesthesia with pentobarbital for intraperitoneal.Dosage with 0.1g/kg (the 2nd group), 0.3g/kg (the 3rd group) or 1.0g/kg (the 4th group) is used the Radix Panacis Quinquefolii flavone in jugular vein.Do not accept any dosage for the 1st group, in contrast.Before and after using, measure HR, MAP, LVP, LVEDP and " ± dp/dtmax ".The gained data are carried out statistical procedures and are summarised in the following table 2.
Simultaneously, 18 rats are divided into two groups.(concentration 200g/l 2g/kg) anaesthetizes them through peritoneum with urethane.With the dosage of 1.0g/kg through groin intravenous administration Radix Panacis Quinquefolii flavone.Matched group is accepted normal saline.Before and after using, observe the number of times of breathing and the variation of frequency, blood pressure and heart rate.The gained data are carried out statistical procedures and are summarised in the following table 3.
As can be seen from Table 2: use the MAP that the Radix Panacis Quinquefolii flavone has reduced cat.LVP and "+dp/dtmax " are dose dependents in the scope of 0.1g/kg, 0.3g/kg and 1.0g/kg." dp/dtmax " has the trend of reduction.Medication does not influence LVEDP or HR.
As can be seen from Table 3: compare with the contrast of accepting normal saline, use the blood pressure that the Radix Panacis Quinquefolii flavone has reduced rat, reduced the number of times of heart rate and breathing simultaneously, and respiratory frequency is not had substantial effect.
As mentioned above, the Radix Panacis Quinquefolii flavone has obviously reduced MAP, LVP and "+the dp/dtmax " of cat, and the hypotensive activity that blood pressure and heart rate are reduced is arranged simultaneously.The mechanism that this explanation blood pressure reduces is because the expansion of peripheral vessels.
Claims (14)
1. compositions, it contains Radix Notoginseng; The Cortex Eucommiae; Polygonatum falcatum, Rhizoma Polygonati rhizome or Siberian Solomonseal rhizome; The hot water of licorice or ethanol extraction, and Mel; It is characterized in that described compositions also contains Radix Panacis Quinquefolii.
2. compositions as claimed in claim 1, wherein said compositions contains Radix Ginseng.
3. compositions as claimed in claim 1, wherein said compositions contains the Denhichi-Tochu-Sei of 10-80 weight %; The Radix Panacis Quinquefolii of 4-50 weight %; The Rhizoma Polygonati rhizome of 4-20 weight % and/or contain the medical herbs of gallic acid, the licorice of 4-15 weight %, wherein said Denhichi-Tochu-Sei is by the Radix Notoginseng of 10-90 weight %, the Cortex Eucommiae of 10-90 weight %, the Radix Ginseng of 5-20 weight %, and the Mel of 0-30 weight % is formed.
4. medicine that contains just like claim 1,2 or 3 described compositionss.
5. claim 1,2 or 3 described compositionss are used for maintaining healthy and improve application in the medicine of nutritional status in preparation.
6. claim 1,2 or 3 described compositionss are used for improving hepatopathy and application in the medicine of the blood pressure that do not raise in preparation.
7. application as claimed in claim 6, wherein said hepatopathy is a hepatitis.
8. application as claimed in claim 7, wherein said hepatitis is selected from hepatitis C, chronic hepatitis and hepatitis B.
9. claim 1,2 or 3 described compositionss are used for preventing or treat application in the pancreatitic medicine in preparation.
10. food supplement that contains just like claim 1,2 or 3 described compositionss.
11. as food supplement as described in the claim 10, described compositions contains the 10-80% heavy Radix Notoginseng and the Cortex Eucommiae, the Radix Panacis Quinquefolii that 4-50% is heavy, the licorice that Osei member that 4-20% is heavy and 4-15% are heavy.
12. the food of a maintaining healthy, it contains the described food supplement of the heavy claim 10 of 0.1-20%.
13. the food of maintaining healthy as claimed in claim 12, it is the form of powder, powdered granule, tablet, beverage and Emulsion.
14. feedstuff that contains just like claim 1,2 or 3 described compositionss.
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