CN100467087C - Cranial nerve electrostimulating device capable of remotely controlling exercise behevior - Google Patents

Cranial nerve electrostimulating device capable of remotely controlling exercise behevior Download PDF

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Publication number
CN100467087C
CN100467087C CNB2005100473364A CN200510047336A CN100467087C CN 100467087 C CN100467087 C CN 100467087C CN B2005100473364 A CNB2005100473364 A CN B2005100473364A CN 200510047336 A CN200510047336 A CN 200510047336A CN 100467087 C CN100467087 C CN 100467087C
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China
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cranial nerve
remote
control
motor behavior
stimulation device
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CNB2005100473364A
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Chinese (zh)
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CN1775323A (en
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王宏
彭靳
崔乃英
李封
王世强
曹英
刘冲
张敏
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东北大学
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Abstract

The present invention relates to a cranial nerves electric stimulator device capable of remotely-controlling animal motion behavior. It is formed from remote controller, sound stimulator, PC machine, cranial nerves electric stimulator, brain stimulation electrode and motion training device (tank). Said invention mainly is used for training animal, also provides its working principle and application method.

Description

The cranial nerve electrical stimulation device of remote-controlled motor behavior

Technical field

The invention belongs to the biomedical engineering technology field, particularly a kind of cranial nerve electrical stimulation device of remote-controlled animal movement behavior.

Background technology

All activities of human or animal are all by brain control, and brain is so perfect to the control of human or animal's physiological activity, and present any machine is all incomparable.The secret of exploring brain becomes the front line science of 21 century.Scientist proposes, and 21 century is " brain science epoch ", and it comprises understands brain, protection brain and create brain.Research is the basic structure of research brain mostly to brain at present, but the Premium Features of research brain, such as many than the basic structure complexity of research brain of the understanding of motor control, learning and memory, emotion, language, consciousness etc., it may making a breakthrough property progress, drive the development of entire society.

Which kind of principle is brain followed actually and is controlled the organ of locomotion of health in an orderly manner to satisfy the needs of people's behavior purpose? so far also be individual an open question still.Along with people step into 21 century, the scholar of subjects such as biology, automatization and computer enters this field one after another, is engaged in the research of the brain science relevant with this subject.

The top layer of brain is called cerebral cortex, and it is the neutral net that is combined by various nerves, has different brain function zones, is controlling the behavior of animal.So-called behavior is that animal is the inter-related various reaction systems that conform and done, and comprises the movement response of stimulation to external world and the reaction of speech and emotion.With the limb motion is example, it is to send the signal of telecommunication or owing to stimulating the signal of telecommunication produce by corticocerebral motor region, this signal of telecommunication is transmitted to peripheral nervous system along nerve fiber from the central nervous system, the signal of telecommunication of nervous system identification and environmental correclation, and carry out interaction between neuron pool, synapse, to realize reaction incident to signal.Relation for stimulus modelity and motor behavior still is the important topic of a needs further investigation at present, we inquire into the behavior effect of nerve electric stimulation to animal to this, seek the relation between the reaction of nerve electric stimulation pattern and animal behavior, set up the proprietary cranial nerve electric stimulation that a cover responds to animal behavior.

Not long ago, the research worker of Brown Univ USA had been implanted one piece of electronic chip in the man's of a serious paralysis brain, and when he wanted to move his arm, chip just transferred to computer to signal, and computer is moving cursor on display screen just.In the test, can do some simple things, such as the control television set from this patient who paralyses fully below the cervical region.Germany scientist had once successfully been formed a circuit with a silicon chip and the neurocyte that absorbs from the Limax brain.The scientists of Chicago Northwest University has been designed a kind of robot that is controlled by the brain of Lampetra japonica (Martens). fish.When the pick off of robot was perceived light, they just sent a signal to the neurocyte of fish.Neurocyte is taken action according to this information, and the indication robot moves towards light source.This reaction helps this fish to swim into along correct road in the ocean usually.But, control external electronic by the mode of remote control and control the motor behavior of human body or animal and do not appear in the newspapers as yet.

Apparatus of the present invention are different with other researchs, it is from other angle research " brain chip ", promptly send instruction by remote controller and give the cranial nerve electrostimulator, this stimulator sends with electric pulse like the cerebral nerve pulsion phase and acts on the motion that cerebral nervous system comes the commander human or animal.It more than is this apparatus features.

Summary of the invention

The objective of the invention is brain and electronic installation are linked together, with electronic installation instead of part brain function, this technology will make the paralytic obtain new life in the successful Application of human body, and the paralytic can be by the electronic installation control individual behavior of implanting.This technology has the important use meaning in military, public security field, the mode of its use for electronic equipment remote control by inserting animal brain is controlled the behavior of animal, make animal in the autotelic activity in the unapproachable area of people, this will be reduced in the human danger that is faced in hazardous environment and the battlefield greatly.

The outfan of apparatus of the present invention is silver-plated stimulating electrodes, and this electrode is implanted in experimenter's brain; Apparatus of the present invention have distant control function, produce different output signal remote controls by this device and control cerebral neural activity, control experimenter's motor behavior at last.

The waveform pattern of cranial nerve electric stimulation pulse signal directly influences the effect of stimulation, and it also is a key technology of the present invention.Here set up the distinctive stimulating method of a cover, promptly stimulated the waveform and the frequency of the neuroelectric pulse that produces in the waveform of electric pulse and frequency and the brain close, made that the signal of the signal of electronic installation generation and cerebral activity is close.

The behavior reaction of animal also is a kind of process of learning and memory, and simple stimulation does not have learning training to get a desired effect.Be provided with corresponding sports-training apparatus (case) in the present invention, this device combines with cranial nerve electrical stimulation device, sonic stimulation device for this reason, has constituted the cranial nerve electrical stimulation device of a cover perfect control animal movement behavior.

Apparatus of the present invention comprise remote controller, sound stimulation device, PC, cranial nerve electrostimulator, brain stimulation electrode, sports-training apparatus (case).Remote controller sends instruction to the cranial nerve electrostimulator, by serial port PC is issued in this instruction then, brings into operation; The cranial nerve electrostimulator sends corresponding electric pulse simultaneously, and this electric pulse enters brain to stimulate cerebral nerve by the brain stimulation electrode of implanting, and cerebral nerve domination body produces the motor behavior reaction.Motor behavior carries out in training box.In order to formulate the pattern of the nerve stimulation signal of telecommunication, designed sound stimulation device in the system, in order to auxiliary cranial nerve electrostimulator.Before electricity irritation, use earlier the sonic stimulation animal, by the PC signal of sounding, PC sends the signal of telecommunication by serial port to the hazardous area of sports-training apparatus or case copper mesh simultaneously, when animal is jumped into opposite side and is the place of safety by the hazardous area, send signal in the mode of infrared ray control and stop acoustical signal by serial port notice PC.

Wherein, the cranial nerve electrostimulator comprises oscillating current generation circuit, power amplifier, transforming circuit and remote control output circuit.The stimulus signal of remote controller emission is input to oscillating current generation circuit, multivibrator output rectangular pulse signal through oscillating current generation circuit, regulate the waveform and the frequency of stimulus signal again through slide rheostat, after power amplifier amplifies signal, drive transforming circuit, the neuroelectric pulse waveform electric pulse close with frequency of output waveform and frequency and brain generation launched this signal by the remote control output circuit then.

Oscillating current generation circuit is a multivibrator, and high-triggering end links to each other with low triggering end, and by capacity earth, voltage controling end also passes through a capacity earth, the termination that resets high potential, and outfan obtains rectangular pulse signal.The frequency of boost pulse is regulated by the slide rheostat that is connected on high-triggering end and discharge end.

Power amplifier comprises direct-coupled dual-stage amplifier, realization be the power amplification function, to drive transforming circuit.

Transforming circuit comprises the coil type AC transformer, coil type AC transformer input is provided the electric current that needs by power amplifier, with drive coil formula AC transformer, the neuroelectric pulse waveform electric pulse close that coil type AC transformer outfan output waveform and frequency and brain produce with frequency.

Remote control output circuit, pulse current adopt remote control control output, to satisfy the demand of particular job.The emitter operating frequency is 315MHZ, and receiver module adopts the manufacturing of SMD paster technique to produce, and is the superregenrative reception mode, and it includes amplifies shaping and decoding circuit.Press the button of emitter, the relay of receiver module is with regard to adhesive, circuit turn-on, and button is unclamped in pulse current output, and relay discharges synchronously, and circuit disconnects.

Sound stimulation device hardware is made up of PC and speaker.The sounding order is produced by PC, and the generation of sound is to utilize Microsoft Foundation Class software, realizes under Microsoft Visual C++6.0 environment.This software can produce the sinusoidal sound wave of different frequency, different amplitudes, exports to speaker by sound card, as the sonic stimulation signal.This software mainly is made up of information input, generation wave file, three parts that play sound, and the specific implementation step is as follows:

1) the input essential information comprises frequency range, reproduction time, frequency change mode, and wherein the difference of frequency change mode is reflected as the rising or the decline of sound;

2) according to the different essential information of input,, generate the sinusoidal wave file of continually varying respectively and be kept at assigned address by PC analysis, processing;

When 3) using, select as required to play different audio files, export different acoustical signals, make the experimenter finish different actions according to different acoustical signals.

The sonorific software implementation method of sound stimulation device in apparatus of the present invention, its operating process execution in step is as follows:

Beginning; Essential informations such as incoming frequency excursion, reproduction time, frequency change mode; Import file name; Establishment also opens file; Write file header and form information; Judge whether to select frequency to raise, select not, period is successively decreased and write data, selection is, period is increased progressively and writes data; Close file; Play sound when needing; Finish.

Sports-training apparatus (case) is divided into two parts: training aids (case) casing and control device.Control device is connected by copper mesh with training aids (case) box bottom, thereby carries out the purpose that electricity irritation reaches training by the sole to experimenter in training aids (case) casing.

Wherein training aids (case) has two doors above the casing, the intermediary crossbeam in bottom is respectively hazardous area and place of safety being divided into two spaces in the case, and the copper mesh of bottom, two spaces is powered respectively by different circuit.

Control device produces the different voltage of two-way by transformator behind the access power supply, and one the tunnel is 140 volts, is used to control the voltage of input copper mesh; Other one the tunnel is 10 volts, is used for providing voltage to the electronic device in the control device.Control device comprises the strength control part and the control section of delaying time, respectively in order to the intensity of control voltage and the delay time of energising back generation voltage.Produce two-way output by on-off circuit at last, flow to the copper mesh of bottom, two spaces of training aids (case) casing respectively.

The present invention has set up one and has applied mechanically electronic installation control brain to reach the Experimental Study System of control body kinematics, for the research of further being engaged in this field provides research means, thereby Premium Features, the creation brain of research brain is had great importance.

Description of drawings

Fig. 1 is apparatus of the present invention theory diagram;

Fig. 2 is a cranial nerve electrostimulator composition frame chart;

The electric pulse sketch map that Fig. 3 produces for the cranial nerve electrostimulator;

Fig. 4 is cranial nerve electrostimulator circuit theory diagrams;

Fig. 5 is a remote control output circuit schematic diagram;

Fig. 6 is the wireless receiving module circuit theory diagrams;

Fig. 7 is the sonic stimulation software flow pattern;

Fig. 8 is an animal training case three-view diagram;

Fig. 9 is an animal training case inner controller theory diagram;

Figure 10 is animal training case inner controller circuit theory diagrams.

The specific embodiment

Below in conjunction with accompanying drawing apparatus of the present invention are described in detail.

As shown in Figure 1, apparatus of the present invention comprise remote controller 1100, sound stimulation device 1000, PC 1020, cranial nerve electrostimulator 1050, brain stimulation electrode 1060, sports-training apparatus (case) 1030.Remote controller 1100 sends instruction to cranial nerve electrostimulator 1050, by serial port 1040 PC 1020 is issued in this instruction then, brings into operation; Cranial nerve electrostimulator 1050 sends corresponding electric pulse simultaneously, and this electric pulse enters brain to stimulate cerebral nerve 1090 by the brain stimulation electrode of implanting 1060, and cerebral nerve 1090 domination bodies produce the motor behavior reaction.Motor behavior 1030 carries out in training box.In order to formulate the pattern of the nerve stimulation signal of telecommunication, designed sound stimulation device 1000 in the system, in order to auxiliary cranial nerve electrostimulator 1050.Before electricity irritation, use earlier the sonic stimulation animal, by the PC signal of sounding, PC 1020 sends the signal of telecommunication by serial port 1010 to the hazardous area of animal training case 1030 copper mesh simultaneously, when animal jumps into opposite side (place of safety) by the hazardous area, send signal in the mode of infrared ray control and stop acoustical signal by serial port 1010 notice PCs 1020.

Wherein, cranial nerve electrostimulator 1050 comprises four parts, as shown in Figure 2, and oscillating current generation circuit, power amplifier, transforming circuit and remote control output circuit.The stimulus signal of remote controller emission is input to oscillating current generation circuit, multivibrator output rectangular pulse signal through oscillating current generation circuit, regulate the waveform and the frequency of stimulus signal again through slide rheostat, after power amplifier amplifies signal, drive transforming circuit, the neuroelectric pulse waveform electric pulse close with frequency of output waveform and frequency and brain generation launched this signal by the remote control output circuit then.

Cranial nerve electrostimulator 1050 can produce double current impulsing, its controllable parameters, and controlled parameter comprises: the width T of positive negative pulse stuffing pAnd T n, amplitude I pAnd I n, the positive negative pulse stuffing interval T d, the boost pulse frequency f 0As shown in Figure 3.In addition, according to actual needs, output pulse application remote control control.

Shown in I among Fig. 4, oscillating current generation circuit is the multivibrator that a 5G555 intervalometer constitutes, high-triggering end TH (6 foot) links to each other with low triggering end TL (2 foot), pass through capacity earth, voltage controling end (5 foot) is also by a capacity earth, reset terminal (4 foot) connects high potential, and outfan (3 foot) can obtain rectangular pulse signal.The frequency of boost pulse is by being connected on the slide rheostat (R of high-triggering end (6 foot) and discharge end 4, R 5) regulate.

Shown in II among Fig. 4, power amplifier comprises direct-coupled dual-stage amplifier (Q 1, Q 2), realization be the power amplification function, to drive transforming circuit.

Shown in III among Fig. 4, transforming circuit comprises coil type AC transformer T1, coil type AC transformer input provides the electric current that needs by power amplifier, and with drive coil formula AC transformer, coil type AC transformer outfan is exported satisfactory pulse current.Coil type AC transformer outfan output pulse frequency 0-50Hz; Continuous adjustable pulse-width: 0.6ms; The pulse current of voltage pulse output: 20V-70V.

Shown in IV among Fig. 4, pulse current adopts remote control control output, and the coding chip of remote control output circuit inside is the SC2262S coding chip with the expanded letter paster, and battery is the special-purpose 12 volts of baby batteries of A27 remote control, transmitting antenna is built-in PCB antenna, and circuit theory diagrams as shown in Figure 5.The emitter operating frequency is 315MHZ, receiver module adopts the manufacturing of SMD paster technique to produce, be the superregenrative reception mode, it includes amplifies shaping and decoding circuit, have seven exits, be respectively 10,11,12,13, GND, 17, VCC, wherein VCC is the 5V feeder ear, GND is an earth terminal, and 17 ends are the effective outfan of decoding, 10,11,12, the 13rd, 10~13 feet of decoding chip PT2272 (SC2272) integrated circuit, for the four figures certificate latchs outfan, when being arranged, can export signal the high level about 5V, the about 2mA of drive current, and corresponding one by one with four buttons on the emitter.Circuit theory diagrams as shown in Figure 6.Press the button of emitter, the relay of receiver module is with regard to adhesive, circuit turn-on, and button is unclamped in pulse current output, and relay discharges synchronously, and circuit disconnects.

Sound stimulation device 1000 hardware are made up of PC and speaker.The sounding order is produced by PC, the generation of sound is to utilize Microsoft Foundation Class software, under Microsoft Visual C++6.0 environment, realize, and can produce the sinusoidal sound wave of different frequency, different amplitudes, export to speaker by sound card, as the sonic stimulation signal.This software mainly by information input, generate wave file, three parts that play sound are formed, software flow pattern as shown in Figure 7, the specific implementation step is as follows:

1, the input essential information comprises frequency range, reproduction time, frequency change mode, and wherein the difference of frequency change mode is reflected as the rising or the decline of sound;

2, according to the different essential information of input,, generate the sinusoidal wave file of continually varying respectively and be kept at assigned address by PC analysis, processing;

3, during use, select as required to play different audio files, export different acoustical signals, make the experimenter finish different actions according to different acoustical signals.

Sports-training apparatus (case) 1030 is divided into two parts: training aids (case) casing and control device.Control device is connected by copper mesh with training aids (case) box bottom, thereby carries out the purpose that electricity irritation reaches training by the sole to experimenter in training aids (case) casing.

As shown in Figure 8, above sports-training apparatus (case) 1030 casings two doors are arranged, the intermediary crossbeam in bottom is respectively hazardous area and place of safety being divided into two spaces in the case, and the copper mesh of bottom, two spaces is powered respectively by different circuit.

The theory diagram of control device realization control function as shown in Figure 9.This control device produces the different voltage of two-way by the coil type transformator after inserting power supply, and one the tunnel is 140 volts, is used to control the voltage of input copper mesh; Other one the tunnel is 10 volts, is used for providing voltage to the electronic device in the control device.

The circuit theory of this control device as shown in figure 10, control device comprises strength control part and time-delay control section, respectively the delay time that produces voltage in order to the intensity and the energising back of control voltage.Produce two-way output by on-off circuit at last, flow to the copper mesh of bottom, two spaces of training aids (case) casing respectively.

During training animal is put into chest place of safety one side, opposite side (hazardous area) copper mesh then has electricity, allows animal be familiar with environment for a moment, dare not go to the hazardous area.Give the animal brain nerve when electrode and send electric impulse signal after 2 seconds, the place of safety becomes the hazardous area, and rabbit should be fled from opposite side (place of safety), and this moment, electrical stimulation signal disappeared, and animal is stayed the place of safety.

After repeatedly training, animal brain receives electric impulse signal and jumps to opposite side at once, and this moment, the hazardous area became the place of safety, and opposite side (hazardous area) then has electricity, finishes learning process.

The concrete work process of this device is:

Remote controller 1100 sends the command request animal and jumps into the place of safety from the hazardous area of training case 1030, animal should be cooked corresponding action, not side it will pay for, be that PC will send signal to the control device of training case 1030 by serial port 1010: switch in training case animal place hazardous area batter portion, animal will jump into the place of safety side like this, after training after a while, animal is as long as one be subjected to the animal that requires that remote controller 1100 sends and jump into the instruction of place of safety side from the hazardous area side of training case, it will jump into the place of safety from the hazardous area of training case, and the nerve electric stimulation of having realized requiring mental skill is controlled the purpose of animal movement behavior.In order to formulate the pattern of the nerve stimulation signal of telecommunication, designed sound stimulation device 1000 in the system.Before electricity irritation, can use the sonic stimulation animal earlier, all the other processes are identical with electricity irritation.

At first the brain stimulation electrode is installed at the head of experimenter-animal, animal is placed in the training box after adapting to, the cranial nerve electrostimulator is placed on training box top, the outfan of cranial nerve electrostimulator is connected with the animal brain stimulating electrode, experimenter's hand-held remote controller sends instruction, and animal jumps into the opposite side place of safety from the hazardous area.

Claims (8)

1, a kind of cranial nerve electrical stimulation device of remote-controlled motor behavior is characterized in that this device comprises remote controller, sound stimulation device, PC, cranial nerve electrostimulator, brain stimulation electrode, sports-training apparatus or case;
Wherein, the cranial nerve electrostimulator comprises oscillating current generation circuit, power amplifier, transforming circuit and remote control output circuit; Oscillating current generation circuit (I) is a multivibrator, high-triggering end links to each other with low triggering end, pass through capacity earth, voltage controling end is also by a capacity earth, the termination that resets high potential, outfan obtains rectangular pulse signal, and (R4 R5) regulates the slide rheostat of the frequency of boost pulse by being connected on high-triggering end and discharge end; Power amplifier (II) comprises direct-coupled dual-stage amplifier (Q1, Q2), realization be the power amplification function, to drive transforming circuit; Transforming circuit (III) comprises coil type AC transformer (T1), coil type AC transformer input is provided the electric current that needs by power amplifier, with drive coil formula AC transformer, the neuroelectric pulse waveform electric pulse close that coil type AC transformer outfan output waveform and frequency and brain produce with frequency; Remote control output circuit (IV), coil type AC transformer output pulse current adopts remote control control output, to satisfy specific (special) requirements;
The work process of this device is: remote controller sends instruction to the cranial nerve electrostimulator, by serial port PC is issued in this instruction then, brings into operation; The cranial nerve electrostimulator sends corresponding electric pulse simultaneously, and this electric pulse enters brain to stimulate cerebral nerve by the brain stimulation electrode of implanting, and cerebral nerve domination body produces the motor behavior reaction; Motor behavior carries out in training box.
2, the cranial nerve electrical stimulation device of a kind of remote-controlled motor behavior as claimed in claim 1 is characterized in that described sound stimulation device, in order to auxiliary cranial nerve electrostimulator; Before electricity irritation, use earlier the sonic stimulation animal, by the PC signal of sounding, PC sends the signal of telecommunication by serial port to the hazardous area of sports-training apparatus or case copper mesh simultaneously, when animal jumps into the opposite side place of safety by the hazardous area, send signal in the mode of infrared ray control and stop acoustical signal by serial port notice PC.
3, the cranial nerve electrical stimulation device of a kind of remote-controlled motor behavior as claimed in claim 2 is characterized in that the specific implementation step that described sound stimulation device cooperates the work of cranial nerve electrostimulator to sound is as follows:
1) the input essential information comprises frequency range, reproduction time, frequency change mode, and wherein the difference of frequency change mode is reflected as the rising or the decline of sound;
2) according to the different essential information of input,, generate the sinusoidal wave file of continually varying respectively and be kept at assigned address by PC analysis, processing;
When 3) using, select as required to play different audio files, export different acoustical signals, make the experimenter finish different actions according to different acoustical signals.
4, the cranial nerve electrical stimulation device of a kind of remote-controlled motor behavior as claimed in claim 1 is characterized in that described sports-training apparatus or case are divided into two parts: training aids casing and control device; Control device is connected by copper mesh with the training aids box bottom.
5, the cranial nerve electrical stimulation device of a kind of remote-controlled motor behavior as claimed in claim 4, it is characterized in that two doors are arranged above the described training aids casing, the intermediary crossbeam in bottom is being divided into two spaces in the case, be respectively hazardous area and place of safety, the copper mesh of bottom, two spaces is powered respectively by different circuit.
6, the cranial nerve electrical stimulation device of a kind of remote-controlled motor behavior as claimed in claim 4, it is characterized in that described control device, produce the different voltage of two-way by the coil type AC transformer after inserting power supply, one the tunnel is used to control the voltage of input copper mesh, and other one the tunnel is used for providing voltage to the electronic device in the control device.
7, the cranial nerve electrical stimulation device of a kind of remote-controlled motor behavior as claimed in claim 4, it is characterized in that described control device comprises the strength control part and the control section of delaying time, respectively in order to the intensity of control voltage and the delay time of energising back generation voltage.
8, the cranial nerve electrical stimulation device of a kind of remote-controlled motor behavior as claimed in claim 4 is characterized in that described control device produces two-way output by on-off circuit, flows to the copper mesh of bottom, two spaces of training aids casing respectively.
CNB2005100473364A 2005-09-30 2005-09-30 Cranial nerve electrostimulating device capable of remotely controlling exercise behevior CN100467087C (en)

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