CL2018001000A1 - Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr. - Google Patents

Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr.

Info

Publication number
CL2018001000A1
CL2018001000A1 CL2018001000A CL2018001000A CL2018001000A1 CL 2018001000 A1 CL2018001000 A1 CL 2018001000A1 CL 2018001000 A CL2018001000 A CL 2018001000A CL 2018001000 A CL2018001000 A CL 2018001000A CL 2018001000 A1 CL2018001000 A1 CL 2018001000A1
Authority
CL
Chile
Prior art keywords
antibodies
antibody conjugates
egfr drug
egfr
drug
Prior art date
Application number
CL2018001000A
Other languages
English (en)
Inventor
Lorenzo Benatuil
Chung-Ming Hsieh
Edward B Reilly
Andrew C Phillips
Fritz G Buchanan
Jonathan A Meulbroek
Jennifer Perez
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52997522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2018001000(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of CL2018001000A1 publication Critical patent/CL2018001000A1/es

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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Anticuerpos y conjugados de anticuerpo y fármaco (ADC) anti-factor de crecimiento epidérmico (EGFR), incluyendo composiciones y métodos para usar dichos anticuerpos y ADC.
CL2018001000A 2014-03-21 2018-04-18 Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr. CL2018001000A1 (es)

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CL2018001000A CL2018001000A1 (es) 2014-03-21 2018-04-18 Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr.
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