CL2018000227A1 - Proteínas inhibidoras de insectos novedosas - Google Patents
Proteínas inhibidoras de insectos novedosasInfo
- Publication number
- CL2018000227A1 CL2018000227A1 CL2018000227A CL2018000227A CL2018000227A1 CL 2018000227 A1 CL2018000227 A1 CL 2018000227A1 CL 2018000227 A CL2018000227 A CL 2018000227A CL 2018000227 A CL2018000227 A CL 2018000227A CL 2018000227 A1 CL2018000227 A1 CL 2018000227A1
- Authority
- CL
- Chile
- Prior art keywords
- tic5290
- coleopters
- lepidopters
- recombining
- methods
- Prior art date
Links
- 241000238631 Hexapoda Species 0.000 title 1
- 108091006086 inhibitor proteins Proteins 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 239000012472 biological sample Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
- A01N63/22—Bacillus
- A01N63/23—B. thuringiensis
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Pest Control & Pesticides (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Insects & Arthropods (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Botany (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Abstract
<p>SE DESCRIBE UNA CLASE DE PROTEÍNA PESTICIDA QUE PRESENTA ACTIVIDAD TÓXICA CONTRA ESPECIES DE PLAGAS DE COLEÓPTEROS, LEPIDÓPTEROS Y HEMÍPTEROS, E INCLUYE, ENTRE OTROS, TIC5290. SE PROPORCIONAN CONSTRUCCIONES DE ADN QUE CONTIENEN UNA SECUENCIA DE ÁCIDO NUCLÉICO RECOMBINANTE QUE CODIFICO TIC5290. SE PROPORCIONAN PLANTAS, CÉLULAS DE PLANTAS SEMILLAS Y PARTES DE PLANTAS TRANSGÉNICAS QUE CONTIENEN SECUENCIAS DE ÁCIDO NUCLÉICO RECOMBINANTE QUE CODIFICAN TIC5290. TAMBIÉN SE PROPORCIONAN MÉTODOS PARA DETECTAR LO PRESENCIA DE LAS SECUENCIAS DE ÁCIDO NUCLÉICO RECOMBINANTE O TIC5290 EN UNA MUESTRA BIOLÓGICA, Y MÉTODOS PARA CONTROLAR PLAGAS DE ESPECIES DE COLEÓPTEROS, LEPIDÓPTEROS Y HEMÍPTEROS QUE UTILIZAN TIC5290.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562199024P | 2015-07-30 | 2015-07-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2018000227A1 true CL2018000227A1 (es) | 2018-04-27 |
Family
ID=57885446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018000227A CL2018000227A1 (es) | 2015-07-30 | 2018-01-26 | Proteínas inhibidoras de insectos novedosas |
Country Status (22)
Country | Link |
---|---|
US (2) | US10100330B2 (es) |
EP (1) | EP3328187B1 (es) |
JP (1) | JP6933641B2 (es) |
CN (1) | CN107849571B (es) |
AR (1) | AR105768A1 (es) |
BR (1) | BR112018001379B1 (es) |
CA (1) | CA2992084A1 (es) |
CL (1) | CL2018000227A1 (es) |
CO (1) | CO2018000801A2 (es) |
CR (1) | CR20180060A (es) |
EC (1) | ECSP18006878A (es) |
ES (1) | ES2904255T3 (es) |
HR (1) | HRP20211858T1 (es) |
HU (1) | HUE057364T2 (es) |
MX (1) | MX2018001258A (es) |
NI (1) | NI201800013A (es) |
PE (1) | PE20180775A1 (es) |
RU (1) | RU2765310C2 (es) |
SV (1) | SV2018005620A (es) |
UA (1) | UA126327C2 (es) |
WO (1) | WO2017019787A1 (es) |
ZA (1) | ZA201800227B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA126327C2 (uk) * | 2015-07-30 | 2022-09-21 | Монсанто Текнолоджі Елелсі | Молекула рекомбінантної нуклеїнової кислоти, яка кодує білок, що проявляє інгібуючу активність відносно комах |
BR112019007180A2 (pt) * | 2016-10-10 | 2019-07-02 | Monsanto Technology Llc | proteínas inibidoras inseticidas |
US11484030B2 (en) | 2017-10-02 | 2022-11-01 | Syngenta Participations Ag | Engineered pesticidal proteins and methods of controlling plant pests |
EP3728606A1 (en) * | 2017-12-22 | 2020-10-28 | Agbiome, Inc. | Pesticidal genes and methods of use |
EP3855921A4 (en) * | 2018-09-25 | 2022-11-30 | Monsanto Technology LLC | NOVEL INSECT CONTROL PROTEINS |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5849870A (en) * | 1993-03-25 | 1998-12-15 | Novartis Finance Corporation | Pesticidal proteins and strains |
NZ335086A (en) * | 1996-10-30 | 2000-11-24 | Mycogen Corp | Bacillus thuringiensis pesticidal toxins and nucleotide sequences which encode these toxins |
US6551962B1 (en) | 2000-10-06 | 2003-04-22 | Monsanto Technology Llc | Method for deploying a transgenic refuge |
US7304162B2 (en) * | 2003-02-21 | 2007-12-04 | Intrexon Corporation | Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
BRPI0412390A (pt) * | 2003-07-07 | 2006-09-19 | Monsanto Technology Llc | proteìnas inseticidas secretadas de espécies bacillus e uso dessas proteìnas |
CA2547933C (en) * | 2003-12-16 | 2014-08-12 | Monsanto Technology Llc | Secreted insecticidal protein and gene compositions from bacillus thuringiensis and uses therefor |
WO2005110068A2 (en) | 2004-04-09 | 2005-11-24 | Monsanto Technology Llc | Compositions and methods for control of insect infestations in plants |
US9121035B2 (en) * | 2005-08-31 | 2015-09-01 | Monsanto Technology Llc | Insecticidal compositions and methods for making insect-resistant transgenic plants |
CA2658677C (en) | 2006-07-21 | 2014-04-22 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
MX2009000774A (es) | 2006-07-21 | 2009-02-17 | Pioneer Hi Bred Int | Gen novedoso de bacillus thuringiensis con actividad lepidoptera. |
US7772465B2 (en) | 2007-06-26 | 2010-08-10 | Pioneer Hi-Bred International, Inc. | Bacillus thuringiensis gene with lepidopteran activity |
US8283524B2 (en) | 2008-05-15 | 2012-10-09 | Pioneer Hi-Bred International, Inc | Bacillus thuringiensis gene with lepidopteran activity |
MX2010013674A (es) | 2008-06-11 | 2011-03-15 | Pioneer Hi Bred Int Inc Star | Gen de bacillus thuringiensis novedoso con actividad lepidoptera. |
US8445749B2 (en) | 2008-09-19 | 2013-05-21 | Pioneer Hi Bred International Inc | Bacillus thuringiensis gene with lepidopteran activity |
US20100077507A1 (en) | 2008-09-22 | 2010-03-25 | Pioneer Hi-Bred International, Inc. | Novel Bacillus Thuringiensis Gene with Lepidopteran Activity |
EA201170961A1 (ru) | 2009-01-23 | 2012-02-28 | Пайонир Хай-Бред Интернэшнл, Инк. | Новый ген bacillus thuringiensis с активностью против lepidoptera |
BRPI1008740A8 (pt) * | 2009-02-27 | 2022-07-05 | Athenix Corp | Proteínas pesticidas e métodos para seu uso. |
BR112012011222A2 (pt) | 2009-11-12 | 2015-09-15 | Pioneer Hi Bred Int | molécula de ácido nucleico isolada, contruto de dna, célula hospedeira, planta transgênica, semente transformada, polipeptídeo isolado com atividade pesticida, composição e métodos para controlar uma população de praga de lepidópteros, para matar uma praga de lepidóptero e para proteger uma planta contra uma praga |
WO2011084324A2 (en) | 2009-12-21 | 2011-07-14 | Pioneer Hi-Bred International, Inc. | Novel bacillus thuringiensis gene with lepidopteran activity |
US8802934B2 (en) | 2010-08-19 | 2014-08-12 | Pioneer Hi Bred International Inc | Bacillus thuringiensis gene with lepidopteran activity |
BR112013015515A2 (pt) | 2010-12-28 | 2018-04-24 | Pioneer Hi Bred Int | molécula de ácido nucleico isolada, construto de dna, célula hospedeira, planta transgênica, semente transformada da planta, polipeptídeo isolado com atividade pesticida, composição, método para controlar uma população de praga de lepidóptero, método para matar uma praga de lepidóptero, método para produzir um polipeptídeo com atividade pesticida, planta que tem incorporado de maneira estável em seu genoma um construto de dna, método para proteger uma planta contra uma praga |
US9328356B2 (en) * | 2011-02-11 | 2016-05-03 | Monsanto Technology Llc | Pesticidal nucleic acids and proteins and uses thereof |
US9238678B2 (en) * | 2011-04-07 | 2016-01-19 | Monsanto Technology Llc | Insect inhibitory toxin family active against hemipteran and/or lepidopteran insects |
JP6230125B2 (ja) * | 2011-08-19 | 2017-11-15 | シンセティック ジェノミクス インコーポレーテッド | 新規殺虫性組成物のハイスループット同定のための統合された方法およびその用途 |
WO2015021354A2 (en) | 2013-08-09 | 2015-02-12 | Monsanto Technology Llc | Pesticidal toxin active against coleopteran and/or hemipteran insects |
UA126327C2 (uk) * | 2015-07-30 | 2022-09-21 | Монсанто Текнолоджі Елелсі | Молекула рекомбінантної нуклеїнової кислоти, яка кодує білок, що проявляє інгібуючу активність відносно комах |
-
2016
- 2016-07-27 UA UAA201802018A patent/UA126327C2/uk unknown
- 2016-07-27 MX MX2018001258A patent/MX2018001258A/es unknown
- 2016-07-27 CA CA2992084A patent/CA2992084A1/en active Pending
- 2016-07-27 BR BR112018001379-0A patent/BR112018001379B1/pt active IP Right Grant
- 2016-07-27 JP JP2018504868A patent/JP6933641B2/ja active Active
- 2016-07-27 WO PCT/US2016/044296 patent/WO2017019787A1/en active Application Filing
- 2016-07-27 HR HRP20211858TT patent/HRP20211858T1/hr unknown
- 2016-07-27 RU RU2018107162A patent/RU2765310C2/ru active
- 2016-07-27 HU HUE16831304A patent/HUE057364T2/hu unknown
- 2016-07-27 EP EP16831304.7A patent/EP3328187B1/en active Active
- 2016-07-27 ES ES16831304T patent/ES2904255T3/es active Active
- 2016-07-27 PE PE2018000135A patent/PE20180775A1/es unknown
- 2016-07-27 CN CN201680043100.XA patent/CN107849571B/zh active Active
- 2016-07-27 CR CR20180060A patent/CR20180060A/es unknown
- 2016-07-27 US US15/221,544 patent/US10100330B2/en active Active
- 2016-07-29 AR ARP160102316A patent/AR105768A1/es unknown
-
2018
- 2018-01-12 ZA ZA2018/00227A patent/ZA201800227B/en unknown
- 2018-01-26 CL CL2018000227A patent/CL2018000227A1/es unknown
- 2018-01-26 CO CONC2018/0000801A patent/CO2018000801A2/es unknown
- 2018-01-26 SV SV2018005620A patent/SV2018005620A/es unknown
- 2018-01-26 NI NI201800013A patent/NI201800013A/es unknown
- 2018-01-29 EC ECIEPI20186878A patent/ECSP18006878A/es unknown
- 2018-06-07 US US16/002,994 patent/US20180346925A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2765310C2 (ru) | 2022-01-28 |
CN107849571A (zh) | 2018-03-27 |
PE20180775A1 (es) | 2018-05-07 |
WO2017019787A1 (en) | 2017-02-02 |
EP3328187B1 (en) | 2021-11-10 |
BR112018001379A2 (pt) | 2018-09-11 |
HUE057364T2 (hu) | 2022-05-28 |
ECSP18006878A (es) | 2018-04-30 |
UA126327C2 (uk) | 2022-09-21 |
US20180346925A1 (en) | 2018-12-06 |
RU2018107162A3 (es) | 2020-01-28 |
MX2018001258A (es) | 2018-04-20 |
JP6933641B2 (ja) | 2021-09-08 |
ES2904255T3 (es) | 2022-04-04 |
SV2018005620A (es) | 2018-08-31 |
AR105768A1 (es) | 2017-11-08 |
CN107849571B (zh) | 2022-04-19 |
RU2018107162A (ru) | 2019-08-28 |
BR112018001379B1 (pt) | 2024-04-30 |
NI201800013A (es) | 2018-06-12 |
CR20180060A (es) | 2018-07-09 |
CO2018000801A2 (es) | 2018-04-10 |
EP3328187A4 (en) | 2019-01-09 |
US20170044568A1 (en) | 2017-02-16 |
ZA201800227B (en) | 2018-12-19 |
HRP20211858T1 (hr) | 2022-03-04 |
US10100330B2 (en) | 2018-10-16 |
CA2992084A1 (en) | 2017-02-02 |
EP3328187A1 (en) | 2018-06-06 |
JP2018525987A (ja) | 2018-09-13 |
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