CH641682A5 - X-ray contrast medium - Google Patents
X-ray contrast medium Download PDFInfo
- Publication number
- CH641682A5 CH641682A5 CH1033378A CH1033378A CH641682A5 CH 641682 A5 CH641682 A5 CH 641682A5 CH 1033378 A CH1033378 A CH 1033378A CH 1033378 A CH1033378 A CH 1033378A CH 641682 A5 CH641682 A5 CH 641682A5
- Authority
- CH
- Switzerland
- Prior art keywords
- ium
- liposomes
- acidumidumum
- acidum
- liver
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title claims description 23
- 239000002502 liposome Substances 0.000 claims description 23
- 210000004185 liver Anatomy 0.000 claims description 12
- 150000003904 phospholipids Chemical class 0.000 claims description 10
- 150000003839 salts Chemical group 0.000 claims description 10
- 210000000952 spleen Anatomy 0.000 claims description 8
- 229940039231 contrast media Drugs 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- -1 N-alkylacylamino Chemical group 0.000 claims description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
- QEVGZEDELICMKH-UHFFFAOYSA-N Diglycolic acid Chemical compound OC(=O)COCC(O)=O QEVGZEDELICMKH-UHFFFAOYSA-N 0.000 claims description 3
- UXIGWFXRQKWHHA-UHFFFAOYSA-N Iotalamic acid Chemical compound CNC(=O)C1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I UXIGWFXRQKWHHA-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- FFINMCNLQNTKLU-UHFFFAOYSA-N adipiodone Chemical compound OC(=O)C1=C(I)C=C(I)C(NC(=O)CCCCC(=O)NC=2C(=C(C(O)=O)C(I)=CC=2I)I)=C1I FFINMCNLQNTKLU-UHFFFAOYSA-N 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- 239000011630 iodine Substances 0.000 claims description 3
- OLAOYPRJVHUHCF-UHFFFAOYSA-N iooxitalamic acid Chemical compound CC(=O)NC1=C(I)C(C(O)=O)=C(I)C(C(=O)NCCO)=C1I OLAOYPRJVHUHCF-UHFFFAOYSA-N 0.000 claims description 3
- 239000002504 physiological saline solution Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- SMQYOVYWPWASGU-UHFFFAOYSA-N Iocarmic acid Chemical compound OC(=O)C1=C(I)C(C(=O)NC)=C(I)C(NC(=O)CCCCC(=O)NC=2C(=C(C(=O)NC)C(I)=C(C(O)=O)C=2I)I)=C1I SMQYOVYWPWASGU-UHFFFAOYSA-N 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 239000012266 salt solution Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 238000007487 urography Methods 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 238000010253 intravenous injection Methods 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 208000005189 Embolism Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 239000012267 brine Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 230000000254 damaging effect Effects 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 238000011835 investigation Methods 0.000 claims 1
- HHFIATHHSBFCBY-UHFFFAOYSA-N ioglicic acid Chemical compound CNC(=O)CNC(=O)C1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I HHFIATHHSBFCBY-UHFFFAOYSA-N 0.000 claims 1
- TYYBFXNZMFNZJT-UHFFFAOYSA-N ioxaglic acid Chemical compound CNC(=O)C1=C(I)C(N(C)C(C)=O)=C(I)C(C(=O)NCC(=O)NC=2C(=C(C(=O)NCCO)C(I)=C(C(O)=O)C=2I)I)=C1I TYYBFXNZMFNZJT-UHFFFAOYSA-N 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 claims 1
- 239000005445 natural material Substances 0.000 claims 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 claims 1
- ZCUFMDLYAMJYST-UHFFFAOYSA-N thorium dioxide Chemical compound O=[Th]=O ZCUFMDLYAMJYST-UHFFFAOYSA-N 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 11
- 238000001990 intravenous administration Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- YVPYQUNUQOZFHG-UHFFFAOYSA-N amidotrizoic acid Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I YVPYQUNUQOZFHG-UHFFFAOYSA-N 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000003325 tomography Methods 0.000 description 2
- HPBZALDPHXCONP-UHFFFAOYSA-N 2,4,6-triiodo-3-(methylcarbamoyl)benzoic acid Chemical compound CNC(=O)C1=C(I)C=C(I)C(C(O)=O)=C1I HPBZALDPHXCONP-UHFFFAOYSA-N 0.000 description 1
- KISFRFNQZTVXGT-UHFFFAOYSA-N 3-acetamido-5-[(2-hydroxyacetyl)amino]-2,4,6-triiodobenzoic acid Chemical compound CC(=O)NC1=C(I)C(NC(=O)CO)=C(I)C(C(O)=O)=C1I KISFRFNQZTVXGT-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 150000003931 anilides Chemical class 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000009606 cholecystography Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229940029355 iodipamide Drugs 0.000 description 1
- FZDZULUFHNDEDJ-UHFFFAOYSA-N ioglycamic acid Chemical compound OC(=O)C1=C(I)C=C(I)C(NC(=O)COCC(=O)NC=2C(=C(C(O)=O)C(I)=CC=2I)I)=C1I FZDZULUFHNDEDJ-UHFFFAOYSA-N 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 210000001944 turbinate Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
- A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1033378A CH641682A5 (en) | 1978-10-05 | 1978-10-05 | X-ray contrast medium |
| DE19792935195 DE2935195A1 (de) | 1978-10-05 | 1979-08-31 | Neues leberkontrastmittel und verfahren zu dessen herstellung |
| FR7924619A FR2437831A1 (fr) | 1978-10-05 | 1979-10-03 | Agent de contraste pour l'examen radiologique du foie et procede pour sa preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1033378A CH641682A5 (en) | 1978-10-05 | 1978-10-05 | X-ray contrast medium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH641682A5 true CH641682A5 (en) | 1984-03-15 |
Family
ID=4362083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1033378A CH641682A5 (en) | 1978-10-05 | 1978-10-05 | X-ray contrast medium |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH641682A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2935195A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2437831A1 (enrdf_load_stackoverflow) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2515960A1 (fr) * | 1981-11-06 | 1983-05-13 | Alkhouri Fallouh Nazir | Nanocapsules ou nanoparticules biodegradables contenant une substance biologiquement active, leur preparation et leur application |
| CS255809B1 (en) * | 1984-12-12 | 1988-03-15 | Daniel Horak | Rentgenocontrast spherical hydrogel particles on the base of polymers and copolymers acrylates and methacrylates and process for preparing them |
| US4680171A (en) * | 1985-03-15 | 1987-07-14 | William Shell | Visualization of a bloodstream circulation with biodegradable microspheres |
| CH672733A5 (enrdf_load_stackoverflow) * | 1987-05-22 | 1989-12-29 | Bracco Ind Chimica Spa | |
| DE3934656A1 (de) * | 1989-10-13 | 1991-04-18 | Schering Ag | Verfahren zur herstellung von waessrigen dispersionen |
| SE9101709L (sv) * | 1991-06-03 | 1992-12-04 | Karlshamns Lipidteknik Ab | Lipidderivat som diagnostikum eller kontrastmedel |
| CN1148812A (zh) * | 1994-03-28 | 1997-04-30 | 尼科梅德成像有限公司 | “脂质体” |
| DE4426439C1 (de) * | 1994-07-26 | 1996-02-29 | Schering Ag | Kontrastmittel zur Darstellung der Leber |
| US6001333A (en) * | 1997-09-12 | 1999-12-14 | See; Jackie R. | Methods of preparing micro encapsulated agents for use in the detection of tumors by CT imaging |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2613172A (en) * | 1949-08-10 | 1952-10-07 | American Cystoscope Makers Inc | X-ray contrast compositions |
| US3356575A (en) * | 1965-04-13 | 1967-12-05 | Leo Ab | Autosterile injectable iodinated oil X-ray contrast medium |
| DE2118219C3 (de) * | 1971-04-10 | 1981-07-16 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Neues Röntgenkontrastmittel |
-
1978
- 1978-10-05 CH CH1033378A patent/CH641682A5/de not_active IP Right Cessation
-
1979
- 1979-08-31 DE DE19792935195 patent/DE2935195A1/de not_active Withdrawn
- 1979-10-03 FR FR7924619A patent/FR2437831A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2437831A1 (fr) | 1980-04-30 |
| DE2935195A1 (de) | 1980-04-17 |
| FR2437831B1 (enrdf_load_stackoverflow) | 1983-03-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69527194T2 (de) | Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel | |
| EP0169299B1 (de) | Verwendung von paramagnetischen Komplexsalzen zur Herstellung von Mitteln für die NMR-Diagnostik | |
| DE69230144T2 (de) | Röntgenkontrastmittel | |
| DE3640708C2 (de) | Verbesserte metallhaltige Pharmazeutika | |
| DE69636635T2 (de) | Kontrastmittel für diagnostische bildgebung mit verlängerter verweilzeit im blut | |
| DE2628517C2 (de) | Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel | |
| EP0405704B1 (de) | Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung | |
| DE2814038C3 (de) | Mit einem Radionuklid für radioaktive Tests markierbares Material | |
| DE3021006C2 (de) | Oberflächenaktives Material und dieses Material enthaltendes pharmazeutisches Mittel gegen Hyalin-Membran-Erkrankung | |
| DE69121562T2 (de) | Kontrastmittel enthaltend einen nicht-ionischen kontrast Wirkstoff und Sodium und Kalzium Sälze | |
| EP0123235A2 (de) | Mikropartikel und Gasblächen enthaltendes Ultraschall-Kontrastmittel | |
| CH641682A5 (en) | X-ray contrast medium | |
| EP0312108B1 (de) | Mittel zur Kontrastierung von bösartigen Neubildungen bei ihrer Diagnostik | |
| DE69020208T2 (de) | Kontrastmittel. | |
| DE60128800T2 (de) | Hydrophobe iodverbindung enthaltende liposome | |
| DE60216770T2 (de) | Ionisches und nicht-ionisches radiographisches kontrastmittel zur verwendung in der kombinierten roentgen- und kernspintomographiediagnostik | |
| EP0855186A2 (de) | Gas enthaltende Mikropartikel, deren Verwendung in der Ultra-schalldiagnostik | |
| DE19744004C1 (de) | Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging | |
| DE3309076C2 (de) | Liposome und Verfahren zu ihrer Herstellung | |
| DE60222843T2 (de) | Hydrophobe Iodverbindung enthaltendes Liposom und dieses enthaltendes Röntgenkontrastmittel | |
| DE69732370T2 (de) | Spinresonanz kontrastmittel für das blut | |
| EP0806969A2 (de) | Kontrastmittelhaltige liposomen für die darstellung des intravasalraumes | |
| CH615344A5 (en) | X-ray contrast medium and process for its preparation | |
| EP0494616A1 (de) | Kontrastmittel für die MR-Diagnostik | |
| CH438584A (de) | Röntgenkontrastmittel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |