CH513111A - Process for the production of new benz-epine derivatives - Google Patents

Process for the production of new benz-epine derivatives

Info

Publication number
CH513111A
CH513111A CH136468A CH136468A CH513111A CH 513111 A CH513111 A CH 513111A CH 136468 A CH136468 A CH 136468A CH 136468 A CH136468 A CH 136468A CH 513111 A CH513111 A CH 513111A
Authority
CH
Switzerland
Prior art keywords
production
epine
benz
derivatives
new
Prior art date
Application number
CH136468A
Other languages
German (de)
Inventor
Karl-Heinz Dr Weber
Karl-Heinz Dr Hauptmann
Zeile Karl Dr Prof
Peter Dr Danneberg
Rolf Dr Giesemann
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Priority to CH791870A priority Critical patent/CH512502A/en
Priority to CH791970A priority patent/CH512429A/en
Publication of CH513111A publication Critical patent/CH513111A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH136468A 1967-02-01 1968-01-30 Process for the production of new benz-epine derivatives CH513111A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CH791870A CH512502A (en) 1967-02-01 1968-01-30 Process for the production of new benz-epine derivatives
CH791970A CH512429A (en) 1967-02-01 1968-01-30 Antidepressive, anticonvulsant benzepine derivs at low

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB0090994 1967-02-01

Publications (1)

Publication Number Publication Date
CH513111A true CH513111A (en) 1971-09-30

Family

ID=6985591

Family Applications (1)

Application Number Title Priority Date Filing Date
CH136468A CH513111A (en) 1967-02-01 1968-01-30 Process for the production of new benz-epine derivatives

Country Status (4)

Country Link
CH (1) CH513111A (en)
DE (1) DE1593760A1 (en)
FR (2) FR1603343A (en)
GB (1) GB1211258A (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2353519A1 (en) * 1975-12-08 1977-12-30 Roussel Uclaf Amino dihydro or tetrahydro benzocycloheptenes - useful as antidepressants
DE2931398A1 (en) 1979-08-02 1981-02-26 Kali Chemie Pharma Gmbh NEW 1-BENZOXEPIN-5 (2H) -ON DERIVATIVES AND THEIR SALTS, METHODS AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE2931399A1 (en) * 1979-08-02 1981-02-26 Kali Chemie Pharma Gmbh NEW 3-AMINO-1-BENZOXEPINE DERIVATIVES AND THEIR SALTS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
PH21961A (en) * 1983-02-15 1988-04-15 Merrell Dow Pharma 2h-(1)benzoxepino(5,4-b)-1,4-oxazine derivative
PH22343A (en) * 1983-02-15 1988-08-12 Merrell Dow Pharma 2h-(1) benzoxepino (5,4-b) 1,4-oxazine derivatives
DE3440296A1 (en) * 1984-11-05 1986-05-15 Kali-Chemie Pharma Gmbh, 3000 Hannover 3-AMINO-2,3-DIHYDRO-1-BENZOXEPINE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4975461A (en) * 1986-06-19 1990-12-04 E. R. Squibb & Sons, Inc. P-aminophenols, derivatives thereof and method of use
AU597671B2 (en) * 1986-06-20 1990-06-07 Suntory Limited 2-Phenylbenzoxepin derivative
FR2698873B1 (en) * 1992-12-07 1995-02-24 Lipha Benzocycloheptenes, benzoxepines and benzothiepins activators of potassium channels, preparation process, pharmaceutical composition containing them.
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
EP0781278B1 (en) * 1994-09-13 2001-03-14 Monsanto Company Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
AU723123B2 (en) * 1996-03-11 2000-08-17 G.D. Searle & Co. Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
EP1440972A1 (en) * 1996-03-11 2004-07-28 G.D. Searle & Co. Novel benzothiepines having pharmaceutical activity.
CN1110494C (en) * 1996-03-11 2003-06-04 G·D·瑟尔公司 Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6221897B1 (en) 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
CN1338944A (en) 1998-12-23 2002-03-06 G.D.瑟尔有限公司 Cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
US6638969B1 (en) 1998-12-23 2003-10-28 G.D. Searle, Llc Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
EP1342475A1 (en) 1998-12-23 2003-09-10 G.D. Searle LLC. Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
PT1140185E (en) 1998-12-23 2003-10-31 Searle Llc COMBINATIONS OF ESTER TRANSFER PROTEIN INHIBITORS OF COLESTERILO WITH BILIARY ACID SEQUESTRANTS FOR CARDIOVASCULAR INDICATIONS
CN1338945A (en) 1998-12-23 2002-03-06 G·D·瑟尔有限公司 Combination of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications
WO2000038721A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
JP2003528830A (en) 2000-03-10 2003-09-30 ファルマシア・コーポレーション Method for producing tetrahydrobenzothiepines
JP2005518347A (en) 2001-11-02 2005-06-23 ジー．ディー． サール エルエルシー Novel mono- and difluorobenzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
WO2003061604A2 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
KR20190135545A (en) 2011-10-28 2019-12-06 루메나 파마수티컬즈, 인코포레이티드 Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
MX369466B (en) 2011-10-28 2019-11-08 Lumena Pharmaceuticals Inc Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases.

Also Published As

Publication number Publication date
FR1603343A (en) 1971-04-05
DE1593760A1 (en) 1972-06-08
FR8052M (en) 1970-06-29
GB1211258A (en) 1970-11-04

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Legal Events

Date Code Title Description
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