CH311576A - Process for the production of a new basic substituted fatty acid amide. - Google Patents

Description

  

  



  Process for the production of a new basic substituted fatty acid amide.



   The subject of the present patent is a process for the preparation of a new base-substituted fatty acid amide, which is marked by the fact that a compound of the formula
EMI1.1
 a compound of the formula
EMI1.2
 in which formulas X and y mean reactive radicals which are split off during the reaction, can act.



   Compounds of the formula I that can be used for a conversion are, for example: The free amine (Y = H), but also its salé, such as, for example, the hydrochloride or the sulfate.



   Twists of the formula II include, for example: diethylaminoacetic acid itself and its reactive functional derivatives such as its halides, its esters, its anhydrides, for example the pure and mixed anhydrides with phosphoric acid, sulfuric acid and carbonic acid etc.



   For example, N- [o- (3'-methoxyphenoxy) ethyl-1] -N-methylamine or a salt thereof can be treated with diethylaminoacetic acid in the presence of a dehydrating agent suitable for these purposes, such as phosphorus pentoxide or phosphorus oxychloride .



   N- [2- (3'-methoxyphenoxy) ethyl-1] -N-methyl; amine or a salt thereof can also be reacted with a diethylaminoacetic acid halide (or a salt of such) or an anhydride .



   It is also possible to acylate N- [2- (3 = methoxy-phenoxy) -ethyl-1] -N-methylamine with a didthylaminoacetic acid ester, preferably an aryl ester, at elevated temperature.



   The N- [2- (3'-methoxyphenoxy) -ethyl-1] -N-methyl-diethylamino-acetamide obtained in this way forms a colorless 61 boiling below 0.06 mm at 157-158.



   The new amide is to be used as a local anesthetic and as an intermediate product for the preparation of further derivatives.



   Example:
17 g of N- [2- (3'-methoxyphenoxy) ethyl-1] N-methylamine in benzene are heated with a mixture of 18 g of diethylaminoacetic acid chloride hydrochloride and 20 g of triethylamine. The triethylamine hydrochloride formed is then removed by shaking with water, the benzene solution is evaporated after drying and the residue is distilled in a high vacuum. The N- [2- (3'-methoxyphenoxy) ethyl-1] -N-methyl-diethylamino acetamide, which is a colorless oil boiling below 0.06 mm at 157 to 158, is thus obtained in good yield.



     The C reaction can also be carried out without a diluent and condensing agent, for example by heating the N- [2 (3'-methoxy-phenoxy) -ethyl-1] -N-methylamine to dryness with diethylaminoacetic acid chloride hydrochloride, then heating the Reaction mass diluted with water and worked up in an obvious way.

 

Claims (1)

PATENT CLAIMS: Process for the preparation of a basic substituted fatty acid mixture, characterized in that a compound of the formula EMI2.1 a compound of the formula EMI2.2 in which If-formulas X and Y mean reactive residues that split off during the reaction, can act. The N-'2- (3 'methoxyphenoxy) -ethyl-1] -N-methyl-diethyla obtained in this way. mino-acetamide is a colorless, boiling below 0.06 mm at 157158 (il. The new ainid is said to be Loliala. Aesthetic and as an intermediate. Find use. SUBCLAIM: Method according to patent claim, characterized in that N- [2- (3'-methoxyphenoxy) ethyl-1] -N-methylamine is reacted with a diethylaminoacetic acid halide.