CH213151A - Process for the preparation of a derivative of 2-amino-6-methylpyridine. - Google Patents
Process for the preparation of a derivative of 2-amino-6-methylpyridine.Info
- Publication number
- CH213151A CH213151A CH213151DA CH213151A CH 213151 A CH213151 A CH 213151A CH 213151D A CH213151D A CH 213151DA CH 213151 A CH213151 A CH 213151A
- Authority
- CH
- Switzerland
- Prior art keywords
- methylpyridine
- amino
- derivative
- preparation
- soluble
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Darstellung eines Derivates des 2-Amirio.6-methylpyridins. Nach dem Verfahren der vorliegenden Erfindung wird ein neues Derivat des 2-Amino-6-methylpyridins erhalten, welches, wie gefunden wurde, eine stark bakterizide Wirkung gegen Kokken entfaltet, wobei,des- sen 1VIethylgruppe für die zu Grunde liegen den physikaliech-chemischen Eigenschaften mitverantwortlich zu machen ist.
Die neue Verbindung soll :daher zur Bekämpfung von durch pathogene Kokken verursachten Krank heiten Verwendung finden.
Das erfindungsgemässe Verfahren zur Darstellung der neuen Verbindung ist da .durch gekennzeichnet, dass man Acetylsulf- anilsäurechlorid mit 2-Amino-6-methylpyri- din umsetzt, wobei sich unter Abspaltung von Chlorwasserstoff 2-(p-Acetylaminoben- zolsulfonylamino-)6-methylpyridin bildet.
Ausführungsbeispiel: 105g 2-Amino-6-methylpyridin, 2,33 g p-Acetylaminobenzolsulfonsäurechlorid und 150 g Soda werden .gut vermengt und mit wenig Wasser befeuchtet.
Die Reaktion er folgt unter beträchtlicherWärmeentwicklung. Das 2-(p-Acetylaminobenzolsulfonylamino-) 6-methylpyridin wird aus verdünnter Essig säure umkristallisiert. Es bildet farblose Nadeln (aus Alkohol), -die bei 215-217 C schmelzen; sie sind leicht löslich in verdünn tem Alkali, wenig löslich in Alkohol, Azeton und Äther, sehr schwer löslich in warmem Wasser.
Process for the preparation of a derivative of 2-Amirio.6-methylpyridine. According to the process of the present invention, a new derivative of 2-amino-6-methylpyridine is obtained which, as has been found, has a strong bactericidal effect against cocci, its 1VIethyl group being the basis for the physicochemical properties is to be made jointly responsible.
The new compound should: therefore be used to combat diseases caused by pathogenic cocci.
The process according to the invention for preparing the new compound is characterized in that acetylsulfanilic acid chloride is reacted with 2-amino-6-methylpyridine, with 2- (p-acetylaminobenzenesulfonylamino) 6-methylpyridine being split off from hydrogen chloride forms.
Exemplary embodiment: 105 g of 2-amino-6-methylpyridine, 2.33 g of p-acetylaminobenzenesulphonic acid chloride and 150 g of soda are mixed well and moistened with a little water.
The reaction occurs with considerable exotherm. The 2- (p-acetylaminobenzene sulfonylamino) 6-methylpyridine is recrystallized from dilute acetic acid. It forms colorless needles (from alcohol) that melt at 215-217 C; they are easily soluble in dilute alkali, slightly soluble in alcohol, acetone and ether, very poorly soluble in warm water.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH213151T | 1939-08-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH213151A true CH213151A (en) | 1941-01-15 |
Family
ID=4448111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH213151D CH213151A (en) | 1939-08-05 | 1939-08-05 | Process for the preparation of a derivative of 2-amino-6-methylpyridine. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH213151A (en) |
-
1939
- 1939-08-05 CH CH213151D patent/CH213151A/en unknown
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