CH168032A - Process for the preparation of a therapeutically valuable derivative of veratrum acid. - Google Patents

Process for the preparation of a therapeutically valuable derivative of veratrum acid.

Info

Publication number
CH168032A
CH168032A CH168032DA CH168032A CH 168032 A CH168032 A CH 168032A CH 168032D A CH168032D A CH 168032DA CH 168032 A CH168032 A CH 168032A
Authority
CH
Switzerland
Prior art keywords
preparation
therapeutically valuable
veratrumsäuredimethylamid
derivative
acid
Prior art date
Application number
Other languages
German (de)
Inventor
F Hoffmann- Aktiengesellschaft
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH168032A publication Critical patent/CH168032A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

  Verfahren zur Darstellung eines therapeutisch wertvollen     Derivates    der     Veratrumsäure.       Es wurde gefunden, dass auch dem bis  her nicht bekannten     Veratrumsäuredimethyl-          amid    wertvolle therapeutische Eigenschaften  zukommen. Gegenstand der vorliegenden Er  findung ist ein Verfahren zur Darstellung  von     Veratrumsäuredimethylamid,    welches da  durch gekennzeichnet ist, dass man auf die       Halogenide    der     Veratrumsäure,        Dimethylamin     einwirken lässt.  



  Das     Veratrumsäuredimethylamid    kristalli  siert in farblosen, glänzenden Nadeln, die  bei 102-1030 schmelzen. Es siedet unter  einem Druck von 12 mm     unzersetzt    bei 203  .  Es ist in kaltem Wasser leicht löslich, ebenso  in Äther, Alkohol und Benzol. In     Petroläther     ist es schwerer löslich.  



  Das     Veratrumsäuredimethylamid    soll als  Arzneimittel verwendet werden.  



  <I>Beispiel:</I>  20 Teile     Veratroylchlorid    werden in 300       Volumteilen        Toluol    gelöst und zu einer Lö  sung von 9 Teilen     Dimethylamin    in 150       Volumteilen        Toluol    gegossen. Es fällt     Di-          methylaminohlorhydrat    aus, das nach einigen  Stunden abgetrennt wird. Nach dem Ab-    destillieren des     Toluols    wird der Rückstand  im Vakuum destilliert. Das     Veratrumsäure-          dimethylamid    destilliert bei einem Druck  von 12 mm bei 203   als farbloses 01 über,  das alsbald erstarrt.

   Nach dem     Umkristalli-          sieren    aus     Petroläther    erhält man es in Form  farbloser, glänzender Kristallnadeln, die bei  102-103   schmelzen.



  Process for the preparation of a therapeutically valuable derivative of veratrum acid. It has been found that veratrumsäuredimethyl amide, which was not previously known, also has valuable therapeutic properties. The subject matter of the present invention is a process for the preparation of veratrumsäuredimethylamid, which is characterized in that dimethylamine is allowed to act on the halides of veratrumsäure.



  The Veratrumsäuredimethylamid crystallized in colorless, shiny needles that melt at 102-1030. It boils undecomposed at 203 under a pressure of 12 mm. It is easily soluble in cold water, as well as in ether, alcohol and benzene. It is more difficult to dissolve in petroleum ether.



  Veratrumsäuredimethylamid should be used as a drug.



  <I> Example: </I> 20 parts of veratroyl chloride are dissolved in 300 parts by volume of toluene and poured into a solution of 9 parts of dimethylamine in 150 parts by volume of toluene. Dimethylamine carbohydrate precipitates and is separated off after a few hours. After the toluene has been distilled off, the residue is distilled in vacuo. The veratrum acid dimethylamide distilled over at a pressure of 12 mm at 203 as a colorless oil, which soon solidified.

   After recrystallization from petroleum ether, it is obtained in the form of colorless, shiny crystal needles which melt at 102-103.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines thera peutisch wertvollen Derivates der Veratrum- säure, dadurch gekennzeichnet, dass man auf die Halogenide der Veratrumsäure Dimethyl- amin einwirken lässt. Das Veratrumsäuredimethylamid kristalli siert in farblosen, glänzenden Nadeln, die bei<B>102</B>-<B>1030</B> schmelzen. Es siedet unter einem Druck von 12 mm unzersetzt bei 203 . Es ist im kalten Wasser leicht löslich, ebenso in Äther, Alkohol und Benzol. In Petroläther ist es schwerer löslich. PATENT CLAIM: Process for the preparation of a therapeutically valuable derivative of veratric acid, characterized in that dimethylamine is allowed to act on the halides of veratric acid. Veratrumsäuredimethylamid crystallizes in colorless, shiny needles, which melt at <B> 102 </B> - <B> 1030 </B>. It boils undecomposed at 203 under a pressure of 12 mm. It is easily soluble in cold water, as well as in ether, alcohol and benzene. It is more difficult to dissolve in petroleum ether. Das Veratrumsäuredimethylamid soll als Arzneimittel verwendet werden. Veratrumsäuredimethylamid should be used as a drug.
CH168032D 1932-07-20 1932-07-20 Process for the preparation of a therapeutically valuable derivative of veratrum acid. CH168032A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH168032T 1932-07-20
CH163700T 1932-07-20

Publications (1)

Publication Number Publication Date
CH168032A true CH168032A (en) 1934-03-15

Family

ID=25717858

Family Applications (1)

Application Number Title Priority Date Filing Date
CH168032D CH168032A (en) 1932-07-20 1932-07-20 Process for the preparation of a therapeutically valuable derivative of veratrum acid.

Country Status (1)

Country Link
CH (1) CH168032A (en)

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