CH163700A - Process for the preparation of a therapeutically valuable derivative of veratrum acid. - Google Patents
Process for the preparation of a therapeutically valuable derivative of veratrum acid.Info
- Publication number
- CH163700A CH163700A CH163700DA CH163700A CH 163700 A CH163700 A CH 163700A CH 163700D A CH163700D A CH 163700DA CH 163700 A CH163700 A CH 163700A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- therapeutically valuable
- acid
- ether
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung eines therapeutiseh wertvollen Derivates der Veratrumsäure. Es wurde gefunden, dass dem bisher nicht bekannten Veratrumsäurediäthylamid wert volle therapeutische Eigenschaften zukom men. Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Darstellung von Ver- atrumsäurediäthylamid, welches dadurch ge kennzeichnet ist, da.ss man auf die Halogenide der Veratrumsäure Diäthylamin einwirken lässt.
Das Veratrumsäurediäthylamid ist ein dickflüssiges, farbloses, schwach bitter schmeckendes Öl, welches unter einem Druck von 12 mm bei 201 bis 205 siedet. Es ist mit Wasser in allen Verhältnissen mischbar. In Alkohol, Äther ist es leicht löslich. Petrol- äther löst wenig.
Das Veratrumsäurediäthylamid soll als Arzneimittel verwendet werden.
<I>Beispiel;</I> 40,1 Teile Veratroylehlorid werden in 400 Teilen absolutem Äther gelöst und zu einer Lösung von 29,$ Teilen Diäthylamin in 100 Teilen absolutem Äther gegossen. Es fällt Diäthylaminchlorliydrat aus, das nach einigen Stunden abgetrennt wird. Nach dem Abdampfen des Äthers wird das zurück bleibende Öl im Vakuum destilliert.
Zur wei teren Reinigung wird das Destillat in wenig Wasser gelöst, durch Zugabe von Pottasche ausgefällt, in Äther aufgenommen und nach dem Trocknen über Pottasche nochmals im Vakuum destilliert, wobei das Veratrum- säurediäthylamid unter einem Druck von 12 mm bei 20'1 bis 205 übergeht.
Process for the preparation of a therapeutically valuable derivative of veratrum acid. It has been found that the previously unknown Veratrumsäurediäthylamid have valuable therapeutic properties. The subject of the present invention is a process for the preparation of veratrum acid diethylamide, which is characterized in that diethylamine is allowed to act on the halides of veratrums acid.
Veratrumsäurediäthylamid is a viscous, colorless, slightly bitter-tasting oil, which boils at 201 to 205 under a pressure of 12 mm. It is miscible with water in all proportions. It is easily soluble in alcohol and ether. Petroleum ether does not dissolve much.
The Veratrumsäurediethylamid should be used as a drug.
<I> Example; </I> 40.1 parts of veratrolyl chloride are dissolved in 400 parts of absolute ether and poured into a solution of 29 parts of diethylamine in 100 parts of absolute ether. Diethylamine chlorohydrate precipitates and is separated off after a few hours. After the ether has evaporated, the remaining oil is distilled in vacuo.
For further purification, the distillate is dissolved in a little water, precipitated by adding potash, taken up in ether and, after drying over potash, distilled again in vacuo, the veratrum acid diethylamide passing over under a pressure of 12 mm at 20-1205 .
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH163700T | 1932-07-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH163700A true CH163700A (en) | 1933-08-31 |
Family
ID=4416756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH163700D CH163700A (en) | 1932-07-20 | 1932-07-01 | Process for the preparation of a therapeutically valuable derivative of veratrum acid. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH163700A (en) |
-
1932
- 1932-07-01 CH CH163700D patent/CH163700A/en unknown
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