CH132907A - Process for the preparation of a halogenated 2-pyridine. - Google Patents

Process for the preparation of a halogenated 2-pyridine.

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Publication number
CH132907A
CH132907A CH132907DA CH132907A CH 132907 A CH132907 A CH 132907A CH 132907D A CH132907D A CH 132907DA CH 132907 A CH132907 A CH 132907A
Authority
CH
Switzerland
Prior art keywords
oxy
diiodopyridine
preparation
halogenated
pyridine
Prior art date
Application number
Other languages
German (de)
Inventor
Schering-Kahlbaum A G
Original Assignee
Schering Kahlbaum Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE132907X external-priority
Application filed by Schering Kahlbaum Ag filed Critical Schering Kahlbaum Ag
Publication of CH132907A publication Critical patent/CH132907A/en

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Description

  

  Verfahren zur Darstellung eines     halogenierten        2-Pyridins.       Bisher ist zur Gewinnung von     haloge-          niertem        2-Pyridon    nur der Weg beschritten  worden, dass man das     halogenierte        2-Amino-          pyridin        diazatierte    und durch Erwärmen mit  Wasser die     Diazogruppe    gegen     Hydroxyl     austauscht.

   Es wurde gefunden, dass man  auch über das     2-Pyridon    durch direkte     Ha-          logenierung    gehen kann, wobei je nach den  Bedingungen mono- oder     dihalogenierte     Verbindungen entstehen. Beim Behandeln  von     2-Pyridon    mit Chlorjod in saurer Lö  sung erhält man das     2-Oxy-3.5-dijod-          pyridin.     



  <I>Beispiel:</I>  20     gr        2-Pyridon    werden in 25 cm' ver  dünnter Salzsäure gelöst und mit 35     gr          Jodmonochlorid    in verdünnter Salzsäure ver  setzt. Nach mehrstündigem Stehen bei ge  wöhnlicher Temperatur scheidet sich das     2-          Oxy-3.        5-jodpyridin    in reiner Form ab.  



  Das     2-Oxy-3.        5-dijodpyridin    bildet gelb  liche Kristalle; es lässt sich aus einem       Alkohol-Pyridingemisch    oder aus Eisessig       umkristallisieren.    Es schmilzt bei 255  , bei    265   C     zersetzt    es sich. In heisser Natron  lauge ist es löslich; beim Erkalten kristal  lisiert die     Natriumverbindung    aus. Das     2-          Oxy-3.        5-dijodpyridin    soll als     Zwischenpro-          dukt    für die Herstellung     pharmazeutischer     Präparate verwendet werden.



  Process for the preparation of a halogenated 2-pyridine. So far, the only way to obtain halogenated 2-pyridone has been to diazate the halogenated 2-aminopyridine and exchange the diazo group for hydroxyl by heating with water.

   It has been found that it is also possible to proceed via the 2-pyridone by direct halogenation, with mono- or dihalogenated compounds being formed depending on the conditions. When 2-pyridone is treated with chloroiodine in acidic solution, 2-oxy-3,5-diiodopyridine is obtained.



  <I> Example: </I> 20 g 2-pyridone are dissolved in 25 cm diluted hydrochloric acid and mixed with 35 g iodine monochloride in dilute hydrochloric acid. After standing for several hours at normal temperature, the 2-Oxy-3 separates. 5-iodopyridine in its pure form.



  The 2-oxy-3. 5-diiodopyridine forms yellowish crystals; it can be recrystallized from an alcohol-pyridine mixture or from glacial acetic acid. It melts at 255, at 265 C it decomposes. It is soluble in hot sodium hydroxide solution; the sodium compound crystallizes out on cooling. The 2-oxy-3. 5-diiodopyridine is intended to be used as an intermediate product for the manufacture of pharmaceutical preparations.

 

Claims (1)

<B>PATENTANSPRUCH:</B> Verfahren zur Darstellung von 2-Oxy- 3.5-dijodpyridin, dadurch gekennzeichnet,. dass man 2-Pyridon mit Chlorjod in saurer Lösung behandelt. Das 2-Oxy-3. 5-dijodpyridin bildet gelb liche Kristalle; es lässt sich aus einem @A.lkohol-Pyridingemisch oder aus Eisessig umkristallisieren. Es schmilzt bei<B>255',</B> bei 265 C zersetzt es sich. In heisser Natron lauge ist es löslich; beim Erkalten kristal lisiert die Natriumverbindung aus. <B> PATENT CLAIM: </B> Process for the preparation of 2-oxy-3,5-diiodopyridine, characterized in that. that 2-pyridone is treated with chloroiodine in acidic solution. The 2-oxy-3. 5-diiodopyridine forms yellowish crystals; it can be recrystallized from an alcohol-pyridine mixture or from glacial acetic acid. It melts at <B> 255 ', </B> at 265 C it decomposes. It is soluble in hot sodium hydroxide solution; the sodium compound crystallizes out on cooling. Das 2-. Oxy-3 . 5-dijodpyridin soll als Zwischenpro dukt für die Herstellung pharmazeutischer Präparate dienen. The 2-. Oxy-3. 5-diiodopyridine is intended to serve as an intermediate product for the manufacture of pharmaceutical preparations.
CH132907D 1927-03-31 1928-01-31 Process for the preparation of a halogenated 2-pyridine. CH132907A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE132907X 1927-03-31

Publications (1)

Publication Number Publication Date
CH132907A true CH132907A (en) 1929-05-15

Family

ID=5664731

Family Applications (1)

Application Number Title Priority Date Filing Date
CH132907D CH132907A (en) 1927-03-31 1928-01-31 Process for the preparation of a halogenated 2-pyridine.

Country Status (1)

Country Link
CH (1) CH132907A (en)

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