CH122521A - Process for the preparation of an aralkylamine. - Google Patents

Process for the preparation of an aralkylamine.

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Publication number
CH122521A
CH122521A CH122521DA CH122521A CH 122521 A CH122521 A CH 122521A CH 122521D A CH122521D A CH 122521DA CH 122521 A CH122521 A CH 122521A
Authority
CH
Switzerland
Prior art keywords
guaiacol
preparation
aralkylamine
parts
halomethylphthalimide
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH122521A publication Critical patent/CH122521A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung     eines        Aralkylamins.       Es wurde gefunden, dass man nach dem  im Hauptpatent beschriebenen Verfahren       4-Oxy-3-methoxybenzylamin    herstellen kann,  wenn man an Stelle des dort verwendeten  Benzols     Guajakol    verwendet.  



  <I>Beispiel:</I>  63 Teile     Guajakol    und 32 Teile     co-Chlor-          methylphtalimid    werden ohne Anwendung  eines     Katalysators    durch Erwärmen bis etwa  auf 120 o C zu     4-Oxy-3-methoxybenzylphtal-          imid    vom Schmelzpunkt 154 o kondensiert,  wobei, wie ersichtlich, das     Guajakol,    das  gleichzeitig Lösungsmittel ist, im Überschuss  vorhanden ist. 50 Teile der Verbindung wer  den mit 50 Teilen Alkohol, 100 Teilen  35     o/oiger        Natriumhydroxydlösung    und 200  Teilen Wasser kalt 2     ,Stunden    lang gerührt.

    Dann wird mit verdünnter Salzsäure ange  säuert und der Alkohol verjagt und etwa  ausgeschiedenes Öl durch Wasserzusatz in  Lösung gebracht. Bei der Aufarbeitung er  hält man das 4-Oxy-3-methoxybenzylamin-         chlorhydrat,    durch Zusatz von     Natriumhydro-          xyd    und     Ausäthern    die freie Base.  



  Das Verfahren lässt sich auch in Gegen  wart eines     Katalysators,    z. B. Chlorzink,  durchführen.  



  Das erhaltene, an sich bekannte Produkt  soll als Zwischenprodukt bei der Darstellung  technisch wichtige Stoffe, wie     Riechstoffe    und  Heilmittel, Verwendung finden.



  Process for the preparation of an aralkylamine. It has been found that 4-oxy-3-methoxybenzylamine can be prepared by the process described in the main patent if guaiacol is used instead of the benzene used there.



  <I> Example: </I> 63 parts of guaiacol and 32 parts of co-chloromethylphthalimide are condensed without using a catalyst by heating to about 120 ° C. to give 4-oxy-3-methoxybenzylphthalimide with a melting point of 154 °, with As can be seen, the guaiacol, which is also a solvent, is present in excess. 50 parts of the compound who stirred the cold with 50 parts of alcohol, 100 parts of 35 o / o sodium hydroxide solution and 200 parts of water for 2 hours.

    Then it is acidified with dilute hydrochloric acid and the alcohol is driven off and any oil that has separated out is brought into solution by adding water. During work-up, the 4-oxy-3-methoxybenzylamine chlorohydrate is obtained, and the free base is obtained by adding sodium hydroxide and ether.



  The method can also be used in the presence of a catalyst, e.g. B. zinc chloride, perform.



  The product obtained, known per se, is intended to be used as an intermediate product in the preparation of technically important substances such as fragrances and medicinal products.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von 4-Oxy-3- methoxybenzylamin, dadurch gekennzeichnet, dass man auf Guajakol w-Halogenmethylphtal- imid einwirken lässt und das so entstandene Kondensationsprodukt spaltet. UNTERANSPRüCHE 1. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man das Guajakol und das a)-Halogenmethylphtalimid in Gegen wart eines Katalysators aufeinander ein wirken lässt. PATENT CLAIM: Process for the preparation of 4-oxy-3-methoxybenzylamine, characterized in that w-halomethylphthalimide is allowed to act on guaiacol and the resulting condensation product is cleaved. SUBClaims 1. The method according to claim, characterized in that the guaiacol and the a) -halomethylphthalimide are allowed to act on one another in the presence of a catalyst. \?. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man das Guajakol im Überschur anwendet, wobei es zugleich die Rolle eines Lösungsmittels spielt. :3. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man die Spaltung des Kondensationsproduktes durch auf einanderfolgende Behandlung mit Alkalien und Säuren herbeiführt. \ ?. Process according to patent claim, characterized in that the guaiacol is used in excess, it at the same time playing the role of a solvent. : 3. Process according to patent claim, characterized in that the cleavage of the condensation product is brought about by successive treatment with alkalis and acids.
CH122521D 1925-03-30 1926-03-23 Process for the preparation of an aralkylamine. CH122521A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE122521X 1925-03-30
CH120519T 1926-03-23

Publications (1)

Publication Number Publication Date
CH122521A true CH122521A (en) 1927-09-16

Family

ID=25709456

Family Applications (1)

Application Number Title Priority Date Filing Date
CH122521D CH122521A (en) 1925-03-30 1926-03-23 Process for the preparation of an aralkylamine.

Country Status (1)

Country Link
CH (1) CH122521A (en)

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