CA3168451A1 - Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller - Google Patents

Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller Download PDF

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Publication number
CA3168451A1
CA3168451A1 CA3168451A CA3168451A CA3168451A1 CA 3168451 A1 CA3168451 A1 CA 3168451A1 CA 3168451 A CA3168451 A CA 3168451A CA 3168451 A CA3168451 A CA 3168451A CA 3168451 A1 CA3168451 A1 CA 3168451A1
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base
cluster
data
base caller
caller
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French (fr)
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Anindita Dutta
Gery VESSERE
Dorna KASHEFHAGHIGHI
Kishore Jaganathan
Amirali Kia
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Illumina Inc
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Illumina Inc
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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/214—Generating training patterns; Bootstrap methods, e.g. bagging or boosting
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G06N3/082—Learning methods modifying the architecture, e.g. adding, deleting or silencing nodes or connections
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/044—Recurrent networks, e.g. Hopfield networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/044—Recurrent networks, e.g. Hopfield networks
    • G06N3/0442—Recurrent networks, e.g. Hopfield networks characterised by memory or gating, e.g. long short-term memory [LSTM] or gated recurrent units [GRU]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
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    • G—PHYSICS
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    • G06N3/02—Neural networks
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    • G06N3/0464—Convolutional networks [CNN, ConvNet]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/0475—Generative networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/048—Activation functions
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/0495—Quantised networks; Sparse networks; Compressed networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/06—Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons
    • G06N3/063—Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G06N3/084—Backpropagation, e.g. using gradient descent
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
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    • G06N3/08—Learning methods
    • G06N3/09—Supervised learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00—Computing arrangements using knowledge-based models
    • G06N5/04—Inference or reasoning models
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/40—Extraction of image or video features
    • G06V10/44—Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
    • G06V10/443—Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components by matching or filtering
    • G06V10/449—Biologically inspired filters, e.g. difference of Gaussians [DoG] or Gabor filters
    • G06V10/451—Biologically inspired filters, e.g. difference of Gaussians [DoG] or Gabor filters with interaction between the filter responses, e.g. cortical complex cells
    • G06V10/454—Integrating the filters into a hierarchical structure, e.g. convolutional neural networks [CNN]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/82—Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Data Mining & Analysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Software Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Computing Systems (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Computational Linguistics (AREA)
  • Medical Informatics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Databases & Information Systems (AREA)
  • Biotechnology (AREA)
  • Multimedia (AREA)
  • Bioethics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Neurology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Signal Processing (AREA)
  • Image Analysis (AREA)
  • Compression, Expansion, Code Conversion, And Decoders (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3168451A 2020-02-20 2021-02-17 Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller Pending CA3168451A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062979385P 2020-02-20 2020-02-20
US62/979,385 2020-02-20
US17/176,151 US12354008B2 (en) 2020-02-20 2021-02-15 Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller
US17/176,151 2021-02-15
PCT/US2021/018422 WO2021168014A1 (en) 2020-02-20 2021-02-17 Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller

Publications (1)

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CA3168451A1 true CA3168451A1 (en) 2021-08-26

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CA3168451A Pending CA3168451A1 (en) 2020-02-20 2021-02-17 Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller

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US (2) US12354008B2 (https=)
EP (1) EP4107737B1 (https=)
JP (1) JP7754822B2 (https=)
KR (1) KR20220144372A (https=)
CN (1) CN115136245A (https=)
AU (1) AU2021224592A1 (https=)
BR (1) BR112022016409A2 (https=)
CA (1) CA3168451A1 (https=)
IL (1) IL295568B1 (https=)
MX (1) MX2022010275A (https=)
MY (1) MY209788A (https=)
WO (1) WO2021168014A1 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
CA3168435A1 (en) 2020-02-20 2021-08-26 Illumina Inc. Artificial intelligence-based many-to-many base calling
WO2021255516A1 (en) * 2020-06-15 2021-12-23 Universidade Do Porto Multi-convolutional two-dimensional attention unit for analysis of a multivariable time series three-dimensional input data
US12254062B2 (en) * 2020-08-26 2025-03-18 International Business Machines Corporation Domain adaptation
KR102232138B1 (ko) * 2020-11-17 2021-03-25 (주)에이아이매틱스 지식 증류 기반 신경망 아키텍처 탐색 방법
US20220301657A1 (en) 2021-03-16 2022-09-22 Illumina, Inc. Tile location and/or cycle based weight set selection for base calling
CN113159173B (zh) * 2021-04-20 2024-04-26 北京邮电大学 一种结合剪枝与知识蒸馏的卷积神经网络模型压缩方法
US11620993B2 (en) * 2021-06-09 2023-04-04 Merlyn Mind, Inc. Multimodal intent entity resolver
EP4125003A1 (en) * 2021-07-16 2023-02-01 Tata Consultancy Services Limited System and method for learning disentangled representations for temporal causal inference
CN114140619B (zh) * 2021-10-31 2024-09-06 浪潮电子信息产业股份有限公司 图像数据生成方法、模型训练方法、装置、设备及介质
CN113987187B (zh) * 2021-11-09 2024-06-28 重庆大学 基于多标签嵌入的舆情文本分类方法、系统、终端及介质
CN114170599B (zh) * 2021-12-14 2024-08-23 华中科技大学 一种基于蒸馏比较的异常物体分割方法
CN114492731B (zh) * 2021-12-23 2024-12-20 北京达佳互联信息技术有限公司 图像处理模型的训练方法及装置、电子设备
CN114299993B (zh) * 2021-12-24 2024-12-03 中北大学 一种基于数据蒸馏的多枪声混合智能分类识别系统及方法
CN114780709B (zh) * 2022-03-22 2023-04-07 北京三快在线科技有限公司 文本匹配方法、装置及电子设备
CN114998648B (zh) * 2022-05-16 2024-07-23 电子科技大学 一种基于梯度架构搜索的表现预测压缩方法
CN119895436A (zh) * 2022-08-29 2025-04-25 蒂普爱可斯有限公司 人工神经网络的分布式计算系统及方法
CN116542320B (zh) * 2023-05-06 2025-05-30 广东工业大学 一种基于持续学习的小样本事件检测方法和系统
CN116451771B (zh) * 2023-06-14 2023-09-15 中诚华隆计算机技术有限公司 图像分类卷积神经网络压缩方法及芯粒器件数据分配方法
US20250021801A1 (en) * 2023-07-12 2025-01-16 Canon Medical Systems Corporation Mapping method and apparatus
CN117095217A (zh) * 2023-08-22 2023-11-21 电子科技大学 多阶段对比知识蒸馏方法
CN117372785B (zh) * 2023-12-04 2024-03-26 吉林大学 一种基于特征簇中心压缩的图像分类方法
CN117393043B (zh) * 2023-12-11 2024-02-13 浙江大学 一种甲状腺乳头状瘤braf基因突变检测装置
CN118942549A (zh) * 2024-04-30 2024-11-12 深圳市真迈生物科技有限公司 碱基识别方法、装置、设备及存储介质
CN118570601B (zh) * 2024-08-05 2024-10-29 广东海洋大学 一种联合高级视觉任务的红外与可见光图像融合方法
CN120762420B (zh) * 2025-09-09 2025-11-07 蜂巢智行(上海)技术有限公司 基于vla架构与蒸馏学习的无人物流车驾驶决策方法及系统

Family Cites Families (195)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US6090592A (en) 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
EP0746865B1 (en) 1994-12-08 2003-03-26 Molecular Dynamics, Inc. Fluorescence imaging system employing a macro scanning objective
US5528050A (en) 1995-07-24 1996-06-18 Molecular Dynamics, Inc. Compact scan head with multiple scanning modalities
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20020055100A1 (en) 1997-04-01 2002-05-09 Kawashima Eric H. Method of nucleic acid sequencing
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
EP1923471B1 (en) 1999-04-20 2012-12-19 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20050181440A1 (en) 1999-04-20 2005-08-18 Illumina, Inc. Nucleic acid sequencing using microsphere arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
WO2002004680A2 (en) 2000-07-07 2002-01-17 Visigen Biotechnologies, Inc. Real-time sequence determination
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
EP1436596A2 (en) 2001-09-28 2004-07-14 Ciencia, Incorporated Compact multiwavelength phase fluorometer
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US20040002090A1 (en) 2002-03-05 2004-01-01 Pascal Mayer Methods for detecting genome-wide sequence variations associated with a phenotype
EP3002289B1 (en) 2002-08-23 2018-02-28 Illumina Cambridge Limited Modified nucleotides for polynucleotide sequencing
US7490085B2 (en) * 2002-12-18 2009-02-10 Ge Medical Systems Global Technology Company, Llc Computer-assisted data processing system and method incorporating automated learning
AU2003290429A1 (en) 2002-12-25 2004-07-22 Casio Computer Co., Ltd. Optical dna sensor, dna reading apparatus, identification method of dna and manufacturing method of optical dna sensor
WO2005003375A2 (en) 2003-01-29 2005-01-13 454 Corporation Methods of amplifying and sequencing nucleic acids
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
EP1641809B2 (en) 2003-07-05 2018-10-03 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
GB0321306D0 (en) 2003-09-11 2003-10-15 Solexa Ltd Modified polymerases for improved incorporation of nucleotide analogues
EP1701785A1 (en) 2004-01-07 2006-09-20 Solexa Ltd. Modified molecular arrays
WO2006020627A1 (en) 2004-08-11 2006-02-23 Aureon Laboratories, Inc. Systems and methods for automated diagnosis and grading of tissue images
US7315019B2 (en) 2004-09-17 2008-01-01 Pacific Biosciences Of California, Inc. Arrays of optical confinements and uses thereof
WO2006064199A1 (en) 2004-12-13 2006-06-22 Solexa Limited Improved method of nucleotide detection
JP4941990B2 (ja) 2005-02-21 2012-05-30 味の素株式会社 Ｎε−アシル−Ｌ−リジン特異的アミノアシラーゼ
US20090081775A1 (en) 2005-05-25 2009-03-26 Stiftesen Unversitetsforskning Bergen Microscope system and screening method for drugs, physical therapies and biohazards
FR2886433B1 (fr) 2005-05-30 2007-09-07 Commissariat Energie Atomique Methode de segmentation d'une sequence d'images tridimensionnelles, notamment en pharmaco-imagerie.
US8045998B2 (en) 2005-06-08 2011-10-25 Cisco Technology, Inc. Method and system for communicating using position information
JP5331476B2 (ja) 2005-06-15 2013-10-30 カリダ・ジェノミックス・インコーポレイテッド 遺伝子解析および化学解析用の単分子アレイ
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
JP2007199397A (ja) 2006-01-26 2007-08-09 Nikon Corp 顕微鏡装置
WO2007107710A1 (en) 2006-03-17 2007-09-27 Solexa Limited Isothermal methods for creating clonal single molecule arrays
EP3722409A1 (en) 2006-03-31 2020-10-14 Illumina, Inc. Systems and devices for sequence by synthesis analysis
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
US7414716B2 (en) 2006-10-23 2008-08-19 Emhart Glass S.A. Machine for inspecting glass containers
US8343746B2 (en) 2006-10-23 2013-01-01 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US20080242560A1 (en) 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
US7835871B2 (en) 2007-01-26 2010-11-16 Illumina, Inc. Nucleic acid sequencing system and method
US8401258B2 (en) 2007-03-16 2013-03-19 Sti Medical Systems, Llc Method to provide automated quality feedback to imaging devices to achieve standardized imaging data
US8703422B2 (en) 2007-06-06 2014-04-22 Pacific Biosciences Of California, Inc. Methods and processes for calling bases in sequence by incorporation methods
US8182993B2 (en) 2007-06-06 2012-05-22 Pacific Biosciences Of California, Inc. Methods and processes for calling bases in sequence by incorporation methods
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
US8407012B2 (en) 2008-07-03 2013-03-26 Cold Spring Harbor Laboratory Methods and systems of DNA sequencing
WO2010019925A1 (en) 2008-08-15 2010-02-18 Brown Technology Partnerships Method and apparatus for estimating body shape
US8175379B2 (en) 2008-08-22 2012-05-08 Adobe Systems Incorporated Automatic video image segmentation
US8392126B2 (en) 2008-10-03 2013-03-05 Illumina, Inc. Method and system for determining the accuracy of DNA base identifications
US20100157086A1 (en) 2008-12-15 2010-06-24 Illumina, Inc Dynamic autofocus method and system for assay imager
WO2010138121A1 (en) 2009-05-28 2010-12-02 Hewlett-Packard Development Company, L.P. Image processing
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
US8182994B2 (en) 2009-09-15 2012-05-22 Illumina Cambridge Limited Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing
US20140152801A1 (en) 2009-10-28 2014-06-05 Alentic Microscience Inc. Detecting and Using Light Representative of a Sample
US9023769B2 (en) 2009-11-30 2015-05-05 Complete Genomics, Inc. cDNA library for nucleic acid sequencing
US8965076B2 (en) 2010-01-13 2015-02-24 Illumina, Inc. Data processing system and methods
US10619195B2 (en) 2010-04-06 2020-04-14 Massachusetts Institute Of Technology Gene-expression profiling with reduced numbers of transcript measurements
EP2569721A4 (en) 2010-05-14 2013-11-27 Datalogic Adc Inc SYSTEMS AND METHODS FOR OBJECT DETECTION USING A LARGE DATABASE
US20110295902A1 (en) 2010-05-26 2011-12-01 Tata Consultancy Service Limited Taxonomic classification of metagenomic sequences
US20120015825A1 (en) 2010-07-06 2012-01-19 Pacific Biosciences Of California, Inc. Analytical systems and methods with software mask
EP2632593B1 (en) 2010-10-27 2021-09-29 Illumina, Inc. Flow cells for biological or chemical analysis
DE102010062341B4 (de) 2010-12-02 2023-05-17 Carl Zeiss Microscopy Gmbh Vorrichtung zur Erhöhung der Tiefendiskriminierung optisch abbildender Systeme
WO2012092515A2 (en) 2010-12-30 2012-07-05 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
US20130060482A1 (en) 2010-12-30 2013-03-07 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
AU2012242525B2 (en) 2011-04-14 2015-09-17 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
EP2718465B1 (en) 2011-06-09 2022-04-13 Illumina, Inc. Method of making an analyte array
CA2859660C (en) 2011-09-23 2021-02-09 Illumina, Inc. Methods and compositions for nucleic acid sequencing
CA2856163C (en) 2011-10-28 2019-05-07 Illumina, Inc. Microarray fabrication system and method
WO2013096692A1 (en) 2011-12-21 2013-06-27 Illumina, Inc. Apparatus and methods for kinetic analysis and determination of nucleic acid sequences
US8660342B2 (en) 2012-01-24 2014-02-25 Telefonica, S.A. Method to assess aesthetic quality of photographs
EP2834622B1 (en) 2012-04-03 2023-04-12 Illumina, Inc. Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
US8906320B1 (en) 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
US10068054B2 (en) 2013-01-17 2018-09-04 Edico Genome, Corp. Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform
AU2013382195B2 (en) 2013-03-13 2019-09-19 Illumina, Inc. Methods and systems for aligning repetitive DNA elements
US10421996B2 (en) 2013-03-14 2019-09-24 Illumina, Inc. Modified polymerases for improved incorporation of nucleotide analogues
ES2641480T3 (es) 2013-03-15 2017-11-10 Ventana Medical Systems, Inc. Sistema de aprendizaje automático basado en objetos de tejido para puntuación automatizada de portaobjetos digitales completos
EP2994544B1 (en) 2013-05-06 2019-10-02 Pacific Biosciences Of California, Inc. Real-time electronic sequencing
ES2875892T3 (es) 2013-09-20 2021-11-11 Spraying Systems Co Boquilla de pulverización para craqueo catalítico fluidizado
US9299004B2 (en) 2013-10-24 2016-03-29 Adobe Systems Incorporated Image foreground detection
RS60736B1 (sr) 2013-12-03 2020-09-30 Illumina Inc Postupci i sistemi za analizu podataka sa slika
KR102102934B1 (ko) 2013-12-10 2020-04-21 일루미나, 인코포레이티드 생물학적 또는 화학적 분석을 위한 바이오센서들 및 이를 제조하기 위한 방법
EP3084002A4 (en) 2013-12-16 2017-08-23 Complete Genomics, Inc. Basecaller for dna sequencing using machine learning
GB201408853D0 (en) 2014-05-19 2014-07-02 Diamond Light Source Ltd Analysis of signals from pixellated detectors of ionizing radiation
US10127448B2 (en) 2014-08-27 2018-11-13 Bae Systems Information And Electronic Systems Integration Inc. Method and system for dismount detection in low-resolution UAV imagery
US10699801B2 (en) 2014-09-12 2020-06-30 Illumina Cambridge Limited Detecting repeat expansions with short read sequencing data
WO2016086744A1 (en) 2014-12-02 2016-06-09 Shanghai United Imaging Healthcare Co., Ltd. A method and system for image processing
CN107735496B (zh) 2014-12-26 2021-05-07 株式会社日立高新技术 核酸分析装置
IL236598A0 (en) 2015-01-05 2015-05-31 Superfish Ltd Image similarity as a function of image weighted image descriptors generated from neural networks
US10410118B2 (en) 2015-03-13 2019-09-10 Deep Genomics Incorporated System and method for training neural networks
EP3286337A4 (en) 2015-04-23 2018-12-12 Cedars-Sinai Medical Center Automated delineation of nuclei for three dimensional (3-d) high content screening
US9836839B2 (en) 2015-05-28 2017-12-05 Tokitae Llc Image analysis systems and related methods
US10061972B2 (en) 2015-05-28 2018-08-28 Tokitae Llc Image analysis systems and related methods
US10185803B2 (en) 2015-06-15 2019-01-22 Deep Genomics Incorporated Systems and methods for classifying, prioritizing and interpreting genetic variants and therapies using a deep neural network
CA2894317C (en) 2015-06-15 2023-08-15 Deep Genomics Incorporated Systems and methods for classifying, prioritizing and interpreting genetic variants and therapies using a deep neural network
WO2016209999A1 (en) 2015-06-22 2016-12-29 Counsyl, Inc. Methods of predicting pathogenicity of genetic sequence variants
CN106434873B (zh) 2015-08-13 2021-08-27 生捷科技控股公司 使核酸分子同步化的方法
US10755810B2 (en) 2015-08-14 2020-08-25 Elucid Bioimaging Inc. Methods and systems for representing, storing, and accessing computable medical imaging-derived quantities
US10176408B2 (en) 2015-08-14 2019-01-08 Elucid Bioimaging Inc. Systems and methods for analyzing pathologies utilizing quantitative imaging
US11094058B2 (en) 2015-08-14 2021-08-17 Elucid Bioimaging Inc. Systems and method for computer-aided phenotyping (CAP) using radiologic images
US11302416B2 (en) * 2015-09-02 2022-04-12 Guardant Health Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications
EP3147650A1 (en) 2015-09-22 2017-03-29 MyCartis N.V. Cross-talk correction in multiplexing analysis of biological sample
US10930372B2 (en) 2015-10-02 2021-02-23 Northrop Grumman Systems Corporation Solution for drug discovery
US10474951B2 (en) 2015-10-23 2019-11-12 Nec Corporation Memory efficient scalable deep learning with model parallelization
WO2017098015A1 (en) 2015-12-10 2017-06-15 Qiagen Gmbh Background compensation
KR102592076B1 (ko) 2015-12-14 2023-10-19 삼성전자주식회사 딥러닝 기반 영상 처리 장치 및 방법, 학습 장치
GB2549554A (en) 2016-04-21 2017-10-25 Ramot At Tel-Aviv Univ Ltd Method and system for detecting an object in an image
JP6953430B2 (ja) 2016-04-22 2021-10-27 イラミーナ インコーポレーテッド ピクセル内における複数部位の発光性造影に使用するためのフォトニック構造をベースとしたデバイス及び組成物、並びにその使用方法
WO2017189469A1 (en) 2016-04-29 2017-11-02 Microsoft Technology Licensing, Llc Trace reconstruction from noisy polynucleotide sequencer reads
US10354747B1 (en) 2016-05-06 2019-07-16 Verily Life Sciences Llc Deep learning analysis pipeline for next generation sequencing
MX2018014856A (es) 2016-06-01 2019-03-07 Quantum Si Inc Llamador de pulso y llamador de base.
US20180107927A1 (en) 2016-06-15 2018-04-19 Deep Genomics Incorporated Architectures for training neural networks using biological sequences, conservation, and molecular phenotypes
WO2018029108A1 (en) 2016-08-08 2018-02-15 F. Hoffmann-La Roche Ag Basecalling for stochastic sequencing processes
CN106529424B (zh) 2016-10-20 2019-01-04 中山大学 一种基于选择性搜索算法的车标检测识别方法及系统
WO2018089783A1 (en) 2016-11-11 2018-05-17 University Of South Florida Automated stereology for determining tissue characteristics
EP4567728A1 (en) 2016-12-22 2025-06-11 Ventana Medical Systems, Inc. Computer scoring based on primary stain and immunohistochemistry images
CN110366596A (zh) 2016-12-28 2019-10-22 埃斯库斯生物科技股份公司 用于对复杂异质群落中的完整微生物株系进行分析、确定其功能关系及相互作用以及基于此来识别和合成生物活性改性剂的方法、设备和系统
CN116612818A (zh) 2017-01-06 2023-08-18 伊鲁米那股份有限公司 移相校正
US10740880B2 (en) 2017-01-18 2020-08-11 Elucid Bioimaging Inc. Systems and methods for analyzing pathologies utilizing quantitative imaging
US10844429B2 (en) 2017-01-18 2020-11-24 Illumina, Inc. Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths
US10491239B1 (en) 2017-02-02 2019-11-26 Habana Labs Ltd. Large-scale computations using an adaptive numerical format
NL2018852B1 (en) 2017-05-05 2018-11-14 Illumina Inc Optical distortion correction for imaged samples
BR112019014683A2 (pt) 2017-03-07 2020-02-18 Illumina, Inc. Sequenciamento com dois canais óticos, com fonte de luz única
US10713794B1 (en) 2017-03-16 2020-07-14 Facebook, Inc. Method and system for using machine-learning for object instance segmentation
EP3872187B1 (en) 2017-04-23 2022-09-21 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
US11028435B2 (en) 2017-05-01 2021-06-08 Illumina, Inc. Optimal index sequences for multiplex massively parallel sequencing
US10552663B2 (en) 2017-05-02 2020-02-04 Techcyte, Inc. Machine learning classification and training for digital microscopy cytology images
GB201707138D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Machine learning analysis of nanopore measurements
ES2989056T3 (es) 2017-05-08 2024-11-25 Illumina Inc Método de secuenciación usando adaptadores cortos universales para la indexación de muestras de polinucleótidos
CN120636518A (zh) 2017-05-12 2025-09-12 密歇根大学董事会 个体和队列药理学表型预测平台
WO2018218103A1 (en) 2017-05-26 2018-11-29 Life Technologies Corporation Methods and systems to detect large rearrangements in brca1/2
US11587644B2 (en) 2017-07-28 2023-02-21 The Translational Genomics Research Institute Methods of profiling mass spectral data using neural networks
WO2019027767A1 (en) 2017-07-31 2019-02-07 Illumina Inc. SEQUENCING SYSTEM COMPRISING AGGREGATION OF MULTIPLEXED BIOLOGICAL SAMPLES
FI3662083T3 (fi) 2017-08-01 2024-11-20 Illumina Inc Geneettisen materiaalin ja kirjastovalmisteen spatiaalinen indeksointi hydrogeelihelmiä ja virtauskennoja käyttämällä
CN107563150B (zh) 2017-08-31 2021-03-19 深圳大学 蛋白质结合位点的预测方法、装置、设备及存储介质
US10706535B2 (en) 2017-09-08 2020-07-07 International Business Machines Corporation Tissue staining quality determination
US11507806B2 (en) 2017-09-08 2022-11-22 Rohit Seth Parallel neural processor for Artificial Intelligence
CA3067230A1 (en) 2017-09-15 2019-03-21 Illumina, Inc. Tuning and calibration features of a sequence-detection system
WO2019075250A1 (en) 2017-10-11 2019-04-18 Beyond Limits, Inc. ENGINE OF RECOMMENDATIONS FOR A COGNITIVE TANK SYSTEM
US10540591B2 (en) 2017-10-16 2020-01-21 Illumina, Inc. Deep learning-based techniques for pre-training deep convolutional neural networks
SG11201912745WA (en) 2017-10-16 2020-01-30 Illumina Inc Deep learning-based splice site classification
WO2019079182A1 (en) 2017-10-16 2019-04-25 Illumina, Inc. SEMI-SUPERVISED APPRENTICESHIP FOR THE LEARNING OF A SET OF NEURONAL NETWORKS WITH DEEP CONVOLUTION
US20200256856A1 (en) 2017-10-26 2020-08-13 Essenlix Corporation System and methods of image-based assay using crof and machine learning
EP3700856A4 (en) 2017-10-26 2021-12-15 Ultima Genomics, Inc. METHODS AND SYSTEMS FOR SEQUENCE CALL
US20200342955A1 (en) 2017-10-27 2020-10-29 Apostle, Inc. Predicting cancer-related pathogenic impact of somatic mutations using deep learning-based methods
AU2018359670B2 (en) 2017-11-06 2021-08-26 Illumina, Inc. Nucleic acid indexing techniques
US10803350B2 (en) 2017-11-30 2020-10-13 Kofax, Inc. Object detection and image cropping using a multi-detector approach
WO2019108888A1 (en) 2017-11-30 2019-06-06 The Research Foundation For The State University Of New York SYSTEM AND METHOD TO QUANTIFY TUMOR-INFILTRATING LYMPHOCYTES (TILs) FOR CLINICAL PATHOLOGY ANALYSIS
EP3721406B1 (en) 2017-12-05 2024-01-24 Ventana Medical Systems, Inc. Method of computing tumor spatial and inter-marker heterogeneity
US11288576B2 (en) 2018-01-05 2022-03-29 Illumina, Inc. Predicting quality of sequencing results using deep neural networks
US11378544B2 (en) 2018-01-08 2022-07-05 Illumina, Inc. High-throughput sequencing with semiconductor-based detection
CN111699531A (zh) 2018-01-12 2020-09-22 生命科技股份有限公司 通过神经网络进行流空间质量得分预测的方法
IL283427B2 (en) 2018-01-15 2023-10-01 Illumina Inc Identifying variants using Empiric ranking of variants
KR20200115590A (ko) * 2018-01-26 2020-10-07 퀀텀-에스아이 인코포레이티드 서열화 디바이스들을 위한 머신 학습 가능형 펄스 및 염기 호출
JP6992590B2 (ja) 2018-02-23 2022-01-13 日本電信電話株式会社 特徴表現装置、特徴表現方法、およびプログラム
US20190318806A1 (en) 2018-04-12 2019-10-17 Illumina, Inc. Variant Classifier Based on Deep Neural Networks
EP3776337B1 (en) 2018-04-13 2024-09-11 Ventana Medical Systems, Inc. Systems for cell shape estimation
US10649459B2 (en) 2018-04-26 2020-05-12 Zoox, Inc. Data segmentation using masks
US12073922B2 (en) 2018-07-11 2024-08-27 Illumina, Inc. Deep learning-based framework for identifying sequence patterns that cause sequence-specific errors (SSEs)
US10635979B2 (en) 2018-07-20 2020-04-28 Google Llc Category learning neural networks
US11741355B2 (en) * 2018-07-27 2023-08-29 International Business Machines Corporation Training of student neural network with teacher neural networks
US11446008B2 (en) 2018-08-17 2022-09-20 Tokitae Llc Automated ultrasound video interpretation of a body part with one or more convolutional neural networks
US11600360B2 (en) 2018-08-20 2023-03-07 Microsoft Technology Licensing, Llc Trace reconstruction from reads with indeterminant errors
RU2706960C1 (ru) 2019-01-25 2019-11-22 Самсунг Электроникс Ко., Лтд. Вычислительно эффективное многоклассовое распознавание изображений с использованием последовательного анализа нейросетевых признаков
EP3640837A1 (en) 2018-10-15 2020-04-22 Koninklijke Philips N.V. System for co-registration of medical images using a classifier
KR102917770B1 (ko) 2018-10-17 2026-01-23 삼성전자주식회사 뉴럴 네트워크의 파라미터를 양자화하는 방법 및 장치
GB201819378D0 (en) 2018-11-28 2019-01-09 Oxford Nanopore Tech Ltd Analysis of nanopore signal using a machine-learning technique
EP3895171B1 (en) 2018-12-10 2025-07-23 Life Technologies Corporation Deep basecaller for sanger sequencing
US10783632B2 (en) 2018-12-14 2020-09-22 Spectral Md, Inc. Machine learning systems and method for assessment, healing prediction, and treatment of wounds
US10789462B2 (en) 2019-01-15 2020-09-29 International Business Machines Corporation Weakly and fully labeled mammogram classification and localization with a dual branch deep neural network
NL2023311B9 (en) 2019-03-21 2021-03-12 Illumina Inc Artificial intelligence-based generation of sequencing metadata
NL2023310B1 (en) 2019-03-21 2020-09-28 Illumina Inc Training data generation for artificial intelligence-based sequencing
US11783917B2 (en) 2019-03-21 2023-10-10 Illumina, Inc. Artificial intelligence-based base calling
NL2023314B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based quality scoring
NL2023312B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based base calling
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
NL2023316B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based sequencing
SG10201902958PA (en) 2019-04-02 2020-11-27 Accenture Global Solutions Ltd Artificial intelligence based plantable blank spot detection
CN110245685B (zh) 2019-05-15 2022-03-25 清华大学 基因组单位点变异致病性的预测方法、系统及存储介质
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
AU2020276115A1 (en) 2019-05-16 2021-01-07 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
CN110223281B (zh) * 2019-06-06 2022-06-28 东北大学 一种数据集中含有不确定数据时的肺结节图像分类方法
EP4018365A1 (en) 2019-08-23 2022-06-29 Memorial Sloan Kettering Cancer Center Identifying regions of interest from whole slide images
US11327178B2 (en) 2019-09-06 2022-05-10 Volvo Car Corporation Piece-wise network structure for long range environment perception
CN110674880B (zh) * 2019-09-27 2022-11-11 北京迈格威科技有限公司 用于知识蒸馏的网络训练方法、装置、介质与电子设备

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