CA3155645A1 - Whole virus quantum mechanical tunneling current and electronic sensors - Google Patents
Whole virus quantum mechanical tunneling current and electronic sensors Download PDFInfo
- Publication number
- CA3155645A1 CA3155645A1 CA3155645A CA3155645A CA3155645A1 CA 3155645 A1 CA3155645 A1 CA 3155645A1 CA 3155645 A CA3155645 A CA 3155645A CA 3155645 A CA3155645 A CA 3155645A CA 3155645 A1 CA3155645 A1 CA 3155645A1
- Authority
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- Canada
- Prior art keywords
- channel
- electrode
- virus
- insulating layer
- tunneling current
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000700605 Viruses Species 0.000 title abstract 5
- 230000005641 tunneling Effects 0.000 title 1
- 239000000758 substrate Substances 0.000 abstract 3
- 238000001514 detection method Methods 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 230000005669 field effect Effects 0.000 abstract 1
- 239000004065 semiconductor Substances 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/0606—Investigating concentration of particle suspensions by collecting particles on a support
- G01N15/0637—Moving support
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N20/00—Machine learning
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
- G01N2333/183—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
- G01N2333/185—Flaviviruses or Group B arboviruses, e.g. yellow fever virus, japanese encephalitis, tick-borne encephalitis, dengue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medical Informatics (AREA)
- Nanotechnology (AREA)
- Software Systems (AREA)
- Public Health (AREA)
- Data Mining & Analysis (AREA)
- Theoretical Computer Science (AREA)
- Mathematical Physics (AREA)
- Artificial Intelligence (AREA)
- General Engineering & Computer Science (AREA)
- Primary Health Care (AREA)
- Evolutionary Computation (AREA)
- Databases & Information Systems (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Computing Systems (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962926376P | 2019-10-25 | 2019-10-25 | |
US62/926,376 | 2019-10-25 | ||
US202063021605P | 2020-05-07 | 2020-05-07 | |
US63/021,605 | 2020-05-07 | ||
PCT/US2020/057375 WO2021081506A1 (en) | 2019-10-25 | 2020-10-26 | Whole virus quantum mechanical tunneling current and electronic sensors |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3155645A1 true CA3155645A1 (en) | 2021-04-29 |
Family
ID=75585821
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3155644A Pending CA3155644A1 (en) | 2019-10-25 | 2020-10-26 | Methods for reducing electrode gap distances in electronic devices and resulting devices having nanometer electrode gaps via liquid phase molecular layer deposition technique |
CA3155645A Pending CA3155645A1 (en) | 2019-10-25 | 2020-10-26 | Whole virus quantum mechanical tunneling current and electronic sensors |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3155644A Pending CA3155644A1 (en) | 2019-10-25 | 2020-10-26 | Methods for reducing electrode gap distances in electronic devices and resulting devices having nanometer electrode gaps via liquid phase molecular layer deposition technique |
Country Status (7)
Country | Link |
---|---|
US (6) | US20220373542A1 (ko) |
EP (2) | EP4049015A4 (ko) |
JP (2) | JP2023500818A (ko) |
KR (2) | KR20220104716A (ko) |
AU (2) | AU2020370606A1 (ko) |
CA (2) | CA3155644A1 (ko) |
WO (5) | WO2021081424A1 (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11337611B2 (en) * | 2020-04-01 | 2022-05-24 | Kaligia Biosciences, LLC | Systems and methods for detecting infectious pathogens |
WO2022018622A1 (en) | 2020-07-20 | 2022-01-27 | United Arab Emirates University | Method and system for virus and protein-antibody interactions detection and monitoring based on optical light intensity and electrical parameters |
US11619589B2 (en) | 2020-07-20 | 2023-04-04 | United Arab Emirates University | Method and system for detection, quantification and/or identification of an analyte in a specimen based on electrical and/or optical response to an electric field |
US20240277252A1 (en) * | 2021-06-22 | 2024-08-22 | Northwestern University | Multiplexed antigen-based detection of sars-cov-2 and other diseases using nanomechanical sensors |
WO2023039091A1 (en) * | 2021-09-08 | 2023-03-16 | Medtronic, Inc. | Electric field therapy via implantable electrodes |
WO2023172987A1 (en) * | 2022-03-08 | 2023-09-14 | Northwestern University | Electron catalyzed molecular recognition |
WO2023177943A1 (en) * | 2022-03-17 | 2023-09-21 | The Penn State Research Foundation | Rapid and sensitive detection of viral particles by coupling redox cycling and electrophoretic enrichment |
TWI826332B (zh) * | 2023-06-08 | 2023-12-11 | 宏碁股份有限公司 | 建立疾病預測模型的方法及系統 |
Family Cites Families (34)
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US7348183B2 (en) * | 2000-10-16 | 2008-03-25 | Board Of Trustees Of The University Of Arkansas | Self-contained microelectrochemical bioassay platforms and methods |
US6951715B2 (en) * | 2000-10-30 | 2005-10-04 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
US20040023253A1 (en) * | 2001-06-11 | 2004-02-05 | Sandeep Kunwar | Device structure for closely spaced electrodes |
US6515325B1 (en) * | 2002-03-06 | 2003-02-04 | Micron Technology, Inc. | Nanotube semiconductor devices and methods for making the same |
US7033476B2 (en) * | 2002-12-31 | 2006-04-25 | Ut-Battelle, Llc | Separation and counting of single molecules through nanofluidics, programmable electrophoresis, and nanoelectrode-gated tunneling and dielectric detection |
AU2004281449B2 (en) * | 2003-08-06 | 2010-12-16 | Bridger Technologies, Inc. | Bridged element for detection of a target substance |
US7318887B2 (en) * | 2003-10-08 | 2008-01-15 | Honeywell International Inc. | Solid state reference electrode |
WO2005043126A2 (en) * | 2003-10-27 | 2005-05-12 | Drexel University | Piezoelectric cantilever sensors |
US20050148065A1 (en) * | 2003-12-30 | 2005-07-07 | Intel Corporation | Biosensor utilizing a resonator having a functionalized surface |
US8246910B2 (en) * | 2006-03-16 | 2012-08-21 | Universal Nanosensor Technologies Inc. | Dielectric sensing method and system |
US20090117571A1 (en) * | 2007-08-15 | 2009-05-07 | State of Oregon by and through the State Board of Higher Education on behalf of Portland State Univ. | Impedance spectroscopy of biomolecules using functionalized nanoparticles |
US8236508B2 (en) * | 2008-01-29 | 2012-08-07 | Drexel University | Detecting and measuring live pathogens utilizing a mass detection device |
CN101231287B (zh) | 2008-02-22 | 2011-09-14 | 东南大学 | 外场诱导电极中排列纳米颗粒制备生物传感器的方法 |
KR101136881B1 (ko) * | 2008-12-03 | 2012-04-20 | 한국전자통신연구원 | 트랜지스터 구조의 바이오 센서 및 그의 제조방법 |
US8810417B2 (en) * | 2009-08-28 | 2014-08-19 | The Invention Science Fund I, Llc | Beverage immersate with detection capability |
JP2013050426A (ja) * | 2011-08-31 | 2013-03-14 | Chiba Univ | Fet型センサを用いたインフルエンザウイルスrnaの検出方法 |
JP2015077652A (ja) * | 2013-10-16 | 2015-04-23 | クオンタムバイオシステムズ株式会社 | ナノギャップ電極およびその製造方法 |
SG11201604734UA (en) * | 2013-12-10 | 2016-07-28 | Agency Science Tech & Res | Surface acoustic wave sensor for influenza detection |
US10017510B2 (en) * | 2014-02-06 | 2018-07-10 | The Regents Of The University Of Colorado, A Body Corporate | Thiol-X click foldamers for polymer affinity and catalysis libraries |
US20180368743A1 (en) * | 2014-06-12 | 2018-12-27 | The Trustees Of Columbia University In The City Of New New York | Graphene-based nanosensor for identifying target analytes |
WO2016047340A1 (ja) * | 2014-09-24 | 2016-03-31 | 富士フイルム株式会社 | ガスセンサ、有機トランジスタ |
US9857328B2 (en) * | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same |
CA3040703A1 (en) * | 2016-10-17 | 2018-04-26 | Context Ai, Llc | Systems and methods for medical diagnosis and biomarker identification using physiological sensors and machine learning |
CN109906375B (zh) * | 2016-11-02 | 2022-02-01 | 株式会社Lg化学 | 量子点生物传感器 |
CA3057155A1 (en) * | 2017-05-09 | 2018-11-15 | Roswell Biotechnologies, Inc. | Binding probe circuits for molecular sensors |
US10565331B2 (en) * | 2017-07-27 | 2020-02-18 | International Business Machines Corporation | Adaptive modeling of data streams |
CN107525929B (zh) * | 2017-08-11 | 2019-10-11 | 佛山科学技术学院 | 一种免疫生物传感器的制备方法及其应用 |
US10386338B2 (en) * | 2017-10-30 | 2019-08-20 | Cynthia Rena Wright | DNA/RNA PEMS microcantilever probe for detection of viral infection and detection of genetic variants |
KR102522179B1 (ko) * | 2017-11-14 | 2023-04-14 | 주식회사 엘지화학 | 박막트랜지스터 센서의 제조 방법 |
US12007356B2 (en) * | 2018-01-26 | 2024-06-11 | Università Degli Studi Di Bari Aldo Moro | Field effect transistor sensor and a corresponding array device |
KR102084088B1 (ko) * | 2018-03-12 | 2020-03-04 | 한국기초과학지원연구원 | 지카 바이러스 검출용 센서 및 이의 제조방법 |
CN110297028B (zh) * | 2018-03-21 | 2021-08-17 | 首都师范大学 | 一种检测h1n1流感病毒的电化学传感器及其制备和检测方法 |
KR20190013454A (ko) * | 2018-05-28 | 2019-02-11 | 후즈비엔 테크놀로지 인스티튜트 인크 | 바이오 감지 장치 |
US10984211B1 (en) * | 2019-10-18 | 2021-04-20 | Taiwan Semiconductor Manufacturing Co., Ltd. | Semiconductor device with bioFET and biometric sensors |
-
2020
- 2020-10-23 WO PCT/US2020/057190 patent/WO2021081424A1/en active Application Filing
- 2020-10-23 US US17/771,653 patent/US20220373542A1/en active Pending
- 2020-10-26 KR KR1020227017712A patent/KR20220104716A/ko unknown
- 2020-10-26 US US17/771,665 patent/US20220412974A1/en active Pending
- 2020-10-26 WO PCT/US2020/057289 patent/WO2021081476A1/en active Application Filing
- 2020-10-26 EP EP20878345.6A patent/EP4049015A4/en active Pending
- 2020-10-26 AU AU2020370606A patent/AU2020370606A1/en active Pending
- 2020-10-26 US US17/770,969 patent/US20220397546A1/en active Pending
- 2020-10-26 JP JP2022524028A patent/JP2023500818A/ja active Pending
- 2020-10-26 CA CA3155644A patent/CA3155644A1/en active Pending
- 2020-10-26 US US17/771,053 patent/US20220390445A1/en active Pending
- 2020-10-26 EP EP20878714.3A patent/EP4048442A4/en active Pending
- 2020-10-26 KR KR1020227017714A patent/KR20220104172A/ko unknown
- 2020-10-26 US US17/080,517 patent/US11009482B1/en active Active
- 2020-10-26 JP JP2022524026A patent/JP7528207B2/ja active Active
- 2020-10-26 WO PCT/US2020/057300 patent/WO2021081478A1/en unknown
- 2020-10-26 CA CA3155645A patent/CA3155645A1/en active Pending
- 2020-10-26 WO PCT/US2020/057375 patent/WO2021081506A1/en unknown
- 2020-10-26 AU AU2020372503A patent/AU2020372503A1/en active Pending
- 2020-10-26 WO PCT/US2020/057384 patent/WO2021081511A1/en active Application Filing
-
2021
- 2021-05-13 US US17/320,014 patent/US20210270771A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4049015A4 (en) | 2024-02-07 |
US11009482B1 (en) | 2021-05-18 |
US20210123883A1 (en) | 2021-04-29 |
EP4048442A1 (en) | 2022-08-31 |
JP2023500818A (ja) | 2023-01-11 |
US20220397546A1 (en) | 2022-12-15 |
WO2021081424A1 (en) | 2021-04-29 |
WO2021081478A1 (en) | 2021-04-29 |
AU2020370606A1 (en) | 2022-06-02 |
CA3155644A1 (en) | 2021-04-29 |
AU2020372503A1 (en) | 2022-06-02 |
JP2023500817A (ja) | 2023-01-11 |
US20220412974A1 (en) | 2022-12-29 |
EP4049015A1 (en) | 2022-08-31 |
JP7528207B2 (ja) | 2024-08-05 |
EP4048442A4 (en) | 2024-01-10 |
US20220390445A1 (en) | 2022-12-08 |
WO2021081511A1 (en) | 2021-04-29 |
WO2021081476A1 (en) | 2021-04-29 |
KR20220104716A (ko) | 2022-07-26 |
US20220373542A1 (en) | 2022-11-24 |
US20210270771A1 (en) | 2021-09-02 |
WO2021081506A1 (en) | 2021-04-29 |
KR20220104172A (ko) | 2022-07-26 |
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