CA3107726A1 - Compositions for use in treating the eye comprising extracts from the genus acronychia - Google Patents
Compositions for use in treating the eye comprising extracts from the genus acronychia Download PDFInfo
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- CA3107726A1 CA3107726A1 CA3107726A CA3107726A CA3107726A1 CA 3107726 A1 CA3107726 A1 CA 3107726A1 CA 3107726 A CA3107726 A CA 3107726A CA 3107726 A CA3107726 A CA 3107726A CA 3107726 A1 CA3107726 A1 CA 3107726A1
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- Prior art keywords
- acronychia
- extracts
- extract
- carbon atoms
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- 239000000284 extract Substances 0.000 title claims abstract description 311
- 239000000203 mixture Substances 0.000 title claims abstract description 127
- 241000158748 Acronychia Species 0.000 title claims description 60
- 150000001875 compounds Chemical class 0.000 claims abstract description 107
- 238000000034 method Methods 0.000 claims abstract description 67
- 230000000694 effects Effects 0.000 claims abstract description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 112
- 241000604865 Licaria Species 0.000 claims description 78
- 229920006395 saturated elastomer Polymers 0.000 claims description 66
- 230000008901 benefit Effects 0.000 claims description 53
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 51
- 206010013774 Dry eye Diseases 0.000 claims description 51
- 241000196324 Embryophyta Species 0.000 claims description 46
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 46
- 125000004122 cyclic group Chemical group 0.000 claims description 44
- 241000186046 Actinomyces Species 0.000 claims description 36
- 125000003118 aryl group Chemical group 0.000 claims description 36
- -1 for example Chemical group 0.000 claims description 35
- 241001312519 Trigonella Species 0.000 claims description 32
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 claims description 31
- 235000003880 Calendula Nutrition 0.000 claims description 31
- 210000004087 cornea Anatomy 0.000 claims description 26
- 238000004519 manufacturing process Methods 0.000 claims description 26
- 230000001580 bacterial effect Effects 0.000 claims description 25
- 230000029142 excretion Effects 0.000 claims description 23
- 241000158778 Acronychia acidula Species 0.000 claims description 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
- 125000003342 alkenyl group Chemical group 0.000 claims description 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- 125000000304 alkynyl group Chemical group 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 10
- 230000035876 healing Effects 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 9
- 125000005907 alkyl ester group Chemical group 0.000 claims description 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 9
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 239000003974 emollient agent Substances 0.000 claims description 8
- 241001079133 Acronychia vestita Species 0.000 claims description 7
- 230000000845 anti-microbial effect Effects 0.000 claims description 7
- 125000004494 ethyl ester group Chemical group 0.000 claims description 7
- 208000024891 symptom Diseases 0.000 claims description 7
- 208000027418 Wounds and injury Diseases 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 239000005711 Benzoic acid Substances 0.000 claims description 5
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- 235000010233 benzoic acid Nutrition 0.000 claims description 5
- 230000003247 decreasing effect Effects 0.000 claims description 5
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 5
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- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 4
- 241001079129 Acronychia acronychioides Species 0.000 claims description 3
- 241000435379 Acronychia baeuerlenii Species 0.000 claims description 3
- 241001601669 Acronychia chooreechillum Species 0.000 claims description 3
- 241001079127 Acronychia crassipetala Species 0.000 claims description 3
- 241001601663 Acronychia eungellensis Species 0.000 claims description 3
- 244000135330 Acronychia laevis Species 0.000 claims description 3
- 244000256618 Acronychia laurifolia Species 0.000 claims description 3
- 241001601661 Acronychia littoralis Species 0.000 claims description 3
- 241000435297 Acronychia oblongifolia Species 0.000 claims description 3
- 241000227584 Acronychia octandra Species 0.000 claims description 3
- 241001601671 Acronychia parviflora Species 0.000 claims description 3
- 241000435376 Acronychia pauciflora Species 0.000 claims description 3
- 240000006880 Acronychia pedunculata Species 0.000 claims description 3
- 241000435377 Acronychia pubescens Species 0.000 claims description 3
- 241000435378 Acronychia suberosa Species 0.000 claims description 3
- 241000435375 Acronychia wilcoxiana Species 0.000 claims description 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 241000933223 Licaria brittoniana Species 0.000 claims description 3
- 241000604820 Licaria triandra Species 0.000 claims description 3
- 241000712689 Velutina Species 0.000 claims description 3
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
- 150000003573 thiols Chemical class 0.000 claims description 3
- 241000132025 Calendula Species 0.000 claims 6
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims 1
- 244000080208 Canella winterana Species 0.000 claims 1
- 235000008499 Canella winterana Nutrition 0.000 claims 1
- 239000000243 solution Substances 0.000 description 166
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- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 description 1
- AWDRATDZQPNJFN-VAYUFCLWSA-N taurodeoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 AWDRATDZQPNJFN-VAYUFCLWSA-N 0.000 description 1
- 108010019783 tear proteins Proteins 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- AODPIQQILQLWGS-GXBDJPPSSA-N tetrahydrocortisol Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CC[C@@H]21 AODPIQQILQLWGS-GXBDJPPSSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical compound [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
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- Medical Informatics (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862703943P | 2018-07-27 | 2018-07-27 | |
| US62/703,943 | 2018-07-27 | ||
| US16/519,166 US10966948B2 (en) | 2019-07-23 | 2019-07-23 | Compositions and methods for treating the eye |
| US16/519,166 | 2019-07-23 | ||
| PCT/IB2019/056344 WO2020021480A2 (en) | 2018-07-27 | 2019-07-24 | Compositions and methods for treating the eye |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3107726A1 true CA3107726A1 (en) | 2020-01-30 |
Family
ID=68051851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3107726A Pending CA3107726A1 (en) | 2018-07-27 | 2019-07-24 | Compositions for use in treating the eye comprising extracts from the genus acronychia |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP3829614A2 (ja) |
| JP (1) | JP7374987B2 (ja) |
| KR (1) | KR20210038635A (ja) |
| CN (2) | CN112888450A (ja) |
| AU (1) | AU2019311848B2 (ja) |
| BR (1) | BR112021001092A2 (ja) |
| CA (1) | CA3107726A1 (ja) |
| WO (1) | WO2020021480A2 (ja) |
| ZA (1) | ZA202101342B (ja) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10966948B2 (en) | 2019-07-23 | 2021-04-06 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US11197841B2 (en) | 2019-07-23 | 2021-12-14 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| CN112739337B (zh) | 2018-07-27 | 2024-05-24 | 强生外科视力公司 | 用于治疗眼睛的组合物和方法 |
| US11969454B2 (en) | 2019-11-19 | 2024-04-30 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| CN112823789B (zh) * | 2019-11-19 | 2024-05-10 | 强生外科视力公司 | 用于治疗眼睛的组合物和方法 |
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| USD435966S1 (en) | 1999-01-29 | 2001-01-09 | Johnson & Johnson Vision Care, Inc. | Contact lens container |
| US7442391B2 (en) | 2002-01-25 | 2008-10-28 | Integrated Botanical Technologies, Llc | Bioactive botanical cosmetic compositions and processes for their production |
| US20030165545A1 (en) | 2002-01-30 | 2003-09-04 | Allergan, Inc. | Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same |
| EP2491939B1 (en) | 2004-01-12 | 2017-09-20 | ISP Investments LLC | Bioactive compositions from theacea plants and processes for their production and use |
| NZ607880A (en) | 2006-02-21 | 2014-11-28 | Akzo Nobel Surface Chemistry Llc | Parthenolide free bioactive ingredients from feverfew (tanacetum parthenium) and processes for their production |
| BRPI0923551A2 (pt) * | 2008-12-24 | 2016-01-26 | Ecobiotics Ltd | extratos de planta da espécie acronichia e seus usos |
| US9480645B2 (en) | 2009-06-02 | 2016-11-01 | Abbott Medical Optics Inc. | Omega-3 oil containing ophthalmic emulsions |
| US20100305046A1 (en) | 2009-06-02 | 2010-12-02 | Abbott Medical Optics Inc. | Stable cyclosporine containing ophthalmic emulsion for treating dry eyes |
| NZ596932A (en) | 2009-06-05 | 2014-04-30 | Allergan Inc | Artificial tears and therapeutic uses |
| AU2018341099B2 (en) | 2017-09-28 | 2023-11-02 | Johnson & Johnson Consumer Inc. | Cosmetic compositions and method of treating the skin |
| CN112739337B (zh) * | 2018-07-27 | 2024-05-24 | 强生外科视力公司 | 用于治疗眼睛的组合物和方法 |
-
2019
- 2019-07-24 CN CN201980050097.8A patent/CN112888450A/zh active Pending
- 2019-07-24 BR BR112021001092-0A patent/BR112021001092A2/pt unknown
- 2019-07-24 AU AU2019311848A patent/AU2019311848B2/en active Active
- 2019-07-24 CN CN202211161743.8A patent/CN115671090A/zh active Pending
- 2019-07-24 CA CA3107726A patent/CA3107726A1/en active Pending
- 2019-07-24 WO PCT/IB2019/056344 patent/WO2020021480A2/en active Application Filing
- 2019-07-24 EP EP19773527.7A patent/EP3829614A2/en active Pending
- 2019-07-24 JP JP2021504364A patent/JP7374987B2/ja active Active
- 2019-07-24 KR KR1020217005786A patent/KR20210038635A/ko unknown
-
2021
- 2021-02-26 ZA ZA2021/01342A patent/ZA202101342B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN115671090A (zh) | 2023-02-03 |
| KR20210038635A (ko) | 2021-04-07 |
| CN112888450A (zh) | 2021-06-01 |
| JP7374987B2 (ja) | 2023-11-07 |
| AU2019311848B2 (en) | 2024-08-01 |
| AU2019311848A1 (en) | 2021-01-21 |
| JP2021533096A (ja) | 2021-12-02 |
| BR112021001092A2 (pt) | 2021-04-20 |
| WO2020021480A3 (en) | 2020-04-30 |
| EP3829614A2 (en) | 2021-06-09 |
| ZA202101342B (en) | 2023-03-29 |
| WO2020021480A2 (en) | 2020-01-30 |
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