CA3101368A1 - Tricyclic heterocyclic compounds as sting activators - Google Patents

Tricyclic heterocyclic compounds as sting activators Download PDF

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Publication number
CA3101368A1
CA3101368A1 CA3101368A CA3101368A CA3101368A1 CA 3101368 A1 CA3101368 A1 CA 3101368A1 CA 3101368 A CA3101368 A CA 3101368A CA 3101368 A CA3101368 A CA 3101368A CA 3101368 A1 CA3101368 A1 CA 3101368A1
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CA
Canada
Prior art keywords
alkyl
cycloalkyl
independently selected
membered heteroaryl
membered heterocycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CA3101368A
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English (en)
French (fr)
Inventor
Liangxing Wu
Neil LAJKIEWICZ
Yingda YE
Zhenwu Li
Wenqing Yao
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Incyte Corp
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Incyte Corp
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Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CA3101368A1 publication Critical patent/CA3101368A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA3101368A 2018-05-25 2019-05-24 Tricyclic heterocyclic compounds as sting activators Pending CA3101368A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862676810P 2018-05-25 2018-05-25
US62/676,810 2018-05-25
US201862730610P 2018-09-13 2018-09-13
US62/730,610 2018-09-13
US201962841587P 2019-05-01 2019-05-01
US62/841,587 2019-05-01
PCT/US2019/033944 WO2019227007A1 (en) 2018-05-25 2019-05-24 Tricyclic heterocyclic compounds as sting activators

Publications (1)

Publication Number Publication Date
CA3101368A1 true CA3101368A1 (en) 2019-11-28

Family

ID=66912949

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3101368A Pending CA3101368A1 (en) 2018-05-25 2019-05-24 Tricyclic heterocyclic compounds as sting activators

Country Status (7)

Country Link
US (2) US10947227B2 (https=)
EP (1) EP3802534B1 (https=)
JP (2) JP7570235B2 (https=)
CA (1) CA3101368A1 (https=)
ES (1) ES2929415T3 (https=)
MA (1) MA52754A (https=)
WO (1) WO2019227007A1 (https=)

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US12180185B2 (en) 2018-11-15 2024-12-31 Hk Inno.N Corporation Compound as protein kinase inhibitor, and pharmaceutical composition comprising thereof

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11524968B2 (en) 2017-10-18 2022-12-13 Hk Inno.N Corporation Heterocyclic compound as a protein kinase inhibitor
US12180185B2 (en) 2018-11-15 2024-12-31 Hk Inno.N Corporation Compound as protein kinase inhibitor, and pharmaceutical composition comprising thereof

Also Published As

Publication number Publication date
WO2019227007A1 (en) 2019-11-28
JP2021525706A (ja) 2021-09-27
MA52754A (fr) 2021-04-14
JP2024133472A (ja) 2024-10-02
US11713317B2 (en) 2023-08-01
JP7570235B2 (ja) 2024-10-21
US20190359608A1 (en) 2019-11-28
US20220073509A1 (en) 2022-03-10
US10947227B2 (en) 2021-03-16
EP3802534B1 (en) 2022-07-13
EP3802534A1 (en) 2021-04-14
ES2929415T3 (es) 2022-11-29

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