CA3079776A1 - A zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition - Google Patents
A zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition Download PDFInfo
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- CA3079776A1 CA3079776A1 CA3079776A CA3079776A CA3079776A1 CA 3079776 A1 CA3079776 A1 CA 3079776A1 CA 3079776 A CA3079776 A CA 3079776A CA 3079776 A CA3079776 A CA 3079776A CA 3079776 A1 CA3079776 A1 CA 3079776A1
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- 239000008174 sterile solution Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000009452 underexpressoin Effects 0.000 description 1
- 210000003501 vero cell Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940051021 yellow-fever virus Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/18—Togaviridae; Flaviviridae
- C07K14/1816—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus), border disease virus
- C07K14/1825—Flaviviruses or Group B arboviruses, e.g. yellow fever virus, japanese encephalitis, tick-borne encephalitis, dengue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- General Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17306553.3 | 2017-11-09 | ||
| EP17306553 | 2017-11-09 | ||
| PCT/EP2018/080677 WO2019092142A1 (en) | 2017-11-09 | 2018-11-08 | A zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3079776A1 true CA3079776A1 (en) | 2019-05-16 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CA3079776A Pending CA3079776A1 (en) | 2017-11-09 | 2018-11-08 | A zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11305003B2 (ko) |
| EP (1) | EP3707154A1 (ko) |
| JP (1) | JP7225254B2 (ko) |
| KR (1) | KR20200090186A (ko) |
| CN (1) | CN111683959A (ko) |
| AU (1) | AU2018365296B2 (ko) |
| BR (1) | BR112020009157A2 (ko) |
| CA (1) | CA3079776A1 (ko) |
| MX (1) | MX2020004833A (ko) |
| PH (1) | PH12020550569A1 (ko) |
| SG (1) | SG11202004234SA (ko) |
| WO (1) | WO2019092142A1 (ko) |
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| US11806393B2 (en) * | 2017-02-10 | 2023-11-07 | La Jolla Institute For Allergy And Immunology | Flavivirus peptide sequences, epitopes, and methods and uses thereof |
| CA3079776A1 (en) | 2017-11-09 | 2019-05-16 | Institut Pasteur | A zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition |
| CN113528465B (zh) * | 2020-04-20 | 2023-07-11 | 中国人民解放军军事科学院军事医学研究院 | 包含突变的寨卡病毒全基因组cDNA的DNA分子及其应用 |
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| ES2427139T3 (es) | 2002-06-20 | 2013-10-29 | Institut Pasteur | Virus recombinantes del sarampión que expresan epítopos de antígenos de virus de ARN y uso de los virus recombinantes para la preparación de composiciones de vacuna |
| DK1375512T3 (da) | 2002-06-20 | 2009-10-26 | Pasteur Institut | Infektiös cDNA af en godkendt vaccinestamme af mæslingevirus. Anvendelse til immunogene sammensætninger |
| FR2870126B1 (fr) | 2004-05-17 | 2009-07-17 | Pasteur Institut | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
| US8158413B2 (en) | 2005-10-17 | 2012-04-17 | Institut Pasteur | Lentiviral vector-based vaccine |
| EP1939214B1 (en) | 2006-12-22 | 2013-07-10 | Institut Pasteur | Cells and methodology to generate non-segmented negative-strand RNA viruses |
| BRPI0813194B8 (pt) | 2007-08-03 | 2021-05-25 | Centre Nat Rech Scient | kit, partículas de vetor lentiviral, composição de vetores plasmídicos, antígeno derivado de hiv-1 quimérico, proteína de envelope de vsv-g, moléculas de ácido nucleico, composição imunogênica e uso de um vetor lentiviral |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| EP3384938A1 (en) | 2011-09-12 | 2018-10-10 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2712871A1 (en) | 2012-09-27 | 2014-04-02 | Institut Pasteur | Recombinant Measles virus expressing Chikungunya virus polypeptides and their applications |
| US20170173128A1 (en) | 2013-12-06 | 2017-06-22 | Moderna TX, Inc. | Targeted adaptive vaccines |
| EP2959915A1 (en) * | 2014-06-23 | 2015-12-30 | Institut Pasteur | A dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection |
| EP3031923A1 (en) | 2014-12-11 | 2016-06-15 | Institut Pasteur | Lentiviral vector-based japanese encephalitis immunogenic composition |
| GB201508099D0 (en) * | 2015-05-12 | 2015-06-24 | Isis Innovation | Dengue vaccines |
| US20180185467A1 (en) * | 2015-06-22 | 2018-07-05 | President And Fellows Of Harvard College | Compositions and methods for modulating viral infection |
| SG10201913630YA (en) * | 2016-02-17 | 2020-03-30 | Curevac Ag | Zika virus vaccine |
| WO2017189891A1 (en) * | 2016-04-27 | 2017-11-02 | Middle Tennessee State University | Methods for treating zika viral infections and associated complications |
| WO2018009603A1 (en) * | 2016-07-08 | 2018-01-11 | The United State of America, as represented by the Secretary, Department of Health and Human Service | Chimeric west nile/zika viruses and methods of use |
| US11344615B2 (en) * | 2016-07-08 | 2022-05-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nucleic acids encoding chimeric dengue/Zika viruses optimized for growth and stability in vero cells |
| WO2018071405A1 (en) * | 2016-10-11 | 2018-04-19 | University Of Miami | Vectors and vaccine cells for immunity against zika virus |
| AU2017405996A1 (en) * | 2017-03-27 | 2019-10-10 | The University Of Queensland | Chimeric insect-specific flaviviruses |
| CA3079776A1 (en) | 2017-11-09 | 2019-05-16 | Institut Pasteur | A zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition |
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2018
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- 2018-11-08 BR BR112020009157-0A patent/BR112020009157A2/pt unknown
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- 2018-11-08 CN CN201880085916.8A patent/CN111683959A/zh active Pending
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2020
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2022
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Also Published As
| Publication number | Publication date |
|---|---|
| CN111683959A (zh) | 2020-09-18 |
| BR112020009157A2 (pt) | 2020-10-27 |
| JP7225254B2 (ja) | 2023-02-20 |
| AU2018365296A1 (en) | 2020-05-21 |
| KR20200090186A (ko) | 2020-07-28 |
| MX2020004833A (es) | 2021-01-08 |
| US20200282043A1 (en) | 2020-09-10 |
| AU2018365296B2 (en) | 2023-11-23 |
| EP3707154A1 (en) | 2020-09-16 |
| PH12020550569A1 (en) | 2021-04-19 |
| US20220233678A1 (en) | 2022-07-28 |
| WO2019092142A1 (en) | 2019-05-16 |
| JP2021502115A (ja) | 2021-01-28 |
| US11305003B2 (en) | 2022-04-19 |
| US11872276B2 (en) | 2024-01-16 |
| SG11202004234SA (en) | 2020-06-29 |
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