CA3064736A1 - Echantillonnage selectif pour evaluer des frequences spatiales structurales avec des mecanismes de contraste specifiques - Google Patents
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Abstract
Conformément à des modes de réalisation, la présente invention concerne un procédé pour l'acquisition de données de résonance magnétique (RM) à des résolutions pouvant descendre jusqu'à des dizaines de microns pour une application en diagnostic in vivo et la surveillance d'une pathologie pour laquelle des modifications de fines textures tissulaires peuvent être utilisées comme marqueurs d'apparition et de progression d'une maladie. Les maladies osseuses, les tumeurs, les maladies neurologiques et les maladies impliquant la croissance fibreuse et/ou la destruction des fibres sont toutes des pathologies cibles. En outre, la technique peut être utilisée dans n'importe quel système biologique ou physique pour lequel une caractérisation à très haute résolution d'une morphologie à petite échelle est nécessaire. Le procédé permet l'acquisition rapide d'un signal à des valeurs sélectionnées dans l'espace k, avec de multiples acquisitions successives à des valeurs k individuelles prises sur une échelle de temps de l'ordre de la microseconde, dans un volume de tissu défini, et la combinaison ultérieure des multiples mesures de façon à rendre maximal le rapport signal sur bruit (SNR). Le volume d'acquisition réduit et l'acquisition uniquement de valeurs de signal à des endroits sélectionnés dans l'espace k, le long de directions sélectionnées, permettent une résolution in vivo bien plus élevée que celle qui pourrait être obtenue avec les techniques d'imagerie par résonance magnétique (IRM) actuelles.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US15/604,465 | 2017-05-24 | ||
US15/604,465 US10061003B2 (en) | 2014-09-01 | 2017-05-24 | Selective sampling for assessing structural spatial frequencies with specific contrast mechanisms |
PCT/US2018/033727 WO2018217658A1 (fr) | 2017-05-24 | 2018-05-21 | Échantillonnage sélectif pour évaluer des fréquences spatiales structurales avec des mécanismes de contraste spécifiques |
Publications (1)
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CA3064736A1 true CA3064736A1 (fr) | 2018-11-29 |
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CA3064736A Pending CA3064736A1 (fr) | 2017-05-24 | 2018-05-21 | Echantillonnage selectif pour evaluer des frequences spatiales structurales avec des mecanismes de contraste specifiques |
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EP (1) | EP3629915A4 (fr) |
JP (1) | JP7273803B2 (fr) |
CN (1) | CN110958854A (fr) |
AU (1) | AU2018273362A1 (fr) |
CA (1) | CA3064736A1 (fr) |
WO (1) | WO2018217658A1 (fr) |
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CN111803068A (zh) * | 2020-08-21 | 2020-10-23 | 上海中医药大学附属曙光医院 | 一种基于虚拟磁共振弹性成像的无创评估肝纤维化的方法 |
CN113156350B (zh) * | 2021-03-25 | 2022-07-19 | 华南理工大学 | 无创光不透明微米级活体组织磁共振断层成像方法及系统 |
CN114371232B (zh) * | 2021-12-22 | 2024-03-22 | 天津国科医工科技发展有限公司 | 基于卡尔曼滤波算法的色谱滤波方法、装置、介质、系统 |
CN114708973B (zh) * | 2022-06-06 | 2022-09-13 | 首都医科大学附属北京友谊医院 | 一种用于对人体健康进行评估的设备和存储介质 |
CN116934757B (zh) * | 2023-09-18 | 2023-11-21 | 电子科技大学 | 一种用于肺结节假阳性删减的方法、设备及存储介质 |
CN117388672B (zh) * | 2023-12-11 | 2024-04-19 | 四川睿杰鑫电子股份有限公司 | 一种电路板用电源通路检测装置及其检测方法 |
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---|---|---|---|---|
JP3393895B2 (ja) * | 1993-09-13 | 2003-04-07 | 株式会社東芝 | 磁気共鳴映像装置 |
JP4265855B2 (ja) | 2000-05-31 | 2009-05-20 | 株式会社日立メディコ | 磁気共鳴イメージング装置 |
US6320380B1 (en) * | 2000-10-03 | 2001-11-20 | Marconi Medical Systems, Inc. | MRI method and apparatus for increasing the efficiency of echo lanar imaging and other late echo techniques |
CA2535942A1 (fr) | 2003-08-21 | 2005-03-10 | Ischem Corporation | Techniques et systemes automatises de detection et d'analyse de plaque vasculaire |
DE102004017852B4 (de) | 2004-04-13 | 2008-11-27 | Siemens Ag | Bewegungskorrigiertes Multi-Shot-Verfahren zur diffusionsgewichteten Bildgebung in der Magnetresonanztomographie |
US8057408B2 (en) * | 2005-09-22 | 2011-11-15 | The Regents Of The University Of Michigan | Pulsed cavitational ultrasound therapy |
RU2423718C2 (ru) * | 2005-11-27 | 2011-07-10 | Эквитас Медикал Лимитед | Оценивание структуры с использованием пространственно-частотного анализа |
JP4993960B2 (ja) | 2006-07-11 | 2012-08-08 | 株式会社日立メディコ | 核磁気共鳴撮像装置 |
WO2008034845A2 (fr) | 2006-09-19 | 2008-03-27 | Nordic Bioscience Imaging A/S | Mesure indiquant une pathologie liée à une structure de cartilage et quantification automatique de celle-ci |
US20100145185A1 (en) * | 2008-12-04 | 2010-06-10 | Xiaole Hong | Extending the resolution of mri data by combining subsets from plural image acquisitions |
JP5360757B2 (ja) * | 2009-04-22 | 2013-12-04 | 独立行政法人情報通信研究機構 | 磁気共鳴画像法および磁気共鳴画像装置 |
JP5442490B2 (ja) | 2010-02-26 | 2014-03-12 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | 磁気共鳴イメージング装置 |
US8966701B2 (en) * | 2012-06-14 | 2015-03-03 | Joseph Dellecave | Sole wipe |
WO2014130813A1 (fr) * | 2013-02-21 | 2014-08-28 | New York University | Procédé et dispositif de quantification précise de temps t2 de relaxation en fonction de séquences rapides de rmn à écho de spin multiple |
US9366740B2 (en) * | 2013-03-14 | 2016-06-14 | Wisconsin Alumni Research Foundation | System and method for vastly undersampled isotropic projection reconstruction with inversion recovery |
JP5762460B2 (ja) | 2013-04-11 | 2015-08-12 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | 磁気共鳴装置およびプログラム |
WO2015092622A2 (fr) * | 2013-12-20 | 2015-06-25 | Koninklijke Philips N.V. | Génération d'une carte d'atténuation guidée de densité dans des systèmes pet/rm |
US9664759B2 (en) * | 2014-09-01 | 2017-05-30 | bioProtonics, L.L.C | Method for assessing structural spatial frequencies using hybrid sampling with non-zero gradient for enhancement of selective sampling |
US9664760B2 (en) | 2014-09-01 | 2017-05-30 | bioProtonics, L.L.C | Selective sampling for assessing structural spatial frequencies with specific contrast mechanisms |
US9655522B2 (en) * | 2014-10-10 | 2017-05-23 | Cedars-Sinai Medical Center | Method and system for “push-button” comprehensive cardiac MR examination using continuous self-gated 3D radial imaging |
JP6576726B2 (ja) | 2015-07-24 | 2019-09-18 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | 磁気共鳴装置 |
EP3359034A4 (fr) | 2015-10-07 | 2019-08-07 | Bioprotonics, Inc. | Échantillonnage sélectif pour évaluer des fréquences spatiales structurales avec des mécanismes de contraste spécifiques |
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EP3629915A1 (fr) | 2020-04-08 |
WO2018217658A1 (fr) | 2018-11-29 |
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JP2020520786A (ja) | 2020-07-16 |
AU2018273362A1 (en) | 2020-01-23 |
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