CA3027761A1 - Procede de fabrication d'acide obeticholique et de ses intermediaires - Google Patents

Procede de fabrication d'acide obeticholique et de ses intermediaires Download PDF

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Publication number
CA3027761A1
CA3027761A1 CA3027761A CA3027761A CA3027761A1 CA 3027761 A1 CA3027761 A1 CA 3027761A1 CA 3027761 A CA3027761 A CA 3027761A CA 3027761 A CA3027761 A CA 3027761A CA 3027761 A1 CA3027761 A1 CA 3027761A1
Authority
CA
Canada
Prior art keywords
compound
formula
preparation
acid
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3027761A
Other languages
English (en)
Inventor
Shunji ZHANG
Sheng Wang
Lu Liu
Weiwei Tian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CA3027761A1 publication Critical patent/CA3027761A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA3027761A 2016-07-13 2017-07-12 Procede de fabrication d'acide obeticholique et de ses intermediaires Abandoned CA3027761A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610551378.X 2016-07-13
CN201610551378 2016-07-13
PCT/CN2017/092554 WO2018010651A1 (fr) 2016-07-13 2017-07-12 Procédé de fabrication d'acide obéticholique et de ses intermédiaires

Publications (1)

Publication Number Publication Date
CA3027761A1 true CA3027761A1 (fr) 2018-01-18

Family

ID=60952792

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3027761A Abandoned CA3027761A1 (fr) 2016-07-13 2017-07-12 Procede de fabrication d'acide obeticholique et de ses intermediaires

Country Status (4)

Country Link
CN (1) CN108602850B (fr)
CA (1) CA3027761A1 (fr)
TW (1) TW201802103A (fr)
WO (1) WO2018010651A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019145977A1 (fr) * 2018-01-25 2019-08-01 Msn Laboratories Private Limited, R&D Center PROCÉDÉ DE PRÉPARATION DE L'ACIDE 3α,7α-DIHYDROXY6α-ÉTHYL-5β-CHOLAN-24-OÏQUE
CN111285914B (zh) * 2018-12-10 2023-02-17 江西青峰药业有限公司 一种奥贝胆酸的制备方法
CN112898369A (zh) * 2019-12-04 2021-06-04 博瑞生物医药（苏州）股份有限公司 用于制备奥贝胆酸的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1568706A1 (fr) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Nouveau agonist steroidal pour FXR
ITMI20050912A1 (it) * 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
CN106459136B (zh) * 2014-09-28 2018-06-26 江苏盛迪医药有限公司 一种奥贝胆酸的制备方法
CN111944006B (zh) * 2014-11-17 2021-12-17 正大天晴药业集团股份有限公司 新的7-酮-6β-烷基胆烷酸衍生物在制备奥贝胆酸以及其在医药领域的用途
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
CN106083978A (zh) * 2015-04-28 2016-11-09 上海迪诺医药科技有限公司 磺酰基氨基羰基衍生物、其药物组合物及应用
CN107531743B (zh) * 2015-04-29 2020-05-05 正大天晴药业集团股份有限公司 鹅去氧胆酸衍生物
CN106008639B (zh) * 2016-03-11 2019-01-08 深圳市塔吉瑞生物医药有限公司 用于预防或治疗fxr-介导疾病的胆烷酸化合物

Also Published As

Publication number Publication date
CN108602850B (zh) 2021-04-06
WO2018010651A1 (fr) 2018-01-18
CN108602850A (zh) 2018-09-28
TW201802103A (zh) 2018-01-16

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FZDE Dead

Effective date: 20200831