CA3018945A1 - Bolaamphiphilic compounds, compositions and uses thereof - Google Patents

Bolaamphiphilic compounds, compositions and uses thereof Download PDF

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Publication number
CA3018945A1
CA3018945A1 CA3018945A CA3018945A CA3018945A1 CA 3018945 A1 CA3018945 A1 CA 3018945A1 CA 3018945 A CA3018945 A CA 3018945A CA 3018945 A CA3018945 A CA 3018945A CA 3018945 A1 CA3018945 A1 CA 3018945A1
Authority
CA
Canada
Prior art keywords
pharmaceutical composition
compound
glh
bolaamphiphilic
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3018945A
Other languages
English (en)
French (fr)
Inventor
Charles Linder
Eliahu Heldman
Sarina Grinberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LAUREN SCIENCES LLC
Original Assignee
LAUREN SCIENCES LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LAUREN SCIENCES LLC filed Critical LAUREN SCIENCES LLC
Publication of CA3018945A1 publication Critical patent/CA3018945A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA3018945A 2015-04-16 2016-04-15 Bolaamphiphilic compounds, compositions and uses thereof Abandoned CA3018945A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562148511P 2015-04-16 2015-04-16
US62/148,511 2015-04-16
US201562258773P 2015-11-23 2015-11-23
US62/258,773 2015-11-23
PCT/US2016/027726 WO2016168580A1 (en) 2015-04-16 2016-04-15 Bolaamphiphilic compounds, compositions and uses thereof

Publications (1)

Publication Number Publication Date
CA3018945A1 true CA3018945A1 (en) 2016-10-20

Family

ID=57126121

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3018945A Abandoned CA3018945A1 (en) 2015-04-16 2016-04-15 Bolaamphiphilic compounds, compositions and uses thereof

Country Status (5)

Country Link
EP (1) EP3283060A4 (de)
AU (1) AU2016248992A1 (de)
CA (1) CA3018945A1 (de)
IL (1) IL255042B (de)
WO (1) WO2016168580A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240018101A1 (en) * 2020-10-21 2024-01-18 University Of San Diego Multivalent terpene-based bolaamphiphiles for gene delivery
CN116829193A (zh) * 2020-11-03 2023-09-29 昂科纳诺医药公司 治疗性pH响应性组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010128504A2 (en) * 2009-05-04 2010-11-11 Ben-Gurion University Of The Negev Research And Development Authority Nano-sized particles comprising multi-headed amphiphiles for targeted drug delivery
CA2883784C (en) * 2012-09-04 2024-05-14 Lauren Sciences Llc Bolaamphiphilic compounds, compositions and uses thereof
EP2892511B1 (de) * 2012-09-04 2021-06-30 Lauren Sciences LLC Bolaamphiphile verbindungen, zusammensetzungen und verwendungen davon
EP2892509A4 (de) * 2012-09-04 2016-05-18 Lauren Sciences Llc Bolaamphiphile verbindungen, zusammensetzungen und verwendungen davon

Also Published As

Publication number Publication date
IL255042B (en) 2022-04-01
IL255042A0 (en) 2017-12-31
AU2016248992A1 (en) 2017-12-07
EP3283060A1 (de) 2018-02-21
WO2016168580A1 (en) 2016-10-20
EP3283060A4 (de) 2018-12-19

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210412

EEER Examination request

Effective date: 20210412

EEER Examination request

Effective date: 20210412

EEER Examination request

Effective date: 20210412

EEER Examination request

Effective date: 20210412

FZDE Discontinued

Effective date: 20231211