CA2998869A1 - T cell receptors recognizing hla-cw8 restricted mutated kras - Google Patents

T cell receptors recognizing hla-cw8 restricted mutated kras Download PDF

Info

Publication number
CA2998869A1
CA2998869A1 CA2998869A CA2998869A CA2998869A1 CA 2998869 A1 CA2998869 A1 CA 2998869A1 CA 2998869 A CA2998869 A CA 2998869A CA 2998869 A CA2998869 A CA 2998869A CA 2998869 A1 CA2998869 A1 CA 2998869A1
Authority
CA
Canada
Prior art keywords
seq
amino acid
tcr
acid sequence
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2998869A
Other languages
English (en)
French (fr)
Other versions
CA2998869C (en
Inventor
Eric TRAN
Yong-Chen LU
Steven A. Rosenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of CA2998869A1 publication Critical patent/CA2998869A1/en
Application granted granted Critical
Publication of CA2998869C publication Critical patent/CA2998869C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82—Translation products from oncogenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
CA2998869A 2015-09-15 2016-09-09 T cell receptors recognizing hla-cw8 restricted mutated kras Active CA2998869C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562218688P 2015-09-15 2015-09-15
US62/218,688 2015-09-15
PCT/US2016/050875 WO2017048593A1 (en) 2015-09-15 2016-09-09 T cell receptors recognizing hla-cw8 restricted mutated kras

Publications (2)

Publication Number Publication Date
CA2998869A1 true CA2998869A1 (en) 2017-03-23
CA2998869C CA2998869C (en) 2025-09-23

Family

ID=

Also Published As

Publication number Publication date
CN108350059B (zh) 2021-10-08
EP3901169A1 (en) 2021-10-27
JP7185524B2 (ja) 2022-12-07
US20230406904A1 (en) 2023-12-21
JP2018535647A (ja) 2018-12-06
IL257840B2 (en) 2023-10-01
JP7461445B2 (ja) 2024-04-03
EP3350213B1 (en) 2021-03-31
US20190040111A1 (en) 2019-02-07
SG10201913868XA (en) 2020-03-30
DK3350213T3 (da) 2021-06-21
CN108350059A (zh) 2018-07-31
ES2879287T3 (es) 2021-11-22
AU2021200833B2 (en) 2022-04-28
JP2023025108A (ja) 2023-02-21
EP3350213A1 (en) 2018-07-25
HK1257902A1 (en) 2019-11-01
US10556940B2 (en) 2020-02-11
AU2022209229B2 (en) 2024-05-23
AU2016323017A1 (en) 2018-04-05
IL257840B1 (en) 2023-06-01
KR102841067B1 (ko) 2025-08-01
SA518391109B1 (ar) 2022-02-14
US20200148739A1 (en) 2020-05-14
MX2018003062A (es) 2018-09-11
AU2022209229A1 (en) 2022-09-15
US11667692B2 (en) 2023-06-06
KR20250117744A (ko) 2025-08-05
KR20180044428A (ko) 2018-05-02
AU2016323017B2 (en) 2020-11-12
WO2017048593A1 (en) 2017-03-23
CN115073583A (zh) 2022-09-20
AU2021200833A1 (en) 2021-03-04
IL257840A (en) 2018-04-30

Similar Documents

Publication Publication Date Title
US20230406904A1 (en) T cell receptors recognizing hla-cw8 restricted mutated kras
US11840561B2 (en) Anti-KRAS-G12D T cell receptors
US11352410B2 (en) Anti-KK-LC-1 T cell receptors
JP7635165B2 (ja) ｐ５３におけるＲ１７５Ｈ又はＹ２２０Ｃ変異を認識するＴ細胞受容体
CA2998869C (en) T cell receptors recognizing hla-cw8 restricted mutated kras
HK1257902B (en) T cell receptors recognizing hla-cw8 restricted mutated kras
WO2022225836A1 (en) Hla class i-restricted t cell receptors against ras with q61k mutation

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210903

EEER Examination request

Effective date: 20210903

EEER Examination request

Effective date: 20210903

EEER Examination request

Effective date: 20210903

EEER Examination request

Effective date: 20210903

EEER Examination request

Effective date: 20210903

EEER Examination request

Effective date: 20210903