CA2942971C - Beta-lactamases with improved properties for therapy - Google Patents

Beta-lactamases with improved properties for therapy Download PDF

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Publication number
CA2942971C
CA2942971C CA2942971A CA2942971A CA2942971C CA 2942971 C CA2942971 C CA 2942971C CA 2942971 A CA2942971 A CA 2942971A CA 2942971 A CA2942971 A CA 2942971A CA 2942971 C CA2942971 C CA 2942971C
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Canada
Prior art keywords
beta
lactamase
lactamases
polar
residue
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Active
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CA2942971A
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English (en)
French (fr)
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CA2942971A1 (en
Inventor
Michael Kaleko
Sheila Connelly
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Theriva Biologics Inc
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Synthetic Biologics Inc
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Publication of CA2942971A1 publication Critical patent/CA2942971A1/en
Application granted granted Critical
Publication of CA2942971C publication Critical patent/CA2942971C/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/50Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y305/00Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02006Beta-lactamase (3.5.2.6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CA2942971A 2014-04-17 2015-04-17 Beta-lactamases with improved properties for therapy Active CA2942971C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461980844P 2014-04-17 2014-04-17
US61/980,844 2014-04-17
US201462046627P 2014-09-05 2014-09-05
US62/046,627 2014-09-05
PCT/US2015/026457 WO2015161243A2 (en) 2014-04-17 2015-04-17 Beta-lactamases with improved properties for therapy

Publications (2)

Publication Number Publication Date
CA2942971A1 CA2942971A1 (en) 2015-10-22
CA2942971C true CA2942971C (en) 2023-03-14

Family

ID=54321063

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2942971A Active CA2942971C (en) 2014-04-17 2015-04-17 Beta-lactamases with improved properties for therapy

Country Status (10)

Country Link
US (14) US9290754B2 (enExample)
EP (1) EP3132033B1 (enExample)
JP (2) JP6685925B2 (enExample)
KR (1) KR102360582B1 (enExample)
CN (1) CN106163546B (enExample)
AU (1) AU2015247382B2 (enExample)
BR (1) BR112016023360B1 (enExample)
CA (1) CA2942971C (enExample)
RU (1) RU2678124C2 (enExample)
WO (1) WO2015161243A2 (enExample)

Families Citing this family (14)

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EP3204495B1 (en) 2014-10-08 2020-04-22 Synthetic Biologics, Inc. Beta-lactamase formulations and uses thereof
US10709773B2 (en) * 2015-03-06 2020-07-14 Synthetic Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
WO2017144495A1 (en) * 2016-02-23 2017-08-31 Da Volterra Beta-lactamase variants
US10982205B2 (en) 2016-02-23 2021-04-20 Da Volterra Beta-lactamase variants
US11517614B2 (en) 2016-06-28 2022-12-06 Synthetic Biologics, Inc. Microbiome protection from oral antibiotics
EP3829637A1 (en) 2018-08-05 2021-06-09 Da Volterra Method for improving anticancer agent efficacy
CN112689506A (zh) 2018-08-05 2021-04-20 达·沃尔泰拉公司 用于治疗移植物抗宿主疾病的组合物
CN109337889B (zh) * 2018-12-26 2020-10-02 广州白云山拜迪生物医药有限公司 一种酶活提高的金属β-内酰胺酶突变体及其构建方法
CN109576250B (zh) * 2018-12-26 2025-04-15 广州白云山拜迪生物医药有限公司 一种酶活提高的头孢菌素酶突变体及其构建方法
EP3965804B1 (en) * 2019-05-06 2025-04-02 Theriva Biologics, Inc. Beta-lactamase compositions for treatment of graft versus host disease
EP4148136A1 (en) 2021-09-08 2023-03-15 Da Volterra An engineered yeast cell for the delivery of antibiotic-inactivating enzymes
WO2024012487A1 (en) * 2022-07-14 2024-01-18 The Hong Kong Polytechnic University Biosensor comprising a modified beta-lactamase and uses thereof
CN115433701B (zh) * 2022-11-08 2023-03-17 南京农业大学 一株变形杆菌及其菌剂和在降解头孢类抗生素中的应用
CN117701543A (zh) * 2023-12-15 2024-03-15 四川省固体废物与化学品管理中心 一种b家族内酰胺酶突变体及其固定化方法与应用

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US2941995A (en) 1957-08-02 1960-06-21 Beecham Res Lab Recovery of solid 6-aminopenicillanic acid
US2982696A (en) 1959-05-01 1961-05-02 Schenley Ind Inc Ion-exchange procedures for the purification of penicillinase
US3070511A (en) 1960-02-10 1962-12-25 Lepetit Spa Process for preparing 6-aminopenicillanic acid
US3150059A (en) 1962-12-26 1964-09-22 Lilly Co Eli Penicillin deacylation via actinoplanaceae fermentation
US3239394A (en) 1964-06-15 1966-03-08 Merck & Co Inc Process for producing 7-amino-cephalosporanic acid
US3499909A (en) 1966-05-18 1970-03-10 Koninklijke Gist Spiritus Process for production of 6-aminopenicillanic acid
US3488729A (en) 1966-08-22 1970-01-06 Lilly Co Eli Cephalothin ester
GB1241844A (en) 1968-08-23 1971-08-04 Beecham Group Ltd Penicillins
GB1463513A (en) 1974-08-13 1977-02-02 Beecham Group Ltd Enzymes
FI59265C (fi) 1974-08-13 1981-07-10 Beecham Group Ltd Foerfarande foer framstaellning av 6-aminopenicillansyra
GB2199582A (en) 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
FR2613624B1 (fr) 1987-04-10 1990-11-23 Roussy Inst Gustave Composition pharmaceutique, administrable par voie orale, destinee a reduire les effets des b-lactamines
CA2007083A1 (en) 1989-01-09 1990-07-09 Nobuhiko Katunuma Pharmaceutical use of trypstatin
CS275231B2 (en) 1989-09-29 1992-02-19 Ustav Makormolekularni Chemie Medicine bottle
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EP0837925A1 (en) 1995-07-07 1998-04-29 Novo Nordisk A/S Production of proteins using bacillus incapable of sporulation
CN1363680A (zh) * 2001-01-05 2002-08-14 上海博德基因开发有限公司 一种新的多肽——β内酰胺酶20.24和编码这种多肽的多核苷酸
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Also Published As

Publication number Publication date
JP7038094B2 (ja) 2022-03-17
US20230313166A1 (en) 2023-10-05
KR102360582B1 (ko) 2022-02-08
US10336995B2 (en) 2019-07-02
RU2678124C2 (ru) 2019-01-23
US11608494B2 (en) 2023-03-21
US20160362674A1 (en) 2016-12-15
EP3132033B1 (en) 2019-10-30
RU2016140627A (ru) 2018-05-17
JP6685925B2 (ja) 2020-04-22
US20180362954A1 (en) 2018-12-20
US9783797B1 (en) 2017-10-10
US20170314006A1 (en) 2017-11-02
US20180023072A1 (en) 2018-01-25
KR20160144996A (ko) 2016-12-19
CN106163546A (zh) 2016-11-23
EP3132033A2 (en) 2017-02-22
AU2015247382B2 (en) 2020-04-23
JP2017515466A (ja) 2017-06-15
US20150297689A1 (en) 2015-10-22
US20200157521A1 (en) 2020-05-21
US9376673B1 (en) 2016-06-28
AU2015247382A1 (en) 2016-09-15
US10767171B2 (en) 2020-09-08
US20160303207A1 (en) 2016-10-20
BR112016023360A2 (enExample) 2017-08-15
RU2016140627A3 (enExample) 2018-11-29
US10584326B2 (en) 2020-03-10
BR112016023360B1 (pt) 2023-03-07
CA2942971A1 (en) 2015-10-22
US11236319B2 (en) 2022-02-01
US9695409B2 (en) 2017-07-04
US9404103B1 (en) 2016-08-02
WO2015161243A2 (en) 2015-10-22
US9464280B1 (en) 2016-10-11
US20180305678A1 (en) 2018-10-25
US20220098566A1 (en) 2022-03-31
US9290754B2 (en) 2016-03-22
EP3132033A4 (en) 2017-11-29
US10087433B1 (en) 2018-10-02
JP2020054368A (ja) 2020-04-09
US20200017844A1 (en) 2020-01-16
US10011824B2 (en) 2018-07-03
US20200347375A1 (en) 2020-11-05
WO2015161243A3 (en) 2016-02-11
CN106163546B (zh) 2021-02-19

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