CA2917460A1 - Analytical method for detecting sulfated oligosaccharides - Google Patents

Analytical method for detecting sulfated oligosaccharides Download PDF

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Publication number
CA2917460A1
CA2917460A1 CA2917460A CA2917460A CA2917460A1 CA 2917460 A1 CA2917460 A1 CA 2917460A1 CA 2917460 A CA2917460 A CA 2917460A CA 2917460 A CA2917460 A CA 2917460A CA 2917460 A1 CA2917460 A1 CA 2917460A1
Authority
CA
Canada
Prior art keywords
hilic
mobile phase
poly
sample
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2917460A
Other languages
English (en)
French (fr)
Inventor
Helen CHAO
ChungYao WANG
Imin HUANG
ChiaYen WU
YungTe CHIANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scinopharm Taiwan Ltd
Original Assignee
Scinopharm Taiwan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scinopharm Taiwan Ltd filed Critical Scinopharm Taiwan Ltd
Publication of CA2917460A1 publication Critical patent/CA2917460A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/30—Partition chromatography
    • B01D15/305—Hydrophilic interaction chromatography [HILIC]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8836—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving saccharides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
CA2917460A 2013-07-11 2013-07-11 Analytical method for detecting sulfated oligosaccharides Abandoned CA2917460A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2013/050147 WO2015005928A1 (en) 2013-07-11 2013-07-11 Analytical method for detecting sulfated oligosaccharides

Publications (1)

Publication Number Publication Date
CA2917460A1 true CA2917460A1 (en) 2015-01-15

Family

ID=52280428

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2917460A Abandoned CA2917460A1 (en) 2013-07-11 2013-07-11 Analytical method for detecting sulfated oligosaccharides

Country Status (8)

Country Link
EP (1) EP3019861A4 (zh)
JP (1) JP6208866B2 (zh)
KR (1) KR20160030963A (zh)
CN (1) CN105431733B (zh)
AU (1) AU2013393832B2 (zh)
CA (1) CA2917460A1 (zh)
IL (1) IL243405A0 (zh)
WO (1) WO2015005928A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN110161147A (zh) * 2019-06-19 2019-08-23 北京三元食品股份有限公司 乳中游离低聚糖的高通量定量测定方法

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MX2016017317A (es) 2014-06-26 2017-08-24 Regeneron Pharma Metodos y composiciones para modificaciones geneticas dirigidas y metodos de uso.
JP6706497B2 (ja) * 2015-12-24 2020-06-10 昭和電工株式会社 親水性化合物の分離分析方法
CN105628820A (zh) * 2016-01-08 2016-06-01 东营天东制药有限公司 一种低分子肝素生产过程中游离硫酸根离子快速检测方法
US11166915B2 (en) 2016-09-16 2021-11-09 Leukocare Ag Method for obtaining efficient viral vector-based compositions for vaccination or gene therapy
WO2018050873A1 (en) 2016-09-16 2018-03-22 Leukocare Ag A novel method for producing low viscous and highly concentrated biopharmaceutical drug products in liquid formulation
WO2018235904A1 (ja) * 2017-06-22 2018-12-27 昭和電工株式会社 オリゴヌクレオチドの混合物の分離分析方法
CN109254101B (zh) * 2017-07-13 2021-07-09 中国科学院大连化学物理研究所 一种母乳酸性寡糖净化和分析方法
CN109459523B (zh) * 2017-09-06 2022-11-08 上海绿谷制药有限公司 一种测定酸性糖可溶性盐重均分子量和含量的方法
CN116879411A (zh) * 2018-07-24 2023-10-13 深圳市海普瑞药业集团股份有限公司 一种达肝素钠亚硝酸降解产物的分析方法及其应用
WO2020020145A1 (zh) * 2018-07-26 2020-01-30 深圳市海普瑞药业集团股份有限公司 低分子肝素糖链分布的分析方法及其应用
CN111239311A (zh) * 2018-11-28 2020-06-05 中国科学院大连化学物理研究所 一种婴幼儿排泄物中酸性糖及酸性糖衍生物的分析方法
CN109633003A (zh) * 2018-12-26 2019-04-16 成都普思生物科技股份有限公司 一种测定远志中远志口山酮ⅲ和3,6，-二芥子酰基蔗糖含量的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090317788A1 (en) * 2005-11-08 2009-12-24 Suomen Punainen Risti, Veripalvelu Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof
US9091695B2 (en) * 2007-06-01 2015-07-28 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
US8696917B2 (en) * 2009-02-09 2014-04-15 Edwards Lifesciences Corporation Analyte sensor and fabrication methods
EP2306199A1 (en) * 2009-09-29 2011-04-06 Academisch Ziekenhuis Leiden Acting Under The Name Leiden University Medical Center Reductive amination and analysis of carbohydrates using 2-picoline borane as reducing agent
CN102101875A (zh) * 2009-12-16 2011-06-22 中国科学院大连化学物理研究所 一种寡糖纯化分离方法
EP2512448B1 (en) * 2009-12-18 2016-07-06 Endotis Pharma Pharmaceutical oral dosage form containing a synthetic oligosaccharide
JP2013516470A (ja) * 2010-01-07 2013-05-13 ポリメディックス・インコーポレーテッド 抗ヘパリン化合物
CN102759596B (zh) * 2012-07-09 2014-08-20 山东大学 一种低分子肝素的离子对反相色谱质谱联用检测方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110161147A (zh) * 2019-06-19 2019-08-23 北京三元食品股份有限公司 乳中游离低聚糖的高通量定量测定方法

Also Published As

Publication number Publication date
EP3019861A4 (en) 2017-02-22
CN105431733B (zh) 2019-01-22
KR20160030963A (ko) 2016-03-21
AU2013393832B2 (en) 2017-11-30
AU2013393832A1 (en) 2016-02-04
WO2015005928A1 (en) 2015-01-15
JP6208866B2 (ja) 2017-10-04
IL243405A0 (en) 2016-02-29
JP2016524166A (ja) 2016-08-12
CN105431733A (zh) 2016-03-23
EP3019861A1 (en) 2016-05-18

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Legal Events

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EEER Examination request

Effective date: 20180703

FZDE Discontinued

Effective date: 20210831

FZDE Discontinued

Effective date: 20210831