CA2878330A1 - New single-dose packaging - Google Patents

New single-dose packaging Download PDF

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Publication number
CA2878330A1
CA2878330A1 CA2878330A CA2878330A CA2878330A1 CA 2878330 A1 CA2878330 A1 CA 2878330A1 CA 2878330 A CA2878330 A CA 2878330A CA 2878330 A CA2878330 A CA 2878330A CA 2878330 A1 CA2878330 A1 CA 2878330A1
Authority
CA
Canada
Prior art keywords
packaging
sealing
incision
item
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2878330A
Other languages
French (fr)
Other versions
CA2878330C (en
Inventor
Thomas Hille
Gabriel WAUER
Helena GALLINGER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme GmbH and Co KG
Original Assignee
LTS Lohmann Therapie Systeme GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP12005237.8 priority Critical
Priority to EP20120005237 priority patent/EP2687458A1/en
Application filed by LTS Lohmann Therapie Systeme GmbH and Co KG filed Critical LTS Lohmann Therapie Systeme GmbH and Co KG
Priority to PCT/EP2013/063922 priority patent/WO2014012787A1/en
Publication of CA2878330A1 publication Critical patent/CA2878330A1/en
Application granted granted Critical
Publication of CA2878330C publication Critical patent/CA2878330C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B11/00Wrapping, e.g. partially or wholly enclosing, articles or quantities of material, in strips, sheets or blanks, of flexible material
    • B65B11/50Enclosing articles, or quantities of material, by disposing contents between two sheets, e.g. pocketed sheets, and securing their opposed free margins
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B61/00Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages
    • B65B61/18Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for making package-opening or unpacking elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52Details
    • B65D75/58Opening or contents-removing devices added or incorporated during package manufacture
    • B65D75/5805Opening or contents-removing devices added or incorporated during package manufacture for tearing a side strip parallel and next to the edge, e.g. by means of a line of weakness
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52Details
    • B65D75/58Opening or contents-removing devices added or incorporated during package manufacture
    • B65D75/5827Tear-lines provided in a wall portion

Abstract

The invention relates to a pack (1) for individual active-substance-containing films or plasters (2), comprising an upper packaging-material element (3) and a lower packing-material element (4), which are connected to one another by means of an all-round sealing surface or sealing seam (5) so as to form a cavity (6) which is enclosed on all sides and is intended for accommodating the film or plaster (2), wherein - the upper packaging-material element (3) and the lower packaging-material element (4), in the region of the sealing surface or of the sealing seam (5), each have at least one cut (7, 8), these cuts being congruent, and - at least one cut (7, 8) is intersected by a folding line or line of inflection (10), wherein the cut (7) in the upper packaging-material element (3) and the congruent cut (8) in the lower packaging-material element (4) are formed such that the respective end point (15, 16) of the cuts (7, 8) is at a distance (M1) from the cavity (6) which corresponds at least to the width (M2) of the sealing seam (5).

Description

New single-dose packaging The invention relates to an item of packaging for single-dose films or patches which contain an active ingredient, comprising an upper packaging-material element and a lower packaging-material element which are connected to one another by means of an encircling sealing face or sealing seam, respectively, in such a manner that a cavity, enclosed on all sides, for receiving the film or patch is formed, wherein the upper packaging-material element and the lower packaging-material element in the region of the sealing face or the sealing seam, respectively, display in each case at least one incision which are congruent, and at least one incision is intersected by a fold or kink line.
Transdermal therapeutic systems (TTS) are patch-like pharmaceutical dosage forms for dispensing active ingredients to the skin. In the simplest case, TTS
consist of a very thin backing layer, an adhesive polymer layer which contains an active ingredient, and optionally of a protective layer which may be peeled off again and which is removed prior to the application of the TTS. The backing layer and the polymer layer have to be very thin, so as to prevent the sensation of a foreign body when wearing the TTS. On account of this property, both layers are susceptible to damage when the packaging is torn open (in the following referred to as "patch").
The same also applies to film-shaped oral pharmaceutical dosage forms, also so-called oral thin films (OTF) or wafers, which are composed of only one polymer layer (in the following referred to as "film").
There is, in principle, a demand for child-safe packaging for such types of pharmaceutical dosage forms or dispensing forms, respectively, which, however, also have to be easy for adults to open.
DE 10 2004 047 445 Al discloses a non-resealable item of packaging for products, in particular pharmaceutical products, which are hazardous to health, comprising a first packaging-material element and a second packaging-material element. The two packaging-material elements here are disposed so as to be on top of one another, and the item of packaging displays at least one first face portion on the periphery or peripheries of which the two packaging-material elements are releasably connected to one another, wherein between the two packaging-material elements at least one cavity, enclosed on all sides, for receiving the packaged item is formed. The item of packaging displays at least one second face portion which is outside the mentioned first face portion or is adjacent thereto, and on the periphery or peripheries of which the two packaging-material elements are releasably connected to one another, and wherein at least one of the two packaging-material elements is provided with at least one structure which runs within the second face portion and which enables tearing of the packaging-material element/elements.
DE 10 2006 041 921 Al discloses an item of packaging for films which contain an active ingredient, which displays a carrier layer and a cover layer which is releasably connected thereto. The item of packaging here displays in paired arrangement two face regions which lie opposite one another and which are separated by a web and within which the cover layer is not connected to the carrier layer, on account of which two spaces, enclosed on all sides, which are separated from one another for receiving the mentioned films in a paired manner are formed. A further face region in which the carrier layer is not connected to the cover layer exists within the mentioned web, on account of which a cavity, enclosed on all sides, is formed and at least one perforation line exists within the web.
In these known embodiments, the upper packaging-material element and the lower packaging-material element are connected to one another in a releasable (peelable) manner.
In another embodiment in the case of single-dose items of packaging, the two packaging-material elements are connected to one another in a non-releasable manner.
This preferably takes place by way of heat-sealing, but may also take place by way of any other suitable sealing method, such as cold-sealing, ultrasonic sealing, laser sealing, or comparable film-welding methods which are known to a person skilled in the art, as long as a non-releasable sealing seam is obtained.
An item of packaging of this type is known from the German laid-open patent specification DE 10 2009 008 217 Al, for example.
In the known embodiments of the item of packaging, the user has to fold over part of the item of packaging along a printed marking line, in order to subsequently open the item of packaging at a likewise marked spot by tearing along a weakening line. Folding over along the printed marking line modifies the positioning of a structure or of an incision in the region of the sealing face or sealing seam, respectively, of the two packaging-material elements on the periphery of the item of packaging and thus enables the item of packaging to be torn open in order to be able to remove the contents from the cavity. The structure or the incision has a length of approx. 3 to 5 'um. The printed marking line intersects the structure or the incision, CA 02878330,2015-01-05 respectively, in a preferably perpendicular manner or at a selected angle.
The necessity for the sealing seam and the packaging-material elements to have to consider the diffusion behavior of the contents of the item of packaging is already pointed out in DE 10 2009 008 217 Al. In the known embodiments the arrangement of the incisions has to be seen as critical_ The prior art here overlooks the fact that the packaging significantly contributes toward the stability of the packaged pharmaceutical dosage form, since the packaging protects the pharmaceutical dosage form from light, humidity, oxygen, and microorganisms.
On account of causing a gap in the seal, the mentioned weakening line weakens the packaging, since more humidity and oxygen can be diffused through the interrupted seal into the interior of the packaging. It is to be noted here that both water vapor and oxygen are very small molecules and the shelf life of the medicine prior to application should at least be two years, ideally even three years or more.
The invention is thus based on the object of providing a single-dose item of packaging of the generic type which improves the embodiments described above. In particular, diffusion of material into the interior of the packaging is to be prevented.
This object is achieved according to the invention in that the incision in the upper packaging-material element and the congruent incision in the lower packaging-material element is configured such that the respective terminal point of the incisions displays a spacing from the cavity which corresponds to at least the width of the sealing seam. Claim 1 thus achieves the object set.

Furthermore, the aspect of child safety is advantageously achieved such that this invention meets the requirements of DIN EN 14375 (child-resistant, non-reclosable packaging for pharmaceutical products -requirements and tests).
The invention, therefore, relates to an item of packaging for single-dose films or patches which contain an active ingredient, comprising an upper packaging-material element and a lower packaging-material element which are connected to one another by means of an encircling sealing face or sealing seam in such a manner that a cavity, enclosed on all sides, for receiving the film or patch is formed, wherein i.) the upper packaging-material element and the lower packaging-material element in the region of the sealing face or the sealing seam display in each case at least one incision which are congruent, and ii.) at least one incision of i.) is intersected by a fold or kink line, and iii.) the incision of i.) in the upper packaging-material element and the congruent incision in the lower packaging-material element is configured such that the respective terminal point of the incisions of i.) displays a spacing (MI) from the cavity or the cavity edge, respectively, which corresponds to at least the width (M2) of the sealing seam.
In a further preferred embodiment of the invention the width of the sealing seam (M2) is 1 to 25 mm, preferably 2 to 10 mm, particularly preferably 4 to 8 mm. Accordingly, the spacing M1 according to the invention of iii.) is at least the length of M2 or more; it is, however, preferable for M1 not to be equal to but longer than M2, in particular to display an additional amount of 20% to 30% in relation to M2. An example which is not final is illustrated in fig. 1. It CA 02878330.2015-01-05 is furthermore preferable for the sealing seams to be configured in a uniform manner. For example, if a width (M2) of the sealing seam of 5 mm is chosen, M1 may be mm and more, preferably 6 to 10 mm.

Design embodiments of the invention are stated in the dependent claims The invention thus provides that the terminal points of the incisions are located at least as far from the cavity as the maximum width of the remaining sealing seams. Each item of packaging on at least three sides displays sealing seams, which consider a width in order to avoid or prevent, respectively, diffusion for the time duration of the maximum shelf life.
The outer layer is preferably printable, such that, for example, product identification marks and aids for tearing open may be attached.
A second layer, or the central layer in the case of a triple-layer construction, is composed of a metal foil, preferably aluminum, having a thickness of 9 - 25 micrometers. This metallic layer makes for tightness of the packaging in relation to humidity and air.
The inner layer is a sealable plastic layer, wherein the sealing seam produced by this layer cannot be reopened.
In one preferred embodiment, the upper packaging-material element and the lower packaging-material element have an identical construction. This has the advantage that only one variety of packaging material is employed and any mix-up can be precluded.
An expedient embodiment provides that the incision in the upper packaging-material element and the incision in the lower packaging-material element is applied in the sealing seam such that said incision is oriented so as to be perpendicular to the nearest outer edge of the cavity. This ensures that the incision is in contact with the encircling sealing face or sealing seam, respectively, at precisely one single point, while in the case of the known embodiments, contact exists across a comparatively large distance.
It is furthermore preferable for said incisions to display sufficient spacing along an incision line from the introduced film or patch, such that no damage arises during tearing open. A suitable spacing M3 is identified in an exemplary manner in fig. 1.
In one particular embodiment, the upper packaging-material element and the lower packaging-material element are configured so as to be in one part and here are folded back along a bending edge.
The connection between the two packaging-material elements is preferably produced by sealing or welding.
Suitable means and methods for producing the sealing faces or the sealing seams, respectively, are known to the person skilled in the art. The seal serves as a barrier to diffusion and permeation and is generally impermeable to active ingredients and to air humidity.
Both hot-sealing methods and cold-sealing methods are considered. Hotmelt adhesives, sealing waxes, sealing dispersions, or adhesives may be used as a material for sealing layers, for example The invention furthermore relates to a method for manufacturing an item of packaging for single-dose films or patches which contain an active ingredient, comprising the steps of i.) providing an upper packaging-material element and a lower packaging-material element which are connected to one another by means of an encircling sealing face or sealing seam, respectively, in such a manner that a cavity, enclosed on all sides, for receiving the film or patch is formed, wherein ii.) in each case at least one incision which are congruent is inflicted on the upper packaging-material element and the lower packaging-material element in the region of the sealing face or the sealing seam, respectively, and iii.) applying a fold or kink line which intersects at least one aforementioned incision of ii.), wherein said incision of ii.) in the upper packaging-material element and the congruent incision in the lower packaging-material element is configured such that the respective terminal point of these incisions displays a spacing (M1) from the abovementioned cavity which corresponds to at least the width (M2) of the sealing seam of i).
The method according to the invention may be further designed as per one of the preceding or following features. In particular, at least one incision of ii.) may be oriented so as to be perpendicular to the nearest outer edge of the cavity of i.), The invention furthermore relates to the use of an item of packaging (1) as claimed in claim 1, for receiving single doses, such as films, wafers or patches, in particular TTS patches, which contain an active ingredient.
Further features and details of the invention are derived from the claims and the following description of exemplary embodiments of the invention, which are illustrated in schematic drawings, in which:
Fig. 1 shows an item of packaging for films which contain an active ingredient in plan view; and Fig. 2 shows the item of packaging of fig. 1, in a sectional side view.
In fig. 1, an item of packaging 1 according to the invention is illustrated in plan view. The item of packaging 1 is a sealed-edge pouch made from an upper packaging-material element 3 and a lower packaging-material element 4. A film 2 which contains an active ingredient is disposed in a cavity 6, enclosed on all sides, between the upper packaging-material element 3 and the lower packaging-material element 4. The cavity 6 is produced by an encircling sealing face or sealing seam 5, respectively, which connects the two packaging-material elements 3, 4 in a non-releasable manner. The cavity 6 and the sealing face or sealing seam 5, respectively, display a common outer edge 6a. An incision 7 is located in the upper packaging-material element 3 in the sealing face or sealing seam 5, respectively, and an incision 8 is located in the lower packaging-material element 4, The two incisions 7 and 8 are congruent. The incision 7 is intersected by a fold or kink line 10 An imaginary extension of the incisions 7 and 8, which is identical to the tear-open edge, displays a spacing M3 from the nearest edge of the film 2 which contains an active ingredient. In one preferred embodiment, the spacing M3 is 4 to 5 mm.
In another embodiment, the upper and lower packaging-material element 3, 4 is configured so as to be in one part and is folded back around a bending edge 17. Here, the sealing seam 5 is dispensed with in this region.
The construction of the item of packaging is illustrated in a sectional illustration, along the line A-A in fig. 1, in fig 2. The individual parts are greatly enlarged and drawn so as to be separate in order to show the construction more clearly. The upper packaging-material element 3 is composed of at least one upper outer layer 11 and an adjoining upper metallic layer 13.
The lower packaging-material layer 4 is likewise composed of a lower outer layer 12 and an adjoining lower metallic layer 14.
The metallic layers 13, 14 are preferably composed of an aluminum foil having a thickness of 9 to 25 micrometers. The foil ensures that the inserted product does not come into contact with air and is not exposed to any humidity.
The upper or the lower packaging-material element 3, 4 displays a sealable layer or sealing layer 9 in at least the region of the sealing face or the sealing seam 5, respectively. The sealing layer 9, however, may also be attached on both, the upper and the lower, packaging-material elements 3, 4. The sealing face or sealing seam 5, respectively, which is produced by this layer 9 cannot be separated again.

List of reference signs:
1 Packaging

2 Film containing active ingredient

3 Upper packaging-material element

4 Lower packaging-material element

5 Sealing face or sealing seam, respectively

6 Cavity 6a Outer edges of cavity 6a

7 Incision

8 Incision

9 Sealing layer

10 Fold or kink line

11 Upper outer layer

12 Lower outer layer

13 Upper metallic layer

14 Lower metallic layer

15 Terminal point of incision 7

16 Terminal point of incision 8

17 Bending edge M1 Spacing 1 M2 Spacing 2 M3 Spacing 3

Claims

claims:
1. An item of packaging (1) for single-dose films or patches (2) which contain an active ingredient, comprising an upper packaging-material element (3) and a lower packaging-material element (4) which are connected to one another by means of an encircling sealing face or sealing seam (5), respectively, in such a manner that a cavity (6), enclosed on all sides, for receiving the film or patch (2) is formed, wherein i.) the upper packaging-material element (3) and the lower packaging-material element (4) in the region of the sealing face or the sealing seam (5), respectively, display in each case at least one incision (7, 8) which are congruent, and ii.) at least one incision (7, 8) is intersected by a fold or kink line (10), characterized in that iii.) the incision (7) in the upper packaging-material element (3) and the congruent incision (8) in the lower packaging-material element (4) is configured such that the respective terminal point (15, 16) of the incisions (7, 8) displays a spacing (M1) from the cavity (6) which corresponds to at least the width (M2) of the sealing seam (5).
2. The item of packaging (1) as claimed in claim 1, characterized in that the incision (7) and the incision (8) are oriented so as to be perpendicular to the nearest outer edge (6a) of the cavity (6).
3. The item of packaging (1) as claimed in claim 1, characterized in that the upper packaging-material element (3) and the lower packaging-material element (4) are configured so as to be in one part and form a bending edge (17).
4. The item of packaging (1) as claimed in claim 1, characterized in that the upper outer layer (11) and/or the lower outer layer (12) are/is configured so as to be printable.
5. The item of packaging (1) as claimed in one of claims 1 to 4, characterized in that the sealing face or the sealing seam (5), respectively, is not peelable.
6. The item of packaging (1) as claimed in one of claims 1 to 5, characterized in that each packaging-material element (3, 4) displays an outer layer (11, 12) and a metallic layer (13, 14), and at least one of the two packaging-material elements (3, 4) displays a sealing layer (9).
7. The item of packaging (1) as claimed in claim 6, characterized in that the sealing layer is selected from hotmelt adhesives, sealing waxes, sealing dispersions, or adhesives.
8. A method for manufacturing an item of packaging (1) for single-dose films or patches which contain an active ingredient, comprising the steps of:
i. providing an upper packaging-material element (3) and a lower packaging-material element (4) which are connected to one another by means of an encircling sealing face or sealing seam (5), respectively, in such a manner that a cavity (6), enclosed on all sides, for receiving the films is formed, wherein i.) in each case at least one incision (71 8) which are congruent is inflicted on the upper packaging-material element (3) and the lower packaging-material element (4) in the region of the sealing face or the sealing seam, respectively, and ii.) applying a fold or kink line (10) which intersects at least one aforementioned incision (7, 8), wherein the incision (7) in the upper packaging-material element (3) and the congruent incision (8) in the lower packaging-material element (4) is configured such that the respective terminal point (15, 16) of the incisions displays a spacing (M1) from the cavity (6) which corresponds to at least the width (M2) of the sealing seam (5), 9. The method for manufacturing an item of packaging (1) for single-dose films which contain an active ingredient, as claimed in claim 8, comprising a further step iv.), wherein at least one incision (7, 8) is oriented so as to be perpendicular to the nearest outer edge (6a) of the cavity (6).
10. The use of an item of packaging (1) as claimed in
claim 1, for receiving single doses, such as films, wafers or patches, in particular TTS
patches, which contain an active ingredient.
CA2878330A 2012-07-17 2013-07-02 New single-dose packaging Active CA2878330C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP12005237.8 2012-07-17
EP20120005237 EP2687458A1 (en) 2012-07-17 2012-07-17 Package for films with a unitary dosage of an active substance
PCT/EP2013/063922 WO2014012787A1 (en) 2012-07-17 2013-07-02 Pack for individual active‑substance‑containing films, and method for producing said pack

Publications (2)

Publication Number Publication Date
CA2878330A1 true CA2878330A1 (en) 2014-01-23
CA2878330C CA2878330C (en) 2020-04-14

Family

ID=46640511

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2878330A Active CA2878330C (en) 2012-07-17 2013-07-02 New single-dose packaging

Country Status (13)

Country Link
EP (2) EP2687458A1 (en)
JP (1) JP6422436B2 (en)
KR (1) KR20150032702A (en)
CN (1) CN104640781B (en)
AU (1) AU2013292245B2 (en)
BR (1) BR112015000813A2 (en)
CA (1) CA2878330C (en)
ES (1) ES2605432T3 (en)
HK (1) HK1209713A1 (en)
MX (1) MX351124B (en)
PL (1) PL2874908T3 (en)
RU (1) RU2633954C2 (en)
WO (1) WO2014012787A1 (en)

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US9597852B2 (en) * 2009-02-10 2017-03-21 Lts Lohmann Therapie-Systeme Ag Childproof, highly inert individual packaging

Also Published As

Publication number Publication date
PL2874908T3 (en) 2017-05-31
CA2878330C (en) 2020-04-14
EP2874908A1 (en) 2015-05-27
RU2015105053A (en) 2016-09-10
ES2605432T3 (en) 2017-03-14
KR20150032702A (en) 2015-03-27
CN104640781A (en) 2015-05-20
JP6422436B2 (en) 2018-11-14
EP2874908B1 (en) 2016-09-07
AU2013292245B2 (en) 2016-08-18
BR112015000813A2 (en) 2017-06-27
CN104640781B (en) 2016-11-09
EP2687458A1 (en) 2014-01-22
WO2014012787A1 (en) 2014-01-23
HK1209713A1 (en) 2016-04-08
RU2633954C2 (en) 2017-10-19
AU2013292245A1 (en) 2015-02-05
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JP2015524290A (en) 2015-08-24
MX351124B (en) 2017-10-02

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