CA2873143A1 - Radio-pharmaceutical complexes - Google Patents
Radio-pharmaceutical complexes Download PDFInfo
- Publication number
- CA2873143A1 CA2873143A1 CA 2873143 CA2873143A CA2873143A1 CA 2873143 A1 CA2873143 A1 CA 2873143A1 CA 2873143 CA2873143 CA 2873143 CA 2873143 A CA2873143 A CA 2873143A CA 2873143 A1 CA2873143 A1 CA 2873143A1
- Authority
- CA
- Canada
- Prior art keywords
- tissue
- complex
- moieties
- moiety
- targeting moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
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- A—HUMAN NECESSITIES
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
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- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
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- Epidemiology (AREA)
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- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
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| PCT/EP2013/059840 WO2013167755A1 (en) | 2012-05-11 | 2013-05-13 | Radio-pharmaceutical complexes |
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| US9273059B2 (en) | 2009-08-24 | 2016-03-01 | Lumiphore, Inc. | Macrocyclic HOPO chelators |
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| US11453652B2 (en) | 2013-03-15 | 2022-09-27 | Lumiphore, Inc. | Di-macrocycles |
| MA41176A (fr) * | 2014-12-17 | 2017-10-24 | Bayer As | Complexes radio-pharmaceutiques |
| WO2017105565A2 (en) * | 2015-09-10 | 2017-06-22 | Memorial Sloan Kettering Cancer Center | Compositions for therapeutics, targeted pet imaging and methods of their use |
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| CR20180581A (es) | 2016-06-10 | 2019-02-11 | Bayer Pharma AG | Complejos radio-farmacéuticos |
| US20200016283A1 (en) * | 2017-02-24 | 2020-01-16 | Bayer As | Combination therapy comprising a radiopharmaceutical and a dna-repair inhibitor |
| EA202092044A1 (ru) * | 2018-03-14 | 2021-03-03 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные рецепторы антигена против cd33 и их применения |
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| CA3119467A1 (en) * | 2018-11-20 | 2020-05-28 | Cornell University | Macrocyclic complexes of radionuclides and their use in radiotherapy of cancer |
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| AR119479A1 (es) | 2019-07-25 | 2021-12-22 | Bayer As | Radiofármacos dirigidos para diagnóstico y tratamiento de cáncer |
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| GB0308731D0 (en) | 2003-04-15 | 2003-05-21 | Anticancer Therapeutic Inv Sa | Method of radiotherapy |
| US7794691B2 (en) * | 2004-06-25 | 2010-09-14 | The European Community, Represented By The European Commission | Radionuclides for medical use |
| EP2497501B1 (en) | 2004-06-25 | 2019-05-01 | The European Union, represented by the European Commission | Radionuclides for medical use |
| EP2051968B1 (en) | 2006-08-15 | 2020-04-29 | The Regents of the University of California | Luminescent macrocyclic lanthanide complexes |
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| ES2496991T3 (es) * | 2010-02-12 | 2014-09-22 | Evonik Degussa Gmbh | Composición cosmética que contiene éster parcial de poliglicerol |
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- 2013-05-13 KR KR1020147034741A patent/KR20150092700A/ko not_active Withdrawn
- 2013-05-13 CN CN201380035189.1A patent/CN104602716A/zh active Pending
- 2013-05-13 US US14/400,020 patent/US20150104385A1/en not_active Abandoned
- 2013-05-13 HK HK15108017.5A patent/HK1207307A1/xx unknown
- 2013-05-13 CN CN201380036807.4A patent/CN104619355A/zh active Pending
- 2013-05-13 CA CA 2873143 patent/CA2873143A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2846843A1 (en) | 2015-03-18 |
| CN104602716A (zh) | 2015-05-06 |
| CA2873144C (en) | 2021-03-16 |
| JP6211066B2 (ja) | 2017-10-11 |
| KR20150092701A (ko) | 2015-08-13 |
| WO2013167756A1 (en) | 2013-11-14 |
| JP6219372B2 (ja) | 2017-10-25 |
| EP2846844B1 (en) | 2020-04-01 |
| WO2013167754A1 (en) | 2013-11-14 |
| CA2873142A1 (en) | 2013-11-14 |
| US20150147272A1 (en) | 2015-05-28 |
| EP2846844A1 (en) | 2015-03-18 |
| US20150104385A1 (en) | 2015-04-16 |
| JP2015517482A (ja) | 2015-06-22 |
| HK1206982A1 (en) | 2016-01-22 |
| CN104540530A (zh) | 2015-04-22 |
| CA2873144A1 (en) | 2013-11-14 |
| US9827336B2 (en) | 2017-11-28 |
| WO2013167755A1 (en) | 2013-11-14 |
| CN104619355A (zh) | 2015-05-13 |
| JP2015517483A (ja) | 2015-06-22 |
| JP2015523326A (ja) | 2015-08-13 |
| KR20150092702A (ko) | 2015-08-13 |
| US20150110817A1 (en) | 2015-04-23 |
| HK1207307A1 (zh) | 2016-01-29 |
| HK1206981A1 (en) | 2016-01-22 |
| KR20150092700A (ko) | 2015-08-13 |
| GB201208309D0 (en) | 2012-06-27 |
| EP2846842A1 (en) | 2015-03-18 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20190514 |