New! View global litigation for patent families

CA2831036A1 - Dermal compositions containing gorgonian extract - Google Patents

Dermal compositions containing gorgonian extract

Info

Publication number
CA2831036A1
CA2831036A1 CA 2831036 CA2831036A CA2831036A1 CA 2831036 A1 CA2831036 A1 CA 2831036A1 CA 2831036 CA2831036 CA 2831036 CA 2831036 A CA2831036 A CA 2831036A CA 2831036 A1 CA2831036 A1 CA 2831036A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
composition
wt
weight
total
gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA 2831036
Other languages
French (fr)
Inventor
Chris Billis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ERMIS LABS, INC.
Original Assignee
Ermis Labs LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/614Cnidaria, e.g. sea anemones, corals, coral animals or jellyfish
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/327Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8105Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • A61K8/8111Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/965Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/007Preparations for dry skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/596Mixtures of surface active compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients

Abstract

A skincare composition comprising Gorgonian extract as an anti-inflammatory component thereof, said skincare composition being selected from among compositions (I) and (II): (I) an aqueous composition comprising from 35 to 65 wt.% water, from 25 to 45 wt.% surfactant, from 0.01 to 0.2 wt.% retinol and from 0.005 to 0.5 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt.%; and (II) a gel composition comprising from 60 to 90 wt.% water, from 1 to 12 wt.% benzoyl peroxide, and from 0.05 to 1.25 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the gel composition, and all weight percentages of all ingredients in the gel composition total to 100 wt.%.

Description

DERMAL COMPOSITIONS CONTAINING GORGONIAN EXTRACT
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of priority under 35 USC 119 of U.S.
Provisional Patent Application No. 61/316,827 filed March 23, 2010 in the name of Chris Billis for "DERMAL COMPOSITIONS CONTAINING GORGONIAN EXTRACT" and also claims the priority under 35 USC 120 of U.S. Patent Application No.
13/044,311 filed March 9, 2011 in the name of Chris Billis for "DERMAL COMPOSITIONS CONTAINING
GORGONIAN EXTRACT." The disclosures of U.S. Provisional Patent Application No.

61/316,827 and U.S. Patent Application No. 13/044,311 are hereby incorporated herein by reference in their entireties, for all purposes.
FIELD

[0002] The present invention relates to dermal compositions for topical administration to enhance skin condition and combat skin disorders such as acne, dermatitis, rosacea and the like.
DESCRIPTION OF THE RELATED ART

[0003] In the use of field of skin care, a wide variety of products have been developed and commercialized for enhancing skin condition, e.g., for combating adverse dermal disorders such as dermatitis, acne, rosacea, and the like. Such products have taken various forms, including, without limitation, facial and skin powders, gels, plasters, saturated wraps, crèmes, rinses, film-forming compositions, transdermal patches, aerosolized sprays, mud formulations, salves, slurries, and pastes.

[0004] These skin products have used a variety of active ingredients, including retinol and retinoids generally, benzoyl peroxide, hexachlorophene, and numerous others.

[0005] The art is continually seeking new dermal formulations that are storage stable, easily applied to the skin, and effective to combat a variety of skin disorders including acne, rosacia and dermatitis.

SUMMARY

[0006] The present invention relates to skin care compositions for topical administration, which are therapeutically effective for conditioning the skin and combating skin disorders including those discussed in the Background section hereof.

[0007] In one aspect, the invention relates to a skincare composition comprising Gorgonian extract as an anti-inflammatory component thereof, such skincare composition being selected from among compositions (I) and (II):
(I) an aqueous composition comprising from 35 to 65 wt.% water, from 25 to 45 wt.%
surfactant, from 0.01 to 0.2 wt.% retinol and from 0.005 to 0.5 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt.%; and (II) a gel composition comprising from 60 to 90 wt.% water, from 1 to 12 wt.%
benzoyl peroxide, and from 0.05 to 1.25 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the gel composition, and all weight percentages of all ingredients in the gel composition total to 100 wt.%.

[0008] In another aspect, the invention relates to an aqueous composition comprising from 35 to 65 wt.% water, from 25 to 45 wt.% surfactant, from 0.01 to 0.2 wt.%
retinol and from 0.005 to 0.5 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt.%.

[0009] In a further aspect, the invention relates to a gel composition comprising from 60 to 90 wt.% water, from 1 to 12 wt.% benzoyl peroxide, and from 0.05 to 1.25 wt.%
Gorgonian extract, wherein all weight percentages are based on total weight of the gel composition, and all weight percentages of all ingredients in the gel composition total to 100 wt.%.

[0010] In a still further aspect, the invention relates to a method of enhancing skin condition, comprising topically administering to skin in need thereof, a skincare composition comprising Gorgonian extract as an anti-inflammatory component thereof, said skincare composition being selected from among compositions (I) and (II):
(I) an aqueous composition comprising from 35 to 65 wt.% water, from 25 to 45 wt.%
surfactant, from 0.01 to 0.2 wt.% retinol and from 0.005 to 0.5 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt.%; and (II) a gel composition comprising from 60 to 90 wt.% water, from 1 to 12 wt.%
benzoyl peroxide, and from 0.05 to 1.25 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the gel composition, and all weight percentages of all ingredients in the gel composition total to 100 wt.%.

[0011] Other aspects, features and embodiments of the invention will be more fully apparent from the ensuing disclosure and appended claims.
DETAILED DESCRIPTION

[0012] The present invention relates to skin treatment compositions that are topically administered to improve the character of the skin, and to combat adverse skin conditions such as acne, dermatitis, and inflammatory dermatoses.

[0013] As used herein, references to compositional ingredients in percents by weight refers to weight percentages based on the total weight of the composition or formulation.

[0014]
Dermatological compositions of the invention may be utilized for treatment of a wide variety of dermal conditions and adverse physiological states manifesting dermally, including, without limitation, dry skin/xerosis, psoriasis, ichthoyosis, keratosis, keratoderma, dermatitis, pruritis, eczema, and acne. Compositions of the invention are usefully employed as skin moisturizers, skin softening agents, skin debridement agents, etc.
In cosmetic formulations, the compositions of the invention may be used with added ingredients that are solely cosmetic. Alternatively, the cosmetic formulation may include ingredients that are both cosmetically efficacious and therapeutically effective, e.g., so-called "cosmeceutical"
ingredients.

[0015] In various embodiments of the invention, the compositions described herein may comprise, consist or consist essentially of the specified ingredients or specific ones thereof.
Further, it will be understood that the formulations of the invention may be widely varied, as regards the absolute amounts and relative proportions thereof, in relation to specific examples, and illustrative compositions.

[0016] The present invention contemplates two principal types of skin care compositions utilizing Gorgonian extract as an anti-inflammatory component thereof.

[0017] The first type of composition is a face wash composition, which as a result of the presence of Gorgonian extract is able to utilize retinol in a highly effective manner in compositions containing very high concentrations of water and surfactant components, e.g., compositions in which water and surfactant components together constitute from 60 to 95 percent by weight (wt.%) of the total composition, more preferably from 65 wt.% to 90 wt.%, and most preferably from 75 to 88 wt.%, on the same total weight of the composition basis, and wherein the weight of surfactant to weight of water is in a ratio of from 0.40 to 1.3, more preferably from 0.5 to 1.0, and most preferably from 0.6 to 0.8. In various embodiments of the invention, the amount of water in the composition is from 35 wt.% to 65 wt.%, more preferably from 40 to 60 wt.%, and most preferably from 45 to 55 wt.%, based on the total weight of the composition.

[0018] The face wash formulations of the invention in specific embodiments thereof may contain retinol in the range of from 0.01 to 0.2 wt.%, based on the total weight of the composition, more preferably from 0.02 to 0.1 wt.%, and most preferably from 0.25 to 0.06 wt.%, on the same total composition weight basis. The Gorgonian extract may be present in the face wash composition in amounts of from 0.005 to 0.5 wt.%, more preferably from 0.01 to 0.1 wt.%, and most preferably from 0.02 to 0.05 wt.%, on the same total composition weight basis.

[0019] The amount of Gorgonian extract in the wash composition may broadly be from 2 to 10 times the amount of retinol in the composition, more preferably from 2.5 to 5 times the amount of retinol in the composition, and most preferably from 3 to 4 times the amount of retinol in the composition, on a weight or a weight percent basis, wherein weights are in the same units, and weight percent is based on total weight of the composition, for each of the two ingredients.

[0020] The retinol wash compositions of the invention in specific embodiments may contain water and surfactant ingredients that together constitute from 60 to 95 wt.% of the wash composition, based on total weight thereof. More preferably, the water and surfactant ingredients in such embodiments constitute from 65 to 90 wt.% of the wash composition, and most preferably from 75 to 85 wt.%, on the same composition total weight basis.

[0021] Outside of the broadest of the foregoing compositional ranges, the composition tends to become markedly less effective as a face wash composition, with respect to cleansing abilities of the composition, or with respect to undesirably high stringency of the retinol active ingredient or retinoic acid byproducts thereof on the skin surface subsequent to administration.

[0022] In this respect, the present invention achieves a therapeutically effective delivery of retinol that avoids skin sensitivity complications of itching, stinging, rashes, etc. that sometimes accompany relatively high dosages of retinol in skin care compositions of the prior art.

[0023] The water used as the principal ingredient in the retinol wash composition is preferably of a highly purified form, and may for example be singly or multiply distilled water that is submitted to additional purification treatment such as filtration, ion exchange treatment, etc.

[0024] The surfactant ingredient utilized in the retinol wash composition may include single or multicomponent surfactant species. In various compositional embodiments, the amount of the surfactant may range from 25 to 45 wt.%, based on total weight of the composition, more preferably from 30 to 40 wt.%, and most preferably from 32 to 38 wt.%, based on total weight of the composition. Any suitable surfactants species may be employed that are compatible with the other ingredients of the formulation and provide suitable use and therapeutic benefit characteristics. Illustrative surfactants that may be employed in the broad practice of the invention include, without limitation, sodium laureth sulfate, cocamidopropyl betaine, disodium laureth sulfosuccinate, lauryl betaine, disodium laureth sulfosuccinate, peg-soy sterol, sodium cocoate, sodium dodecylbenzene sulfonate, and sodium stearate.
Particularly preferred surfactant species include sodium laureth sulfate, commercially available from Cognis/DeWolf under the trademark STANDAPOL ES2, and cocamidopropyl betaine, commercially available from Cognis/DeWolf under the trademark VELVETEX BK
35.

[0025] The retinol ingredient may be provided as a pure single component ingredient, or as one component of a multicomponent ingredient, including for example the retinol in a vehicle or carrier composition that may for example include preservatives, polymers and emollients, as well as other ingredients. A preferred retinol multicomponent ingredient is available from Tagra under the trademark TAGRAVIT R1, which contains retinol, polymethylmethacrylate, butyl hydroxy toluene (BHT) and tricaprylin, a mixture of glycerin and caprylic acid.

[0026] The Gorgonian extract, sometimes referred to as sea whip extract, contains caprylic and capric triglycerides. A preferred Gorgonian extract is commercially available from Lipo as Gorgonian Extract GC.

[0027] In addition to the principal ingredients of water, surfactant, retinol and Gorgonian extract, the retinol wash compositions of the invention may contain any vehicular or carrier components, additives, excipients, and functional components to improve application and/or performance properties of the composition.

[0028] The retinol wash composition may for example contain thickener, humectant and emollient components, and the combination of such ingredients in various specific embodiments of the invention may constitute from 5 to 20 wt.% of the total composition weight, more preferably from 7.5 to 17.5 wt.%, and most preferably from 8 to 15 wt.%, on the same total composition weight basis.

[0029] Such thickener, humectant and emollient components may be of any suitable type or types, and single component as well as multicomponent ingredients are contemplated within the broad scope of the invention.

[0030] Thickener ingredients may for example comprise polysaccharides, carbomers, starches, gums, waxes, sorbitols, cellulosic materials, polymers, clays, silica, or any other useful for getting materials. A preferred thickener in retinol wash compositions of the invention is acrylate copolymer commercially available under the trademark CARBOPOL
AQUA SF-1 from Lubrizol/Protameen.

[0031] Humectants useful in the retinol wash compositions of the invention may be of any suitable type, and for example may include glycerin, propylene glycol, alpha hydroxy acids, glyceryl triacetate, polyols, sorbitol, xylitol, maltitol, polydextrose, quillaia, lactic acid, urea, and the like. A preferred humectant is glycerin USP grade.

[0032] Emollients employed in the retinol wash compositions of the invention can be of widely varying types, including, for example, aloe vera, jojoba oil, soybean oil, silicones, hydrocarbons, alkylene oxide copolymers, lanolin, squalene, tocopherols, phytosterols, and the like. A preferred emollient class is dimethicone emollients, with PEG-8 dimethicone, commercially available under the trademark ZENICONE DMC-1 from Zenitech being a preferred emollient species.

[0033] In addition to thickeners, humectants and emollients, retinol wash compositions of the invention may in specific embodiments contain pH adjusting agents, including both acid and base pH adjustment agents, such as citric acid, sodium hydroxide, etc., wherein acid and base species may be in suitable aqueous solution, and additional or alternative ingredients, including, without limitation, preservatives, foaming agents and foaming boosters, fragrances, exfoliants, and colorants.

[0034] In specific embodiments, the wash composition may be formulated to have a pH
of between 6 and 7, and a viscosity in a range of from 3000 to 4500 centipoise, as measured by a No. 4 Brookfield spindle at a rotational speed of 20 RPM.

[0035] Compositions of the invention may be made up in simple mixing/blending operations, using slow speed agitation to avoid excessive aeration, with gentle heating optionally being employed to solubilize and homogenize specific ingredients as necessary.

[0036] The wash composition of the invention may be applied by hand, or by an absorptive applicator such as a pad, sponge or the like, to facial or other skin areas. The composition once applied may be retained on the skin and allowed to dry thereon, or it may be blotted or otherwise rinsed away with water after a short residence time on the skin, e.g., a period of from 30 seconds to several minutes.

[0037] The wash composition may be packaged in a rigid or squeeze bottle, and the container may be equipped with an aerosol or pump head to facilitate dispensing.
Alternatively, the wash composition may be impregnated in a pad or sponge applicator that is packaged for single use application by a user. The package may contain use instructions and normal packaging indicia.

[0038] The other principal type of skin care composition of the invention is a gel serum composition containing Gorgonian extract in combination with benzoyl peroxide as active ingredients.

[0039] In such a gel serum composition, use of Gorgonian extract permits high levels of benzoyl peroxide to be employed, e.g., from 1 to 12 wt.%, based on total weight of the composition, in gel formulations containing high levels of water to enable highly effective skin hydration to be achieved concurrently with the therapeutic effect of benzoyl peroxide.

[0040] The gel serum compositions of the invention in various embodiments may contain from 60 to 90 wt.% water, based on total weight of the composition, more preferably from 65 to 85 wt.% water, and most preferably from 70 to 80 wt.%, on the same total composition weight basis.

[0041] Gel serum compositions in various formulations may contain benzoyl peroxide in an amount of from 1 to 12 wt.%, based on total weight of a composition, more preferably from 2 to 10 wt.%, and most preferably from 5 to 8 wt.%, on the same total weight composition basis.

[0042] Gel serum formulations in various embodiments may contain from 0.05 to 1.25 wt.% Gorgonian extract, more preferably from 0.1 to 1.0 wt.%, and most preferably from 0.2 to 0.75 wt.%, on the same total weight composition basis.

[0043] In various embodiments of the invention, the total amount of benzoyl peroxide and Gorgonian extract is from 2 to 15 wt.%, based on total weight of the composition, more preferably from 4 to 12 wt.%, and most preferably from 5 to 10 wt.%, on the same total composition weight basis.

[0044] In various embodiments of the invention, the ratio of benzoyl peroxide to Gorgonian extract may be in a range of from 5 to 20, more preferably from 8 to 18, and most preferably from 10 to 15, when the ratio is calculated as a weight ratio with benzoyl peroxide and Gorgonian extract expressed in the same weight units or weight percentages.

[0045] In still other embodiments of the invention, the gel serum composition may contain thickener, humectant and emollient components, in which the total weight percent of such components, based on total weight of the composition, is in the range of from 2 to 18 wt.%, more preferably from 4 to 15 wt.%, and most preferably from 6 to 12 wt.%. It will be recognized that one or multiple species of each of such components may be employed in the composition.

[0046] Outside of the broadest of the foregoing compositional ranges, the gel serum composition tends to become markedly less effective, with respect to skin conditioning abilities of the composition, or with respect to the therapeutic effect of the benzoyl peroxide active ingredient.

[0047] The aforementioned thickener, humectant and emollient components may be of any suitable type or types, and single component as well as multicomponent ingredients are contemplated within the broad scope of the invention.

[0048] Thickener ingredients may for example comprise polysaccharides, carbomers, starches, gums, waxes, sorbitols, cellulosic materials, polymers, clays, silica, or any other useful for getting materials. Preferred thickener ingredients in gel serum compositions of the invention include acrylates/C10_30 alkyl acrylate crosspolymer commercially available under the trademark PEMULEN TR1, carbomer commercially available under the trademark CARBOPOL ULTREZ 10 Polymer, and acrylates/C10_30 alkyl acrylate crosspolymer commercially available under the trademark CARBOPOL ULTREZ 21 Polymer, all from Lubrizol/Protameen.

[0049] Humectants useful in the benzoyl peroxide gel serum compositions of the invention may be of any suitable type, and for example may include glycerin, propylene, alpha hydroxy acids, glyceryl triacetate, polyols, sorbitol, xylitol, maltitol, polydextrose, quillaia, lactic acid, urea, and the like. Preferred humectants include glycerin USP grade and pentylene glycol.

[0050] Emollients employed in the benzoyl peroxide gel serum compositions of the invention can be of widely varying types, including, for example, aloe vera, jojoba oil, soybean oil, silicones, hydrocarbons, alkylene oxide copolymers, lanolin, squalene, tocopherols, phytosterols, and the like. A preferred emollient class is dimethicone and trimethicone emollients, with dimethicone, a silicone emollient commercially available under the trademark DC 200 Fluid 100 CST from Dow Corning/Univar, and phenyl trimethicone, a silicone emollient commercially available under the trademark DC 556 Fluid from Dow Corning being preferred emollient species.

[0051] The Gorgonian extract, or sea whip extract, contains caprylic and capric triglycerides. A preferred Gorgonian extract is commercially available from Lipo as Gorgonian Extract GC.

[0052] A preferred benzoyl peroxide ingredient for use in the benzoyl peroxide gel serum compositions of the invention is the benzoyl peroxide commercially available from a Sigma-Aldrich/Arkema as Luperox A75FP, #513474.

[0053] In addition to thickeners, humectants and emollients, benzoyl peroxide serum gel compositions of the invention may in specific embodiments contain pH adjusting agents, including both acid and base pH adjustment agents, such as citric acid, sodium hydroxide, etc., wherein acid and base species may be in suitable aqueous solution, and additional or alternative ingredients, including, without limitation, preservatives, penetration enhancers, chelating agents, fragrances, exfoliants, and colorants.

[0054] In specific embodiments, the benzoyl peroxide gel serum composition may be formulated to have a pH of between 5 and 6, and a viscosity in a range of from 20,000 to 40,000 centipoise, as measured under temperature-controlled conditions (Brookfield TC unit) at a rotational speed of 5 RPM.

[0055] The benzoyl peroxide gel serum compositions of the invention may be made up in simple mixing/blending operations, using slow speed agitation to avoid excessive aeration, with gentle heating optionally being employed to solubilize and homogenize specific ingredients as necessary.

[0056] The benzoyl peroxide gel serum compositions of the invention may be applied by hand, or by an applicator such as a pad, sponge or the like, to facial or other skin areas. The composition once applied may be retained on the skin for a predetermined period of time achieving the desired therapeutic benefit, and thereafter it may be wiped or otherwise rinsed away with water or other suitable removal medium.

[0057] The gel serum composition may be packaged in a rigid or squeeze bottle, and the container may be equipped with a pump head to facilitate dispensing.
Alternatively, the gel serum composition may be impregnated in a pad, cloth or sponge applicator that is packaged for single use application by a user. The package may contain use instructions and normal packaging indicia.

[0058] Thus, the invention contemplates skincare compositions comprising Gorgonian extract as an anti-inflammatory component thereof, in which such skincare composition is selected from among compositions (I) and (II):
(I) an aqueous composition comprising from 35 to 65 wt.% water, from 25 to 45 wt.%
surfactant, from 0.01 to 0.2 wt.% retinol and from 0.005 to 0.5 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt.%; and (II) a gel composition comprising from 60 to 90 wt.% water, from 1 to 12 wt.%
benzoyl peroxide, and from 0.05 to 1.25 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the gel composition, and all weight percentages of all ingredients in the gel composition total to 100 wt.%.

[0059] The aforementioned aqueous composition comprising from 35 to 65 wt.%
water, from 25 to 45 wt.% surfactant, from 0.01 to 0.2 wt.% retinol and from 0.005 to 0.5 wt.%
Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt.%, provides a composition useful for skin wash, e.g., face wash, purposes.

[0060] Such skincare composition may comprise an aqueous composition comprising from 35 to 65 wt.% water, from 25 to 45 wt.% surfactant, from 0.01 to 0.2 wt.%
retinol and from 0.005 to 0.5 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt.%. The skincare composition may be formulated, wherein the water and surfactant together constitute from 60 to 95 percent by weight (wt.%) of the total composition, more preferably from 65 to 90 percent by weight (wt.%) of the total composition, and most preferably from 75 to 88 percent by weight (wt.%) of the total composition.

[0061] The weight of surfactant to weight of water in such skincare composition may be in a ratio of from 0.40 to 1.3, from 0.5 to 1.0, or from 0.6 to 0.8, in various embodiments.
The composition may contain water in an amount from 40 to 60 wt.%, based on the total weight of the composition, or from 45 to 55 wt.%, based on the total weight of the composition, in respective embodiments. A retinol may be contained in the composition in a range of from 0.02 to 0.1 wt.%, based on the total weight of the composition, or from 0.25 to 0.06 wt.%, based on the total weight of the composition, in respective embodiments.
Gorgonian extract may be present in the composition in an amount of from 0.01 to 0.1 wt.%, based on total weight of the composition, or in an amount of from 0.02 to 0.05 wt.%, based on total weight of the composition, in respective embodiments. The amount of Gorgonian extract in the composition may be from 2 to 10 times the amount of retinol in the composition, from 2.5 to 5 times the amount of retinol in the composition, or from 3 to 4 times the amount of retinol in the composition, in various embodiments.

[0062] The skincare composition may be formulated so that the water and surfactant together constitute from 60 to 95% wt.% of the wash composition, based on total weight thereof, or from 65 to 90 wt.% of the wash composition, based on total weight thereof, or from 75 to 85 wt.% of the wash composition, based on total weight thereof, in respective embodiments. The amount of surfactant in the skincare composition may be from 30 to 40 wt.%, based on total weight of the composition, or from 32 to 38 wt.%, based on total weight of the composition, in respective embodiments. Surfactants useful in the skincare composition include sodium laureth sulfate, cocamidopropyl betaine, disodium laureth sulfosuccinate, lauryl betaine, disodium laureth sulfosuccinate, peg-10 soy sterol, sodium cocoate, sodium dodecylbenzene sulfonate, and sodium stearate, with sodium laureth sulfate and cocamidopropyl betaine being usefully employed in combination.

[0063] The skincare composition may further include thickener, humectant and emollient ingredients, e.g., wherein such ingredients together constitute from 5 to 20 wt.% of the total composition weight, from 7.5 to 17.5 wt.% of the total composition weight, or from 8 to 15 wt.% of the total composition weight, in various embodiments. Thickeners may be employed in the skincare composition, such as polysaccharides, carbomers, starches, gums, waxes, sorbitols, cellulosic materials, polymers, clays, and silica, with an acrylate copolymer thickener being preferred. The skincare composition may be formulated with a humectant selected from among glycerin, propylene glycol, alpha hydroxy acids, glyceryl triacetate, polyols, sorbitol, xylitol, maltitol, polydextrose, quillaia, lactic acid, and urea, with glycerin being preferred. In emollients, such as aloe vera, jojoba oil, soybean oil, silicones, hydrocarbons, alkylene oxide copolymers, lanolin, squalene, tocopherols, phytosterols, and mixtures thereof may be employed in the composition, e.g., a dimethicone emollient.

[0064] The skincare wash composition may include one or more ingredients such as pH
adjusting agents, preservatives, foaming agents, foaming boosters, fragrances, exfoliants, and colorants. The composition may have a pH of between 6 and 7, and/or a viscosity in a range of from 3000 to 4500 centipoise, as measured by a No. 4 Brookfield spindle at a rotational speed of 20 RPM.

[0065] Gel compositions of the invention are contemplated, comprising from 60 to 90 wt.% water, from 1 to 12 wt.% benzoyl peroxide, and from 0.05 to 1.25 wt.%
Gorgonian extract, wherein all weight percentages are based on total weight of the gel composition, and all weight percentages of all ingredients in the gel composition total to 100 wt.%.

[0066] In specific embodiments, the gel composition may include from 65 to 85 wt.%
water, based on weight of the gel composition, or from 70 to 80% wt.% water, based on weight of the gel composition, in respective embodiments. The gel composition may contain benzoyl peroxide in an amount of from 2 to 10 wt.%, based on weight of the gel composition, or in an amount of from 5 to 8 wt.%, based on weight of the gel composition, in respective embodiments. The amount of Gorgonian extract in the gel composition may be from 0.1 to 1.0 wt.%, based on weight of the gel composition, or from 0.2 to 0.75 wt.%, based on weight of the gel composition, in respective embodiments.

[0067] The gel composition may be formulated to contain a total amount of benzoyl peroxide and Gorgonian extract of from 2 to 15 wt.%, based on total weight of the composition, from 4 to 12 wt.%, based on total weight of the composition, or from 5 to 10 wt.%, based on total weight of the composition, in various embodiments. The weight ratio of benzoyl peroxide to Gorgonian extract in the gel compositions of the invention may be in a range of from 5 to 20, or from 8 to 18, or from 10 to 15, in respective embodiments.

[0068] Formulations of the gel composition may further include thickener, humectant and emollient components, e.g., compositions in which the thickener, humectant and emollient components have a total weight in a range of from 2 to 18 wt.%, based on total weight of the composition, or from 4 to 15 wt.%, based on total weight of the composition, or from 6 to 12 wt.%, based on total weight of the composition, in various embodiments. The gel composition can include a thickener selected from among polysaccharides, carbomers, starches, gums, waxes, sorbitols, cellulosic materials, polymers, clays, and silica, e.g., a thickener including acrylates/C10_30 alkyl acrylate crosspolymer, carbomer, and acrylates/C10_30 alkyl acrylate crosspolymer.

[0069] A humectant may be included in the gel composition, selected from among glycerin, propylene, alpha hydroxy acids, glyceryl triacetate, polyols, sorbitol, xylitol, maltitol, polydextrose, quillaia, lactic acid, and urea, e.g., a humectant including glycerin and pentylene glycol.

[0070] An emollient may be included in the gel composition, selected from among aloe vera, jojoba oil, soybean oil, silicones, hydrocarbons, alkylene oxide copolymers, lanolin, squalene, tocopherols, and phytosterols, such as an emollient including dimethicone and trimethicone emollient species, e.g., an emollient including dimethicone and phenyl trimethicone emollient species. Compositions may further include additional ingredients such as pH adjustment agents, preservatives, penetration enhancers, chelating agents, fragrances, exfoliants, and colorants. The gel composition may have a pH of between 5 and 6, and/or a viscosity in a range of from 20,000 to 40,000 centipoise, as measured under temperature-controlled conditions (Brookfield TC unit) at a rotational speed of 5 RPM.

[0071] The advantages and features of the invention are further illustrated with reference to the following examples, which are not to be construed as in any way limiting the scope of the invention but rather as illustrative of embodiments of the invention in specific applications thereof.

[0072] Example 1 A face wash formulation was made up with the composition set out in Table 1 below.
Table 1 0.03% Retinol Wash Formulation Ingredient Weight % Function Water 50.2 solvent/diluent Acrylate Copolymer 8.0 thickener Sodium Laureth Sulfate 30.0 surfactant 20% NaOH Solution (aq) 1.3 pH adjusting agent Cocamidopropyl betaine 5.0 surfactant Glycerin 2.5 humectant PEG-8 dimethicone 1.0 emollient Chlorphenesin 0.2 preservative Methylisothiazolinone 0.1 preservative Cocamide MEA 0.5 foaming agent/foaming booster Fragrance 0.1 fragrance Caprylic/capric triglyceride 0.1 Gorgonian extract antiinflammatory Retinol/BHT/PMMA/TC 0.5 active ingredient Polyethylene 0.1 exfoliant 20% citric acid solution (aq) 0.1 pH adjusting agent Pylam 0.1% solution (aq) 0.3 colorant TOTAL 100 %

[0073] The acrylates copolymer (Carbopol Aqua SF-1; Lubrizol/Protameen) was slowly added to the water under slow agitation, followed by slow addition of the sodium laureth sulfate (Standapol E52, Cognis/Dewolf), and the resulting mixture was heated to temperature in a range of 70-75 C. Sodium hydroxide (20% NaOH) solution then was added under slow mixing to avoid aeration and adjust pH of the mixture to a value in a range of 6.2 to 6.6. The cocamidopropyl betaine surfactant (Velvatex BK35, Cognis/Dewolf) then was added under mixing conditions, followed by mixing addition of the glycerin humectant (99.7%, kosher USP, Acme-Hardesty), PEG-8 dimethicone emollient (Zenicone DMC-1, Zenitech), the chlorphenesin preservative (Elestab CPN, Cognis/Dewolf), and methylisothiazolinone preservative (Microcare MT, Thor Specialties) to yield a first part of the formulation.

[0074] In a separate container, the cocamide MEA (Monamid CMA, Uniqema) was heated to 75 C to melt same, following which temperature was reduced to 45 C
and the fragrance (Dove Cool Moisture Type #75457, Belle Aire) and Gorgonian extract (Gorgonian extract GC antiiflammatory, caprylic/capric triglyceride sea whip extract, Lipo) were added to the cocamide MEA and mixed until uniform, to form a second part of the formulation, which was added to the first part of the formulation, and the resulting batch of material was cooled to temperature of 30-35 C.

[0075] The retinol active ingredient (Tagravit R1, a mixture of retinol, butylhydroxytoluene (BHT), tricaprylin (TC), and polymethylmethacrylate (PMMA)), polyethylene exfoliant (Asensa SC 221, Honeywell/Tr-K), citric acid (20%
aqueous solution, PCI), and Pylam colorant Blue 1 were added under mixing conditions to complete the formulation.

[0076] Example 2 A gel serum formulation was made up with the composition set out in Table 2 below.
Table 2 Benzoyl Peroxide Gel Serum Formulation Ingredient Weight % Function Water 76.58 solvent/diluent Disodium EDTA 0.10 chelating agent Acrylates/C10-30 Alkyl acrylate crosspolymer 0.20 thickener Carbomer 0.50 thickener Acrylates/C10-30 Alkyl acrylate crosspolymer 0.15 thickener Glycerin 3.00 humectant Pentylene glycol 3.00 humectant Dimethicone 1.00 silicone emollient Caprylic/capric triglyceride 0.50 anti-inflammatory Phenyl trimethicone 1.00 silicone emollient Sodium hydroxide 0.50 pH adjuster Dimethyl isosorbide 5.00 penetration enhancer Benzoyl peroxide 6.67 anti-acne Sensiva SC-10 (trade name) 0.80 preservative Phenoxyethanol 1.00 preservative TOTAL 100%

[0077] The disodium EDTA (NA2EDTA) was dissolved in water and then an acrylates crosspolymer (Pemulen TR1) was slowly dispersed in the water and mixed until uniform.
Once uniform, the carbomer (Carbopol ultrez 10 polymer), and remaining acrylates crosspolymer (Carbopol ultrez 21 polymer) were slowly dispersed. Following dispersal, Glycerin (Glycerin 99.7% (Kosher) USP) and pentylene glycol (Hydrolite 5) were added.

[0078] Dimethicone (DC 200 Fluid 100 CST), caprylic/capric triglyceride (Gorgonian Extract GC) and phenyl trimethicone (DC 556 Fluid) were combined and slowly added to the first part of the formulation. The sodium hydroxide (Sodium hydroxide 20%
solution) was then added to adjust the pH of the mixture to a value in a range of 5.0-5.75.

[0079] Dimethyl isosorbide (Arlasolve DMI-PC) and benzoyl peroxide (Luperox A75FP, Part# 513474) were combined, and homogenized for 20 minutes at 3,000 RPM. The mixture was not allowed to get hot. The particle size of the benzoyl peroxide was monitored every 5-7 minutes to make certain that particles, while visible, still rubbed into the skin smoothly without feeling particulate. Following homogenization, the mixture of Dimethyl isosorbide (Arlasolve DMI-PC) and benzoyl peroxide (Luperox A75FP, Part# 513474) was slowly mixed to combine with the existing formulation. The newly combined mixture was then homogenized for 10 minutes at 3,500 RPM, again the size of the benzoyl peroxide particles was monitored every 5 minutes to ensure that particles could not be felt on skin.

[0080] Sensiva SC-10 was added to the homogenized mixture by careful mixing, and then phenoxyethanol (Phenoxetol) was added to the mixture by careful mixing to complete the formulation.

[0081] While the invention has been described herein in reference to specific aspects, features and illustrative embodiments of the invention, it will be appreciated that the utility of the invention is not thus limited, but rather extends to and encompasses numerous other variations, modifications and alternative embodiments, as will suggest themselves to those of ordinary skill in the field of the present invention, based on the disclosure herein.
Correspondingly, the invention as hereinafter claimed is intended to be broadly construed and interpreted, as including all such variations, modifications and alternative embodiments, within its spirit and scope.

Claims (20)

THE CLAIMS

What is claimed is:
1. A skincare composition comprising Gorgonian extract as an anti-inflammatory component thereof, said skincare composition being selected from among compositions (I) and (II):
(I) an aqueous composition comprising from 35 to 65 wt.% water, from 25 to 45 wt.%
surfactant, from 0.01 to 0.2 wt.% retinol and from 0.005 to 0.5 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt.%; and (II) a gel composition comprising from 60 to 90 wt.% water, from 1 to 12 wt.%
benzoyl peroxide, and from 0.05 to 1.25 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the gel composition, and all weight percentages of all ingredients in the gel composition total to 100 wt.%.
2. The skincare composition of claim 1, comprising an aqueous composition comprising from 35 to 65 wt.% water, from 25 to 45 wt.% surfactant, from 0.01 to 0.2 wt.%
retinol and from 0.005 to 0.5 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt.%.
3. The skincare composition of claim 2, wherein said water and surfactant together constitute from 60 to 95 percent by weight (wt.%) of the total composition.
4. The skincare composition of claim 2, wherein the weight of surfactant to weight of water is in a ratio of from 0.40 to 1.3.
5. The skincare composition of claim 2, wherein the amount of Gorgonian extract in the composition is from 2 to 10 times the amount of retinol in the composition.
6. The skincare composition of claim 2, wherein said water and surfactant together constitute from 60 to 95% wt.% of the wash composition, based on total weight thereof.
7. The skincare composition of claim 2, wherein the surfactant comprises one or more surfactant species selected from the group consisting of sodium laureth sulfate, cocamidopropyl betaine, disodium laureth sulfosuccinate, lauryl betaine, disodium laureth sulfosuccinate, peg-10 soy sterol, sodium cocoate, sodium dodecylbenzene sulfonate, and sodium stearate.
8. The skincare composition of claim 2, further comprising thickener, humectant and emollient ingredients, consisting from 5 to 20 wt.% of the total composition weight
9. The skincare composition of claim 2, further comprising an acrylate copolymer thickener and glycerin.
10. The skincare composition of claim 2, having a pH of between 6 and 7 and a viscosity in a range of from 3000 to 4500 centipoise, as measured by a No. 4 Brookfield spindle at a rotational speed of 20 RPM.
11. The skincare composition of claim 1, comprising a gel composition comprising from 60 to 90 wt.% water, from 1 to 12 wt.% benzoyl peroxide, and from 0.05 to 1.25 wt.%
Gorgonian extract, wherein all weight percentages are based on total weight of the gel composition, and all weight percentages of all ingredients in the gel composition total to 100 wt.%.
12. The gel composition of claim 11, wherein the total amount of benzoyl peroxide and Gorgonian extract is from 4 to 12 wt.%, based on total weight of the composition.
13. The gel composition of claim 11, wherein the weight ratio of benzoyl peroxide to Gorgonian extract is in a range of from 5 to 20.
14. The gel composition of claim 11, further comprising thickener, humectant and emollient components, wherein the thickener, humectant and emollient components have a total weight in a range of from 2 to 18 wt.%, based on total weight of the composition.
15. The gel composition of claim 11, further comprising (i) a thickener selected from the group consisting of polysaccharides, carbomers, starches, gums, waxes, sorbitols, cellulosic materials, polymers, clays, and silica, and (ii) a humectant selected from the group consisting of glycerin, propylene, alpha hydroxy acids, glyceryl triacetate, polyols, sorbitol, xylitol, maltitol, polydextrose, quillaia, lactic acid, and urea.
16. The gel composition of claim 11, having a pH of between 5 and 6.
17. The gel composition of claim 11, having viscosity in a range of from 20,000 to 40,000 centipoise, as measured under temperature-controlled conditions (Brookfield TC
unit) at a rotational speed of 5 RPM.
18. A method of enhancing skin condition, comprising topically administering to skin in need thereof, a skincare composition comprising Gorgonian extract as an anti-inflammatory component thereof, said skincare composition being selected from among compositions (I) and (II):
(I) an aqueous composition comprising from 35 to 65 wt.% water, from 25 to 45 wt.%
surfactant, from 0.01 to 0.2 wt.% retinol and from 0.005 to 0.5 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt.%; and (II) a gel composition comprising from 60 to 90 wt.% water, from 1 to 12 wt.%
benzoyl peroxide, and from 0.05 to 1.25 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the gel composition, and all weight percentages of all ingredients in the gel composition total to 100 wt.%.
19. The method of claim 18, wherein the skincare composition comprises an aqueous composition comprising from 35 to 65 wt.% water, from 25 to 45 wt.%
surfactant, from 0.01 to 0.2 wt.% retinol and from 0.005 to 0.5 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the aqueous face wash composition, and all weight percentages of all ingredients in the aqueous face wash composition total to 100 wt.%.
20. The method of claim 18, wherein the skincare composition comprises a gel composition comprising from 60 to 90 wt.% water, from 1 to 12 wt.% benzoyl peroxide, and from 0.05 to 1.25 wt.% Gorgonian extract, wherein all weight percentages are based on total weight of the gel composition, and all weight percentages of all ingredients in the gel composition total to 100 wt.%.
CA 2831036 2010-03-23 2011-03-23 Dermal compositions containing gorgonian extract Pending CA2831036A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US31682710 true 2010-03-23 2010-03-23
US61/316,827 2010-03-23
US13/044,311 2011-03-09
US13044311 US9180112B2 (en) 2010-03-23 2011-03-09 Dermal compositions containing gorgonian extract
PCT/US2011/029660 WO2011119758A3 (en) 2010-03-23 2011-03-23 Dermal compositions containing gorgonian extract

Publications (1)

Publication Number Publication Date
CA2831036A1 true true CA2831036A1 (en) 2011-09-29

Family

ID=44656782

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2831036 Pending CA2831036A1 (en) 2010-03-23 2011-03-23 Dermal compositions containing gorgonian extract

Country Status (3)

Country Link
US (2) US9180112B2 (en)
CA (1) CA2831036A1 (en)
WO (1) WO2011119758A3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012221224A1 (en) * 2012-11-20 2014-05-22 Beiersdorf Ag Hydrodispersion having improved performance
US9861645B2 (en) 2012-12-28 2018-01-09 Rak Holdings Llc Anti-itch scalp treatment compositions and combinations
US20160310403A1 (en) * 2015-04-27 2016-10-27 Shiseido Company, Ltd. Skin cosmetic product

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849410A (en) 1985-04-15 1989-07-18 The Regents Of The University Of California Pseudopterosin and synthetic derivatives thereof
US4745104A (en) 1985-04-15 1988-05-17 The Regents Of The University Of California Pseudopterosin and synthetic derivatives thereof
US5204093A (en) 1989-04-06 1993-04-20 Victor Steven A Shaving cream composition for the treatment of acne vulgaris and pseudofolliculitis barbae and method of producing and using same
US5106609A (en) 1990-05-01 1992-04-21 The Procter & Gamble Company Vehicle systems for use in cosmetic compositions
US5420118A (en) 1990-11-30 1995-05-30 Richardson-Vicks Inc. Gel type cosmetic compositions
US5470884A (en) 1994-05-19 1995-11-28 Procter & Gamble Anti-acne compositions
US5449519C1 (en) 1994-08-09 2001-05-01 Revlon Consumer Prod Corp Cosmetic compositions having keratolytic and anti-acne activity
EP0777464A1 (en) 1994-08-26 1997-06-11 THE PROCTER & GAMBLE COMPANY Personal cleansing compositions
US5597808A (en) 1995-06-07 1997-01-28 Osteoarthritis Sciences, Incorporated Use of pseudopterosins for promoting wound healing
US5624911A (en) 1995-06-07 1997-04-29 The Regents Of The University Of California Ether derivatives of pseudopterosin
DE69628629T2 (en) 1995-06-30 2004-04-29 Shiseido Co. Ltd. emulsion composition
US5939082A (en) 1995-11-06 1999-08-17 The Procter & Gamble Company Methods of regulating skin appearance with vitamin B3 compound
US6238678B1 (en) 1995-11-06 2001-05-29 The Procter & Gamble Company Methods of regulating skin appearance with vitamin B3 compound
GB9612067D0 (en) 1996-06-10 1996-08-14 Smithkline Beecham Plc Composition
US5811114A (en) 1996-06-12 1998-09-22 E-L Management Corp. Stabilized hinokitiol and compositions containing same
WO1998000100A1 (en) 1996-07-03 1998-01-08 The Board Of Regents Of The University Of Oklahoma Enhancement of skin pigmentation by prostaglandins
US5763234A (en) 1996-07-25 1998-06-09 Florida Atlantic University Secosteroids, and method for producing same
US6342208B1 (en) 1996-08-02 2002-01-29 Plum Kerni Produktion A/S Oil-in-water emulsion containing C10-C24 fatty acid derivatives for treating skin of mammals
US6338855B1 (en) 1996-10-25 2002-01-15 The Procter & Gamble Company Cleansing articles for skin and/or hair which also deposit skin care actives
US6001377A (en) 1997-05-23 1999-12-14 The Procter & Gamble Company Skin care compositions and method of improving skin appearance
US5997890A (en) 1997-05-23 1999-12-07 The Procter & Gamble Company Skin care compositions and method of improving skin appearance
US5972359A (en) 1997-05-23 1999-10-26 The Procter & Gamble Company Skin care compositions and method of improving skin appearance
US6174533B1 (en) 1997-05-23 2001-01-16 The Procter & Gamble Company Skin care compositions and method of improving skin appearance
US5968528A (en) 1997-05-23 1999-10-19 The Procter & Gamble Company Skin care compositions
KR20010013377A (en) 1997-06-04 2001-02-26 데이비드 엠 모이어 Mild, leave-on antimicrobial compositions
ES2384552T3 (en) 1997-09-05 2012-07-06 The Procter & Gamble Company Cleaning and conditioning the skin or hair with improved deposition of conditioning ingredients
ES2186199T3 (en) 1997-09-12 2003-05-01 Procter & Gamble Cleaning and conditioning article for skin or hair.
US6228894B1 (en) 1998-04-17 2001-05-08 Enhanced Derm Technologies, Inc. Softgel-compatible composition containing retinol
US6120758A (en) 1998-07-16 2000-09-19 Shaklee Corporation Preservative system for topically applied products
US7396526B1 (en) 1998-11-12 2008-07-08 Johnson & Johnson Consumer Companies, Inc. Skin care composition
US20030162760A1 (en) * 1999-01-26 2003-08-28 Eiko Masatsuji Dermal agent
FR2789329B1 (en) 1999-02-05 2001-03-02 Oreal Cosmetic and / or dermatological constituted by an emulsion of oil-in-water type formed dispersed lipid vesicles in an aqueous phase containing at least one active hydrophilic acid
US6423329B1 (en) 1999-02-12 2002-07-23 The Procter & Gamble Company Skin sanitizing compositions
US6555119B1 (en) 1999-04-14 2003-04-29 The Procter & Gamble Company Transparent micro emulsion
US6492326B1 (en) 1999-04-19 2002-12-10 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
US6444647B1 (en) 1999-04-19 2002-09-03 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
US6217913B1 (en) 1999-07-15 2001-04-17 Fatemeh Mohammadi Cosmetic compositions with gorgonian extract
US6649178B2 (en) 2000-06-13 2003-11-18 Fatemeh Mohammadi Cosmetic composition for stressed skin under extreme conditions
US6524598B2 (en) 2000-07-10 2003-02-25 The Procter & Gamble Company Cosmetic compositions
US20020022040A1 (en) * 2000-07-10 2002-02-21 The Proctor & Gamble Company Methods of enhancing delivery of oil-soluble skin care actives
US6475500B2 (en) 2000-07-10 2002-11-05 The Procter & Gamble Company Anhydrous cosmetic compositions
US6787571B2 (en) 2000-11-28 2004-09-07 The Regents Of The University Of California Anti-inflammatory compounds derived from Pseudopterorgorgia elisabethae
US6544562B2 (en) 2001-06-25 2003-04-08 Blistex Inc. Acne treatment including dual-package system
US6680062B2 (en) * 2001-10-05 2004-01-20 Color Access, Inc. Anti-irritating rosacea treatment
US20030072777A1 (en) 2001-10-05 2003-04-17 Maes Daniel H. Combinatorial anti-acne compositions
US6585961B1 (en) 2001-11-30 2003-07-01 Richard F. Stockel Antimicrobial compositions
US7338793B2 (en) 2002-01-25 2008-03-04 Florida Atlantic University Methods and compositions for cyclizing diterpenes
US6780622B2 (en) 2002-01-25 2004-08-24 Florida Atlantic University Diterpene cyclase and methods of use
US7235249B2 (en) 2002-03-28 2007-06-26 The Procter & Gamble Company Methods for regulating the condition of mammalian keratinous tissue via topical application of vitamin B6 compositions
US7208460B2 (en) 2002-04-26 2007-04-24 Salvona Ip, Llc Multi component controlled delivery system for soap bars
US20030211069A1 (en) 2002-05-09 2003-11-13 The Procter & Gamble Company Rinsable skin conditioning compositions
US7108860B2 (en) 2002-06-06 2006-09-19 Playtex Products, Inc. Sunscreen compositions
US20030232091A1 (en) 2002-06-17 2003-12-18 Adi Shefer Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
EP1523297A1 (en) 2002-07-19 2005-04-20 THE PROCTER & GAMBLE COMPANY Mask composition containing emulsified liquid composition
FR2843963B1 (en) 2002-08-30 2004-10-22 Sederma Sa New molecules differential equations of noraporphine
US7098189B2 (en) 2002-12-16 2006-08-29 Kimberly-Clark Worldwide, Inc. Wound and skin care compositions
US7285570B2 (en) 2003-04-17 2007-10-23 The Procter & Gamble Company Compositions and methods for regulating mammalian keratinous tissue
US6927205B2 (en) 2003-04-28 2005-08-09 Procyte Corporation Compositions and methods for treatment of psoriasis
US20060198800A1 (en) 2003-08-14 2006-09-07 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
US7217690B2 (en) 2003-10-07 2007-05-15 Kimberly-Clark Worldwide, Inc. Compositions of sunflower trypsin inhibitors
CN1893911B (en) 2003-11-17 2010-12-29 赛德玛公司 Formula including tetrapeptide and tripeptide mixture
CA2552607C (en) 2004-01-07 2012-04-17 E-L Management Corporation Cosmetic composition and method for retarding hair growth
US7001592B1 (en) 2005-01-31 2006-02-21 Aquea Scientific Corporation Sunscreen compositions and methods of use
US6998113B1 (en) 2005-01-31 2006-02-14 Aquea Scientific Corporation Bodywashes containing additives
US7037513B1 (en) 2005-01-31 2006-05-02 Aquea Scientific Corporation Bodywash additives
US7025952B1 (en) 2005-01-31 2006-04-11 Aquea Scientific Corporation Methods of preparation and use of bodywashes containing additives
US20070048234A1 (en) * 2005-03-30 2007-03-01 Revance Therapeutics, Inc. Compositions and methods for treating acne
US7252834B2 (en) 2005-04-25 2007-08-07 Clemson University Research Foundation (Curf) Elastin stabilization of connective tissue
FR2885522A1 (en) 2005-05-13 2006-11-17 Sederma Soc Par Actions Simpli Cosmetic or dermopharmaceutical composition containing teprenone
US20090035392A1 (en) 2005-11-01 2009-02-05 Randall Wilkinson User-adjustable treatment methods, systems and compositions for treating acne
US7544375B1 (en) 2006-06-12 2009-06-09 Swiss Skin Repair, Inc. Composition
US20080102045A1 (en) 2006-10-05 2008-05-01 Shim Elisabeth K Topical preparations containing antioxidant extracts of broccoli, green tea, and red tea
US7691419B2 (en) 2007-12-20 2010-04-06 Dileva Rose Marie Compositions and methods for treating skin conditions in mammals
WO2009105265A3 (en) 2008-02-21 2009-12-03 Vatrix Medical, Inc. Treatment of aneurysm with application of connective tissue stabilization agent in combination with a delivery vehicle

Also Published As

Publication number Publication date Type
WO2011119758A3 (en) 2012-01-19 application
WO2011119758A2 (en) 2011-09-29 application
US20160058802A1 (en) 2016-03-03 application
US9180112B2 (en) 2015-11-10 grant
US20110236499A1 (en) 2011-09-29 application

Similar Documents

Publication Publication Date Title
US5296476A (en) Skin care compositions
US7387787B2 (en) Water soluble sheet composition
US20060110415A1 (en) Topical Delivery System for Cosmetic and Pharmaceutical Agents
US20040143026A1 (en) Bioadhesive hydrophilic composition for treatment of mammalian skin
US5621008A (en) N-acyl-ethylene-triacetic acids
US20020111281A1 (en) Anhydrous creams, lotions and gels
US7368122B1 (en) Skin cream
EP0614656B1 (en) Aqueous gels containing expanded hollow microspheres
WO1998058628A1 (en) Cosmetic composition containing a whitening agent and an exfoliant
WO2006048747A1 (en) Topical pharmaceutical compositions containing an antiacne compound and antibiotic compound
US20030044366A1 (en) Skin care composition that changes color upon drying
WO2007031883A2 (en) Composition comprising at least one naphthoic acid derivative and at least one compound of polyurethane polymer type or derivatives thereof, preparation processes therefor and uses thereof
US6977081B1 (en) Facial cream composition containing allantoin
WO2005025486A2 (en) Skincare compositions comprising salicyclic acid
Tanghetti et al. A current review of topical benzoyl peroxide: new perspectives on formulation and utilization
JPH11139951A (en) Cosmetic
US20070003504A1 (en) Method of enhanced benzoyl peroxide application
WO2008087354A2 (en) Cream-gel comprising at least one retinoid and benzoyl peroxide
JP2003155238A (en) Skin care preparation
EP1192940A1 (en) Compositions and methods for promoting clear skin using an alkanolamine
US20120328544A1 (en) Dermatological Treatment Methods And Formulations
CN102525861A (en) Cool body lotion and household paper
US20100068162A1 (en) Compositions Having Silicone Properties
CN102225040A (en) Pearl skin-caring oil-controlling essence
US20070140993A1 (en) Skincare compositions

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160323