CA2577018A1 - Inherently radiopaque bioresorbable polymers for multiple uses - Google Patents

Inherently radiopaque bioresorbable polymers for multiple uses

Info

Publication number
CA2577018A1
CA2577018A1 CA 2577018 CA2577018A CA2577018A1 CA 2577018 A1 CA2577018 A1 CA 2577018A1 CA 2577018 CA2577018 CA 2577018 CA 2577018 A CA2577018 A CA 2577018A CA 2577018 A1 CA2577018 A1 CA 2577018A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
medical device
stent
group consisting
independently
selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2577018
Other languages
French (fr)
Other versions
CA2577018C (en )
Inventor
Donald K. Brandom
Joan Zeltinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
REVA Medical Inc
Original Assignee
Reva Medical, Inc.
Donald K. Brandom
Joan Zeltinger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/38Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives derived from phenols
    • C08G65/40Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives derived from phenols from phenols (I) and other compounds (II), e.g. OH-Ar-OH + X-Ar-X, where X is halogen atom, i.e. leaving group
    • C08G65/4006(I) or (II) containing elements other than carbon, oxygen, hydrogen or halogen as leaving group (X)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18Materials at least partially X-ray or laser opaque
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/04Aromatic polycarbonates
    • C08G64/06Aromatic polycarbonates not containing aliphatic unsaturation
    • C08G64/08Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/18Block or graft polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • A61F2002/91591Locking connectors, e.g. using male-female connections
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00Materials specially adapted for additive manufacturing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00Products made by additive manufacturing

Abstract

Preferred embodiments of the present invention relate to polymeric medical devices, such as stents. More particularly, the compositions disclosed herein comprise halogen-containing phenol moeities, that may be used for medical devices and other uses whereby bioresorbable and radiopaque and physicomechanical properties are desired.

Claims (30)

1. An inherently radiopaque, biocompatible, bioresorbable polymer, wherein said polymer comprises one or more recurring units of the Formula (I):

wherein:
X1 and X2 are each independently selected from the group consisting of Br and I;
y1 and y2 are each independently zero or an integer in the range of 1 to 4, with the proviso that the sum of y1 and y2 is at least 1;

R1 is R13 and R14 are each independently selected from the group consisting of -CH=CH-, -(CH2)c-, -(CHJ1)-, -CHJ2-CHJ3-, -CH=CH-(CHJ1)-, and -(CH2),-(CHJ1 )-;
c is zero or an integer in the range of 1 to 8;
J1, J2 and J3 are each independently selected from the group consisting of H, Br, I, -NH-Q2 and -C(=Z8)-OQ3;
Q1, Q2 and Q3 are each independently H or a non-crystallizable group comprising from about 1 to about 30 carbons;
Z7 and Z8 are each independetly O or S;
A1 is selected from the group consisting of R5 is selected from the group consisting of H, C1 - C30 alkyl, and C1 - C30 heteroalkyl.
2. A medical device comprising the polymer of Claim 1.
3. The medical device of Claim 2, wherein said medical device is configured for placement in a region selected from vascular, musculoskeletal/orthopedic, nervous, respiratory, reproductive, urinary, digestive, endocrine, hematopoietic, or integumentary system.
4. The medical device of Claim 2, wherein said medical device is configured for use in vivo.
5. The medical device of Claim 2, wherein said medical device is configured for use ex vivo.
6. The medical device of Claim 5, wherein said medical device is configured for use in vitro.
7. The medical device of Claim 2, wherein said medical device comprises a stent.
8. The medical device of Claim 7, wherein said stent further comprises a configuration selected from the group consisting of a sheet stent, a braided stent, a self-expanding stent, a wire stent, a deformable stent, and a slide-and-lock stent.
9. The medical device of Claim 7, wherein said stent comprises at least two substantially non-deforming elements arranged to form a tubular member, the non-deforming elements being slidably interconnected for allowing the tubular member to expand from a collapsed diameter to an expanded diameter.
10. The medical device of Claim 7, wherein said stent further comprises a tubular member comprising a series of slideably-engaged radial elements and a locking mechanism adapted to permit one-way sliding of the radial elements, such that said tubular member is configured to expand from a first collapsed diameter to a second expanded diameter with minimum recoil.
11. The medical device of Claim 2, further comprising an effective amount of a therapeutic agent.
12. The medical device of Claim 11, wherein said therapeutic agent is selected from the group consisting of antiproliferative agent, anti-inflammatory agent, anti-matrix metalloproteinase agent, lipid lowering agent, cholesterol modifying agent, anti-thrombotic agent, and antiplatelet agent.
13. The medical device of Claim 11, wherein said effective amount is sufficient to provide an effect selected from the group consisting of inhibition of restenosis, inhibition of thrombosis, inhibition of plaque formation, inhibition of plaque rupture, inhibition of inflammation, lowering of cholesterol, and promote healing.
14. The medical device of Claim 2, wherein X1 and X2 are iodine.
15. The medical device of Claim 2 further comprising a non-halogenated coating.
16. The medical device of Claim 2, wherein said polymer forms a coating on at least a portion of said medical device.
17. A system for treating a site within a vessel, comprising the stent of Claim 7 and a catheter having a deployment means, wherein said catheter is adapted to deliver the stent to said site and said deployment means is adapted to deploy the stent.
18. A method for re-treatment of a body lumen, comprising:
deploying a first stent along a region within a blood vessel, wherein said first stent is the stent of Claim 7, and wherein said first stent resides for a period of time; and deploying at a later time a second stent, along the approximate same region within the blood vessel, such that the blood vessel is re-treated.
19. The polymer of Claim 1, further comprising one or more recurring units of the Formula (II):

wherein:
B is -O-(CHR6)p O)q-;

R6 is H or C1 to C3 alkyl;
p and q are each individually an integer in the range of about 1 to about 100;

A2 is selected from the group consisting of R7 is H or a C, to C30 hydrocarbon; and R11 is selected from the group consisting of C1 - C30 alkyl, C1 - C30 heteroalkyl, C5 - C30 aryl, C6 - C30 alkylaryl, and C2 - C30 heteroaryl.
20. A medical device comprising the polymer of Claim 19.
21. The polymer of Claim 19, further comprising one or more recurring units of the Formula (Ia):

wherein:
X3 and X4 are each independently selected from the group consisting of Br and I;
y3 and y4 are each independently zero or an integer in the range of 1 to 4;
R2 is selected from the group consisting of:

R8 and R9 are each independently H or a non-crystallizable C1 to C30 hydrocarbon;
Z4, Z5 and Z6 are each independently O or S;
a and b are each independently an integer in the range of 1 to 8;
A3 is selected from the group consisting of R10 is selected from the group consisting of H, C1 - C30 alkyl, and C1 - C30 heteroalkyl; and R12 is selected from the group consisting of C1 - C30 alkyl, C1 - C30 heteroalkyl, C5 - C30 aryl, C6 - C30 alkylaryl, and C2 - C30 heteroaryl.
22. A medical device comprising the polymer of Claim 21.
23. The polymer of Claim 1, wherein R1 is:

wherein R3 is H or a non-crystallizable C1 to C29 hydrocarbon;
Z1 and Z2 are each independently O or S; and m is an integer in the range of 1 to 8.
24. A medical device comprising the polymer of Claim 23.
25. The polymer of Claim 1, wherein R1 is:

wherein R3 is H or a non-crystallizable C, to C29 hydrocarbon;
Z1 and Z2 are each independently O or S; and j and m are each independently an integer in the range of 1 to 8.
26. A medical device comprising the polymer of Claim 25.
27. The polymer of Claim 1, wherein R1 is:

wherein R3 and R4 are each independently H or a non-crystallizable C1 to C29 hydrocarbon;
Z1, Z2 and Z3 are each independently O or S; and j and m are each independently an integer in the range of 1 to 8.
28. A medical device comprising the polymer of Claim 27.
29. The medical device of Claim 2, further comprising an effective amount of a radiopacifying agent.
30. The medical device of Claim 2, further comprising an effective amount of a magnetic resonance enhancing agent.
CA 2577018 2004-08-13 2005-08-09 Inherently radiopaque bioresorbable polymers for multiple uses Active CA2577018C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US60152604 true 2004-08-13 2004-08-13
US60/601,526 2004-08-13
PCT/US2005/028228 WO2006020616A1 (en) 2004-08-13 2005-08-09 Inherently radiopaque bioresorbable polymers for multiple uses

Publications (2)

Publication Number Publication Date
CA2577018A1 true true CA2577018A1 (en) 2006-02-23
CA2577018C CA2577018C (en) 2012-03-27

Family

ID=35276651

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2577018 Active CA2577018C (en) 2004-08-13 2005-08-09 Inherently radiopaque bioresorbable polymers for multiple uses

Country Status (7)

Country Link
US (1) US7473417B2 (en)
EP (1) EP1778761A1 (en)
JP (1) JP4768736B2 (en)
CN (1) CN101014642B (en)
CA (1) CA2577018C (en)
RU (1) RU2396289C2 (en)
WO (1) WO2006020616A1 (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070142901A1 (en) * 1998-02-17 2007-06-21 Steinke Thomas A Expandable stent with sliding and locking radial elements
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
WO2004021923A3 (en) * 2002-09-04 2004-05-27 Reva Medical Inc A slide and lock stent and method of manufacture from a single piece shape
WO2004110315A1 (en) * 2003-06-16 2004-12-23 Nanyang Technological University Polymeric stent and method of manufacture
US8999364B2 (en) 2004-06-15 2015-04-07 Nanyang Technological University Implantable article, method of forming same and method for reducing thrombogenicity
WO2005030268A1 (en) * 2003-09-25 2005-04-07 Rutgers, The State University Inherently radiopaque polymeric products for embolotherapy
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US7381219B2 (en) 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US8052749B2 (en) * 2003-12-23 2011-11-08 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US8703113B2 (en) 2004-07-08 2014-04-22 Reva Medical Inc. Side-chain crystallizable polymers for medical applications
RU2383558C2 (en) 2004-07-08 2010-03-10 Рева Медикал, Инк. Polymers with crystallising side chains for medical use
US7763065B2 (en) 2004-07-21 2010-07-27 Reva Medical, Inc. Balloon expandable crush-recoverable stent device
US20060034769A1 (en) * 2004-08-13 2006-02-16 Rutgers, The State University Radiopaque polymeric stents
JP4768736B2 (en) 2004-08-13 2011-09-07 レヴァ メディカル、 インコーポレイテッドReva Medical, Inc. Inherently radiopaque bioresorbable polymers for multiple use
US7901451B2 (en) 2004-09-24 2011-03-08 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US8292944B2 (en) 2004-12-17 2012-10-23 Reva Medical, Inc. Slide-and-lock stent
KR100511618B1 (en) * 2005-01-17 2005-08-24 이경범 Multi-layer coating of drug release controllable coronary stent and method for manufacturing the same
US7962208B2 (en) 2005-04-25 2011-06-14 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US7914574B2 (en) 2005-08-02 2011-03-29 Reva Medical, Inc. Axially nested slide and lock expandable device
US9149378B2 (en) 2005-08-02 2015-10-06 Reva Medical, Inc. Axially nested slide and lock expandable device
US20070160672A1 (en) * 2006-01-06 2007-07-12 Vipul Bhupendra Dave Methods of making bioabsorbable drug delivery devices comprised of solvent cast films
US20070158880A1 (en) * 2006-01-06 2007-07-12 Vipul Bhupendra Dave Methods of making bioabsorbable drug delivery devices comprised of solvent cast tubes
US20070162110A1 (en) * 2006-01-06 2007-07-12 Vipul Bhupendra Dave Bioabsorbable drug delivery devices
US8440214B2 (en) * 2006-01-31 2013-05-14 Boston Scientific Scimed, Inc. Medical devices for therapeutic agent delivery with polymeric regions that contain copolymers having both soft segments and uniform length hard segments
EP1988851A2 (en) 2006-02-14 2008-11-12 Sadra Medical, Inc. Systems and methods for delivering a medical implant
WO2007114823A9 (en) * 2006-04-06 2008-10-09 Reva Medical Inc Embolic prosthesis for treatment of vascular aneurysm
WO2007134239A3 (en) * 2006-05-12 2008-01-10 Cordis Corp Balloon expandable bioabsorbable drug eluting flexible stent
EP2032614A2 (en) * 2006-06-06 2009-03-11 Rutgers, The State University Of New Jersey Iodinated polymers
DE102006038232A1 (en) * 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Endoprosthesis and methods for producing such
US8507639B2 (en) * 2006-09-11 2013-08-13 Boston Scientific Scimed, Inc. Radiopaque amide polymers and medical devices formed thereof
CN101528160A (en) 2006-10-17 2009-09-09 鲁特格斯州立大学 N-substituted monomers and polymers
US8067055B2 (en) * 2006-10-20 2011-11-29 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method of use
US20080097591A1 (en) 2006-10-20 2008-04-24 Biosensors International Group Drug-delivery endovascular stent and method of use
US20080103584A1 (en) * 2006-10-25 2008-05-01 Biosensors International Group Temporal Intraluminal Stent, Methods of Making and Using
US20100113506A1 (en) * 2007-01-17 2010-05-06 Hiroyuki Kawano Composition for preventing or treating thrombus- or embolus- associated disease
US7704275B2 (en) 2007-01-26 2010-04-27 Reva Medical, Inc. Circumferentially nested expandable device
US20080269874A1 (en) 2007-04-30 2008-10-30 Yunbing Wang Implantable medical devices fabricated from polymers with radiopaque groups
EP1992371A1 (en) * 2007-05-15 2008-11-19 Occlutech GmbH Bio reabsorbable polymer materials opaque to X-rays and occlusion instruments made thereof
US8328867B2 (en) * 2007-06-08 2012-12-11 Medtronic Vascular, Inc. Drug loaded implantable medical device
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
KR100930167B1 (en) * 2007-09-19 2009-12-07 삼성전기주식회사 Ultra-wide-angle optical system
US8608049B2 (en) * 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US20110230973A1 (en) * 2007-10-10 2011-09-22 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
WO2009070180A1 (en) 2007-11-30 2009-06-04 Reva Medical, Inc. Axially-radially nested expandable device
US7972373B2 (en) * 2007-12-19 2011-07-05 Advanced Technologies And Regenerative Medicine, Llc Balloon expandable bioabsorbable stent with a single stress concentration region interconnecting adjacent struts
US8231926B2 (en) 2007-12-21 2012-07-31 Innovatech, Llc Marked precoated medical device and method of manufacturing same
US7714217B2 (en) 2007-12-21 2010-05-11 Innovatech, Llc Marked precoated strings and method of manufacturing same
US8231927B2 (en) 2007-12-21 2012-07-31 Innovatech, Llc Marked precoated medical device and method of manufacturing same
US7811623B2 (en) * 2007-12-21 2010-10-12 Innovatech, Llc Marked precoated medical device and method of manufacturing same
US8048471B2 (en) * 2007-12-21 2011-11-01 Innovatech, Llc Marked precoated medical device and method of manufacturing same
US20090187256A1 (en) * 2008-01-21 2009-07-23 Zimmer, Inc. Method for forming an integral porous region in a cast implant
US20090198286A1 (en) * 2008-02-05 2009-08-06 Zimmer, Inc. Bone fracture fixation system
US8206636B2 (en) 2008-06-20 2012-06-26 Amaranth Medical Pte. Stent fabrication via tubular casting processes
WO2010033640A1 (en) * 2008-09-16 2010-03-25 Rutgers, The State University Of New Jersey Bioresorbable polymers synthesized from monomer analogs of natural metabolites
ES2627860T3 (en) 2008-10-10 2017-07-31 Boston Scientific Scimed, Inc. to place medical devices medical devices and installation systems
CA2737753C (en) 2008-10-10 2017-03-14 Reva Medical, Inc. Expandable slide and lock stent
CA2737764A1 (en) * 2008-10-11 2010-04-15 Rutgers, The State University Of New Jersey Biocompatible polymers for medical devices
US8343088B2 (en) * 2008-10-21 2013-01-01 Douglas Bates Apparatus and method for treating occluded infection collections of the digestive tract
WO2011014859A1 (en) 2009-07-31 2011-02-03 Rutgers, The State University Of New Jersey Biocompatible polymers for medical devices
US8702716B1 (en) 2009-09-21 2014-04-22 Reva Medical Inc. Devices, compositions and methods for bone and tissue augmentation
EP2486081A4 (en) 2009-10-11 2013-03-20 Univ Rutgers Biocompatible polymers for medial devices
US20110208190A1 (en) * 2010-02-23 2011-08-25 University Of Connecticut Natural Polymer-Based Porous Orthopedic Fixation Screw for Bone Repair and Regeneration
US8523936B2 (en) 2010-04-10 2013-09-03 Reva Medical, Inc. Expandable slide and lock stent
EP2600902A4 (en) 2010-08-06 2015-01-07 Endoshape Inc Radiopaque shape memory polymers for medical devices
US8900652B1 (en) 2011-03-14 2014-12-02 Innovatech, Llc Marked fluoropolymer surfaces and method of manufacturing same
JP2014527425A (en) 2011-07-12 2014-10-16 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Coupling system for medical equipment
EP2938388A1 (en) * 2012-12-31 2015-11-04 Clearstream Technologies Limited Balloon catheter with transient radiopaque marking
CA2899309A1 (en) 2013-02-08 2014-08-14 Endoshape, Inc. Radiopaque polymers for medical devices
US9408732B2 (en) 2013-03-14 2016-08-09 Reva Medical, Inc. Reduced-profile slide and lock stent
RU2565810C1 (en) * 2014-06-16 2015-10-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кемеровский технологический институт пищевой промышленности" Method of personalised intraoperative contact local hyperthermia for treatment of locally advanced malignant tumours
WO2016004222A1 (en) 2014-07-01 2016-01-07 Georgia Regents University Bio-compatible radiopaque dental fillers for imaging
RU2603480C2 (en) * 2014-12-24 2016-11-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) Radiopaque agent based on barium sulphate and method for its production
RU2620162C1 (en) * 2016-04-18 2017-05-23 Акционерное общество "Медсил" X-ray-contrast marker for chronic constipation diagnostics and capsule with x-ray contrast markers

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4638045A (en) * 1985-02-19 1987-01-20 Massachusetts Institute Of Technology Non-peptide polyamino acid bioerodible polymers
US4863735A (en) * 1985-02-19 1989-09-05 Massachusetts Institute Of Technology Biodegradable polymeric drug delivery system with adjuvant activity
US4980449A (en) * 1988-07-14 1990-12-25 Rutgers, The State University Polyiminocarbonate synthesis
US5194581A (en) * 1989-03-09 1993-03-16 Leong Kam W Biodegradable poly(phosphoesters)
US5216115A (en) * 1990-06-12 1993-06-01 Rutgers, The State University Of New Jersey Polyarylate containing derivatives of the natural amino acid L-tyrosine
US5198507A (en) * 1990-06-12 1993-03-30 Rutgers, The State University Of New Jersey Synthesis of amino acid-derived bioerodible polymers
US5192225A (en) * 1990-11-08 1993-03-09 Yazaki Corporation Connector locking connection detection device
US5469867A (en) * 1992-09-02 1995-11-28 Landec Corporation Cast-in place thermoplastic channel occluder
US5466439A (en) * 1992-11-12 1995-11-14 Magnetic Research, Inc. Polymeric contrast enhancing agents for magnetic resonance images
US5443477A (en) * 1994-02-10 1995-08-22 Stentco, Inc. Apparatus and method for deployment of radially expandable stents by a mechanical linkage
US6831116B2 (en) * 1995-03-07 2004-12-14 Landec Corporation Polymeric modifying agents
JP3946250B2 (en) * 1995-03-31 2007-07-18 ラトガーズ,ザ・ステート・ユニバーシィティ Improved synthesis of tyrosine-derived diphenol monomers
US5587507A (en) * 1995-03-31 1996-12-24 Rutgers, The State University Synthesis of tyrosine derived diphenol monomers
US6319492B1 (en) 1996-11-27 2001-11-20 Rutgers, The State University Copolymers of tyrosine-based polyarylates and poly(alkylene oxides)
US5658995A (en) * 1995-11-27 1997-08-19 Rutgers, The State University Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide)
US5912225A (en) * 1997-04-14 1999-06-15 Johns Hopkins Univ. School Of Medicine Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same
WO1998058012A1 (en) * 1997-06-18 1998-12-23 Guilford Pharmaceuticals Inc. Two-stage solution polymerization of high molecular weight poly(phosphoesters)
DE69842217D1 (en) * 1997-11-07 2011-05-19 State University Radiopacity polymeric Biomateriale
US6492462B2 (en) * 1998-01-16 2002-12-10 Landec Corporation Side chain crystalline polymer as rheology modifier for crosslinked polymer
EP0930343A3 (en) * 1998-01-16 2000-05-31 Landec Corporation Low profile additives for crosslink resins
US6623521B2 (en) * 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
CA2316945A1 (en) * 1998-02-23 1999-08-26 Mnemoscience Gmbh Shape memory polymers
US6015424A (en) * 1998-04-28 2000-01-18 Microvention, Inc. Apparatus and method for vascular embolization
US6273909B1 (en) * 1998-10-05 2001-08-14 Teramed Inc. Endovascular graft system
WO2000037562A1 (en) * 1998-12-18 2000-06-29 Bayer Aktiengesellschaft Use of polycarbonates containing iodine and/or bromine for moulded parts with high x-ray contrast and moulded parts produced with same
US6200338B1 (en) * 1998-12-31 2001-03-13 Ethicon, Inc. Enhanced radiopacity of peripheral and central catheter tubing
US6599448B1 (en) * 2000-05-10 2003-07-29 Hydromer, Inc. Radio-opaque polymeric compositions
US6550480B2 (en) * 2001-01-31 2003-04-22 Numed/Tech Llc Lumen occluders made from thermodynamic materials
US7455687B2 (en) * 2002-12-30 2008-11-25 Advanced Cardiovascular Systems, Inc. Polymer link hybrid stent
US6932930B2 (en) * 2003-03-10 2005-08-23 Synecor, Llc Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same
WO2005030268A1 (en) * 2003-09-25 2005-04-07 Rutgers, The State University Inherently radiopaque polymeric products for embolotherapy
RU2383558C2 (en) 2004-07-08 2010-03-10 Рева Медикал, Инк. Polymers with crystallising side chains for medical use
JP4768736B2 (en) 2004-08-13 2011-09-07 レヴァ メディカル、 インコーポレイテッドReva Medical, Inc. Inherently radiopaque bioresorbable polymers for multiple use

Also Published As

Publication number Publication date Type
CA2577018C (en) 2012-03-27 grant
CN101014642A (en) 2007-08-08 application
JP4768736B2 (en) 2011-09-07 grant
US7473417B2 (en) 2009-01-06 grant
CN101014642B (en) 2010-04-21 grant
JP2008510034A (en) 2008-04-03 application
EP1778761A1 (en) 2007-05-02 application
US20060036316A1 (en) 2006-02-16 application
RU2396289C2 (en) 2010-08-10 grant
RU2007108783A (en) 2008-09-20 application
WO2006020616A1 (en) 2006-02-23 application

Similar Documents

Publication Publication Date Title
WO2006135479A3 (en) Anti-scarring agents, therapeutic compositions, and use thereof
WO2007019439A3 (en) Block copolymer compositions and uses thereof
WO2007100699A3 (en) Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
WO2004099068A3 (en) Nanofiber surfaces for use in enhanced surface area applications
WO2006082060A8 (en) Resorbable surgical suture material
WO2010005723A3 (en) Drug loaded polymeric nanoparticles and methods of making and using same
WO2008088030A1 (en) Composition for prevention or treatment of disease associated with thrombus or embolus
CA2527976A1 (en) Stents
WO2009064861A3 (en) Nitric oxide-releasing diazeniumdiolated polymers, compositions, medical devices, and uses thereof
WO2008088507A3 (en) Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents
WO2005001078A3 (en) Regeneration and repair of neural tissue using postpartum-derived cells
WO2007064895A3 (en) Polymer compositions, coatings and devices, and methods of making and using the same
WO2010129514A3 (en) Synergistic effects of blending multiple additives in uhmwpe
CA2462053A1 (en) Starch networks as absorbent or superabsorbent materials and their preparation by extrusion
WO2006124713A3 (en) 4-biarylyl-1-phenylazetidin-2-ones
WO2007024501A3 (en) Nitric oxide-releasing biodegradable polymers useful as medical devices and coatings therefore
WO2007030266A3 (en) Nitric oxide-releasing polymers derived from modified polyimines
WO2004039248A3 (en) Repairing or replacing tissues or organs
WO2005101112A3 (en) Optical films and methods of making the same
WO2007002204A3 (en) Pyrosequencing methods and related compostions
WO2011090760A4 (en) Heteroaryl compounds and uses thereof
WO2006043984A3 (en) Crosslinked amine polymers
WO2005092039A3 (en) Crosslinked amine polymers
WO2007143698A3 (en) Iodinated polymers
WO2008157589A4 (en) Flexible member with variable flexibility for providing dynamic stability to a spine

Legal Events

Date Code Title Description
EEER Examination request