CA2573332A1 - Compositions and formulations of decitabine polymorphs and methods of use thereof - Google Patents
Compositions and formulations of decitabine polymorphs and methods of use thereof Download PDFInfo
- Publication number
- CA2573332A1 CA2573332A1 CA002573332A CA2573332A CA2573332A1 CA 2573332 A1 CA2573332 A1 CA 2573332A1 CA 002573332 A CA002573332 A CA 002573332A CA 2573332 A CA2573332 A CA 2573332A CA 2573332 A1 CA2573332 A1 CA 2573332A1
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- CA
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- Prior art keywords
- decitabine
- polymorph
- endotherm
- characterizable
- approximately
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- GZXOHHPYODFEGO-UHFFFAOYSA-N triglycine sulfate Chemical class NCC(O)=O.NCC(O)=O.NCC(O)=O.OS(O)(=O)=O GZXOHHPYODFEGO-UHFFFAOYSA-N 0.000 description 1
- 125000002264 triphosphate group Chemical group [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 230000006444 vascular growth Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 201000007790 vitelliform macular dystrophy Diseases 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/890,828 | 2004-07-13 | ||
| US10/890,828 US20060014949A1 (en) | 2004-07-13 | 2004-07-13 | Compositions and formulations of decitabine polymorphs and methods of use thereof |
| PCT/US2005/024676 WO2006017278A1 (en) | 2004-07-13 | 2005-07-12 | Compositions and formulations of decitabine polymorphs and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2573332A1 true CA2573332A1 (en) | 2006-02-16 |
Family
ID=35600347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002573332A Abandoned CA2573332A1 (en) | 2004-07-13 | 2005-07-12 | Compositions and formulations of decitabine polymorphs and methods of use thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060014949A1 (https=) |
| EP (1) | EP1765076A4 (https=) |
| JP (1) | JP5159307B2 (https=) |
| CN (1) | CN101014246A (https=) |
| AU (3) | AU2005271814B2 (https=) |
| CA (1) | CA2573332A1 (https=) |
| WO (1) | WO2006017278A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| JP5528807B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JO2778B1 (en) | 2007-10-16 | 2014-03-15 | ايساي انك | Certain Compounds, Compositions and Methods |
| JP5687687B2 (ja) | 2009-04-06 | 2015-03-18 | 大塚製薬株式会社 | 癌を治療するための（２’−デオキシ−リボフラノシル）−１，３，４，７−テトラヒドロ−（１，３）ジアゼピン−２−オン誘導体 |
| WO2010129211A2 (en) * | 2009-04-27 | 2010-11-11 | Dr. Reddy's Laboratories Ltd. | Preparation of decitabine |
| CN101781347B (zh) * | 2009-12-21 | 2012-09-12 | 南京卡文迪许生物工程技术有限公司 | 地西他滨多晶型物和药用组合物 |
| EP2750768B1 (en) | 2011-08-30 | 2018-10-03 | Astex Pharmaceuticals, Inc. | Decitabine derivative formulations |
| EP2766041B1 (en) | 2011-10-12 | 2018-12-05 | Children's Medical Center Corporation | Combinatorial compositions and methods of treating hemoglobinopathies |
| US20140094598A1 (en) | 2012-10-01 | 2014-04-03 | Johnson Matthey Public Limited Company | Method for the purification of decitabine |
| CN103191144B (zh) * | 2013-04-25 | 2014-06-18 | 李伟丽 | 一种治疗癌症的药物组合物及应用 |
| AU2016287585B2 (en) | 2015-07-02 | 2020-12-17 | Otsuka Pharmaceutical Co., Ltd. | Lyophilized pharmaceutical compositions |
| WO2019025256A1 (en) | 2017-08-01 | 2019-02-07 | Bayer Aktiengesellschaft | COMBINATION OF MIDH1 INHIBITORS AND DNA HYPOMETHYLATION (AHM) AGENTS |
| KR20200035438A (ko) | 2017-08-03 | 2020-04-03 | 오쓰까 세이야꾸 가부시키가이샤 | 약물 화합물 및 이의 정제 방법 |
| JP7089603B2 (ja) | 2018-06-11 | 2022-06-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 眼疾患を治療するための脱メチル化 |
| PH12022552250A1 (en) | 2020-02-25 | 2023-11-13 | Otsuka Pharma Co Ltd | Combination decitabine and cedazuridine solid oral dosage forms |
| EP4138843A4 (en) | 2020-04-23 | 2024-07-10 | Southern Research Institute | COMPOSITION FOR THE TREATMENT OF BLOOD CANCER USING 4'-THIO-5-AZA-2'-DEOXYCYTIDINE AND USES THEREOF |
| WO2022020747A1 (en) * | 2020-07-23 | 2022-01-27 | Southern Research Institute | Polymorophs of 5-aza-4'-thio-2-deoxycytidine |
| CN119943194A (zh) * | 2023-11-03 | 2025-05-06 | 中国石油天然气股份有限公司 | 一种分子筛晶胞参数确定方法和装置 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1050899A (https=) * | 1963-12-22 | |||
| CH527207A (de) * | 1968-05-08 | 1972-08-31 | Ceskoslovenska Akademie Ved | Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen |
| DE2012888C3 (de) * | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden |
| JPS5213741B2 (https=) * | 1972-05-22 | 1977-04-16 | ||
| JPS5527077A (en) * | 1978-08-16 | 1980-02-26 | Shin Meiwa Ind Co Ltd | Solids scraper for sludge dehydrator |
| US6613753B2 (en) * | 2001-02-21 | 2003-09-02 | Supergen, Inc. | Restore cancer-suppressing functions to neoplastic cells through DNA hypomethylation |
| KR101150250B1 (ko) * | 2001-03-01 | 2012-06-12 | 아보트 래버러토리즈 | 시스-ｆｔｃ의 다형 및 기타 결정형 |
| US20040162263A1 (en) * | 2002-10-31 | 2004-08-19 | Supergen, Inc., A Delaware Corporation | Pharmaceutical formulations targeting specific regions of the gastrointesinal tract |
-
2004
- 2004-07-13 US US10/890,828 patent/US20060014949A1/en not_active Abandoned
-
2005
- 2005-07-12 JP JP2007521565A patent/JP5159307B2/ja not_active Expired - Lifetime
- 2005-07-12 CA CA002573332A patent/CA2573332A1/en not_active Abandoned
- 2005-07-12 EP EP05771356A patent/EP1765076A4/en not_active Withdrawn
- 2005-07-12 CN CNA2005800299116A patent/CN101014246A/zh active Pending
- 2005-07-12 AU AU2005271814A patent/AU2005271814B2/en not_active Ceased
- 2005-07-12 WO PCT/US2005/024676 patent/WO2006017278A1/en not_active Ceased
-
2011
- 2011-02-09 AU AU2011200539A patent/AU2011200539A1/en not_active Abandoned
- 2011-02-09 AU AU2011200540A patent/AU2011200540A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011200540A8 (en) | 2011-03-10 |
| WO2006017278A1 (en) | 2006-02-16 |
| AU2011200540A1 (en) | 2011-03-03 |
| AU2011200539A1 (en) | 2011-03-03 |
| JP2008506690A (ja) | 2008-03-06 |
| EP1765076A1 (en) | 2007-03-28 |
| JP5159307B2 (ja) | 2013-03-06 |
| EP1765076A4 (en) | 2009-04-22 |
| US20060014949A1 (en) | 2006-01-19 |
| AU2005271814B2 (en) | 2010-11-11 |
| CN101014246A (zh) | 2007-08-08 |
| AU2005271814A1 (en) | 2006-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130712 |