CA2568805C - Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique - Google Patents
Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique Download PDFInfo
- Publication number
- CA2568805C CA2568805C CA2568805A CA2568805A CA2568805C CA 2568805 C CA2568805 C CA 2568805C CA 2568805 A CA2568805 A CA 2568805A CA 2568805 A CA2568805 A CA 2568805A CA 2568805 C CA2568805 C CA 2568805C
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- Prior art keywords
- wetting
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- Expired - Fee Related
Links
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0427—Electrowetting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/088—Passive control of flow resistance by specific surface properties
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
- F05C—INDEXING SCHEME RELATING TO MATERIALS, MATERIAL PROPERTIES OR MATERIAL CHARACTERISTICS FOR MACHINES, ENGINES OR PUMPS OTHER THAN NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES
- F05C2225/00—Synthetic polymers, e.g. plastics; Rubber
- F05C2225/04—PTFE [PolyTetraFluorEthylene]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micromachines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0406080A FR2871150B1 (fr) | 2004-06-04 | 2004-06-04 | Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique |
| FR0406080 | 2004-06-04 | ||
| PCT/FR2005/001385 WO2006003293A2 (fr) | 2004-06-04 | 2005-06-06 | Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2568805A1 CA2568805A1 (fr) | 2006-01-12 |
| CA2568805C true CA2568805C (fr) | 2012-08-28 |
Family
ID=34946857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2568805A Expired - Fee Related CA2568805C (fr) | 2004-06-04 | 2005-06-06 | Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080110753A1 (de) |
| EP (1) | EP1781409B1 (de) |
| JP (1) | JP4763690B2 (de) |
| KR (1) | KR101179411B1 (de) |
| CN (1) | CN101031362B (de) |
| AT (1) | ATE540756T1 (de) |
| CA (1) | CA2568805C (de) |
| FR (1) | FR2871150B1 (de) |
| WO (1) | WO2006003293A2 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2871076A1 (fr) * | 2004-06-04 | 2005-12-09 | Univ Lille Sciences Tech | Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique |
| JP4632300B2 (ja) * | 2005-02-14 | 2011-02-16 | 国立大学法人 筑波大学 | 送液装置 |
| JP4893197B2 (ja) * | 2006-09-28 | 2012-03-07 | ブラザー工業株式会社 | 液体移送装置 |
| US8702938B2 (en) * | 2007-09-04 | 2014-04-22 | Advanced Liquid Logic, Inc. | Droplet actuator with improved top substrate |
| CN104297506B (zh) | 2007-10-02 | 2017-05-03 | 赛拉诺斯股份有限公司 | 模块化现场护理装置及其应用 |
| JP5383138B2 (ja) * | 2008-10-01 | 2014-01-08 | シャープ株式会社 | エレクトロウエッティングバルブ付き送液構造体、これを用いたマイクロ分析チップ及び分析装置 |
| US8877512B2 (en) * | 2009-01-23 | 2014-11-04 | Advanced Liquid Logic, Inc. | Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator |
| US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
| US8734628B2 (en) * | 2010-03-10 | 2014-05-27 | Empire Technology Development, Llc | Microfluidic channel device with array of drive electrodes |
| EP2567213B1 (de) | 2010-05-05 | 2018-01-24 | The Governing Council of the Universtiy of Toronto | Verfahren zur verarbeitung getrockneter proben mithilfe einer digitalen mikrofluidischen vorrichtung |
| CN101865928B (zh) * | 2010-05-06 | 2012-07-18 | 大连理工大学 | 一种基于电场作用的超疏水表面微液滴操控方法 |
| JP4949506B2 (ja) * | 2010-07-16 | 2012-06-13 | シャープ株式会社 | 流路構造体及びその製造方法、並びに、分析チップ及び分析装置 |
| CA2813090C (en) * | 2010-10-01 | 2019-11-12 | The Governing Council Of The University Of Toronto | Digital microfluidic devices and methods incorporating a solid phase |
| JP2012150098A (ja) * | 2010-12-28 | 2012-08-09 | Sharp Corp | 検体検出用チップ、それを用いたセンサ、及び検体検出方法 |
| SG192069A1 (en) | 2011-01-21 | 2013-08-30 | Theranos Inc | Systems and methods for sample use maximization |
| US9268915B2 (en) | 2011-09-25 | 2016-02-23 | Theranos, Inc. | Systems and methods for diagnosis or treatment |
| US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
| US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
| US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
| US8840838B2 (en) | 2011-09-25 | 2014-09-23 | Theranos, Inc. | Centrifuge configurations |
| US9619627B2 (en) | 2011-09-25 | 2017-04-11 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
| US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
| US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
| US9250229B2 (en) | 2011-09-25 | 2016-02-02 | Theranos, Inc. | Systems and methods for multi-analysis |
| US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
| CN108490204A (zh) * | 2011-09-25 | 2018-09-04 | 赛拉诺斯知识产权有限责任公司 | 用于多重分析的系统和方法 |
| CN102824933B (zh) * | 2012-09-20 | 2014-09-03 | 复旦大学 | 一种单向液滴输运的数字微流芯片电极配置方法 |
| US9366647B2 (en) * | 2013-03-14 | 2016-06-14 | Taiwan Semiconductor Manufacturing Company, Ltd. | Optical detection for bio-entities |
| US10422806B1 (en) | 2013-07-25 | 2019-09-24 | Theranos Ip Company, Llc | Methods for improving assays of biological samples |
| TWI507690B (zh) * | 2014-09-02 | 2015-11-11 | Silicon Optronics Inc | 生物晶片構裝 |
| US20200390811A1 (en) * | 2015-04-23 | 2020-12-17 | The Trustees Of The University Of Pennsylvania | Compositions to disrupt protein kinase a anchoring and uses thereof |
| CN108026494A (zh) | 2015-06-05 | 2018-05-11 | 米罗库鲁斯公司 | 限制蒸发和表面结垢的空气基质数字微流控装置和方法 |
| CN208562324U (zh) | 2015-06-05 | 2019-03-01 | 米罗库鲁斯公司 | 空气基质数字微流控(dmf)装置 |
| US11148138B2 (en) * | 2015-09-02 | 2021-10-19 | Tecan Trading Ag | Magnetic conduits in microfluidics |
| EP3500660A4 (de) | 2016-08-22 | 2020-03-04 | Miroculus Inc. | Rückkopplungssystem für parallele tröpfchensteuerung in einer digitalen mikrofluidischen vorrichtung |
| EP3563151A4 (de) | 2016-12-28 | 2020-08-19 | Miroculus Inc. | Digitale mikrofluidische vorrichtung und verfahren |
| WO2018187476A1 (en) | 2017-04-04 | 2018-10-11 | Miroculus Inc. | Digital microfluidic apparatuses and methods for manipulating and processing encapsulated droplets |
| WO2019023133A1 (en) | 2017-07-24 | 2019-01-31 | Miroculus Inc. | DIGITAL MICROFLUIDIC SYSTEMS AND METHODS WITH INTEGRATED PLASMA COLLECTION DEVICE |
| CA3073058A1 (en) | 2017-09-01 | 2019-03-07 | Miroculus Inc. | Digital microfluidics devices and methods of using them |
| EP3796999A4 (de) | 2018-05-23 | 2022-03-09 | Miroculus Inc. | Steuerung der verdampfung in digitaler mikrofluidik |
| EP3932537A4 (de) * | 2019-02-25 | 2023-01-04 | National Institute Of Advanced Industrial Science And Technology | Open-space-artige vorrichtung zum manipulieren von flüssigkeiten |
| EP3953041A4 (de) | 2019-04-08 | 2023-01-25 | Miroculus Inc. | Digitale mikrofluidikvorrichtungen mit mehreren patronen und verfahren zur verwendung |
| US11524298B2 (en) | 2019-07-25 | 2022-12-13 | Miroculus Inc. | Digital microfluidics devices and methods of use thereof |
| CN111804354B (zh) | 2020-04-07 | 2021-09-21 | 苏州大学 | 液滴无损转移装置及方法、液滴微反应方法 |
| US11772093B2 (en) | 2022-01-12 | 2023-10-03 | Miroculus Inc. | Methods of mechanical microfluidic manipulation |
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| WO1998000705A1 (en) * | 1996-06-28 | 1998-01-08 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
| JP3791999B2 (ja) * | 1997-03-24 | 2006-06-28 | 株式会社アドバンス | 液体微粒子ハンドリング装置 |
| JP3829491B2 (ja) * | 1998-08-27 | 2006-10-04 | 株式会社日立製作所 | プローブチップ、プローブチップ作成方法、試料検出方法、及び試料検出装置 |
| US6565727B1 (en) * | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
| JP2002031638A (ja) * | 2000-07-17 | 2002-01-31 | Mitsubishi Chemicals Corp | 生体試料検出用チップ及び生体試料検出方法 |
| JP2002027984A (ja) * | 2000-07-17 | 2002-01-29 | Mitsubishi Chemicals Corp | マイクロリアクタチップ，化学反応試験方法及びマイクロリアクタチップ用薄膜部材 |
| US6773566B2 (en) * | 2000-08-31 | 2004-08-10 | Nanolytics, Inc. | Electrostatic actuators for microfluidics and methods for using same |
| JP2003222611A (ja) * | 2001-11-20 | 2003-08-08 | Nec Corp | 分離装置、分離方法および分離装置の製造方法 |
| US7163612B2 (en) * | 2001-11-26 | 2007-01-16 | Keck Graduate Institute | Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like |
| JP2003230829A (ja) * | 2001-12-06 | 2003-08-19 | Hitachi Ltd | 平面マイクロファクトリー |
| US7459127B2 (en) * | 2002-02-26 | 2008-12-02 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
| JP2003294733A (ja) * | 2002-03-29 | 2003-10-15 | Sumitomo Bakelite Co Ltd | 細胞内蛋白量の同定方法及び基板 |
| JP3914806B2 (ja) * | 2002-04-09 | 2007-05-16 | 三菱化学株式会社 | 分析用チップ |
| KR100455293B1 (ko) * | 2002-05-15 | 2004-11-06 | 삼성전자주식회사 | 친수성 영역과 소수성 영역으로 구성되는 생물분자용어레이 판의 제조방법 |
| JPWO2004008132A1 (ja) * | 2002-07-11 | 2005-11-10 | 三菱電機株式会社 | 生体分子分離セル及びその製造方法並びにｄｎａ分取装置 |
| JP2004061229A (ja) * | 2002-07-26 | 2004-02-26 | Hitachi Ltd | 感染症検査装置、検査方法、及び感染検査用マイクロファブリケーション |
| US7329545B2 (en) * | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
| US6911132B2 (en) * | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
| US6989234B2 (en) * | 2002-09-24 | 2006-01-24 | Duke University | Method and apparatus for non-contact electrostatic actuation of droplets |
| JP4590542B2 (ja) * | 2003-06-10 | 2010-12-01 | 国立大学法人九州工業大学 | マイクロ液滴輸送デバイス |
| JP4385124B2 (ja) * | 2004-03-12 | 2009-12-16 | 国立大学法人九州工業大学 | 電気的制御可能な微量液滴輸送デバイス |
| FR2871076A1 (fr) * | 2004-06-04 | 2005-12-09 | Univ Lille Sciences Tech | Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique |
| US20060266700A1 (en) * | 2005-05-31 | 2006-11-30 | General Electric Company | Porous structures with engineered wettability properties and methods of making them |
-
2004
- 2004-06-04 FR FR0406080A patent/FR2871150B1/fr not_active Expired - Fee Related
-
2005
- 2005-06-06 EP EP05775767A patent/EP1781409B1/de not_active Not-in-force
- 2005-06-06 CN CN2005800240790A patent/CN101031362B/zh not_active Expired - Fee Related
- 2005-06-06 US US11/628,416 patent/US20080110753A1/en not_active Abandoned
- 2005-06-06 AT AT05775767T patent/ATE540756T1/de active
- 2005-06-06 KR KR1020067025513A patent/KR101179411B1/ko not_active IP Right Cessation
- 2005-06-06 CA CA2568805A patent/CA2568805C/fr not_active Expired - Fee Related
- 2005-06-06 JP JP2007514033A patent/JP4763690B2/ja not_active Expired - Fee Related
- 2005-06-06 WO PCT/FR2005/001385 patent/WO2006003293A2/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070053165A (ko) | 2007-05-23 |
| WO2006003293A2 (fr) | 2006-01-12 |
| JP2008502882A (ja) | 2008-01-31 |
| CN101031362B (zh) | 2012-01-11 |
| EP1781409A2 (de) | 2007-05-09 |
| US20080110753A1 (en) | 2008-05-15 |
| FR2871150B1 (fr) | 2006-09-22 |
| EP1781409B1 (de) | 2012-01-11 |
| JP4763690B2 (ja) | 2011-08-31 |
| CA2568805A1 (fr) | 2006-01-12 |
| FR2871150A1 (fr) | 2005-12-09 |
| ATE540756T1 (de) | 2012-01-15 |
| CN101031362A (zh) | 2007-09-05 |
| KR101179411B1 (ko) | 2012-09-07 |
| WO2006003293A3 (fr) | 2006-09-21 |
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