CA2507561A1 - A method for preparing a medical solution for the manufacture of a medicament for peritoneal dialysis - Google Patents
A method for preparing a medical solution for the manufacture of a medicament for peritoneal dialysis Download PDFInfo
- Publication number
- CA2507561A1 CA2507561A1 CA002507561A CA2507561A CA2507561A1 CA 2507561 A1 CA2507561 A1 CA 2507561A1 CA 002507561 A CA002507561 A CA 002507561A CA 2507561 A CA2507561 A CA 2507561A CA 2507561 A1 CA2507561 A1 CA 2507561A1
- Authority
- CA
- Canada
- Prior art keywords
- solution
- acetylated
- sugars
- weight
- compartment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract 13
- 239000008155 medical solution Substances 0.000 title claims abstract 7
- 238000000502 dialysis Methods 0.000 title claims abstract 3
- 239000003814 drug Substances 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- 239000000243 solution Substances 0.000 claims abstract 17
- 150000002337 glycosamines Chemical class 0.000 claims abstract 11
- 235000000346 sugar Nutrition 0.000 claims abstract 7
- 150000008163 sugars Chemical class 0.000 claims abstract 7
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract 6
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 5
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 5
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 5
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 5
- 238000007865 diluting Methods 0.000 claims 2
- MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 claims 1
- MSWZFWKMSRAUBD-CBPJZXOFSA-N 2-amino-2-deoxy-D-mannopyranose Chemical compound N[C@@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-CBPJZXOFSA-N 0.000 claims 1
- 229920002101 Chitin Polymers 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-OZRXBMAMSA-N N-acetyl-beta-D-mannosamine Chemical compound CC(=O)N[C@@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-OZRXBMAMSA-N 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 239000007857 degradation product Substances 0.000 claims 1
- 239000000385 dialysis solution Substances 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229940070376 protein Drugs 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0035—Gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/007—Particle radiation, e.g. electron-beam, alpha or beta radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultra-violet radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Method for preparing a medical solution, comprising the steps of a) providing a solution comprising one or more acetylated or deacetylated amino sugar/sugars in at least one compartment of a container at a pH from 2.5 to 5.0, and b) terminal sterilisation of said at least one compartment and the contents therein, is disclosed, as well as a solution used for preparing the medical solution, a container containing said solution, and use of said solution for the manufacture of a medicament for peritoneal dialysis.
Claims (16)
1. A method for preparing a medical solution, comprising the steps of:
a) providing a solution comprising one or more acetylated or deacetylated amino sugars in at least one compartment of a container, said solution having a pH of
a) providing a solution comprising one or more acetylated or deacetylated amino sugars in at least one compartment of a container, said solution having a pH of
2.0-5.0, and b) terminal sterilisation of said at least one compartment and the contents therein.
2. The method according to claim 1, wherein the pH
is 2.5-3.5, preferably 3Ø
2. The method according to claim 1, wherein the pH
is 2.5-3.5, preferably 3Ø
3. The method according to claim 1, wherein said one or more acetylated or deacetylated amino sugar/sugars is/are chosen from N-acetylglucosamine (NAG), galactos-amine, N-acetylgalactosamine, mannosamine, and N-acetyl-mannosamine in the form of monomers, oligomers and/or polymers thereof including chitin, and human glucose-aminoglycans, as well as derivatives thereof.
4. Method according to any one of the previous claims, wherein said one or more acetylated or deacetyla-ted amino sugar/sugars is/are present in a concentration of 15-40% by weight, preferably 20-40% by weight, most preferably at least 30% by weight, with the basis of the solution in said at least one compartment.
5. The method according to any one of the previous claims, wherein said one or more acetylated or deacetyla-ted amino sugar/sugars is N-acetylglucosamine (NAG).
6. The method according to any one of the preceding claims, wherein the terminal sterilisation is heat sterilisation at a temperature of at least 100°C, prefer-ably at 121°C, and/or radiation sterilisation.
7. The method according to any one of the preceding claims, wherein each compartment of the container is de-limited from the other/others during the terminal sterilisation, and wherein the terminally sterilised solution containing one or more acetylated or deacetylat-ed amino sugars is/are mixed with a terminally sterilised pH adjusting and diluting solution in at least one other terminally sterilised compartment of the container, thereby finally preparing the medical solution.
8. The method according to claim 7, wherein the pH
in the finally prepared medical solution is 6.0-8.0, preferably 7.4.
in the finally prepared medical solution is 6.0-8.0, preferably 7.4.
9. The method according to claim 7 or 8, wherein the concentration of acetylated or deacetylated amino sugar/-sugars in the finally prepared solution is/are 0.2-l5.0%
by weight, preferably 0.5-6.0% by weight.
by weight, preferably 0.5-6.0% by weight.
10. The method according to any one of the preceding claims, wherein physiologically compatible constituents in the form of carbohydrates, preferably glucose, pro-teins, peptides, and antioxidants are present in one or more of said compartments.
11. The method according to any one of the preceding claims, wherein the medical solution prepared is a peri-toneal dialysis solution.
12. A solution comprising one or more acetylated or deacetylated amino sugar/sugars and having a pH of 2.0-5.0, preferably 2.5-3.5, most preferably 3.0, wherein said solution is terminally sterilised and contains low levels of cytotoxic degradation products.
13. The solution according to claim 12, wherein said one or more acetylated or deacetylated amino sugar/sugars is/are present in a concentration of 15-40% by weight, preferably 20-40% by weight, most preferably at least 30%
by weight.
by weight.
14. The solution according to any one of claims 12 and 13, wherein the acetylated or deacetylated amino sugar/sugars is/are as defined in claim 3, and preferably is N-acetylglucosamine.
15. A container comprising at least one compartment containing a solution according to any one of claims 12-14.
16. Use of a solution according to any one of claims 12-14 for the manufacture of a medicament for peritoneal dialysis, wherein it is mixed with a terminally sterilis-ed pH adjusting and diluting solution.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43258002P | 2002-12-10 | 2002-12-10 | |
| SE0203671-3 | 2002-12-10 | ||
| SE0203671A SE524530C2 (en) | 2002-12-10 | 2002-12-10 | Solution useful in the manufacture of medicament for peritoneal dialysis e.g. continuous ambulatory peritoneal dialysis comprises acetylated or deacetylated amino sugar having specified pH |
| US60/432,580 | 2002-12-10 | ||
| PCT/SE2003/001920 WO2004052268A1 (en) | 2002-12-10 | 2003-12-10 | A method for preparing a medical solution for the manufacture of a medicament for peritoneal dialysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2507561A1 true CA2507561A1 (en) | 2004-06-24 |
| CA2507561C CA2507561C (en) | 2011-09-20 |
Family
ID=32510744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2507561A Expired - Lifetime CA2507561C (en) | 2002-12-10 | 2003-12-10 | A method for preparing a medical solution for the manufacture of a medicament for peritoneal dialysis |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7790102B2 (en) |
| EP (1) | EP1569596B1 (en) |
| JP (1) | JP4361492B2 (en) |
| KR (1) | KR101142863B1 (en) |
| AT (1) | ATE403412T1 (en) |
| AU (1) | AU2003302889B2 (en) |
| CA (1) | CA2507561C (en) |
| DE (1) | DE60322738D1 (en) |
| ES (1) | ES2311754T3 (en) |
| WO (1) | WO2004052268A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60321213D1 (en) * | 2002-12-10 | 2008-07-03 | Gambro Lundia Ab | METHOD FOR PREPARING A MEDICAL SOLUTION FOR PREPARING A MEDICAMENT FOR DIEPERITONEAL DIALYSIS |
| US8367731B2 (en) | 2005-05-30 | 2013-02-05 | Fresenius Medical Care Deutschland Gmbh | Peritoneal dialysis fluid |
| US7736328B2 (en) | 2007-07-05 | 2010-06-15 | Baxter International Inc. | Dialysis system having supply container autoconnection |
| AU2017261342A1 (en) | 2016-05-06 | 2018-12-13 | Gambro Lundia Ab | Systems and methods for peritoneal dialysis having point of use dialysis fluid preparation using water accumulator and disposable set |
| DE102019103222B3 (en) | 2019-02-08 | 2020-06-25 | Elmos Semiconductor Aktiengesellschaft | Device for auto-configuration of automotive ultrasonic sensors on different data buses in different applications and corresponding method |
| CN112505175B (en) * | 2020-11-20 | 2023-01-31 | 西安乐析医疗科技有限公司 | Method for determining content of impurities in peritoneal dialysis solution |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1792346C3 (en) * | 1968-08-22 | 1980-10-23 | Rotta Research Laboratorium S.P.A., San Fruttuoso Di Monza, Mailand (Italien) | Pharmaceutical preparation for the treatment of degenerative joint diseases |
| SE9103395D0 (en) * | 1991-11-18 | 1991-11-18 | Gambro Ab | SYSTEM USING ENSTERIL MEDICAL SOLUTION CONTAINING GLUCOSE OR GLUCOSE-LIKE SUBSTANCES AND A SOLUTION INTENDED FOR THIS SYSTEM |
| CA2155910C (en) | 1995-08-11 | 1999-12-14 | George Wu | Biocompatible aqueous solution for use in continuous ambulatory peritoneal dialysis |
| SE512349C2 (en) * | 1997-11-28 | 2000-03-06 | Gambro Lundia Ab | Multi-chamber container for medical solution, procedure for preparation of medical solution for peritoneal dialysis and use of such container for preparation of medical solution |
| DE60321213D1 (en) * | 2002-12-10 | 2008-07-03 | Gambro Lundia Ab | METHOD FOR PREPARING A MEDICAL SOLUTION FOR PREPARING A MEDICAMENT FOR DIEPERITONEAL DIALYSIS |
-
2003
- 2003-12-10 WO PCT/SE2003/001920 patent/WO2004052268A1/en active Application Filing
- 2003-12-10 JP JP2004558966A patent/JP4361492B2/en not_active Expired - Lifetime
- 2003-12-10 CA CA2507561A patent/CA2507561C/en not_active Expired - Lifetime
- 2003-12-10 AT AT03812743T patent/ATE403412T1/en not_active IP Right Cessation
- 2003-12-10 KR KR1020057010472A patent/KR101142863B1/en active IP Right Grant
- 2003-12-10 DE DE60322738T patent/DE60322738D1/en not_active Expired - Lifetime
- 2003-12-10 AU AU2003302889A patent/AU2003302889B2/en not_active Expired
- 2003-12-10 US US10/538,777 patent/US7790102B2/en active Active
- 2003-12-10 EP EP03812743A patent/EP1569596B1/en not_active Expired - Lifetime
- 2003-12-10 ES ES03812743T patent/ES2311754T3/en not_active Expired - Lifetime
-
2011
- 2011-08-24 US US13/216,541 patent/US20120083468A1/en not_active Abandoned
-
2015
- 2015-03-24 US US14/666,451 patent/US9918999B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050085489A (en) | 2005-08-29 |
| ES2311754T3 (en) | 2009-02-16 |
| US20120083468A1 (en) | 2012-04-05 |
| EP1569596B1 (en) | 2008-08-06 |
| JP2006509555A (en) | 2006-03-23 |
| CA2507561C (en) | 2011-09-20 |
| US20160038522A1 (en) | 2016-02-11 |
| KR101142863B1 (en) | 2012-05-21 |
| US7790102B2 (en) | 2010-09-07 |
| JP4361492B2 (en) | 2009-11-11 |
| ATE403412T1 (en) | 2008-08-15 |
| US20060045794A1 (en) | 2006-03-02 |
| AU2003302889B2 (en) | 2008-09-11 |
| WO2004052268A1 (en) | 2004-06-24 |
| DE60322738D1 (en) | 2008-09-18 |
| EP1569596A1 (en) | 2005-09-07 |
| US9918999B2 (en) | 2018-03-20 |
| AU2003302889A1 (en) | 2004-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20231211 |