CA2497544C - Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors - Google Patents

Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors Download PDF

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Publication number
CA2497544C
CA2497544C CA2497544A CA2497544A CA2497544C CA 2497544 C CA2497544 C CA 2497544C CA 2497544 A CA2497544 A CA 2497544A CA 2497544 A CA2497544 A CA 2497544A CA 2497544 C CA2497544 C CA 2497544C
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Prior art keywords
compound
group
pharmaceutically acceptable
aryl
alkyl
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Expired - Fee Related
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CA2497544A
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English (en)
French (fr)
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CA2497544A1 (en
Inventor
Timothy J. Guzi
Kamil Paruch
Michael P. Dwyer
Ronald J. Doll
Viyyoor Moopil Girijavallabhan
Carmen S. Alvarez
Tin-Yau Chan
Chad Knutson
Vincent Madison
Thierry O. Fischmann
Lawrence W. Dillard
Vinh D. Tran
Zhen Min He
Ray Anthony James
Haengsoon Park
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P35/00—Antineoplastic agents
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    • A61P35/00—Antineoplastic agents
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  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
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  • Cardiology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
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CA2497544A 2002-09-04 2003-09-03 Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors Expired - Fee Related CA2497544C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40802902P 2002-09-04 2002-09-04
US60/408,029 2002-09-04
PCT/US2003/027491 WO2004026229A2 (en) 2002-09-04 2003-09-03 Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors

Publications (2)

Publication Number Publication Date
CA2497544A1 CA2497544A1 (en) 2004-04-01
CA2497544C true CA2497544C (en) 2010-11-02

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CA2497544A Expired - Fee Related CA2497544C (en) 2002-09-04 2003-09-03 Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors

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US (2) US7067661B2 (US07544672-20090609-C00177.png)
EP (1) EP1534712B1 (US07544672-20090609-C00177.png)
JP (2) JP4790265B2 (US07544672-20090609-C00177.png)
KR (1) KR20050033659A (US07544672-20090609-C00177.png)
CN (1) CN1701073B (US07544672-20090609-C00177.png)
AR (1) AR041133A1 (US07544672-20090609-C00177.png)
AT (1) ATE362474T1 (US07544672-20090609-C00177.png)
AU (1) AU2003298571B2 (US07544672-20090609-C00177.png)
CA (1) CA2497544C (US07544672-20090609-C00177.png)
DE (1) DE60313872T2 (US07544672-20090609-C00177.png)
ES (1) ES2283868T3 (US07544672-20090609-C00177.png)
HK (1) HK1071572A1 (US07544672-20090609-C00177.png)
MX (1) MXPA05002572A (US07544672-20090609-C00177.png)
MY (2) MY145332A (US07544672-20090609-C00177.png)
NZ (1) NZ539161A (US07544672-20090609-C00177.png)
PE (1) PE20041000A1 (US07544672-20090609-C00177.png)
TW (1) TWI329645B (US07544672-20090609-C00177.png)
WO (1) WO2004026229A2 (US07544672-20090609-C00177.png)
ZA (1) ZA200501846B (US07544672-20090609-C00177.png)

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