CA2488850A1 - Galectine-3, tronquee au niveau de son extremite n-terminale, a liberation prolongee et anticorps aux ligands glucidiques de la galectine -3 a utiliser dans le traitement ducancer - Google Patents

Galectine-3, tronquee au niveau de son extremite n-terminale, a liberation prolongee et anticorps aux ligands glucidiques de la galectine -3 a utiliser dans le traitement ducancer Download PDF

Info

Publication number
CA2488850A1
CA2488850A1 CA002488850A CA2488850A CA2488850A1 CA 2488850 A1 CA2488850 A1 CA 2488850A1 CA 002488850 A CA002488850 A CA 002488850A CA 2488850 A CA2488850 A CA 2488850A CA 2488850 A1 CA2488850 A1 CA 2488850A1
Authority
CA
Canada
Prior art keywords
galectin
terminally truncated
truncated galectin
protein
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002488850A
Other languages
English (en)
Inventor
Gary A. Jarvis
Constance M. John
Hakon Leffler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
MANDALMED Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MANDALMED Inc filed Critical MANDALMED Inc
Publication of CA2488850A1 publication Critical patent/CA2488850A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne une composition présentant une quantité efficace de galectine-3, tronquée au niveau de son extrémité <I>N</I>-terminale, dans un excipient pharmaceutiquement acceptable ou une quantité efficace d'une séquence d'acide nucléique codant pour la galectine-3, tronquée au niveau de son extrémité <I>N</I>-terminale, dans un excipient pharmaceutiquement acceptable. La présente invention concerne également une méthode de traitement du cancer, consistant à administrer à un patient nécessitant un tel traitement une quantité efficace de galectine-3, tronquée au niveau de son extrémité <I>N</I>-terminale, dans un excipient pharmaceutiquement acceptable ou une quantité efficace d'une séquence d'acide nucléique codant pour la galectine-3, tronquée au niveau de son extrémité <I>N</I>-terminale, dans un excipient pharmaceutiquement acceptable. Cette invention concerne en outre un anticorps, se liant spécifiquement à des ligands glucidiques de la galectine-3, un traitement contre le cancer renfermant une quantité efficace de galectine-3, tronquée au niveau de son extrémité <I>N</I>-terminale, dans un excipient pharmaceutiquement acceptable ou une quantité efficace d'une séquence d'acide nucléique codant pour la galectine-3, tronquée au niveau de son extrémité <I>N</I>-terminale, dans un excipient pharmaceutiquement acceptable.
CA002488850A 2001-06-08 2002-06-10 Galectine-3, tronquee au niveau de son extremite n-terminale, a liberation prolongee et anticorps aux ligands glucidiques de la galectine -3 a utiliser dans le traitement ducancer Abandoned CA2488850A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29697001P 2001-06-08 2001-06-08
US60/296,970 2001-06-08
PCT/US2002/018478 WO2002100343A2 (fr) 2001-06-08 2002-06-10 Galectine-3, tronquee au niveau de son extremite n-terminale, a liberation prolongee et anticorps aux ligands glucidiques de la galectine-3 a utiliser dans le traitement du cancer

Publications (1)

Publication Number Publication Date
CA2488850A1 true CA2488850A1 (fr) 2002-12-19

Family

ID=23144316

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002488850A Abandoned CA2488850A1 (fr) 2001-06-08 2002-06-10 Galectine-3, tronquee au niveau de son extremite n-terminale, a liberation prolongee et anticorps aux ligands glucidiques de la galectine -3 a utiliser dans le traitement ducancer

Country Status (4)

Country Link
EP (1) EP1534317A4 (fr)
AU (1) AU2002322066A1 (fr)
CA (1) CA2488850A1 (fr)
WO (1) WO2002100343A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
JP2006522163A (ja) 2003-04-07 2006-09-28 グリコジェネシス， インク． ガレクチンアンタゴニストの組成物と使用
JP5903270B2 (ja) * 2008-10-29 2016-04-13 ビージー メディシン， インコーポレイテッド ガレクチン−３の免疫アッセイ
CN102488619B (zh) 2011-12-05 2014-08-06 上海交通大学 连续生产艾塞那肽微球的装置及控制微球释放速度的方法
WO2014100703A2 (fr) 2012-12-20 2014-06-26 Henry Ford Health System Méthode de traitement de l'insuffisance cardiaque diastolique par inhibition de la galectine-3
WO2015085207A1 (fr) * 2013-12-05 2015-06-11 Texas Tech University System Galectine-3 pour le traitement du cancer des ovaires
EP3102247A4 (fr) * 2014-02-03 2017-09-13 Texas Tech University System Inhibiteur de galectine 3 (gal-3) associé à des effets anti-myélome et anti-tumeurs solides additifs, à une ostéoclastogenèse et une protection d'organes diminuées lorsqu'il est utilisé en combinaison avec des inhibiteurs du protéasome
AU2015311857A1 (en) 2014-09-03 2017-03-23 Genesegues, Inc. Therapeutic nanoparticles and related compositions, methods and systems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62502939A (ja) * 1985-04-23 1987-11-26 メディカル・バイオロジ−・インスティチュ−ト 分子クロ−ニングによるＩｇＥ結合蛋白質の同定
US20020019009A1 (en) * 1999-12-09 2002-02-14 Roggen Erwin Ludo High throughput screening (HTS) assays
AU2001243622A1 (en) * 2000-03-13 2001-09-24 La Jolla Institute For Allergy And Immunology Monocyte chemoattractant activity of galectin-3

Also Published As

Publication number Publication date
EP1534317A2 (fr) 2005-06-01
WO2002100343A3 (fr) 2005-03-17
AU2002322066A1 (en) 2002-12-23
WO2002100343A2 (fr) 2002-12-19
EP1534317A4 (fr) 2005-10-12

Similar Documents

Publication Publication Date Title
US7820797B2 (en) Glycolipopeptide antibodies
JP6889199B2 (ja) ｐ９７のフラグメントおよびその使用
US9211345B2 (en) Glycopeptide and uses thereof
JP6676589B2 (ja) 薬物動態特性の改善されたコンプスタチンアナログ
US6770622B2 (en) N-terminally truncated galectin-3 for use in treating cancer
US20150299290A1 (en) Immunogenic vaccine
JP4187277B2 (ja) グリコシル化し得る抗原結合単鎖タンパク質、それらの生成および使用
US9783578B2 (en) Immunosuppression modulating compounds
CN103096915A (zh) 免疫抑制调节化合物
CZ304876B6 (cs) Fragment Aβ vázaný k nosičovému peptidu, farmaceutický prostředek pro prevenci nebo léčení onemocnění spojeného s amyloidními deposity Aβ v mozku pacienta jej obsahující a jeho použití
US6238667B1 (en) Method of affinity cross-linking biologically active immunogenic peptides to antibodies
US20060241022A1 (en) Selectin targeting bioconjugates
EA007218B1 (ru) Предотвращение и лечение амилоидогенного заболевания
US20050181987A1 (en) Compositions and methods for treatment of cancer
US6245334B1 (en) Method of causing selective immunosuppression using HL-60-related lectins
JP2008515975A (ja) 抗癌化合物および方法
JP2002517999A (ja) 抗血管形成タンパク質およびその使用方法
CA2488850A1 (fr) Galectine-3, tronquee au niveau de son extremite n-terminale, a liberation prolongee et anticorps aux ligands glucidiques de la galectine -3 a utiliser dans le traitement ducancer
US20050032673A1 (en) Sustained release N-terminally truncated galectin-3 and antibodies to galectin-3 carbohydrate ligands for use in treating disease
WO1994011497A1 (fr) Procede d&#39;obtention d&#39;une immunosuppression selective a l&#39;aide de lectines apparentees a hl-60
WO1996011700A1 (fr) Utilisation de substances activatrices de la phospholipase a2 pour reduire les neoplasmes chez les mammiferes
EP1627885B1 (fr) Polypeptide favorisant l&#39;absorption par le systeme digestif
CN112292393A (zh) 双功能血脑疗法
CN106215179A (zh) 免疫原性疫苗
US6406679B1 (en) Use of HL-60-related lectins in drug delivery and detection of lectin-expressing cells

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead