CA2477835C - Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring - Google Patents

Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring Download PDF

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Publication number
CA2477835C
CA2477835C CA2477835A CA2477835A CA2477835C CA 2477835 C CA2477835 C CA 2477835C CA 2477835 A CA2477835 A CA 2477835A CA 2477835 A CA2477835 A CA 2477835A CA 2477835 C CA2477835 C CA 2477835C
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CA
Canada
Prior art keywords
laser
ions
pulse rate
analyte
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2477835A
Other languages
English (en)
French (fr)
Other versions
CA2477835A1 (en
Inventor
Thomas R. Covey
John J. Corr
William H. Fisher
Tung Chau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DH Technologies Development Pte Ltd
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DH Technologies Development Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DH Technologies Development Pte Ltd filed Critical DH Technologies Development Pte Ltd
Publication of CA2477835A1 publication Critical patent/CA2477835A1/en
Application granted granted Critical
Publication of CA2477835C publication Critical patent/CA2477835C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
    • H01J49/4215—Quadrupole mass filters
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H01J49/0481—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for collisional cooling
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2477835A 2002-03-28 2003-03-27 Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring Expired - Fee Related CA2477835C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36819502P 2002-03-28 2002-03-28
US60/368,195 2002-03-28
PCT/IB2003/001915 WO2003083448A2 (en) 2002-03-28 2003-03-27 Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring

Publications (2)

Publication Number Publication Date
CA2477835A1 CA2477835A1 (en) 2003-10-09
CA2477835C true CA2477835C (en) 2011-11-22

Family

ID=28675456

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2477835A Expired - Fee Related CA2477835C (en) 2002-03-28 2003-03-27 Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring

Country Status (6)

Country Link
US (2) US20060151691A1 (https=)
EP (1) EP1488446A2 (https=)
JP (2) JP2005521874A (https=)
AU (1) AU2003230093A1 (https=)
CA (1) CA2477835C (https=)
WO (1) WO2003083448A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405397B2 (en) * 2002-03-28 2008-07-29 Mds Sciex Inc. Laser desorption ion source with ion guide coupling for ion mass spectroscopy
US7388194B2 (en) * 2002-03-28 2008-06-17 Mds Sciex Inc. Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
CA2567459A1 (en) * 2004-05-19 2005-12-01 Applera Corporation Expression quantification using mass spectrometry
US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
US20060183238A1 (en) * 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
US20070037286A1 (en) * 2005-02-09 2007-02-15 Subhasish Purkayastha Thyroxine-containing compound analysis methods
JP4830450B2 (ja) * 2005-11-02 2011-12-07 株式会社島津製作所 質量分析装置
US7423260B2 (en) * 2005-11-04 2008-09-09 Agilent Technologies, Inc. Apparatus for combined laser focusing and spot imaging for MALDI
WO2007065266A1 (en) * 2005-12-07 2007-06-14 Mds Inc., Doing Business Through Its Mds Sciex Division Automated analysis of complex matrices using mass spectrometer
US7750312B2 (en) * 2006-03-07 2010-07-06 Dh Technologies Development Pte. Ltd. Method and apparatus for generating ions for mass analysis
MX2008013394A (es) * 2006-04-21 2008-10-31 Wyeth Corp Metodos para tamizado de alta emision de lineas celulares.
JP2009544122A (ja) * 2006-07-19 2009-12-10 エムディーエス アナリティカル テクノロジーズ， ア ビジネス ユニット オブ エムディーエス インコーポレイテッド， ドゥーイング ビジネス スルー イッツ サイエックス ディビジョン 共鳴励起イオン移動を提供するために質量分析計を動作する方法
US8173956B2 (en) * 2006-07-19 2012-05-08 Dh Technologies Pte. Ltd. Dynamic pixel scanning for use with MALDI-MS
JP5227556B2 (ja) * 2007-09-06 2013-07-03 株式会社日立製作所 分析装置
CA2690487A1 (en) 2009-01-21 2010-07-21 Schlumberger Canada Limited Downhole mass spectrometry
JP5454484B2 (ja) * 2011-01-31 2014-03-26 株式会社島津製作所 三連四重極型質量分析装置
AU2013207952B2 (en) 2012-01-10 2017-03-09 Expression Pathology, Inc. SRM/MRM assay for the insulin receptor protein
CN103227096B (zh) * 2012-01-30 2016-06-22 华中师范大学 一种激光诱导电子捕获质谱解析离解脂质分子方法
CN104813162B (zh) * 2012-11-22 2017-03-08 株式会社岛津制作所 串联四极型质量分析装置
US8624181B1 (en) * 2013-03-15 2014-01-07 Agilent Technologies, Inc. Controlling ion flux into time-of-flight mass spectrometers
US9373486B2 (en) * 2013-05-21 2016-06-21 Dh Technologies Development Pte. Ltd. Species detection using mass spectrometry
US20180033598A1 (en) * 2015-02-06 2018-02-01 Dh Technologies Development Pte. Ltd. Lipid Screening Platform Allowing a Complete Solution for Lipidomics Research
KR102618817B1 (ko) 2020-09-22 2023-12-27 세메스 주식회사 제조 공장에서 반송 차량을 제어하는 방법, 차량 제어 장치, 및 물품 반송 시스템

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331702B1 (en) * 1999-01-25 2001-12-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
CA2227806C (en) * 1998-01-23 2006-07-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US6348688B1 (en) * 1998-02-06 2002-02-19 Perseptive Biosystems Tandem time-of-flight mass spectrometer with delayed extraction and method for use
US6507019B2 (en) * 1999-05-21 2003-01-14 Mds Inc. MS/MS scan methods for a quadrupole/time of flight tandem mass spectrometer
ATE480005T1 (de) * 1999-06-11 2010-09-15 Applied Biosystems Llc Maldi ionenquelle mit gasimpuls, vorrichtung und verfahren zur ermittlung des molekulargewichtes labilen moleküle
DE10027794A1 (de) * 2000-06-07 2001-12-13 Basf Ag Verfahren zur Analyse Enzym-katalysierter Umsetzungen mit MALDI-TOF-Massenspektrometrie
US6747274B2 (en) * 2001-07-31 2004-06-08 Agilent Technologies, Inc. High throughput mass spectrometer with laser desorption ionization ion source

Also Published As

Publication number Publication date
US20030213901A1 (en) 2003-11-20
US6930305B2 (en) 2005-08-16
AU2003230093A8 (en) 2003-10-13
JP2005521874A (ja) 2005-07-21
JP2009282038A (ja) 2009-12-03
WO2003083448A3 (en) 2003-12-31
AU2003230093A1 (en) 2003-10-13
US20060151691A1 (en) 2006-07-13
CA2477835A1 (en) 2003-10-09
EP1488446A2 (en) 2004-12-22
WO2003083448A2 (en) 2003-10-09

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