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Topical anti-cancer compositions and methods of use thereof

Info

Publication number
CA2423524A1
CA2423524A1 CA 2423524 CA2423524A CA2423524A1 CA 2423524 A1 CA2423524 A1 CA 2423524A1 CA 2423524 CA2423524 CA 2423524 CA 2423524 A CA2423524 A CA 2423524A CA 2423524 A1 CA2423524 A1 CA 2423524A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
composition
method
anti
agents
comprises
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2423524
Other languages
French (fr)
Other versions
CA2423524C (en )
Inventor
Stanley S. Shapiro
Miri Seiberg
Christine Paine
Allan H. Conney
Mou-Tuan Huang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Johnson and Johnson Consumer Companies Inc
Original Assignee
Johnson & Johnson Consumer Companies, Inc.
Stanley S. Shapiro
Miri Seiberg
Christine Paine
Allan H. Conney
Mou-Tuan Huang
Rutgers, The State University Of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/671Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/51Chelating agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/522Antioxidants; Radical scavengers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/886Inflammation, skin
    • Y10S514/887Topical treatment

Abstract

Described are skin-care compositions containing non denatured soy products and optionally other anti-cancer or anti-aging agents. The compositions can be applied topically to reduce the risk of UV-induced cutaneous tumors.

Claims

further comprises at least one sunscreen.

10. The method of claim 1, wherein said composition further comprises from about 1 to about 99% soy bean milk, from about 0.1 to about 20% emulsifier, and a preservative in an effective amount.

11. The method of claim 10 wherein said composition further comprises an anti-oxidant.

12. The method of claim 10, wherein said composition further composition further comprises an anti cancer agent.

13. The method claim 10, wherein said composition further comprises at least one agent selected from the group consisting of anti-oxidants, sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.

14. The method of claim 1, wherein said composition further comprises from about 0.1 to about 20% soy bean powder or soy milk powder, from about 0.1 to about 20%
emulsifier, and a preservative in an effective amount.

15. The method of claim 14, wherein said composition further comprises an anti-cancer agent.

16. The method of claim 14, wherein said composition further comprises an anti-oxidant.

17. The method of claim 14, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants, sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.

18. A method for preventing and reducing the risk of skin cancer comprising topical application of at least one composition containing a non-denatured, soy product in an amount of from about 0.01-99% by weight in a carrier.

19. The method of claim 18, wherein said composition is applied at least once daily on a continuous basis.

20. The method of claim 18, wherein said composition is applied at least twice daily for at least eight weeks and at least once daily on a continuous basis thereafter.

21. The method of claim 18, wherein said soy product composition comprises 0.05-80% by weight and is applied for at least about four to about ten weeks followed by topical application of a composition comprising 0.01-20%
by weight of said soy product on a daily basis thereafter.

22. The method of claim 18, wherein said composition further comprises a cosmetically acceptable vehicle.

23. The method of claim 18, wherein said composition further comprises at least one anti-inflammatory agent.

24. The method of claim 18, wherein said composition further comprises at least one anti-cancer agent.

25. The method of claim 18, wherein said composition further comprises at least one anti-oxidant.

26. The method of claim 18, wherein said composition further comprises at least one sunscreen.

27. The method of claim 18, wherein said composition further comprises from about 1 to about 99% soy bean milk, from about 0.1 to about 20% emulsifier, and a preservative in an effective amount.

28. The method of claim 27, wherein said composition further comprises an anti-oxidant.

29. The method of claim 27, wherein said compositions further comprises an anti-cancer agent.

30. The method of claim 27, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants, sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.

31. The method of claim 18, wherein said composition further comprises from about 0.1 to about 20% soy bean powder or soy milk powder, from about 0.1 to about 20%
emulsifier, and a preservative in an effective amount.

32. The method of claim 31, wherein said composition further comprisese an anti-oxidant.

33. The method of claim 31, wherein said composition further comprises an anti-cancer agent.

34. The method of claim 31, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants, sunscreens,.
moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.

35. A method of inhibiting the progression of a cutaneous tumor comprising topical application of at least one composition containing a non-denatured, soybean trypsin inhibitor in an amount of from about 0.01-99% by weight.

36. The method of claim 35, wherein said composition is applied at least once daily on a continuous basis.

37. The method of claim 35, wherein said composition is applied at least twice daily for at least eight weeks and at least once daily on a continuous basis thereafter.

38. The method of claim 35, wherein said composition comprises 0.1-10% by weight of said non denatured soybean trypsin inhibitor and is applied for at least about four to about ten weeks followed by topical application of a composition comprising a non-denatured soybean trypsin inhibitor at 0.01-10% by weight of said soybean trypsin inhibitor on a daily basis thereafter.

39. The method of claim 35, wherein said non-denatured soybean trypsin inhibitor is contained within liposomes suspended in a cosmetically acceptable carrier.

40. The method. of claim 38, wherein said non-denatured soybean trypsin inhibitor is contained within in liposomes suspended in a cosmetically acceptable carrier.

41. The method of claim 35, wherein said composition further comprises a cosmetically acceptable vehicle.

42. The method of claim 35, wherein said composition further comprises at least one anti-inflammatory agent.

43. The method of claim 35 wherein said composition further comprises at least one anti-cancer agent.

44. The method of claim 35, wherein said composition further comprises at least one anti-oxidant.

45. The method of claim 35, wherein said composition further comprises at least one sunscreen.

46. The method of claim 35, wherein said composition further comprises from about 0.01 to about 99% soy bean trypsin inhibitor, from about 0.1 to about 20%
emulsifier, and a preservative in an effective amount.

47. The method of claim 46, wherein said composition further comprises an anti-oxidant.

48. The method of claim 46, wherein said composition further comprises an anti-cancer agent.

49. The method of claim 46, wherein said composition further comprises at least one compound selected from the group consisting of anti-oxidants; sunscreens, moisturizers, bleaching agents, depigmentation agents, darkening agents, surfactants, foaming agents, conditioners, humectants, fragrances, anti-aging agents, anti-inflammatory agents, and anti-cancer agents.
CA 2423524 2000-10-27 2003-03-25 Topical anti-cancer compositions and methods of use thereof Expired - Fee Related CA2423524C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/108,248 2002-03-27
US10108248 US7309688B2 (en) 2000-10-27 2002-03-27 Topical anti-cancer compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
CA2423524A1 true true CA2423524A1 (en) 2003-09-27
CA2423524C CA2423524C (en) 2011-05-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2423524 Expired - Fee Related CA2423524C (en) 2000-10-27 2003-03-25 Topical anti-cancer compositions and methods of use thereof

Country Status (4)

Country Link
US (3) US7309688B2 (en)
CA (1) CA2423524C (en)
DE (3) DE03251884T1 (en)
EP (1) EP1348441B1 (en)

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