CA2408616C - Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation - Google Patents
Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation Download PDFInfo
- Publication number
- CA2408616C CA2408616C CA002408616A CA2408616A CA2408616C CA 2408616 C CA2408616 C CA 2408616C CA 002408616 A CA002408616 A CA 002408616A CA 2408616 A CA2408616 A CA 2408616A CA 2408616 C CA2408616 C CA 2408616C
- Authority
- CA
- Canada
- Prior art keywords
- embryo
- embryos
- fluid
- channel
- fluid channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0636—Focussing flows, e.g. to laminate flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Fluid Mechanics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/570,483 US6695765B1 (en) | 1999-04-08 | 2000-05-12 | Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation |
US09/570,483 | 2000-05-12 | ||
PCT/US2001/014822 WO2001088087A2 (en) | 2000-05-12 | 2001-05-08 | Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2408616A1 CA2408616A1 (en) | 2001-11-22 |
CA2408616C true CA2408616C (en) | 2007-10-02 |
Family
ID=24279818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002408616A Expired - Fee Related CA2408616C (en) | 2000-05-12 | 2001-05-08 | Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1280465A4 (xx) |
JP (1) | JP2003533221A (xx) |
KR (1) | KR20030009482A (xx) |
CN (1) | CN1441652A (xx) |
AU (2) | AU2001259635B2 (xx) |
BR (1) | BR0110768A (xx) |
CA (1) | CA2408616C (xx) |
IL (1) | IL152650A (xx) |
MX (1) | MXPA02011150A (xx) |
RU (1) | RU2002130577A (xx) |
WO (1) | WO2001088087A2 (xx) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003224817B2 (en) * | 2002-04-01 | 2008-11-06 | Fluidigm Corporation | Microfluidic particle-analysis systems |
JP2007501633A (ja) * | 2003-05-06 | 2007-02-01 | ベル ブルック ラブズ リミテッド ライアビリティ カンパニー | 微小規模の流体ハンドリングシステムにおける三次元細胞培養 |
JP2006527028A (ja) * | 2003-06-06 | 2006-11-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 微細流体精子の抽出と授精の一体型装置 |
GB0321158D0 (en) * | 2003-09-10 | 2003-10-08 | Central Research Lab Ltd | Apparatus and method for handling cells,embryos or oocytes |
EP1609850A1 (en) | 2004-06-24 | 2005-12-28 | Biovir v/Jacob Mollenbach | Culture dish for culturing biological cells |
JP2006055072A (ja) * | 2004-08-20 | 2006-03-02 | Fujitsu Ltd | 搬送制御装置及び方法 |
KR100947398B1 (ko) * | 2005-03-18 | 2010-03-12 | 가부시키가이샤 이씨아이 | 세포 관찰 지원 기구, 및 이를 이용한 세포 관찰 방법 |
GB0508983D0 (en) | 2005-05-03 | 2005-06-08 | Oxford Gene Tech Ip Ltd | Cell analyser |
US20070084706A1 (en) * | 2005-10-18 | 2007-04-19 | Shuichi Takayama | Microfluidic cell culture device and method for using same |
US20070090166A1 (en) * | 2005-10-18 | 2007-04-26 | Shuichi Takayama | Microfluidic cell culture device |
US20110104730A1 (en) * | 2007-08-24 | 2011-05-05 | Smart Biosystems Aps | Mesoscale bioreactor platform for perfusion |
TW200920841A (en) * | 2007-09-25 | 2009-05-16 | Cytyc Corp | Microfluidic apparatus for manipulating imaging and analyzing cells of a cytological specimen |
KR100891487B1 (ko) * | 2007-11-01 | 2009-04-01 | 한국과학기술원 | 미세유체제어기술 기반으로 한 난모세포 또는 난자의 핵제거 시스템 |
WO2009079474A1 (en) * | 2007-12-14 | 2009-06-25 | The University Of North Carolina At Chapel Hill | Methods, systems, and computer readable media for facilitating automation of blastocyst microinjection |
CN102112593A (zh) * | 2008-08-01 | 2011-06-29 | 智能生物系统公司 | 生物反应器平台的腔室 |
GB2464300A (en) * | 2008-10-10 | 2010-04-14 | Univ Dublin City | Microfluidic multiplexed cellular and molecular analysis device and method |
GB0821636D0 (en) | 2008-11-26 | 2008-12-31 | Ucl Business Plc | Device |
WO2010141320A1 (en) * | 2009-06-01 | 2010-12-09 | Mariposa Biotechnology, Inc. | Device for removing cumulus from oocytes |
US8621943B2 (en) * | 2009-09-30 | 2014-01-07 | Weyerhaeuser Nr Company | Method of singulating embryos |
EP2316565A1 (en) * | 2009-10-26 | 2011-05-04 | Fei Company | A micro-reactor for observing particles in a fluid |
CN101947124B (zh) | 2010-06-25 | 2012-07-04 | 博奥生物有限公司 | 一种集成式微流控芯片装置及其使用方法 |
US9482659B2 (en) * | 2010-09-27 | 2016-11-01 | Progyny, Inc. | Apparatus, method, and system for the automated imaging and evaluation of embryos, oocytes and stem cells |
CN104254596B (zh) * | 2012-04-16 | 2016-09-07 | 康奈尔大学 | 自动化胞浆内精子注射辅助授精系统 |
US10371622B2 (en) | 2013-03-14 | 2019-08-06 | Inguran, Llc | Device for high throughput sperm sorting |
AU2015203738B2 (en) * | 2013-03-14 | 2017-10-05 | Inguran, Llc | Apparatus and methods for high throughput sperm sorting |
AU2013202632B2 (en) * | 2013-03-14 | 2015-04-16 | Inguran, Llc | Apparatus and methods for high throughput sperm sorting |
US10662408B2 (en) | 2013-03-14 | 2020-05-26 | Inguran, Llc | Methods for high throughput sperm sorting |
US9757726B2 (en) | 2013-03-14 | 2017-09-12 | Inguran, Llc | System for high throughput sperm sorting |
GB201512600D0 (en) * | 2015-07-17 | 2015-08-26 | Koniku Ltd | Cell culture, transport and investigation |
WO2018208332A2 (en) | 2017-02-17 | 2018-11-15 | Koniku, Inc. | Systems for detection |
KR101959208B1 (ko) * | 2017-05-24 | 2019-03-19 | 한국기계연구원 | 액적기반 바이오칩, 이를 이용한 종양 생산방법, 및 이를 통해 생산된 종양의 전이성 판단방법 |
US20210161635A1 (en) * | 2018-04-04 | 2021-06-03 | The General Hospital Corporation | Microfluidic Systems and Methods to Denude Mammalian Oocytes |
WO2020005802A1 (en) * | 2018-06-24 | 2020-01-02 | University Of Oregon | Microinjection chip, device, system and uses thereof for unicellular or multicellular organisms |
FR3084121B1 (fr) * | 2018-07-17 | 2021-01-15 | Skf Aerospace France | Assemblage mecanique et dispositif mecanique |
CN111073817A (zh) * | 2018-10-22 | 2020-04-28 | 曾繁根 | 用于精子分选、卵子培育、体外受精的整合式晶片及方法 |
CN111378556A (zh) * | 2018-12-29 | 2020-07-07 | 青岛华大智造普惠科技有限公司 | 微流控芯片及其制备方法、单细胞微液滴的制备方法 |
US20220218896A1 (en) * | 2019-05-24 | 2022-07-14 | University Of Houston System | Apparatus and methods for medical applications of laser driven microfluid pumps |
KR102267433B1 (ko) * | 2019-07-29 | 2021-06-21 | 연세대학교 산학협력단 | 세포배양 플레이트 |
KR102243812B1 (ko) * | 2019-08-13 | 2021-04-22 | 경희대학교 산학협력단 | 체외수정 자동화 장치 및 그것의 동작 방법 |
DE102020214862B4 (de) * | 2020-11-26 | 2022-08-04 | Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Körperschaft des öffentlichen Rechts | System und Vorrichtung zur Charakterisierung von Veränderungen des Reifungsvorgangs einer Eizelle, sowie deren Verwendung |
CN117660183B (zh) * | 2024-01-31 | 2024-04-16 | 山东大学 | 胚胎微流控动态培养皿及其培养方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993022053A1 (en) * | 1992-05-01 | 1993-11-11 | Trustees Of The University Of Pennsylvania | Microfabricated detection structures |
WO1999061888A2 (en) * | 1998-05-22 | 1999-12-02 | California Institute Of Technology | Microfabricated cell sorter |
US6193647B1 (en) * | 1999-04-08 | 2001-02-27 | The Board Of Trustees Of The University Of Illinois | Microfluidic embryo and/or oocyte handling device and method |
-
2001
- 2001-05-08 KR KR1020027015046A patent/KR20030009482A/ko active IP Right Grant
- 2001-05-08 CN CN01812654A patent/CN1441652A/zh active Pending
- 2001-05-08 AU AU2001259635A patent/AU2001259635B2/en not_active Ceased
- 2001-05-08 CA CA002408616A patent/CA2408616C/en not_active Expired - Fee Related
- 2001-05-08 EP EP01933192A patent/EP1280465A4/en not_active Withdrawn
- 2001-05-08 RU RU2002130577/15A patent/RU2002130577A/ru not_active Application Discontinuation
- 2001-05-08 MX MXPA02011150A patent/MXPA02011150A/es not_active Application Discontinuation
- 2001-05-08 AU AU5963501A patent/AU5963501A/xx active Pending
- 2001-05-08 IL IL152650A patent/IL152650A/en not_active IP Right Cessation
- 2001-05-08 BR BR0110768-2A patent/BR0110768A/pt not_active Application Discontinuation
- 2001-05-08 JP JP2001585296A patent/JP2003533221A/ja active Pending
- 2001-05-08 WO PCT/US2001/014822 patent/WO2001088087A2/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
WO2001088087A3 (en) | 2002-03-28 |
AU5963501A (en) | 2001-11-26 |
CA2408616A1 (en) | 2001-11-22 |
BR0110768A (pt) | 2003-03-11 |
IL152650A0 (en) | 2003-06-24 |
EP1280465A2 (en) | 2003-02-05 |
WO2001088087A2 (en) | 2001-11-22 |
MXPA02011150A (es) | 2004-08-19 |
KR20030009482A (ko) | 2003-01-29 |
AU2001259635B2 (en) | 2005-05-19 |
CN1441652A (zh) | 2003-09-10 |
EP1280465A4 (en) | 2004-10-20 |
IL152650A (en) | 2006-12-31 |
JP2003533221A (ja) | 2003-11-11 |
RU2002130577A (ru) | 2004-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20140508 |