New! View global litigation for patent families

CA2378976A1 - Method of controlling body temperature while reducing shivering - Google Patents

Method of controlling body temperature while reducing shivering

Info

Publication number
CA2378976A1
CA2378976A1 CA 2378976 CA2378976A CA2378976A1 CA 2378976 A1 CA2378976 A1 CA 2378976A1 CA 2378976 CA2378976 CA 2378976 CA 2378976 A CA2378976 A CA 2378976A CA 2378976 A1 CA2378976 A1 CA 2378976A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
method
group
receptor
acceptable
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2378976
Other languages
French (fr)
Other versions
CA2378976C (en )
Inventor
Michael W. Dae
Timothy R. Machold
Wade A. Keller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoll Circulation Inc
Original Assignee
Radiant Medical, Inc.
Michael W. Dae
Timothy R. Machold
Wade A. Keller
Zoll Circulation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • A61F7/123Devices for heating or cooling internal body cavities using a flexible balloon containing the thermal element
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017Electrical control of surgical instruments
    • A61B2017/00022Sensing or detecting at the treatment site
    • A61B2017/00084Temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0054Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
    • A61F2007/0056Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F2007/0295Compresses or poultices for effecting heating or cooling for heating or cooling or use at more than one temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • A61F2007/126Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/36General characteristics of the apparatus related to heating or cooling

Abstract

This invention is using a heat exchange device (240) in combination with an anti-shivering mechanism that temporarily reduces shivering for lowering the body temperature of a patient. Various anti-shivering agents are disclosed including dopamine receptor blockers, dopamine receptor agonists, opioid agonist antagonist analgesics, serotonin 5 HT1a agonists, and pharmaceutically acceptable salts of any members of this group.

Claims (47)

1. A method for controlling the temperature of all or a portion of a patient's body to a temperature below its set point temperature, while reducing shivering, comprising the steps of: (a) sensing the temperature of all or a portion of the patient's body; (b) generating a signal based upon said sensed temperature; (c) controlling the temperature of all or a portion of the patient's body based upon said signal;
and (d) administering an anti-shivering mechanism to said patient.
2. The method of Claim 1 wherein said administering an anti-shivering mechanism comprises administering a therapeutically effective amount of an anti-shivering agent to said patient.
3. The method of Claim 1 wherein said administering an anti-shivering mechanism comprises applying warmth to the skin of said patient.
4. The method of Claim 1 wherein said administering an anti-shivering mechanism comprises administering a therapeutically effective amount of an anti-shivering agent to said patient and applying warmth to the skin of said patient.
5. The method of Claim 1 wherein the temperature controlling step (c) includes lowering the temperature below the set point temperature.
6. The method of Claim 1 wherein the temperature controlling step (c) includes raising the temperature from an initial temperature below the set point temperature.
7. The method of Claim 6 wherein the temperature controlling step (c) includes raising the temperature at a predetermined rate.
8. The method of Claim 6 wherein the temperature controlling step (c) includes maintaining the temperature at a stable temperature below the set point temperature.
9. The method of Claim 8 wherein the stable temperature is normothermia.
10. The method of Claim 1 wherein the temperature controlling step (c) includes placing a heat exchange device having a heat exchange region into the vascular system of the patient and controlling the temperature of the heat exchange region for a sufficient time to affect the temperature of all or a portion of the patient's body.
11. The method of Claim 10 wherein the heat exchange device is a catheter and the heat exchange region comprises a balloon on said catheter, the temperature of said balloon being controlled by the circulation of a heat exchange fluid through the interior of said balloon.
12. The method of Claim 2 wherein said anti-shivering agent is selected from the group consisting o~ dopamine receptor blockers; dopamine receptor agonists; .kappa.
opioid receptor agonists; opioid agonist-antagonist analgesics; serotonin 5HT1a receptor agonists; and their pharmaceutically acceptable salts.
13. The method of Claim 12 wherein said anti-shivering agent is selected from the group consisting of buspirone, ipsapirone, 8-hydroxy-2-(di-n-propylamino)tetralin and flesinoxan.
14. The method of Claim 2 wherein said anti-shivering agent is a combination of agents selected from the group consisting of: dopamine receptor blockers; dopamine receptor agonists; .kappa. opioid receptor agonists; opioid agonist-antagonist analgesics; serotonin 5HT1a receptor agonists; and their pharmaceutically acceptable salts.
15. The method of Claim 14 wherein said anti-shivering agent is a combination of a .kappa.
opioid receptor agonist and an agent selected from the group consisting of:
dopamine receptor blockers; dopamine receptor agonists; and their pharmaceutically acceptable salts.
16. The method of Claim 15 wherein said .kappa. opioid receptor agonist is selected from the group consisting of: bremazocine: nalorphine; ketazocine; ethylketazocine;
tifluadom;
trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzene acetamide;
(5a,7a,8B)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro(4,5)-dec-8-yl]benzene acetamide; and their pharmaceutically acceptable salts.
17. The method of Claim 15 wherein said dopamine receptor blocker is selected from the group consisting of phenothiazines and neuroleptic drugs, wherein said phenothiazines have the formula:

wherein R1 is selected from the group consisting of -H, halo, haloalkyl, alkyl and alkoxy; and R2 is selected from the group consisting of halo, an aliphatic group having a terminal tertiary amino nitrogen atom, an aliphatic group having a terminal piperidine substituent, and an aliphatic group having a piperazine substituent, and pharmaceutically acceptable salts thereof, and said neuroleptic drugs are selected from the group consisting of chlorprothixene, thiothixene, pimozide, penfluridol, loxapine, clozapine, sulpiride, haloperidol, disulfiram, and their pharmaceutically acceptable salts; and said dopamine receptor agonist is selected from the group consisting of amantadine, bromocriptine, piribidil, apomorphine, lisuride, pergolide, mesulergine, and their pharmaceutically acceptable salts.
18. The method of Claim 17 wherein said phenothiazine is selected from the group consisting of: chlorpromazine; triflupromazine; thioridazine; mesoridazine;
piperacetazine; fluphenazine; trifluoperazine; acetophenazine; carphenazine;
fluphenazine; perphenazine; prochlorperazine; and their pharmaceutically acceptable salts.
19. The method of Claim 18 wherein said phenothiazine is chlorpromazine, thorazine, or a pharmaceutically acceptable salt thereof.
20. The method of Claim 15 wherein said combination further comprises a mu opioid receptor antagonist or a pharmaceutically acceptable salt thereof.
21. The method of Claim 14 wherein said anti-shivering agent is a combination of a dopamine receptor blocker and an opioid agonist-antagonist analgesic; and their pharmaceutically acceptable salts.
22. The method of Claim 21 wherein said dopamine receptor blocker is a phenothiazine having the formula:

wherein R1 is selected from the group consisting of -H, halo, haloalkyl, alkyl and alkoxy; and R2 is selected from the group consisting of halo, an aliphatic group having a terminal tertiary amino nitrogen atom, an aliphatic group having a terminal piperidine substituent, and an aliphatic group having a piperazine substituent; and pharmaceutically acceptable salts thereof.
23. The method of Claim 22 wherein said phenothiazine is selected from the group consisting of: chlorpromazine; triflupromazine; thioridazine; mesoridazine;
piperacetazine; fluphenazine; trifluoperazine; acetophenazine; carphenazine;
fluphenazine; perphenazine; prochlorperazine; and their pharmaceutically acceptable salts.
24. The method of Claim 23 wherein said phenothiazine is chlorpromazine, thorazine or a pharmaceutically acceptable salt thereof.
25. The method of Claim 21 wherein said opioid agonist-antagonist analgesic is selected from the group consisting of: nalorphine; pentazocine; buprenorphine;
butorphanol;
nalbuphine; cyclazozine; dezozine; and nalorphone; and their pharmaceutically acceptable salts.
26. The method of Claim 25 wherein said opioid agonist-antagonist analgesic is nalbuphine and its pharmaceutically acceptable salts.
27. A method of controlling the temperature of a patient below the set point temperature comprising the steps of: (a) employing internal in vivo core temperature regulation;
and (b) administration of an anti-shivering mechanism.
28. The method of Claim 27 wherein said administering an anti-shivering mechanism comprises administering a therapeutically effective amount of an anti-shivering agent to said patient.
29. The method of Claim 27 wherein said administering an anti-shivering mechanism comprises applying warmth to the skin of said patient.
30. The method of Claim 27 wherein said administering an anti-shivering mechanism comprises administering a therapeutically effective amount of an anti-shivering agent to said patient and applying warmth to the skin of said patient.
31. The method of Claim 27 wherein the step of employing internal in vivo core temperature regulation comprises placing a heat exchange device in the blood vessels of the patient, said heat exchange device having a heat exchange region, said heat exchange region being in contact with the flowing blood of the patient; and controlling the temperature of the heat exchange region for a sufficient time to affect the temperature of the patient.
32. The method of Claim 31 wherein the heat exchange device is a catheter having a shaft for the circulation of heat exchange fluid therein, and said heat exchange region is a balloon; and said step of controlling the temperature of the heat exchange region includes circulation of heat exchange fluid through said shaft and through the interior of said balloon.
33. The method of Claim 28 wherein said anti-shivering agent is selected from the group consisting of: dopamine receptor blockers; dopamine receptor agonists; K
opioid receptor agonists; opioid agonist-antagonist analgesics; serotonin SHTIa receptor agonists; and their pharmaceutically acceptable salts.
34. The method of Claim 33 wherein said anti-shivering agent is selected from the group consisting of buspirone, ipsapirone, 8-hydroxy-2-(di-n-propylamino)tetralin and flesinoxan.
35. The method of Claim 28 wherein said anti-shivering agent is a combination of agents selected from the group consisting of: dopamine receptor blockers; dopamine receptor agonists; K opioid receptor agonists; opioid agonist-antagonist analgesics;
serotonin SHTla receptor agonists; and their pharmaceutically acceptable salts.
36. The method of Claim 35 wherein said anti-shivering agent is a combination of a x opioid receptor agonist and an agent selected from the group consisting of:
dopamine receptor Mockers; dopamine receptor agonists; and their pharmaceutically acceptable salts.
37. The method of Claim 36 wherein said K opioid receptor agonist is selected from the group consisting of: bremazocine: nalorphine; ketazocine; ethylketazocine;
tifluadom;

traps-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzene acetamide;
(5a,7a,8B)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro(4,5)-dec-8-yl]benzene acetamide; and their pharmaceutically acceptable salts.
38. The method of Claim 36 wherein said dopamine receptor blocker is selected from the group consisting of phenothiazines and neuroleptic drugs, wherein said phenothiazines have the formula:

wherein R1 is selected from the group consisting of -H, halo, haloalkyl, alkyl and alkoxy; and R2 is selected from the group consisting of halo, an aliphatic group having a terminal tertiary amino nitrogen atom, an aliphatic group having a terminal piperidine substituent, and an aliphatic group having a piperazine substituent, and pharmaceutically acceptable salts thereof, and said neuroleptic drugs are selected from the group consisting of chlorprothixene, thiothixene, pimozide, penfluridol, loxapine, clozapine, sulphide, haloperidol, disulfiram, and their pharmaceutically acceptable salts; and said dopamine receptor agonist is selected from the group consisting of amantadine, bromocriptine, piribidil, apomorphine, lisuride, pergolide, mesulergine, and their pharmaceutically acceptable salts.
39. The method of Claim 38 wherein said phenothiazine is selected from the group consisting of: chlorpromazine; triflupromazine; thioridazine; mesoridazine;
piperacetazine; fluphenazine; trifluoperazine; acetophenazine; carphenazine;
fluphenazine; perphenazine; prochlorperazine; and their pharmaceutically acceptable salts.
40. The method of Claim 39 wherein said phenothiazine is chlorpromazine, thorazine, or a pharmaceutically acceptable salt thereof.
41. The method of Claim 36 wherein said combination further comprises a mu opioid receptor antagonist or a pharmaceutically acceptable salt thereof.
42. The method of Claim 35 wherein said anti-shivering agent is a combination of a dopamine receptor Mocker and an opioid agonist-antagonist analgesic; and their pharmaceutically acceptable salts.
43 43. The method of Claim 42 wherein said dopamine receptor blocker is a phenothiazine having the formula:

wherein R1 is selected from the group consisting of -H, halo, haloalkyl, alkyl and alkoxy; and R2 is selected from the group consisting of halo, an aliphatic group having a terminal tertiary amino nitrogen atom, an aliphatic group having a terminal piperidine substituent, and an aliphatic group having a piperazine substituent; and pharmaceutically acceptable salts thereof.
44. The method of Claim 43 wherein said phenothiazine is selected from the group consisting of: chlorpromazine; triflupromazine; thioridazine; mesoridazine;
piperacetazine; fluphenazine; trifluoperazine; acetophenazine; carphenazine;
fluphenazine; perphenazine; prochlorperazine; and their pharmaceutically acceptable salts.
45. The method of Claim 44 wherein said phenothiazine is chlorpromazine, thorazine or a pharmaceutically acceptable salt thereof.
46. The method of Claim 42 wherein said opioid agonist-antagonist analgesic is selected from the group consisting of: nalorphine; pentazocine; buprenorphine;
butorphanol;
nalbuphine; cyclazozine; dezozine; and nalorphone; and their pharmaceutically acceptable salts.
47. The method of Claim 46 wherein said opioid agonist-antagonist analgesic is nalbuphine and its pharmaceutically acceptable salts.
CA 2378976 1999-08-11 2000-07-26 Method of controlling body temperature while reducing shivering Active CA2378976C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US09372714 US6231594B1 (en) 1999-08-11 1999-08-11 Method of controlling body temperature while reducing shivering
US09/372,714 1999-08-11
PCT/US2000/020321 WO2001010323A1 (en) 1999-08-11 2000-07-26 Method of controlling body temperature while reducing shivering

Publications (2)

Publication Number Publication Date
CA2378976A1 true true CA2378976A1 (en) 2001-02-15
CA2378976C CA2378976C (en) 2010-02-09

Family

ID=23469323

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2378976 Active CA2378976C (en) 1999-08-11 2000-07-26 Method of controlling body temperature while reducing shivering

Country Status (7)

Country Link
US (4) US6231594B1 (en)
EP (1) EP1212000B1 (en)
JP (1) JP4787919B2 (en)
CA (1) CA2378976C (en)
DE (2) DE60025362T2 (en)
ES (1) ES2256024T3 (en)
WO (1) WO2001010323A1 (en)

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551349B2 (en) 1998-03-24 2003-04-22 Innercool Therapies, Inc. Selective organ cooling apparatus
US6974463B2 (en) 1999-02-09 2005-12-13 Innercool Therapies, Inc. System and method for patient temperature control employing temperature projection algorithm
US6096068A (en) 1998-01-23 2000-08-01 Innercool Therapies, Inc. Selective organ cooling catheter and method of using the same
US6702841B2 (en) 1998-01-23 2004-03-09 Innercool Therapies, Inc. Method of manufacturing a heat transfer element for in vivo cooling
US7288109B2 (en) * 2002-04-04 2007-10-30 Innercool Therapies. Inc. Method of manufacturing a heat transfer element for in vivo cooling without undercuts
US7458984B2 (en) * 1998-01-23 2008-12-02 Innercool Therapies, Inc. System and method for inducing hypothermia with active patient temperature control employing catheter-mounted temperature sensor and temperature projection algorithm
US6830581B2 (en) 1999-02-09 2004-12-14 Innercool Therspies, Inc. Method and device for patient temperature control employing optimized rewarming
US6471717B1 (en) * 1998-03-24 2002-10-29 Innercool Therapies, Inc. Selective organ cooling apparatus and method
WO2003015673A9 (en) * 2001-08-15 2004-05-06 Innercool Therapies Inc System and method for patient temperature control employing temperature projection algorithm
US6251130B1 (en) 1998-03-24 2001-06-26 Innercool Therapies, Inc. Device for applications of selective organ cooling
US7914564B2 (en) * 1999-02-09 2011-03-29 Innercool Therapies, Inc. System and method for patient temperature control employing temperature projection algorithm
US6312452B1 (en) 1998-01-23 2001-11-06 Innercool Therapies, Inc. Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device
US6464716B1 (en) 1998-01-23 2002-10-15 Innercool Therapies, Inc. Selective organ cooling apparatus and method
US6491039B1 (en) 1998-01-23 2002-12-10 Innercool Therapies, Inc. Medical procedure
WO2003015672A1 (en) * 2001-08-15 2003-02-27 Innercool Therapies, Inc. Method and apparatus for patient temperature control employing administration of anti-shivering
US7371254B2 (en) 1998-01-23 2008-05-13 Innercool Therapies, Inc. Medical procedure
US6585752B2 (en) 1998-06-23 2003-07-01 Innercool Therapies, Inc. Fever regulation method and apparatus
WO2003013344A3 (en) * 2001-08-09 2003-09-25 Innercool Therapies Inc Method and device for patient temperature control employing optimized rewarming
US6261312B1 (en) 1998-06-23 2001-07-17 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6869440B2 (en) * 1999-02-09 2005-03-22 Innercool Therapies, Inc. Method and apparatus for patient temperature control employing administration of anti-shivering agents
US6685732B2 (en) 1998-03-31 2004-02-03 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US7291144B2 (en) 1998-03-31 2007-11-06 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US6231595B1 (en) 1998-03-31 2001-05-15 Innercool Therapies, Inc. Circulating fluid hypothermia method and apparatus
US6602276B2 (en) 1998-03-31 2003-08-05 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US6905494B2 (en) 1998-03-31 2005-06-14 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US6645234B2 (en) 1998-04-21 2003-11-11 Alsius Corporation Cardiovascular guiding catheter with heat exchange properties and methods of use
US6126684A (en) 1998-04-21 2000-10-03 The Regents Of The University Of California Indwelling heat exchange catheter and method of using same
US8128595B2 (en) * 1998-04-21 2012-03-06 Zoll Circulation, Inc. Method for a central venous line catheter having a temperature control system
US6520933B1 (en) 1998-04-21 2003-02-18 Alsius Corporation Central venous line cooling catheter having a spiral-shaped heat exchange member
US6338727B1 (en) * 1998-08-13 2002-01-15 Alsius Corporation Indwelling heat exchange catheter and method of using same
US6620189B1 (en) * 2000-02-28 2003-09-16 Radiant Medical, Inc. Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter
US6673098B1 (en) * 1998-08-24 2004-01-06 Radiant Medical, Inc. Disposable cassette for intravascular heat exchange catheter
US6146411A (en) 1998-12-24 2000-11-14 Alsius Corporation Cooling system for indwelling heat exchange catheter
US6554797B1 (en) 1999-02-19 2003-04-29 Alsius Corporation Method and system for patient temperature management and central venous access
US6460544B1 (en) 1999-03-11 2002-10-08 Alsius Corporation Method and apparatus for establishing and maintaining therapeutic hypothemia
US6149670A (en) * 1999-03-11 2000-11-21 Alsius Corporation Method and system for treating cardiac arrest using hypothermia
US6368304B1 (en) 1999-02-19 2002-04-09 Alsius Corporation Central venous catheter with heat exchange membrane
US6299599B1 (en) * 1999-02-19 2001-10-09 Alsius Corporation Dual balloon central venous line catheter temperature control system
US6719724B1 (en) 1999-02-19 2004-04-13 Alsius Corporation Central venous line catheter having multiple heat exchange elements and multiple infusion lumens
US6585692B1 (en) 1999-02-19 2003-07-01 Alsius Corporation Method and system for patient temperature management and central venous access
US6458150B1 (en) 1999-02-19 2002-10-01 Alsius Corporation Method and apparatus for patient temperature control
US6682551B1 (en) 1999-03-11 2004-01-27 Alsius Corporation Method and system for treating cardiac arrest using hypothermia
US6726710B2 (en) 1999-08-16 2004-04-27 Alsius Corporation Method and system for treating cardiac arrest using hypothermia
US6165207A (en) 1999-05-27 2000-12-26 Alsius Corporation Method of selectively shaping hollow fibers of heat exchange catheter
US6231594B1 (en) 1999-08-11 2001-05-15 Radiant Medical, Inc. Method of controlling body temperature while reducing shivering
US6325818B1 (en) 1999-10-07 2001-12-04 Innercool Therapies, Inc. Inflatable cooling apparatus for selective organ hypothermia
WO2001041708A9 (en) * 1999-12-07 2002-05-10 Alsius Corp Method and system for treating stroke using hypothermia
US6811551B2 (en) * 1999-12-14 2004-11-02 Radiant Medical, Inc. Method for reducing myocardial infarct by application of intravascular hypothermia
US6379378B1 (en) 2000-03-03 2002-04-30 Innercool Therapies, Inc. Lumen design for catheter
US6648906B2 (en) 2000-04-06 2003-11-18 Innercool Therapies, Inc. Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid
US6592612B1 (en) * 2000-05-04 2003-07-15 Cardeon Corporation Method and apparatus for providing heat exchange within a catheter body
US6383210B1 (en) 2000-06-02 2002-05-07 Innercool Therapies, Inc. Method for determining the effective thermal mass of a body or organ using cooling catheter
US6726708B2 (en) 2000-06-14 2004-04-27 Innercool Therapies, Inc. Therapeutic heating and cooling via temperature management of a colon-inserted balloon
US6719779B2 (en) 2000-11-07 2004-04-13 Innercool Therapies, Inc. Circulation set for temperature-controlled catheter and method of using the same
US6530945B1 (en) 2000-11-28 2003-03-11 Alsius Corporation System and method for controlling patient temperature
US6719723B2 (en) * 2000-12-06 2004-04-13 Innercool Therapies, Inc. Multipurpose catheter assembly
US6450987B1 (en) 2001-02-01 2002-09-17 Innercool Therapies, Inc. Collapsible guidewire lumen
US6582457B2 (en) * 2001-02-15 2003-06-24 Radiant Medical, Inc. Method of controlling body temperature while reducing shivering
US6544282B1 (en) 2001-02-21 2003-04-08 Radiant Medical, Inc. Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
US6451045B1 (en) * 2001-02-22 2002-09-17 Alsius Corporation Heat exchange catheter having a helically wrapped heat exchanger
US6641603B2 (en) 2001-04-13 2003-11-04 Alsius Corporation Heat exchange catheter having helically wound reinforcement
US6709448B2 (en) 2001-04-13 2004-03-23 Alsius Corporation Open core heat exchange catheter, system and method
US6641602B2 (en) * 2001-04-13 2003-11-04 Alsius Corporation Method and device including a colo-rectal heat exchanger
US6752786B2 (en) * 2001-05-31 2004-06-22 Radiant Medical, Inc. Moving heat exchange catheter system
US6706060B2 (en) * 2001-06-05 2004-03-16 Alsius Corporation Heat exchange catheter
US6679906B2 (en) 2001-07-13 2004-01-20 Radiant Medical, Inc. Catheter system with on-board temperature probe
US20070213793A1 (en) * 2001-08-06 2007-09-13 Radiant Medical, Inc. Use of endovascular hypothermia in organ and/or tissue transplantations
US20030065922A1 (en) * 2001-09-28 2003-04-03 Fredlund John R. System and method of authenticating a digitally captured image
US6800068B1 (en) 2001-10-26 2004-10-05 Radiant Medical, Inc. Intra-aortic balloon counterpulsation with concurrent hypothermia
US6572640B1 (en) * 2001-11-21 2003-06-03 Alsius Corporation Method and apparatus for cardiopulmonary bypass patient temperature control
US7077825B1 (en) 2002-01-16 2006-07-18 Radiant Medical, Inc. Method for gastric cooling using balloon catheter
US6685733B1 (en) * 2002-04-10 2004-02-03 Radiant Medical, Inc. Methods and systems for reducing substance-induced renal damage
US6866638B2 (en) * 2002-08-12 2005-03-15 Radiant Medical, Inc. Temperature sensing system with retrograde sensor
US7186222B1 (en) * 2002-09-10 2007-03-06 Radiant Medical, Inc. Vascular introducer with temperature monitoring probe and systems for endovascular temperature control
US20040087606A1 (en) * 2002-11-01 2004-05-06 Voorhees Marc E. Shivering suppression during cooling to lower body temperature
CA2411569A1 (en) * 2002-11-12 2004-05-12 Ross E. Mantle Medical device for the extravascular recirculation of fluid in body cavities at controlled temperature and pressure
US7319090B2 (en) * 2002-11-27 2008-01-15 University Of North Carolina At Chapel Hill Methods of treating cerebral ischemia
US7278984B2 (en) * 2002-12-31 2007-10-09 Alsius Corporation System and method for controlling rate of heat exchange with patient
JP2006516963A (en) * 2003-02-04 2006-07-13 クリサリス テクノロジーズ インコーポレイテッドChrysalis Technologies Incorporated Aerosol formulations and buspirone, buprenorphine, triazolam, aerosol delivery of cyclobenzaprine and zolpidem
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040167466A1 (en) * 2003-02-21 2004-08-26 Drasler William J. Delivering cooled fluid to sites inside the body
US20040167467A1 (en) * 2003-02-21 2004-08-26 Kent Harrison Delivering cooled fluid to sites inside the body
US7300453B2 (en) * 2003-02-24 2007-11-27 Innercool Therapies, Inc. System and method for inducing hypothermia with control and determination of catheter pressure
US7104985B2 (en) * 2003-03-06 2006-09-12 Martinelli Michael A Apparatus and method for causing selective necrosis of abnormal cells
WO2004083797A3 (en) * 2003-03-14 2004-12-29 Thermosurgery Technologies Inc Hyperthermia treatment system
US7758623B2 (en) * 2003-03-17 2010-07-20 The Board Of Trustees Of The Leland Stanford Junior University Transesophageal heat exchange catheter for cooling of the heart
US20040199114A1 (en) * 2003-04-01 2004-10-07 Alsius Corporation Intravascular heat exchange catheter with tissue preservative
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US6893454B2 (en) * 2003-04-28 2005-05-17 Alsius Corporation Intrarectal heat exchange catheter
US20040215163A1 (en) * 2003-04-28 2004-10-28 Walker Blair D. Intravascular heat exchange catheter with multiple coolant inlet holes to balloon
WO2005007168A1 (en) * 2003-07-23 2005-01-27 Douglas Pharmaceuticals Limited A stable clozapine suspension formulation
JP2007503266A (en) * 2003-08-25 2007-02-22 メディヴァンス インコーポレイテッドMedivance Incorporated Active body cooling by vasodilation to lower the body temperature
US7122047B2 (en) * 2003-11-14 2006-10-17 The Board Of Trustees Of The Leland Stanford Junior University Controlled heat transfer with mammalian bodies
US7326195B2 (en) * 2003-11-18 2008-02-05 Boston Scientific Scimed, Inc. Targeted cooling of tissue within a body
US20050159728A1 (en) * 2004-01-15 2005-07-21 Thomas Medical Products, Inc. Steerable sheath
WO2005070035A3 (en) * 2004-01-22 2005-12-08 Amir Belson Respiratory system for inducing therapeutic hypothermia
DE602005018763D1 (en) * 2004-02-18 2010-02-25 Sepracor Inc Dopamine agonists-combination therapy with sedatives for improving the quality of sleep
JP4520183B2 (en) * 2004-03-09 2010-08-04 Hoya株式会社 Ultrasound endoscope and the multi-lumen tube ultrasonic endoscope
US7959657B1 (en) * 2004-07-07 2011-06-14 Harsy Douglas R Portable thermal therapeutic apparatus and method
US20060025840A1 (en) * 2004-08-02 2006-02-02 Martin Willard Cooling tissue inside the body
US20060136023A1 (en) * 2004-08-26 2006-06-22 Dobak John D Iii Method and apparatus for patient temperature control employing administration of anti-shivering agents
US8353942B2 (en) 2004-09-16 2013-01-15 Thomas Lad Merrill Cooling guide catheter and associated method of use
US20060058859A1 (en) * 2004-09-16 2006-03-16 Merrill Thomas L Cooling catheter and method with adjunctive therapy capability
US20060064146A1 (en) * 2004-09-17 2006-03-23 Collins Kenneth A Heating/cooling system for indwelling heat exchange catheter
US7892269B2 (en) * 2005-04-18 2011-02-22 Zoll Circulation, Inc. External heat exchange pad for patient
US20060190062A1 (en) * 2005-02-23 2006-08-24 Worthen William J System and method for reducing shivering when using external cooling pads
US7070612B1 (en) 2005-02-23 2006-07-04 Alsius Corporation System and method for bringing hypothermia rapidly onboard
US20060190066A1 (en) * 2005-02-23 2006-08-24 Worthen William J System and method for bringing hypothermia rapidly onboard
US7425216B2 (en) * 2005-03-01 2008-09-16 Alsius Corporation System and method for treating cardiac arrest and myocardial infarction
US20060276864A1 (en) * 2005-06-03 2006-12-07 Alsius Corporation Systems and methods for sensing patient temperature in temperature management system
US20060293732A1 (en) * 2005-06-27 2006-12-28 Collins Kenneth A Thermoelectric cooler (TEC) heat exchanger for intravascular heat exchange catheter
EP1895956B1 (en) * 2005-06-29 2016-01-20 Radiant Medical, Inc. Devices and systems for rapid endovascular cooling
US7181927B2 (en) * 2005-07-01 2007-02-27 Alsius Corporation Primary heat exchanger for patient temperature control
US7951182B2 (en) 2005-07-14 2011-05-31 Zoll Circulation, Inc. System and method for leak detection in external cooling pad
US20070093697A1 (en) * 2005-10-21 2007-04-26 Theranova, Llc Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature
US7850723B1 (en) * 2005-11-28 2010-12-14 Innercool Therapies, Inc. Method and apparatus for patient temperature control employing titration of therapy using EEG signals
US20070150033A1 (en) * 2005-12-22 2007-06-28 Cherlin Johnson Cooling blanket
US20070225781A1 (en) * 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
US20060258422A1 (en) * 2006-04-18 2006-11-16 Walker Jay S Methods and apparatus for free play mode operation of gaming devices
US8425583B2 (en) 2006-04-20 2013-04-23 University of Pittsburgh—of the Commonwealth System of Higher Education Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia
US9492313B2 (en) 2006-04-20 2016-11-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders
US7822485B2 (en) 2006-09-25 2010-10-26 Zoll Circulation, Inc. Method and apparatus for spinal cooling
US7867266B2 (en) 2006-11-13 2011-01-11 Zoll Circulation, Inc. Temperature management system with assist mode for use with heart-lung machine
US7892270B2 (en) * 2006-11-21 2011-02-22 Zoll Circulation Inc. Temperature management system and method for burn patients
US8353893B2 (en) 2007-03-07 2013-01-15 Zoll Circulation, Inc. System and method for rapidly cooling cardiac arrest patient
WO2008124644A1 (en) * 2007-04-05 2008-10-16 Velomedix, Inc Automated therapy system and method
WO2008124643A1 (en) * 2007-04-05 2008-10-16 Velomedix, Inc. Device and method for safe access to a body cavity
US9737692B2 (en) * 2007-05-18 2017-08-22 Zoll Circulation, Inc. System and method for effecting non-standard fluid line connections
CA2693774A1 (en) * 2007-07-09 2009-01-15 Velomedix, Inc. Hypothermia devices and methods
US8475509B2 (en) * 2007-08-09 2013-07-02 Zoll Circulation, Inc. Devices and methods for using endovascular cooling to treat septic shock and other disorders
US9566185B2 (en) 2007-10-12 2017-02-14 Medivance Incorporated System and method for patient temperature control
US20090131835A1 (en) * 2007-11-16 2009-05-21 Medivance Incorporated Patient temperature response control system and method
CA2707981C (en) * 2007-12-11 2016-05-10 Theravance, Inc. 3-carboxypropyl-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
WO2009076399A3 (en) 2007-12-11 2009-09-17 Theravance, Inc. Aminotetralin compounds as mu opioid receptor antagonists
DE102008013860A1 (en) * 2008-03-12 2009-09-24 Siemens Aktiengesellschaft Catheter device for treatment of septum of heart, has coupling device arranged at proximal end in proximity of catheter tip to transport and position occluder, where sensor is provided in area of catheter tip for imaging
GB2498274B (en) * 2008-10-08 2013-08-21 Bedrock Inv S Llc Shivering during therapeutic temperature control
WO2010054312A1 (en) * 2008-11-07 2010-05-14 Velomedix, Inc. Devices and methods for monitoring core temperature and an intraperitoneal parameter
CN102245564B (en) 2008-12-10 2015-04-01 施万生物制药研发Ip有限责任公司 Crystalline forms of a 3-carboxypropyl-aminotetralin compound
EP2393460A4 (en) * 2009-02-06 2012-06-27 Velomedix Inc Method and apparatus for inducing therapeutic hypothermia
US8608696B1 (en) 2009-02-24 2013-12-17 North Carolina State University Rapid fluid cooling devices and methods for cooling fluids
US9622670B2 (en) 2010-07-09 2017-04-18 Potrero Medical, Inc. Method and apparatus for pressure measurement
WO2012142273A1 (en) 2011-04-12 2012-10-18 Revogenex Inc. Intravenous administration of tramadol
US9918980B2 (en) 2011-04-29 2018-03-20 Rutgers, The State University Of New Jersey Method of treating dyskinesia
CA2841863A1 (en) 2011-07-25 2013-01-31 Neurosave, Inc. Non-invasive systems, devices, and methods for selective brain cooling
US9283110B2 (en) 2011-09-20 2016-03-15 Zoll Circulation, Inc. Patient temperature control catheter with outer sleeve cooled by inner sleeve
US9314370B2 (en) 2011-09-28 2016-04-19 Zoll Circulation, Inc. Self-centering patient temperature control catheter
US8888832B2 (en) 2011-09-28 2014-11-18 Zoll Circulation, Inc. System and method for doubled use of patient temperature control catheter
US9259348B2 (en) 2011-09-28 2016-02-16 Zoll Circulation, Inc. Transatrial patient temperature control catheter
US9717625B2 (en) 2012-09-28 2017-08-01 Zoll Circulation, Inc. Intravascular heat exchange catheter with non-round coiled coolant path
US9433528B2 (en) 2012-09-28 2016-09-06 Zoll Circulation, Inc. Intravascular heat exchange catheter with rib cage-like coolant path
US9241827B2 (en) 2012-09-28 2016-01-26 Zoll Circulation, Inc. Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops
US9801756B2 (en) 2012-09-28 2017-10-31 Zoll Circulation, Inc. Intravascular heat exchange catheter and system with RFID coupling
US9278023B2 (en) 2012-12-14 2016-03-08 Zoll Circulation, Inc. System and method for management of body temperature
US20160058613A1 (en) * 2013-04-10 2016-03-03 James Palazzolo Detecting and Responding to Preshivering
US9474644B2 (en) 2014-02-07 2016-10-25 Zoll Circulation, Inc. Heat exchange system for patient temperature control with multiple coolant chambers for multiple heat exchange modalities
US9784263B2 (en) 2014-11-06 2017-10-10 Zoll Circulation, Inc. Heat exchange system for patient temperature control with easy loading high performance peristaltic pump
EP3250276A1 (en) * 2015-01-27 2017-12-06 EBB Therapeutics, Inc. Method and apparatuses for modulating sleep by chemical activation of temperature receptors
US9693949B1 (en) 2015-12-22 2017-07-04 Revogenex Ireland Ltd Intravenous administration of tramadol

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3425419A (en) * 1964-08-08 1969-02-04 Angelo Actis Dato Method of lowering and raising the temperature of the human body
GB2101114B (en) 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
FR2567754B1 (en) 1984-07-20 1987-05-29 Cortial therapeutic application aminomethylene-2-substituted 1,3-indanediones nitrogen
US4758562A (en) 1985-12-18 1988-07-19 Temple University Of The Commonwealth System Of Higher Education Method for inducing hypothermia and/or poikilothermia
CA1335069C (en) * 1988-08-30 1995-04-04 Wilbur R. Williams Apparatus and method for determining cardiac output by thermodilution without injection
US4941475A (en) * 1988-08-30 1990-07-17 Spectramed, Inc. Thermodilution by heat exchange
US5120713A (en) 1990-09-10 1992-06-09 Applied Research Systems Ars Holding N.V. Treatment of obesity with an alpha-2-adrenergic agonist and a growth hormone releasing peptide
US5486208A (en) 1993-02-10 1996-01-23 Ginsburg; Robert Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification
US5837003A (en) 1993-02-10 1998-11-17 Radiant Medical, Inc. Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification
US5716386A (en) * 1994-06-27 1998-02-10 The Ohio State University Non-invasive aortic impingement and core and cerebral temperature manipulation
US5510490A (en) 1994-01-11 1996-04-23 Council Of Scientific & Industrial Research Process for the preparation of epibatidine
US5486204A (en) * 1994-09-20 1996-01-23 University Of Texas Health Science Center Houston Method of treating a non-penetrating head wound with hypothermia
US6156057A (en) * 1995-08-12 2000-12-05 Fox; James Allan Method for inducing hypothermia
US5863934A (en) 1995-09-21 1999-01-26 Amy F. T. Arnsten Use of lofexidine in the treatment of behavioral disorders
US6206004B1 (en) * 1996-12-06 2001-03-27 Comedicus Incorporated Treatment method via the pericardial space
US6033383A (en) 1996-12-19 2000-03-07 Ginsburg; Robert Temperature regulating catheter and methods
US5879329A (en) 1997-01-22 1999-03-09 Radiant Medical, Inc. Infusion systems and methods for introducing fluids into the body within a desired temperature range
US6843800B1 (en) 1998-01-23 2005-01-18 Innercool Therapies, Inc. Patient temperature regulation method and apparatus
US6410554B1 (en) * 1998-03-23 2002-06-25 Merck & Co., Inc. Combination therapy for the treatment of benign prostatic hyperplasia
US6231595B1 (en) * 1998-03-31 2001-05-15 Innercool Therapies, Inc. Circulating fluid hypothermia method and apparatus
US6420137B1 (en) 1998-11-25 2002-07-16 American Home Products Corporation Nucleic acid encoding human neurotensin subtype 2 receptor
US6299599B1 (en) 1999-02-19 2001-10-09 Alsius Corporation Dual balloon central venous line catheter temperature control system
US6231594B1 (en) 1999-08-11 2001-05-15 Radiant Medical, Inc. Method of controlling body temperature while reducing shivering

Also Published As

Publication number Publication date Type
ES2256024T3 (en) 2006-07-16 grant
US6702839B1 (en) 2004-03-09 grant
US7008444B2 (en) 2006-03-07 grant
US20040073280A1 (en) 2004-04-15 application
WO2001010323A1 (en) 2001-02-15 application
EP1212000A1 (en) 2002-06-12 application
EP1212000B1 (en) 2006-01-04 grant
DE60025362T2 (en) 2006-09-28 grant
JP2003506385A (en) 2003-02-18 application
US6572638B1 (en) 2003-06-03 grant
DE60025362D1 (en) 2006-03-30 grant
EP1212000A4 (en) 2002-10-25 application
CA2378976C (en) 2010-02-09 grant
US6231594B1 (en) 2001-05-15 grant
JP4787919B2 (en) 2011-10-05 grant

Similar Documents

Publication Publication Date Title
WO2001016147A1 (en) Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof
WO2002062389A1 (en) Remedies for urinary diseases comprising lpa receptor controlling agents
WO2001066546A1 (en) Spiro compounds, process for preparing the same and use thereof as drugs
WO2008051599A3 (en) Combination therapies for treating alzheimer's disease using i. a. dimebon and dolepezil
WO2000044770A1 (en) Substituted phenethylamine derivatives
GB2338342B (en) Method for crystalizing amorphous silicon layer and method for fabricating tft
Glazer Does loxapine have" atypical" properties? Clinical evidence.
WO2001008661A3 (en) Opioid sustained-released formulation
CA2350195A1 (en) Rapid onset formulation of pyridoxine hydrochloride and doxylamine succinate
JPH04323755A (en) Dma device
WO2003010168A1 (en) 4-oxoimidazolidine-2-spiropiperidine derivative
WO2001034143A1 (en) Preventive or therapeutic agents for inflammatory diseases of intestine
CN2465687Y (en) Bag type water circulation continuous cooling device
WO2002067895A3 (en) Implant dosage form and use thereof for the delivery of a cholesterol lowering agent
CN2524689Y (en) Multifunction drilling guide device for department of eorhopedics
CA2471952A1 (en) Fluoro substituted cycloalkanoindoles and their use as prostaglandin d2 receptor antagonists
WO1999061059A1 (en) Minoxidil compositions for external use
JPH07214292A (en) Method for repairing tap hole of vessel for molten metal
WO2001000266A3 (en) Device for positioning a breathing apparatus
WO2003049689A3 (en) Isoflavone composition for oral delivery
KITANO On the Author of Madhyantavibhaga I. 3
Perez Expanded communications for gen-set controller.
Chang et al. Microstructure and microhardness of surface laser glazed Fe-Sb alloy
GB0310759D0 (en) Liner hanger
JPS62188310A (en) Wafer mounting method and device therefor

Legal Events

Date Code Title Description
EEER Examination request