CA2348842A1 - Muco-adhesive polymers, use thereof and method for producing the same - Google Patents

Muco-adhesive polymers, use thereof and method for producing the same Download PDF

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Publication number
CA2348842A1
CA2348842A1 CA002348842A CA2348842A CA2348842A1 CA 2348842 A1 CA2348842 A1 CA 2348842A1 CA 002348842 A CA002348842 A CA 002348842A CA 2348842 A CA2348842 A CA 2348842A CA 2348842 A1 CA2348842 A1 CA 2348842A1
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CA
Canada
Prior art keywords
muco
producing
same
adhesive polymers
polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002348842A
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French (fr)
Other versions
CA2348842C (en
Inventor
Andreas Bernkop-Schnurch
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Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2348842A1 publication Critical patent/CA2348842A1/en
Application granted granted Critical
Publication of CA2348842C publication Critical patent/CA2348842C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Abstract

Mucoadhesive polymers assembled of not more than 10 different monomers and comprising at least one non-terminal thiol group, as well as drugs containing these polymers are described.
CA002348842A 1998-11-04 1999-11-04 Muco-adhesive polymers, use thereof and method for producing the same Expired - Lifetime CA2348842C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ATA1828/98 1998-11-04
AT0182898A AT406054B (en) 1998-11-04 1998-11-04 Process for improving the mucoadhesion of polymers, and the preparation and use of these
PCT/AT1999/000265 WO2000025823A1 (en) 1998-11-04 1999-11-04 Muco-adhesive polymers, use thereof and method for producing the same

Publications (2)

Publication Number Publication Date
CA2348842A1 true CA2348842A1 (en) 2000-05-11
CA2348842C CA2348842C (en) 2009-05-12

Family

ID=3521872

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002348842A Expired - Lifetime CA2348842C (en) 1998-11-04 1999-11-04 Muco-adhesive polymers, use thereof and method for producing the same

Country Status (11)

Country Link
US (1) US7354600B1 (en)
EP (1) EP1126881B1 (en)
JP (2) JP4744693B2 (en)
CN (1) CN1230203C (en)
AT (2) AT406054B (en)
AU (1) AU760929B2 (en)
CA (1) CA2348842C (en)
DE (1) DE59909764D1 (en)
DK (1) DK1126881T3 (en)
ES (1) ES2222740T3 (en)
WO (1) WO2000025823A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8530632B2 (en) 2008-04-24 2013-09-10 Medtronic Xomed, Inc. Chitosan-containing protective composition
US8802652B2 (en) 2008-04-24 2014-08-12 Medtronic, Inc. Rehydratable polysaccharide particles and sponge
US9198997B2 (en) 2008-04-24 2015-12-01 Medtronic, Inc. Rehydratable thiolated polysaccharide particles and sponge
US9333220B2 (en) 2008-04-24 2016-05-10 Medtronic, Inc. Method for treating the ear, nose, sinus or throat

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT406054B (en) * 1998-11-04 2000-02-25 Andreas Bernkop-Schnuerch Process for improving the mucoadhesion of polymers, and the preparation and use of these
WO2002068383A2 (en) † 2001-02-22 2002-09-06 Anika Therapeutics, Inc. Thiol-modified hyaluronan
WO2004067582A1 (en) * 2003-01-28 2004-08-12 Akzo Nobel Coatings International B.V. Curable composition comprising a compound having radically polymerizable olefinically unsaturated groups, an oxidation-reduction enzyme, and a thiol-functional compound
US8932983B1 (en) 2005-12-07 2015-01-13 Crystal Clear Technologies, Inc. Chitosan based adsorbent
GB0526136D0 (en) * 2005-12-22 2006-02-01 Unilever Plc Antiperspirant compositions
WO2007071375A1 (en) * 2005-12-22 2007-06-28 Unilever Plc Antiperspirant compositions
US8257720B2 (en) 2009-04-20 2012-09-04 Conopco, Inc. Stabilized cationic ammonium compounds and compositions comprising the same
US8324255B2 (en) 2009-09-15 2012-12-04 Conopco, Inc. Chelator stabilized cationic ammonium compounds and compositions comprising the same
WO2011039259A2 (en) 2009-09-30 2011-04-07 Thiomatrix Forschungs- Und Beratungs Gmbh Mucoadhesive polymers having vitamin b partial structures
CN102399295B (en) 2010-09-09 2013-11-06 常州百瑞吉生物医药有限公司 Low-sulfhydrylation-modification-degree biocompatible high-molecular sulfhydrylation derivatives, cross-linking material thereof, and purpose thereof
EP2597110A1 (en) 2011-11-28 2013-05-29 Fundación Cidetec Self-healing material and method for the preparation thereof
SI3139903T1 (en) 2014-05-07 2019-10-30 Croma Pharma Ges M B H Aqueous ophthalmic solution and method for treating dry eye syndrome
JP2018532753A (en) 2015-10-30 2018-11-08 クロマ−ファーマ ゲゼルシャフト エム．ベー．ハー． Therapeutic use of sterile aqueous eye drops
WO2017072236A1 (en) 2015-10-30 2017-05-04 Croma-Pharma Gesellschaft M.B.H. Therapeutic use of a sterile aqueous ophthalmic solution
WO2018202783A1 (en) 2017-05-03 2018-11-08 Croma-Pharma Gmbh Sterile aqueous ophthalmic solution containing n-(n-acetylcysteinyl)-chitosan for treating non-infectious corneal disorders
US20230056811A1 (en) 2020-02-07 2023-02-23 Bioadhesive Ophthalmics Mucoadhesive solid or semisolid ocular delivery systems based on preactivated thiomers
CN116390718A (en) * 2021-01-29 2023-07-04 孙益民 Mucoadhesive drug delivery
WO2023012239A1 (en) 2021-08-03 2023-02-09 Bioadhesive Ophthalmics Mucoadhesive ocular delivery system for the treatment of glaucoma

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3778527D1 (en) * 1986-10-06 1992-05-27 Kuraray Co ADHESIVES IN PARTICULAR FOR DENTAL PURPOSES.
FR2687071B1 (en) * 1992-02-10 1995-06-23 Exsymol Sa VECTOR FOR THERAPEUTIC OR COSMETIC (S) ACTIVE INGREDIENT (S) FOR EXTERNAL USE AND THERAPEUTIC OR COSMETIC COMPOSITION COMPRISING SUCH A VECTOR.
FR2692582B1 (en) * 1992-06-18 1998-09-18 Flamel Tech Sa NEW CROSSLINKABLE DERIVATIVES OF COLLAGEN, THEIR PROCESS FOR OBTAINING IT AND THEIR APPLICATION TO THE PREPARATION OF BIOMATERIALS.
FR2699184B1 (en) * 1992-12-16 1995-03-10 Flamel Tech Sa New collagen derivatives, their process for obtaining and their application to the preparation of biomaterials.
US5665383A (en) 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of immunostimulating agents for in vivo delivery
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5670468A (en) * 1993-04-09 1997-09-23 The Procter & Gamble Company Machine dishwashing method employing a metallo catalyst and enzymatic source of hydrogen peroxide
FR2707878A1 (en) * 1993-07-21 1995-01-27 Imedex New adhesive compositions for surgical use.
FR2707992B1 (en) * 1993-07-21 1995-10-13 Flamel Tech Sa New organic products containing reactive thiol functions, one of their preparation processes and the biomaterials containing them.
FR2723957A1 (en) * 1994-08-29 1996-03-01 Flamel Tech Sa BIOPOLYMER MODIFIED BY INCORPORATION OF CROSS-LINKING SULFUR GROUPS, ONE OF ITS METHODS OF OBTAINING AND ITS APPLICATIONS IN THE MANUFACTURE OF BIOMATERIALS
NZ503548A (en) * 1996-02-09 2001-09-28 Amgen Inc A fusion protein comprising an IL-1ra receptor antagonist with a constant domain of human immunoglobulin at the carboxy terminus
AT406054B (en) * 1998-11-04 2000-02-25 Andreas Bernkop-Schnuerch Process for improving the mucoadhesion of polymers, and the preparation and use of these
US6514535B2 (en) * 1999-05-21 2003-02-04 Noveon Ip Holdings Corp. Bioadhesive hydrogels with functionalized degradable crosslinks

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8530632B2 (en) 2008-04-24 2013-09-10 Medtronic Xomed, Inc. Chitosan-containing protective composition
US8802652B2 (en) 2008-04-24 2014-08-12 Medtronic, Inc. Rehydratable polysaccharide particles and sponge
US9198997B2 (en) 2008-04-24 2015-12-01 Medtronic, Inc. Rehydratable thiolated polysaccharide particles and sponge
US9333220B2 (en) 2008-04-24 2016-05-10 Medtronic, Inc. Method for treating the ear, nose, sinus or throat
US9433636B2 (en) 2008-04-24 2016-09-06 Medtronic, Inc. Protective gel based on chitosan and oxidized polysaccharide
US9561248B2 (en) 2008-04-24 2017-02-07 Medtronic, Inc. Method for rehydrating polysaccharide particles
US10420794B2 (en) 2008-04-24 2019-09-24 Medtronic, Inc. Polysaccharide particle mixture

Also Published As

Publication number Publication date
CN1325312A (en) 2001-12-05
AT406054B (en) 2000-02-25
JP2002528518A (en) 2002-09-03
ES2222740T3 (en) 2005-02-01
WO2000025823A1 (en) 2000-05-11
JP4744693B2 (en) 2011-08-10
CN1230203C (en) 2005-12-07
ATA182898A (en) 1999-06-15
JP2011140655A (en) 2011-07-21
CA2348842C (en) 2009-05-12
AU760929B2 (en) 2003-05-22
AU1018200A (en) 2000-05-22
DK1126881T3 (en) 2004-10-18
EP1126881B1 (en) 2004-06-16
ATE269105T1 (en) 2004-07-15
US7354600B1 (en) 2008-04-08
DE59909764D1 (en) 2004-07-22
EP1126881A1 (en) 2001-08-29

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Effective date: 20191104