CA2345938A1 - Polymorphisme du gene tgf-beta correle a l'osteoporose - Google Patents

Polymorphisme du gene tgf-beta correle a l'osteoporose Download PDF

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Publication number
CA2345938A1
CA2345938A1 CA002345938A CA2345938A CA2345938A1 CA 2345938 A1 CA2345938 A1 CA 2345938A1 CA 002345938 A CA002345938 A CA 002345938A CA 2345938 A CA2345938 A CA 2345938A CA 2345938 A1 CA2345938 A1 CA 2345938A1
Authority
CA
Canada
Prior art keywords
tgf
gene
osteoporosis
beta
intron
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002345938A
Other languages
English (en)
Inventor
Timothy David Spector
Richard William Keen
Fernando Gibson
Helen Ruth Molloy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sequenom Gemini Ltd
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2345938A1 publication Critical patent/CA2345938A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne des méthodes et un appareil destinés à diagnostiquer une maladie ou une prédisposition a la maladie. Elle concerne en particulier des méthodes de diagnostic de l'ostéoporose et de détermination de la densité minérale osseuse chez un patient ainsi que des traitements et des thérapies propres à retarder ou à empêcher l'apparition de la maladie chez des individus à risque.
CA002345938A 1998-10-16 1999-10-18 Polymorphisme du gene tgf-beta correle a l'osteoporose Abandoned CA2345938A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9822682.2 1998-10-16
GBGB9822682.2A GB9822682D0 (en) 1998-10-16 1998-10-16 Diagnostic method and apparatus based on polymorphism in a TGF-B-Gene
PCT/GB1999/003446 WO2000023618A1 (fr) 1998-10-16 1999-10-18 Polymorphisme du gene tgf-beta correle a l'osteoporose

Publications (1)

Publication Number Publication Date
CA2345938A1 true CA2345938A1 (fr) 2000-04-27

Family

ID=10840750

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002345938A Abandoned CA2345938A1 (fr) 1998-10-16 1999-10-18 Polymorphisme du gene tgf-beta correle a l'osteoporose

Country Status (6)

Country Link
EP (1) EP1121464A1 (fr)
JP (1) JP2002527116A (fr)
AU (1) AU6221999A (fr)
CA (1) CA2345938A1 (fr)
GB (1) GB9822682D0 (fr)
WO (1) WO2000023618A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0129642D0 (en) * 2001-12-11 2002-01-30 King S College London Detection of disease dve to oestrogen deficiency

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78197A (en) * 1985-03-22 1991-07-18 Genentech Inc Nucleic acid encoding tgf-beta and its uses
IL109990A (en) * 1993-06-21 1999-06-20 Lilly Co Eli Materials and methods for screening anti-osteoporosis agents
CA2243191A1 (fr) * 1996-01-17 1997-08-07 David John Grainger Procede et appareil de diagnostic
EP0955378A1 (fr) * 1998-04-06 1999-11-10 Bente Lomholt Langdahl Méthode et trousse pour la détection de la variation de séquence dans le gène hhumai de TGF-1 beta1

Also Published As

Publication number Publication date
EP1121464A1 (fr) 2001-08-08
JP2002527116A (ja) 2002-08-27
GB9822682D0 (en) 1998-12-09
WO2000023618A8 (fr) 2000-06-15
WO2000023618A1 (fr) 2000-04-27
WO2000023618B1 (fr) 2000-07-27
AU6221999A (en) 2000-05-08

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Legal Events

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