CA2337072A1 - Improved process for the preparation of salts and esters of clavulanic acid - Google Patents

Improved process for the preparation of salts and esters of clavulanic acid Download PDF

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Publication number
CA2337072A1
CA2337072A1 CA002337072A CA2337072A CA2337072A1 CA 2337072 A1 CA2337072 A1 CA 2337072A1 CA 002337072 A CA002337072 A CA 002337072A CA 2337072 A CA2337072 A CA 2337072A CA 2337072 A1 CA2337072 A1 CA 2337072A1
Authority
CA
Canada
Prior art keywords
clavulanic acid
amine
solution
clavulanate
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002337072A
Other languages
English (en)
French (fr)
Inventor
Ageeth Geertruida Lefferts
Pieter Theodorus Kerkhof
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2337072A1 publication Critical patent/CA2337072A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
CA002337072A 1998-07-16 1999-07-13 Improved process for the preparation of salts and esters of clavulanic acid Abandoned CA2337072A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98202390.5 1998-07-16
EP98202390 1998-07-16
PCT/EP1999/005026 WO2000004028A1 (en) 1998-07-16 1999-07-13 Improved process for the preparation of salts and esters of clavulanic acid

Publications (1)

Publication Number Publication Date
CA2337072A1 true CA2337072A1 (en) 2000-01-27

Family

ID=8233939

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002337072A Abandoned CA2337072A1 (en) 1998-07-16 1999-07-13 Improved process for the preparation of salts and esters of clavulanic acid

Country Status (6)

Country Link
EP (1) EP1095046A1 (de)
CN (1) CN1312814A (de)
AU (1) AU5411099A (de)
CA (1) CA2337072A1 (de)
TR (1) TR200100082T2 (de)
WO (1) WO2000004028A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1284978E (pt) * 2000-05-13 2004-12-31 Smithkline Beecham Plc Processo para a purificacao de um sal de acido clavulanico
US20100055749A1 (en) * 2006-12-01 2010-03-04 Van Der Does Thomas Process for the production of clavulanic acid
CN103304583B (zh) * 2013-07-09 2016-01-20 山东新时代药业有限公司 一种从克拉维酸胺盐结晶母液中回收克拉维酸的方法
CN104450813B (zh) * 2014-11-22 2017-04-12 太原理工大学 一种二苯甲胺的合成方法
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法
CN109535184B (zh) * 2017-09-21 2020-11-20 联邦制药(内蒙古)有限公司 一种克拉维酸叔辛胺制备克拉维酸钾的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
US5741903A (en) * 1993-03-26 1998-04-21 Gist-Brocades N.V. Diamine salts for purification of clavulanic acid
RO112113B1 (ro) * 1993-03-26 1997-05-30 Gist Brocades Nv Saruri diaminice ale acidului clavulanic si procedeu pentru prepararea acestora
CA2271847A1 (en) * 1996-11-11 1998-05-22 Gist-Brocades B.V. Process for the preparation of salts and esters of clavulanic acid
AU1234999A (en) * 1997-11-10 1999-05-31 Gist-Brocades B.V. Crystallization of beta-lactam compounds

Also Published As

Publication number Publication date
CN1312814A (zh) 2001-09-12
WO2000004028A1 (en) 2000-01-27
EP1095046A1 (de) 2001-05-02
TR200100082T2 (tr) 2001-06-21
AU5411099A (en) 2000-02-07

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20030714