CA2332275A1 - Derives de benzofuranne, composition pharmaceutique renfermant ces derives et procede de preparation du principe actif - Google Patents

Derives de benzofuranne, composition pharmaceutique renfermant ces derives et procede de preparation du principe actif Download PDF

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Publication number
CA2332275A1
CA2332275A1 CA002332275A CA2332275A CA2332275A1 CA 2332275 A1 CA2332275 A1 CA 2332275A1 CA 002332275 A CA002332275 A CA 002332275A CA 2332275 A CA2332275 A CA 2332275A CA 2332275 A1 CA2332275 A1 CA 2332275A1
Authority
CA
Canada
Prior art keywords
group
formula
dimethyl
atom
benzofuran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002332275A
Other languages
English (en)
Inventor
Zoltan Tamas Nagy
Levente Ondi
Eva Schmidt
Gabor Szenasi
Katalin Pallagi
Istvan Gacsalyi
Endre Rivo
Istvan Gyertyan
Gyorgy Levay
Tamas Szabados
Andras Egyed
Bela Agai
Aniko Kovacs Niklosne
Gyula Simig
Ildiko Gyonos Nagyne
Katalin Megyeri Ivanicsne
Jozsef Reiter
Szabolcs Kertesz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egis Pharmaceuticals PLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9801085A external-priority patent/HUP9801085A3/hu
Priority claimed from HU9801086A external-priority patent/HUP9801086A3/hu
Application filed by Individual filed Critical Individual
Publication of CA2332275A1 publication Critical patent/CA2332275A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

L'invention concerne de nouveaux dérivés de benzofuranne de formule (I), leur procédé de préparation et les compositions pharmaceutiques renfermant ces principes actifs.
CA002332275A 1998-05-14 1999-05-13 Derives de benzofuranne, composition pharmaceutique renfermant ces derives et procede de preparation du principe actif Abandoned CA2332275A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
HU9801085A HUP9801085A3 (en) 1998-05-14 1998-05-14 Piperazinyl-alkyl-benzofurane derivatives, pharmaceutical compositions containing them as active ingredient and process for producing the active ingredient
HUP9801085 1998-05-14
HUP9801086 1998-05-14
HU9801086A HUP9801086A3 (en) 1998-05-14 1998-05-14 Benzofurane derivatives, pharmaceutical compositions containing them as active ingredient process for producing the active ingredient and intermediates of them
PCT/HU1999/000038 WO1999058527A2 (fr) 1998-05-14 1999-05-13 Derives de benzofuranne, composition pharmaceutique renfermant ces derives et procede de preparation du principe actif

Publications (1)

Publication Number Publication Date
CA2332275A1 true CA2332275A1 (fr) 1999-11-18

Family

ID=89996544

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002332275A Abandoned CA2332275A1 (fr) 1998-05-14 1999-05-13 Derives de benzofuranne, composition pharmaceutique renfermant ces derives et procede de preparation du principe actif

Country Status (9)

Country Link
EP (1) EP1077973A2 (fr)
JP (1) JP2002514643A (fr)
KR (1) KR20010043618A (fr)
AU (1) AU753706B2 (fr)
CA (1) CA2332275A1 (fr)
HR (1) HRP20000750A2 (fr)
PL (1) PL345309A1 (fr)
SK (1) SK17212000A3 (fr)
WO (1) WO1999058527A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2049501A (en) * 1999-12-20 2001-07-03 Eli Lilly And Company Benzofuran derivatives
WO2001046177A1 (fr) * 1999-12-20 2001-06-28 Eli Lilly And Company Derives de benzofuranne
FR2845992B1 (fr) * 2002-10-16 2005-02-04 Pf Medicament Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie
US20080319209A1 (en) * 2005-02-17 2008-12-25 Guozhi Wang Process for Preparing (Disubstitutedpropenyl) Phenylalkyl Substituted Dihydrobenzofurans
HU230729B1 (hu) * 2007-05-30 2017-12-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Új, szelektív 5HT7-receptorgátló benzofurán-származékok és eljárás előállításukra
HU230761B1 (hu) * 2007-05-30 2018-03-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Új, szelektív 5HT6-receptorgátló benzofurán-származékok és eljárás előállításukra
GB201312499D0 (en) * 2013-07-12 2013-08-28 Isis Innovation Therapeutic compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH474511A (fr) * 1966-06-24 1969-06-30 F. Hoffmann-La Roche & Co. Aktiengesellschaft
DE2235597A1 (de) * 1972-07-20 1974-01-31 Boehringer Mannheim Gmbh 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung
FR2353291A1 (fr) * 1976-05-31 1977-12-30 Parcor Nouveaux derives du benzofuranne
US4110536A (en) * 1977-04-18 1978-08-29 Miles Laboratories, Inc. Derivatives of 5-(indol-3-yl)hydantoin
US4612309A (en) * 1984-10-23 1986-09-16 William H. Rorer, Inc. Antisecretory bicyclic benzo-oxy heterocyclic ethers and thioethers
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
FR2681319B1 (fr) * 1991-09-12 1995-02-17 Synthelabo Derives de 1-(phenoxyalkyl)piperidine, leur preparation et leur application en therapeutique.
AU699152B2 (en) * 1994-09-27 1998-11-26 Janssen Pharmaceutica N.V. N-substituted piperidinyl bicyclic benzoate derivatives
TW490465B (en) * 1994-11-24 2002-06-11 Janssen Pharmaceutica Nv Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
NZ330263A (en) * 1996-02-15 1999-06-29 Janssen Pharmaceutica Nv Esters of 3-hydroxy-piperidinemethanol derivatives to improve gastric emptying

Also Published As

Publication number Publication date
PL345309A1 (en) 2001-12-03
WO1999058527A3 (fr) 2000-01-27
AU4052999A (en) 1999-11-29
HRP20000750A2 (en) 2001-06-30
SK17212000A3 (sk) 2001-05-10
AU753706B2 (en) 2002-10-24
WO1999058527A2 (fr) 1999-11-18
EP1077973A2 (fr) 2001-02-28
KR20010043618A (ko) 2001-05-25
JP2002514643A (ja) 2002-05-21

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Legal Events

Date Code Title Description
FZDE Discontinued