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Softgel-compatible composition containing retinol

Info

Publication number
CA2328945A1
CA2328945A1 CA 2328945 CA2328945A CA2328945A1 CA 2328945 A1 CA2328945 A1 CA 2328945A1 CA 2328945 CA2328945 CA 2328945 CA 2328945 A CA2328945 A CA 2328945A CA 2328945 A1 CA2328945 A1 CA 2328945A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
retinol
compatible
composition
include
containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2328945
Other languages
French (fr)
Other versions
CA2328945C (en )
Inventor
Marie A. Rinaldi
Paul C. Tutschek
Subhash J. Saxena
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Catalent Pharma Solutions Inc
Heron Therapeutics LLC
Original Assignee
Advanced Polymer Systems, Inc.
Marie A. Rinaldi
Paul C. Tutschek
Subhash J. Saxena
R.P. Scherer Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07Retinol compounds, e.g. vitamin A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/962Capsule, e.g. gelatin
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/962Capsule, e.g. gelatin
    • Y10S514/963Microcapsule-sustained or differential release
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/964Sustained or differential release type
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/964Sustained or differential release type
    • Y10S514/965Discrete particles in supporting matrix

Abstract

A softgel-compatible composition containing retinol comprises retinol-impregnated microparticles. The composition may include an optionally thickened silicone oil, or may include an emulsion comprising a silicone oil. Ascorbic acid may be present as ascorbic acid-impregnated microparticles and/or within the emulsion. Such compositions are compatible with softgels, and may also be used in other dispensing containers, such as sachets, tubes, and airless pumps.
CA 2328945 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol Active CA2328945C (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US09/062,138 1998-04-17
US09062138 US5891470A (en) 1998-04-17 1998-04-17 Softgel formulation containing retinol
US09272893 US6228894B1 (en) 1998-04-17 1999-03-19 Softgel-compatible composition containing retinol
US09/272,893 1999-03-19
PCT/US1999/008559 WO1999053904A3 (en) 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol

Publications (2)

Publication Number Publication Date
CA2328945A1 true true CA2328945A1 (en) 1999-10-28
CA2328945C CA2328945C (en) 2007-07-03

Family

ID=26741915

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2328945 Active CA2328945C (en) 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol

Country Status (7)

Country Link
US (1) US6228894B1 (en)
JP (1) JP4338894B2 (en)
CA (1) CA2328945C (en)
DE (2) DE69912262D1 (en)
EP (1) EP1071404B1 (en)
ES (1) ES2211075T3 (en)
WO (1) WO1999053904A3 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1112059A2 (en) * 1998-09-08 2001-07-04 Industria E Comércio de Cosméticos Natura Ltda. Process and composition for enhancing the action of vitamin a on the cellular activity of an individual, and use of vitamin c
US6468516B1 (en) * 1999-03-19 2002-10-22 Warner-Lambert Company Composition and manufacture of topical pharmaceutical and cosmetic semi-solid post-foaming dosage forms in a pouch
CA2408137C (en) * 2000-05-05 2011-04-19 R.P. Scherer Technologies, Inc. Oil-in-water emulsion formulation containing hydroquinone and retinol
EP1269994A3 (en) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
JP2003104827A (en) * 2001-09-28 2003-04-09 Kose Corp Cosmetic
US20030232091A1 (en) * 2002-06-17 2003-12-18 Adi Shefer Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
JP4260113B2 (en) * 2002-12-18 2009-04-30 コリアナ・コスメティック・カンパニー・リミテッド Novel retinol derivative and cosmetic compositions containing the same
US20050031699A1 (en) 2003-06-26 2005-02-10 L'oreal Porous particles loaded with cosmetically or pharmaceutically active compounds
US8920918B2 (en) * 2005-10-31 2014-12-30 Kee Action Sports Technology Holdings, Llc Oil and polyethylene glycol fill material for use in paintball shells
EP2120889A1 (en) * 2006-12-20 2009-11-25 Novartis AG Gelatin capsules comprising an acid
KR20100125278A (en) * 2008-02-01 2010-11-30 암콜 인터내셔널 코포레이션 Improved skin brightening compositions
FR2931661B1 (en) * 2008-05-30 2010-07-30 Galderma Res & Dev Novel depigmenting compositions in the form of an anhydrous composition without petrolatum and without elastomer comprising a phenol derivative and a solubilized retinoid.
FR2931662B1 (en) * 2008-05-30 2010-07-30 Galderma Res & Dev Novel depigmenting compositions in the form of an anhydrous composition without petrolatum and without elastomer comprising a phenol derivative dissolves.
EP2334286A1 (en) * 2008-09-12 2011-06-22 Amcol International Corporation Low ph retinoid topical compositions
US20100064927A1 (en) * 2008-09-17 2010-03-18 Aldo Perrone Starch-based paintball fill material
US9180112B2 (en) * 2010-03-23 2015-11-10 Ermis Labs, LLC Dermal compositions containing gorgonian extract
KR101080186B1 (en) * 2010-06-21 2011-11-07 주식회사 필라이트솔루션 Improved led lamp

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4369180A (en) 1981-09-10 1983-01-18 Randolph C. Karrh Cosmetic facial preparation containing aloe vera
US4826828A (en) 1985-04-22 1989-05-02 Avon Products, Inc. Composition and method for reducing wrinkles
US4690825A (en) 1985-10-04 1987-09-01 Advanced Polymer Systems, Inc. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen
US5145675A (en) 1986-03-31 1992-09-08 Advanced Polymer Systems, Inc. Two step method for preparation of controlled release formulations
JP2622955B2 (en) 1986-07-29 1997-06-25 エイボン プロダクツ インコ−ポレイテツド Anhydrous cosmetics
DE3880593T2 (en) * 1987-08-31 1993-10-21 Advanced Polymer Systems Inc Pharmaceutical preparations with delayed release.
EP0374217A4 (en) 1988-04-22 1990-12-05 Advanced Polymer Systems, Inc. Porous particles in preparations involving immiscible phases
US4873091A (en) 1988-05-23 1989-10-10 Advanced Polymer Systems, Inc. Controlled release formulating employing resilient microbeads
US5055300A (en) 1988-06-17 1991-10-08 Basic Bio Systems, Inc. Time release protein
US5073365A (en) 1989-06-01 1991-12-17 Advanced Polymer Systems Clinical and personal care articles enhanced by lubricants and adjuvants
US5559149A (en) 1990-01-29 1996-09-24 Johnson & Johnson Consumer Products, Inc. Skin care compositions containing retinoids
JP3014780B2 (en) 1990-01-29 2000-02-28 ジヨンソン・アンド・ジヨンソン・コンシユーマー・プロダクツ・インコーポレーテツド Skin care composition
US5082661A (en) 1990-09-26 1992-01-21 Elizabeth Arden Co., Division Of Conopco, Inc. Odorless cosmetic compositions in gelatin capsules
DE69130020D1 (en) 1991-06-27 1998-09-24 Johnson & Johnson Consumer Stabilized, skin care preparations containing retinoids
CA2101101C (en) 1992-08-06 2005-07-05 Mohammed Yusuf Skin care compositions comprising a retinoid and an imidazole
US5516793A (en) 1993-04-26 1996-05-14 Avon Products, Inc. Use of ascorbic acid to reduce irritation of topically applied active ingredients
US5587149A (en) 1995-02-06 1996-12-24 R.P. Scherer Corporation Topical application emulsions
FR2737122B1 (en) 1995-07-25 1997-09-12 Oreal the stable composition containing ascorbic acid
US5851538A (en) 1995-12-29 1998-12-22 Advanced Polymer Systems, Inc. Retinoid formulations in porous microspheres for reduced irritation and enhanced stability
US5750123A (en) 1996-06-28 1998-05-12 Chesebrough-Pond's Co., Division Of Conopco, Inc. Vitamin C delivery system
JP2001505227A (en) 1997-09-16 2001-04-17 イー―エル マネージメント コーポレイション Stability anhydrous mixed product
US6017549A (en) 1997-09-30 2000-01-25 E-L Management Corp. Non-irritating cosmetic and pharmaceutical compositions
US6194452B1 (en) 1997-11-07 2001-02-27 Howard Murad Stable pharmaceutical compositions including ascorbic acid and methods of using same
US5891470A (en) * 1998-04-17 1999-04-06 Advanced Polymer Systems, Inc. Softgel formulation containing retinol

Also Published As

Publication number Publication date Type
CA2328945C (en) 2007-07-03 grant
EP1071404B1 (en) 2003-10-22 grant
WO1999053904A2 (en) 1999-10-28 application
ES2211075T3 (en) 2004-07-01 grant
DE69912262T2 (en) 2004-08-26 grant
JP4338894B2 (en) 2009-10-07 grant
DE69912262D1 (en) 2003-11-27 grant
JP2002512184A (en) 2002-04-23 application
WO1999053904A3 (en) 1999-12-23 application
US6228894B1 (en) 2001-05-08 grant
EP1071404A2 (en) 2001-01-31 application

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Legal Events

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