CA2319039A1 - Biotin-binding receptor molecules - Google Patents
Biotin-binding receptor molecules Download PDFInfo
- Publication number
- CA2319039A1 CA2319039A1 CA002319039A CA2319039A CA2319039A1 CA 2319039 A1 CA2319039 A1 CA 2319039A1 CA 002319039 A CA002319039 A CA 002319039A CA 2319039 A CA2319039 A CA 2319039A CA 2319039 A1 CA2319039 A1 CA 2319039A1
- Authority
- CA
- Canada
- Prior art keywords
- leu
- thr
- protein
- glu
- asn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000027455 binding Effects 0.000 title claims abstract description 16
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title claims description 37
- 229960002685 biotin Drugs 0.000 title claims description 20
- 239000011616 biotin Substances 0.000 title claims description 20
- 235000020958 biotin Nutrition 0.000 title claims description 18
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 32
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 29
- 230000001086 cytosolic effect Effects 0.000 claims abstract description 5
- 230000000694 effects Effects 0.000 claims abstract description 3
- 108090001008 Avidin Proteins 0.000 claims description 20
- 108010090804 Streptavidin Proteins 0.000 claims description 9
- 102000035013 scavenger receptor class A Human genes 0.000 claims description 9
- 108091005451 scavenger receptor class A Proteins 0.000 claims description 9
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 230000005714 functional activity Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000003259 recombinant expression Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 108700021042 biotin binding protein Proteins 0.000 abstract description 2
- 102000043871 biotin binding protein Human genes 0.000 abstract description 2
- 102000035160 transmembrane proteins Human genes 0.000 abstract description 2
- 108091005703 transmembrane proteins Proteins 0.000 abstract description 2
- 108020001507 fusion proteins Proteins 0.000 description 16
- 102000037865 fusion proteins Human genes 0.000 description 16
- 239000002299 complementary DNA Substances 0.000 description 14
- 210000004027 cell Anatomy 0.000 description 12
- 102000005962 receptors Human genes 0.000 description 11
- 108020003175 receptors Proteins 0.000 description 11
- 150000001413 amino acids Chemical group 0.000 description 8
- 241001430294 unidentified retrovirus Species 0.000 description 8
- 239000013598 vector Substances 0.000 description 7
- 239000002773 nucleotide Substances 0.000 description 6
- 125000003729 nucleotide group Chemical group 0.000 description 6
- 239000013612 plasmid Substances 0.000 description 6
- 241000880493 Leptailurus serval Species 0.000 description 5
- UGXVKHRDGLYFKR-CIUDSAMLSA-N Asn-Asp-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CC(N)=O UGXVKHRDGLYFKR-CIUDSAMLSA-N 0.000 description 4
- IBLAOXSULLECQZ-IUKAMOBKSA-N Asn-Ile-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CC(N)=O IBLAOXSULLECQZ-IUKAMOBKSA-N 0.000 description 4
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- TTXMOJWKNRJWQJ-FXQIFTODSA-N Ala-Arg-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)C)CCCN=C(N)N TTXMOJWKNRJWQJ-FXQIFTODSA-N 0.000 description 2
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- XLZCLJRGGMBKLR-PCBIJLKTSA-N Asn-Ile-Phe Chemical compound NC(=O)C[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 XLZCLJRGGMBKLR-PCBIJLKTSA-N 0.000 description 2
- HMUKKNAMNSXDBB-CIUDSAMLSA-N Asn-Met-Glu Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(O)=O HMUKKNAMNSXDBB-CIUDSAMLSA-N 0.000 description 2
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9803757.5 | 1998-02-23 | ||
| GBGB9803757.5A GB9803757D0 (en) | 1998-02-23 | 1998-02-23 | Fusion proteins |
| GB9813653.4 | 1998-06-24 | ||
| GBGB9813653.4A GB9813653D0 (en) | 1998-06-24 | 1998-06-24 | Fusion proteins |
| PCT/GB1999/000546 WO1999042577A2 (en) | 1998-02-23 | 1999-02-23 | Biotin-binding receptor molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2319039A1 true CA2319039A1 (en) | 1999-08-26 |
Family
ID=26313170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002319039A Abandoned CA2319039A1 (en) | 1998-02-23 | 1999-02-23 | Biotin-binding receptor molecules |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7208291B2 (https=) |
| EP (1) | EP1056850B1 (https=) |
| JP (1) | JP2002504328A (https=) |
| KR (1) | KR100722578B1 (https=) |
| CN (1) | CN1195852C (https=) |
| AT (1) | ATE274058T1 (https=) |
| AU (1) | AU750444B2 (https=) |
| CA (1) | CA2319039A1 (https=) |
| DE (1) | DE69919515T2 (https=) |
| DK (1) | DK1056850T3 (https=) |
| ES (1) | ES2226340T3 (https=) |
| HU (1) | HUP0101614A3 (https=) |
| NO (1) | NO328139B1 (https=) |
| PL (1) | PL195990B1 (https=) |
| PT (1) | PT1056850E (https=) |
| WO (1) | WO1999042577A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040209294A1 (en) * | 2002-09-02 | 2004-10-21 | National Food Research Institute | Method to produce a receptor chip using biotinylated protein |
| US9623117B2 (en) * | 2011-04-04 | 2017-04-18 | Wisconsin Alumni Research Foundation | Method for selective targeting and entry of bacterial toxins to cells |
| CN113354744A (zh) * | 2013-12-20 | 2021-09-07 | 弗雷德哈钦森癌症研究中心 | 带标签的嵌合效应分子及其受体 |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839293A (en) * | 1986-02-24 | 1989-06-13 | The Trustees Of Columbia University In The City Of New York | DNA encoding streptavidin, streptavidin produced therefrom, fused polypeptides which include amino acid sequences present in streptavidin and uses thereof |
| US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| CA1340977C (en) | 1988-11-15 | 2000-04-25 | Monty Krieger | Scavenger receptor protein and antibody thereto |
| US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
| US5846537A (en) | 1995-06-07 | 1998-12-08 | University Of Rochester | Modified avidin and streptavidin and methods of use thereof |
| US6497881B1 (en) * | 1995-11-30 | 2002-12-24 | New York University | High efficiency tissue specific compound delivery system using streptavidin-protein a fusion protein |
-
1999
- 1999-02-23 KR KR1020007009270A patent/KR100722578B1/ko not_active Expired - Fee Related
- 1999-02-23 HU HU0101614A patent/HUP0101614A3/hu not_active Application Discontinuation
- 1999-02-23 DE DE69919515T patent/DE69919515T2/de not_active Expired - Lifetime
- 1999-02-23 ES ES99906341T patent/ES2226340T3/es not_active Expired - Lifetime
- 1999-02-23 DK DK99906341T patent/DK1056850T3/da active
- 1999-02-23 AT AT99906341T patent/ATE274058T1/de not_active IP Right Cessation
- 1999-02-23 PL PL99343079A patent/PL195990B1/pl not_active IP Right Cessation
- 1999-02-23 CN CNB998032174A patent/CN1195852C/zh not_active Expired - Fee Related
- 1999-02-23 PT PT99906341T patent/PT1056850E/pt unknown
- 1999-02-23 AU AU26312/99A patent/AU750444B2/en not_active Ceased
- 1999-02-23 CA CA002319039A patent/CA2319039A1/en not_active Abandoned
- 1999-02-23 JP JP2000532517A patent/JP2002504328A/ja active Pending
- 1999-02-23 WO PCT/GB1999/000546 patent/WO1999042577A2/en not_active Ceased
- 1999-02-23 EP EP99906341A patent/EP1056850B1/en not_active Expired - Lifetime
-
2000
- 2000-08-22 NO NO20004195A patent/NO328139B1/no not_active IP Right Cessation
-
2003
- 2003-07-11 US US10/618,570 patent/US7208291B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69919515D1 (de) | 2004-09-23 |
| JP2002504328A (ja) | 2002-02-12 |
| US20040185059A1 (en) | 2004-09-23 |
| HUP0101614A2 (hu) | 2001-09-28 |
| WO1999042577A3 (en) | 1999-10-21 |
| PL343079A1 (en) | 2001-07-30 |
| DK1056850T3 (da) | 2004-11-29 |
| PT1056850E (pt) | 2004-12-31 |
| NO328139B1 (no) | 2009-12-14 |
| DE69919515T2 (de) | 2005-04-07 |
| KR20010085196A (ko) | 2001-09-07 |
| PL195990B1 (pl) | 2007-11-30 |
| ES2226340T3 (es) | 2005-03-16 |
| AU2631299A (en) | 1999-09-06 |
| EP1056850A2 (en) | 2000-12-06 |
| US7208291B2 (en) | 2007-04-24 |
| AU750444B2 (en) | 2002-07-18 |
| NO20004195L (no) | 2000-08-22 |
| EP1056850B1 (en) | 2004-08-18 |
| CN1195852C (zh) | 2005-04-06 |
| ATE274058T1 (de) | 2004-09-15 |
| CN1291230A (zh) | 2001-04-11 |
| KR100722578B1 (ko) | 2007-05-28 |
| HUP0101614A3 (en) | 2006-04-28 |
| WO1999042577A2 (en) | 1999-08-26 |
| NO20004195D0 (no) | 2000-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |