CA2314929A1 - Regulator with artificial load to maintain regulated delivery - Google Patents
Regulator with artificial load to maintain regulated delivery Download PDFInfo
- Publication number
- CA2314929A1 CA2314929A1 CA002314929A CA2314929A CA2314929A1 CA 2314929 A1 CA2314929 A1 CA 2314929A1 CA 002314929 A CA002314929 A CA 002314929A CA 2314929 A CA2314929 A CA 2314929A CA 2314929 A1 CA2314929 A1 CA 2314929A1
- Authority
- CA
- Canada
- Prior art keywords
- skin resistance
- electrotransport device
- load voltage
- skin
- voltage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
Abstract
An electrotransport device with a drug delivery regulating apparatus delivers a proper drug dosage rate over time by adapting to variable skin resistance values. The electrotransport device adapts to a decline in skin resistance over a time that the electrotransport device is used, and to different skin resistances at different skin surface locations. One drug delivery regulating apparatus includes a voltage booster, a serially connectable artificial impedance, and a feedback sensor, which are all connected to a controller. This apparatus outputs a load voltage across two electrodes. The controller monitors the output of the feedback sensor to determine the skin resistance, or a load current, or the load voltage. Based on the monitored value, the load voltage across the electrodes is controlled, so that a targeted drug dose rate is maintained even as the initial skin resistance drops over the period that the electrotransport device is used. The artificial impedance is selectively controlled to prevent overdose where the skin resistance falls below a predetermined resistance, such that a load voltage greater than a supply voltage could result in an overdose.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6974597P | 1997-12-16 | 1997-12-16 | |
US60/069,745 | 1997-12-16 | ||
PCT/US1998/026187 WO1999030773A1 (en) | 1997-12-16 | 1998-12-09 | Regulator with artificial load to maintain regulated delivery |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2314929A1 true CA2314929A1 (en) | 1999-06-24 |
CA2314929C CA2314929C (en) | 2008-09-02 |
Family
ID=22090953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002314929A Expired - Fee Related CA2314929C (en) | 1997-12-16 | 1998-12-09 | Regulator with artificial load to maintain regulated delivery |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1039950A1 (en) |
JP (1) | JP2002508228A (en) |
KR (1) | KR20010033208A (en) |
CN (1) | CN1154525C (en) |
AU (1) | AU1997699A (en) |
CA (1) | CA2314929C (en) |
WO (1) | WO1999030773A1 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE960312A1 (en) | 1995-06-02 | 1996-12-11 | Alza Corp | An electrotransport delivery device with voltage boosting¹circuit |
US6687536B1 (en) * | 1999-12-09 | 2004-02-03 | Iomed, Inc. | Connection system for an iontophoretic drug delivery device |
AU2001238226A1 (en) * | 2000-02-18 | 2001-08-27 | University Of Utah Research Foundation | Methods for delivering agents using alternating current |
JP2001286569A (en) | 2000-04-05 | 2001-10-16 | Polytronics Ltd | Endermism device |
US6821254B2 (en) | 2000-07-21 | 2004-11-23 | Institute Of Critical Care Medicine | Cardiac/respiratory arrest detector |
JP2010502270A (en) * | 2006-08-29 | 2010-01-28 | アルザ・コーポレーシヨン | Chemical electrotransport with hydration measurements in hydratable reservoirs |
WO2008087884A1 (en) * | 2007-01-16 | 2008-07-24 | Tti Ellebeau, Inc. | Method for predicting medicament dose and program therefor |
JP2010531202A (en) * | 2007-06-26 | 2010-09-24 | アルザ・コーポレーシヨン | Methods and devices for transdermal electrotransport delivery of lofentanil and carfentanil |
US20090043244A1 (en) * | 2007-08-08 | 2009-02-12 | Inan Omer T | Electrotransport Drug Delivery Device Adaptable to Skin Resistance Change |
US20090312689A1 (en) * | 2008-06-05 | 2009-12-17 | Alza Corporation | Adjustable Current Electrotransport Fentanyl Delivery Device |
CA2944660A1 (en) * | 2008-12-30 | 2010-07-08 | Teva Pharmaceuticals International Gmbh | Electronic control of drug delivery system |
EA026254B1 (en) | 2010-11-23 | 2017-03-31 | Тева Фармасьютикалс Интернешнл Гмбх | User-activated self-contained co-packaged iontophoretic drug delivery system |
US8428708B1 (en) | 2012-05-21 | 2013-04-23 | Incline Therapeutics, Inc. | Self-test for analgesic product |
US8428709B1 (en) | 2012-06-11 | 2013-04-23 | Incline Therapeutics, Inc. | Current control for electrotransport drug delivery |
GB201414695D0 (en) * | 2014-08-19 | 2014-10-01 | Femeda Ltd | Electrostimulation related devices and methods |
KR101725087B1 (en) | 2014-12-29 | 2017-04-26 | 주식회사 효성 | Power control device for sub-module of mmc converter |
CA3085320A1 (en) * | 2017-12-12 | 2019-06-20 | Radio Systems Corporation | Method and apparatus for applying, monitoring, and adjusting a stimulus to a pet |
KR20210074434A (en) | 2019-12-11 | 2021-06-22 | 박상훈 | Insulin infusion device using magnetic |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3991755A (en) | 1973-07-27 | 1976-11-16 | Medicon, Inc. | Iontophoresis apparatus for applying local anesthetics |
US4141359A (en) | 1976-08-16 | 1979-02-27 | University Of Utah | Epidermal iontophoresis device |
US4250878A (en) | 1978-11-22 | 1981-02-17 | Motion Control, Inc. | Non-invasive chemical species delivery apparatus and method |
JPS56501274A (en) | 1979-10-10 | 1981-09-10 | ||
US4292968A (en) * | 1979-11-26 | 1981-10-06 | Sybron Corporation | Electric supply for ion therapy |
US5207752A (en) | 1990-03-30 | 1993-05-04 | Alza Corporation | Iontophoretic drug delivery system with two-stage delivery profile |
US5213568A (en) | 1990-03-30 | 1993-05-25 | Medtronic Inc. | Activity controlled electrotransport drug delivery device |
CA2084734C (en) * | 1991-12-17 | 1998-12-01 | John L. Haynes | Iontophoresis system having features for reducing skin irritation |
US5498235A (en) | 1994-09-30 | 1996-03-12 | Becton Dickinson And Company | Iontophoresis assembly including patch/controller attachment |
IE960312A1 (en) * | 1995-06-02 | 1996-12-11 | Alza Corp | An electrotransport delivery device with voltage boosting¹circuit |
US6167301A (en) * | 1995-08-29 | 2000-12-26 | Flower; Ronald J. | Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit |
-
1998
- 1998-12-09 WO PCT/US1998/026187 patent/WO1999030773A1/en not_active Application Discontinuation
- 1998-12-09 EP EP98964714A patent/EP1039950A1/en not_active Withdrawn
- 1998-12-09 CA CA002314929A patent/CA2314929C/en not_active Expired - Fee Related
- 1998-12-09 CN CNB988122677A patent/CN1154525C/en not_active Expired - Fee Related
- 1998-12-09 JP JP2000538748A patent/JP2002508228A/en not_active Withdrawn
- 1998-12-09 KR KR1020007006600A patent/KR20010033208A/en not_active Application Discontinuation
- 1998-12-09 AU AU19976/99A patent/AU1997699A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2314929C (en) | 2008-09-02 |
KR20010033208A (en) | 2001-04-25 |
WO1999030773A1 (en) | 1999-06-24 |
CN1282261A (en) | 2001-01-31 |
AU1997699A (en) | 1999-07-05 |
CN1154525C (en) | 2004-06-23 |
JP2002508228A (en) | 2002-03-19 |
EP1039950A1 (en) | 2000-10-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |