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CA2306837A1 - Treatment of female sexual dysfunction - Google Patents

Treatment of female sexual dysfunction

Info

Publication number
CA2306837A1
CA2306837A1 CA 2306837 CA2306837A CA2306837A1 CA 2306837 A1 CA2306837 A1 CA 2306837A1 CA 2306837 CA2306837 CA 2306837 CA 2306837 A CA2306837 A CA 2306837A CA 2306837 A1 CA2306837 A1 CA 2306837A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
vasoactive
female
sexual
muscle
dysfunction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2306837
Other languages
French (fr)
Other versions
CA2306837C (en )
Inventor
Virgil A. Place
Leland F. Wilson
Paul C. Doherty, Jr.
Mark S. Hanamoto
Alfred P. Spivack
Neil Gesundheit
Sean R. Bennett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vivus Inc
Original Assignee
Asivi, Llc.
Virgil A. Place
Leland F. Wilson
Paul C. Doherty, Jr.
Mark S. Hanamoto
Alfred P. Spivack
Neil Gesundheit
Sean R. Bennett
Vivus, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/15Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/295Iron group metal compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/48Ergoline derivatives, e.g. lysergic acid, ergotamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A61K31/5585Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/02Suppositories; Bougies; Bases therefor; Ovules

Abstract

Methods and formulations for treating female sexual dysfunction are provided.
A
pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment.
Suitable vasoactive agents are vasodilators, including endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, and others. The formulations are also useful for preventing the occurrence of yeast infections, improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. A clitoral drug delivery device is also provided.
CA 2306837 1997-10-28 1998-10-28 Treatment of female sexual dysfunction Expired - Fee Related CA2306837C (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US95905797 true 1997-10-28 1997-10-28
US08/959,064 1997-10-28
US08959064 US5877216A (en) 1997-10-28 1997-10-28 Treatment of female sexual dysfunction
US08/959,057 1997-10-28
US18131698 true 1998-10-27 1998-10-27
US09/181,316 1998-10-27
PCT/US1998/022927 WO1999021562A1 (en) 1997-10-28 1998-10-28 Treatment of female sexual dysfunction

Publications (2)

Publication Number Publication Date
CA2306837A1 true true CA2306837A1 (en) 1999-05-06
CA2306837C CA2306837C (en) 2007-05-08

Family

ID=27391395

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2306837 Expired - Fee Related CA2306837C (en) 1997-10-28 1998-10-28 Treatment of female sexual dysfunction

Country Status (5)

Country Link
US (6) US6469016B1 (en)
EP (1) EP1027057A4 (en)
JP (2) JP2001520999A (en)
CA (1) CA2306837C (en)
WO (1) WO1999021562A1 (en)

Families Citing this family (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060222647A1 (en) * 1993-05-27 2006-10-05 Beavo Joseph A Methods and compositions for modulating the activity of PDE5
GB9301192D0 (en) 1993-06-09 1993-03-17 Trott Francis W Flower shaped mechanised table
JPH11513390A (en) * 1995-10-06 1999-11-16 アーチ デベロップメント コーポレイション Methods and compositions for viral enhancement of cell killing
US20050065161A1 (en) * 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
DK0792641T3 (en) 1996-02-28 2001-10-08 Pfizer The use of estrogen antagonists and estrogen agonists for the inhibition of pathological conditions
GB9608408D0 (en) 1996-04-23 1996-06-26 Adams Michael A Treatment of erectile dysfunction
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
JP2001525803A (en) 1997-05-06 2001-12-11 カナカリス、パーナジオティス Misoprostol and / or miso professional stall acid application for the preparation of erectile dysfunction therapeutic agents
JP2002505676A (en) 1997-06-23 2002-02-19 クイーンズ ユニバーシティー アット キングストン Trace dosing regimen
US6593369B2 (en) 1997-10-20 2003-07-15 Vivus, Inc. Methods, compositions, and kits for enhancing female sexual desire and responsiveness
US6403597B1 (en) 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
US20040044080A1 (en) * 1997-10-28 2004-03-04 Place Virgil A. Treatment of dyspareunia with topically administered nitroglycerin formulations
US20020013304A1 (en) * 1997-10-28 2002-01-31 Wilson Leland F. As-needed administration of an androgenic agent to enhance female sexual desire and responsiveness
EP1027054A4 (en) * 1997-10-28 2002-11-04 Vivus Inc Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US20040014761A1 (en) * 1997-10-28 2004-01-22 Place Virgil A. Treatment of female sexual dysfunction with phosphodiesterase inhibitors
US6548490B1 (en) 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
EP1027057A4 (en) * 1997-10-28 2003-01-02 Vivus Inc Treatment of female sexual dysfunction
US6541487B1 (en) * 1998-05-01 2003-04-01 R.T. Alamo Ventures I, Llc PDE III inhibitors for treating sexual dysfunction
US6465445B1 (en) * 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
RU2221569C2 (en) * 1998-06-11 2004-01-20 Андорешерш, Инк. ANDROST-5-ENE-3β,17β-DIOL-CONTAINING PHARMACEUTICAL COMPOSITIONS AND ITS USING
US6897239B1 (en) 1998-08-14 2005-05-24 Lavipharm S.A. Use of misoprostol and/or metabolites of misoprostol for treating sexual dysfunction in women
GB9818524D0 (en) * 1998-08-25 1998-10-21 Futura Medical Limited Inorgasmia treatment
FR2786101B1 (en) * 1998-11-24 2002-07-05 Aventis Laboratoire Use of nicergoline for the treatment of spasticity
US6825234B2 (en) 1998-12-10 2004-11-30 Nexmed (Holdings) , Inc. Compositions and methods for amelioration of human female sexual dysfunction
US20070191320A1 (en) * 1998-12-10 2007-08-16 Nexmed Holdings, Inc. Methods of treatment for female sexual arousal disorder
WO2000040248A1 (en) * 1999-01-08 2000-07-13 Synphora Ab Method and composition for treatment of female sexual dysfunction
WO2000051978A1 (en) 1999-03-01 2000-09-08 Nitromed, Inc. Nitrosated and nitrosylated prostaglandins, compositions and metods of use
EP1173167A4 (en) 1999-04-30 2004-07-14 Lilly Icos Llc Treatment of female arousal disorder
US6303606B1 (en) 1999-05-07 2001-10-16 Recordati, S.A., Chemical And Pharmaceutical Company Use of selective antagonists of the α1B-adrenergic receptor for improvement of sexual dysfunction
US20050100618A1 (en) * 1999-07-01 2005-05-12 Thompson Ronald J. Method of using a compound of menthol and L-arginine as a preparation for the topical delivery of Icariin, a herbal product produced from the Epimedium genus of the Berberidaceal family of plants, for the treatment of sexual dysfunction
US20050186294A1 (en) * 1999-07-01 2005-08-25 Thompson James M. Method of using a compound of menthol and L-arginine as a preparation for the topical delivery of vardenafil for the treatment of female sexual dysfunction
US20040254153A1 (en) * 1999-11-08 2004-12-16 Pfizer Inc Compounds for the treatment of female sexual dysfunction
DE60016877T2 (en) * 1999-11-08 2005-12-15 Pfizer Inc. NEP inhibitors for the treatment of female sexual disorders
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
DE60131644T2 (en) * 2000-05-09 2008-10-30 Nitromed, Inc., Lexington Infrared thermography and treatment of sexual dysfunctions
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20040092494A9 (en) * 2000-08-30 2004-05-13 Dudley Robert E. Method of increasing testosterone and related steroid concentrations in women
US6821978B2 (en) * 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
JP2004522710A (en) * 2000-11-17 2004-07-29 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニーWarner−Lambert Companyllc Treatment of sexual dysfunction
US20020107230A1 (en) * 2000-12-22 2002-08-08 Waldon R. Forrest Methods and formulations for the treatment of female sexual dysfunction
US20020132832A1 (en) * 2001-01-05 2002-09-19 Mills Thomas M. Treatment of erectile dysfunction
WO2002069906A3 (en) 2001-03-06 2003-11-20 Cellegy Pharma Inc Compounds and methods for the treatment of urogenital disorders
US20030022875A1 (en) * 2001-07-27 2003-01-30 Wilson Leland F. As-needed administration of orally active androgenic agents to enhance female sexual desire and responsiveness
US6607525B2 (en) 2001-08-01 2003-08-19 Nicolas Franco Apparatus and method for treating urinary stress incontinence
EP1442042A1 (en) * 2001-11-09 2004-08-04 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
US20030108512A1 (en) * 2001-12-10 2003-06-12 Robert Shorr Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
US6673841B2 (en) * 2001-12-20 2004-01-06 Whan In Pharm. Co., Ltd. Alprostadil alkyl ester-containing composition for external application
US20030158184A1 (en) * 2001-12-21 2003-08-21 Garvey David S. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
EP1340503A1 (en) * 2002-03-01 2003-09-03 CHIESI FARMACEUTICI S.p.A. Solution aerosol formulation containing esters of 3, 17-dihydroxy oestratriene derivates for pulmonary delivery
US6899890B2 (en) * 2002-03-20 2005-05-31 Kv Pharmaceutical Company Bioadhesive drug delivery system
GB0208704D0 (en) * 2002-04-16 2002-05-29 Futura Medical Dev Ltd Condom
US7005408B2 (en) * 2002-05-01 2006-02-28 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US20040059190A1 (en) * 2002-07-08 2004-03-25 Matlock David L. Method of colpoplasty
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US8119150B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
WO2004037225A3 (en) 2002-10-25 2004-12-29 Foamix Ltd Cosmetic and pharmaceutical foam
US7700076B2 (en) * 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
ES2532906T3 (en) 2002-10-25 2015-04-01 Foamix Pharmaceuticals Ltd. cosmetic and pharmaceutical foam
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US20070020213A1 (en) 2002-10-25 2007-01-25 Foamix Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7306812B2 (en) 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US20060189695A1 (en) * 2003-06-25 2006-08-24 Cardiovascular Institute, Ltd External preparation for improving coital function
KR101146867B1 (en) * 2003-07-11 2012-05-16 인데나 에스피아 Combinations of vasoactive agents and their use in the treatment of sexual dysfunctions
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20050181057A1 (en) * 2004-02-13 2005-08-18 Rosenberg Paul K. Vaginal lubricant
US20050187429A1 (en) * 2004-02-23 2005-08-25 Poppas Dix P. Vaginal rejuvenation
US20050244402A1 (en) * 2004-04-30 2005-11-03 Villanueva Julie M Absorption of pain-causing agents
EP1750766B1 (en) 2004-05-11 2013-07-03 Emotional Brain B.V. Pharmaceutical formulations and uses thereof in the treatment of female sexual dysfunction
US6949067B1 (en) 2004-05-11 2005-09-27 Dann Jeffrey A Device and method for enhancing female sexual stimulation
US8147399B2 (en) 2004-05-11 2012-04-03 Gloth David A Device and method for applying a biocompatible substance to a female stimulation device
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
WO2006042409A1 (en) * 2004-10-20 2006-04-27 Endorecherche, Inc. Sex steroid precursors alone or in combination with a selective estrogen receptor modulator and/or with estrogens and/or a type 5 cgmp phosphodiesterase inhibitor for the prevention and treatment of vaginal dryness and sexual dysfunction in postmenopausal women
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
WO2007054818A3 (en) 2005-05-09 2008-10-23 Foamix Ltd Foamable vehicle and pharmaceutical compositions thereof
KR20080047375A (en) 2005-07-29 2008-05-28 콘서트 파마슈티컬즈, 인크. Novel pharmaceutical compounds
JP2009507925A (en) * 2005-09-13 2009-02-26 エラン ファーマ インターナショナル リミテッド Nanoparticles tadalafil formulation
WO2007035954A3 (en) * 2005-09-23 2007-11-22 Duramed Pharmaceuticals Inc Vaginal tablets comprising misoprostol and methods of making and using the same
EP1937276B1 (en) 2005-10-12 2012-11-21 Unimed Pharmaceuticals, LLC Improved testosterone gel and method of use
CA2626337C (en) 2005-10-19 2015-12-29 Chavah Pty Ltd Reduction of side effects from aromatase inhibitors used for treating breast cancer
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
EP1790343A1 (en) 2005-11-11 2007-05-30 Emotional Brain B.V. Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction
US8703179B2 (en) * 2006-05-11 2014-04-22 Kimberly-Clark Worldwide, Inc. Mucosal formulation
CA2654152A1 (en) 2006-06-02 2007-12-13 Pear Tree Women's Health Care Method of treating atrophic vaginitis
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
EP1925307A1 (en) 2006-11-03 2008-05-28 Emotional Brain B.V. Use of 3-alpha-androstanediol in the treatment of sexual dysfunction
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
WO2008095136A2 (en) 2007-01-31 2008-08-07 Henkin Robert I Methods for detection of biological substances
WO2008118644A1 (en) * 2007-03-23 2008-10-02 The Regents Of The University Of California Treatment of female sexual dysfunction by compounds that positively modulate ampa-type glutamate receptors
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US8268806B2 (en) 2007-08-10 2012-09-18 Endorecherche, Inc. Pharmaceutical compositions
US20090197892A1 (en) * 2007-08-21 2009-08-06 Nawaz Ahmad Anhydrous compositions useful for attaining enhanced sexual wellness
WO2009069006A3 (en) 2007-11-30 2009-11-12 Foamix Ltd. Foam containing benzoyl peroxide
WO2009072007A3 (en) 2007-12-07 2009-11-12 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
WO2009090558A3 (en) 2008-01-14 2010-12-23 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US20090185995A1 (en) * 2008-01-18 2009-07-23 Stacy Vochecowicz Lubricious, non-tacky personal lubricant
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8580801B2 (en) 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US8308678B2 (en) 2008-09-23 2012-11-13 Mcneil-Ppc, Inc. Pre-filled applicator device
WO2010041141A3 (en) 2008-10-07 2010-06-17 Foamix Ltd. Oil-based foamable carriers and formulations
WO2010042044A1 (en) * 2008-10-10 2010-04-15 Milux Holding S.A. A system, an apparatus, and a method for treating a sexual dysfunctional female patient
EP2381957B1 (en) * 2009-01-13 2015-01-07 Lubris LLC Therapeutic modulation of vaginal epithelium boundary lubrication
US20100227925A1 (en) * 2009-03-09 2010-09-09 Ruth Chatfield Sensitizing compound and method for increasing sexual sensitivity
CA2760186A1 (en) 2009-04-28 2010-11-04 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
WO2010138275A4 (en) * 2009-05-27 2011-04-28 St Anne Cora Method and device for female urinary incontinence
US9408683B2 (en) 2009-05-27 2016-08-09 Parapatch, Inc. Method and device for treating female pelvic nerve dysfunction
RU2545784C2 (en) 2009-06-19 2015-04-10 Наноформ Хунгари Лтд. Nanostructured sildenafil base, its pharmaceutically acceptable salts and cocrystals, their compositions method of preparing them and pharmaceutical compositions containing them
US20110002966A1 (en) * 2009-07-01 2011-01-06 Alex Lovett Vaginal Suppository System and Method
WO2011013008A4 (en) 2009-07-29 2011-07-14 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A4 (en) 2009-07-29 2011-06-23 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US8641671B2 (en) 2009-07-30 2014-02-04 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
CN103079632A (en) * 2009-09-29 2013-05-01 梅迪梅特里科斯个性化药物传输私人有限公司 Intrauterine electronic capsule for administering a substance
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
CA2776474A1 (en) 2009-10-02 2011-04-07 Foamix Ltd. Topical tetracycline compositions
US9757388B2 (en) 2011-05-13 2017-09-12 Acerus Pharmaceuticals Srl Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
CN102816099A (en) * 2011-06-09 2012-12-12 上海天伟生物制药有限公司 High-purity carboprost tromethamine, and preparation method and application thereof
ES2395801B1 (en) * 2011-06-23 2014-06-06 María Carmen PARDINA PALLEJÀ "Transvaginal pentoxifylline for the treatment of infertility"
US20130231317A1 (en) * 2011-07-19 2013-09-05 Michael S. Riepl Dhea bioadhesive controlled release gel
US9320744B2 (en) * 2011-10-19 2016-04-26 Dhea Llc DHEA bioadhesive controlled release gel
EP2782584A4 (en) 2011-11-23 2015-12-23 Therapeuticsmd Inc Natural combination hormone replacement formulations and therapies
US20150133421A1 (en) 2012-11-21 2015-05-14 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
WO2013098592A1 (en) 2011-12-29 2013-07-04 Universidad De Chile Vaginal ring which includes dhea or dhea sulphate and optionally an agent for modulating the release of the active principle, which can be used to increase the ovarian reserve in women and to relieve symptoms associated with menopause
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
EP3209301A4 (en) 2014-10-22 2018-03-14 Havah Therapeutics Pty Ltd Methods of reducing mammographic breast density and/or breast cancer risk
WO2017147274A1 (en) * 2016-02-24 2017-08-31 Eastern Virginia Medical School An improved formulation of long-acting levonorgestrel butanoate injectable depot suspension
USD798462S1 (en) 2016-04-01 2017-09-26 Parapatch, Inc. Clitoral adhesive device
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3967618A (en) 1969-04-01 1976-07-06 Alza Corporation Drug delivery device
US3948254A (en) 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
US3800038A (en) 1972-04-21 1974-03-26 Biolog Concepts Inc Uterine administraton of eutectic solid solutions of steroid hormones in a steroidal lipid carrier
US4014987A (en) 1974-06-04 1977-03-29 Alza Corporation Device for delivery of useful agent
US4112942A (en) 1974-10-09 1978-09-12 Reckitt & Colman Products Limited Method of preparing and administering a foam enema
US4128577A (en) 1975-12-29 1978-12-05 The Upjohn Company 15-Methyl- and 16-phenoxy-PGF2 α, amides
US4254145A (en) 1978-08-16 1981-03-03 American Cyanamid Company Topical application of prostaglandin hypotensive agents
DE3126924A1 (en) 1981-07-03 1983-01-20 Schering Ag 9-fluoro-prostaglandin derivatives, methods of making and use as medicaments
EP0089768B1 (en) 1982-03-22 1990-09-26 Upjohn Limited Compositions containing prostaglandins
US4961931A (en) 1982-07-29 1990-10-09 Alza Corporation Method for the management of hyperplasia
US4564362A (en) 1983-07-07 1986-01-14 Burnhill Michael S Vaginal device
US4521421A (en) 1983-09-26 1985-06-04 Eli Lilly And Company Treatment of sexual dysfunction
US4654362A (en) 1983-12-05 1987-03-31 Janssen Pharmaceutica, N.V. Derivatives of 2,2'-iminobisethanol
US4507323A (en) 1984-07-25 1985-03-26 Burroughs Wellcome Co. Treatment of psychosexual dysfunctions
DE3769160D1 (en) 1986-01-24 1991-05-16 Akzo Nv A pharmaceutical preparation for preparation of a hydrogel or suspension of high viscosity.
DE8710635U1 (en) * 1987-04-17 1988-01-14 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A., Rom/Roma, It
US5242391A (en) * 1990-04-25 1993-09-07 Alza Corporation Urethral insert for treatment of erectile dysfunction
GB9012469D0 (en) 1990-06-05 1990-07-25 Glaxo Group Ltd Medicaments
US4976692A (en) 1990-09-13 1990-12-11 Travenol Laboratories (Israel) Ltd. Catheter particularly useful for inducing labor and/or for the application of a pharmaceutical substance to the cervix of the uterus
US5773457A (en) * 1995-02-15 1998-06-30 Cesar Roberto Dias Nahoum Compositions
US5698589A (en) 1993-06-01 1997-12-16 International Medical Innovations, Inc. Water-based topical cream containing nitroglycerin and method of preparation and use thereof
GB9301192D0 (en) 1993-06-09 1993-03-17 Trott Francis W Flower shaped mechanised table
US5565466A (en) * 1993-08-13 1996-10-15 Zonagen, Inc. Methods for modulating the human sexual response
GB9423910D0 (en) 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
US5731339A (en) * 1995-04-28 1998-03-24 Zonagen, Inc. Methods and formulations for modulating the human sexual response
DK0792641T3 (en) * 1996-02-28 2001-10-08 Pfizer The use of estrogen antagonists and estrogen agonists for the inhibition of pathological conditions
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6150400A (en) * 1997-06-30 2000-11-21 Presutti Laboratories Method for treating vulvar vestibulitis
US20020004529A1 (en) 1997-10-20 2002-01-10 Gary W. Neal Methods, compositions, and kits for enhancing female sexual desire and responsiveness
US5877216A (en) * 1997-10-28 1999-03-02 Vivus, Incorporated Treatment of female sexual dysfunction
EP1027057A4 (en) * 1997-10-28 2003-01-02 Vivus Inc Treatment of female sexual dysfunction
US5891915A (en) 1998-05-01 1999-04-06 Wysor; Michael S. Method for enhancing female sexual response and an ointment therefor
US6031002A (en) 1998-05-01 2000-02-29 Michael Ebert Method for enhancing female sexual response and a composition therefor

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