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Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same

Info

Publication number
CA2281473A1
CA2281473A1 CA 2281473 CA2281473A CA2281473A1 CA 2281473 A1 CA2281473 A1 CA 2281473A1 CA 2281473 CA2281473 CA 2281473 CA 2281473 A CA2281473 A CA 2281473A CA 2281473 A1 CA2281473 A1 CA 2281473A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
dosage
form
forms
dispersing
rapidly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2281473
Other languages
French (fr)
Other versions
CA2281473C (en )
Inventor
Jaedeok Yoo
Sandeep Kumar
Donald C. Monkhouse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Therics, Inc.
Jaedeok Yoo
Sandeep Kumar
Donald C. Monkhouse
Massachusetts Institute Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00Products made by additive manufacturing

Abstract

A rapidly dispersing dosage form is described, which releases its active ingredients within a period of less than about ninety seconds.
These dosage forms exhibit a three-dimensional shape that is retained for adequate storage but is readily dispersed in the presence of excess moisture. Also disclosed are methods of administration of a medicament and a process for the preparation of rapidly dispersing dosage forms.
CA 2281473 1997-02-20 1998-02-20 Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same Active CA2281473C (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US3888397 true 1997-02-20 1997-02-20
US3828497 true 1997-02-20 1997-02-20
US60/038,883 1997-02-20
US60/038,284 1997-02-20
PCT/US1998/003256 WO1998036738A1 (en) 1997-02-20 1998-02-20 Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same

Publications (2)

Publication Number Publication Date
CA2281473A1 true true CA2281473A1 (en) 1998-08-27
CA2281473C CA2281473C (en) 2007-01-16

Family

ID=26715043

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2281473 Active CA2281473C (en) 1997-02-20 1998-02-20 Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same

Country Status (7)

Country Link
US (3) US6471992B1 (en)
JP (3) JP4563516B2 (en)
CA (1) CA2281473C (en)
DE (1) DE69840495D1 (en)
EP (1) EP0973507B1 (en)
ES (1) ES2318869T3 (en)
WO (1) WO1998036738A1 (en)

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JP4563516B2 (en) 1997-02-20 2010-10-13 マサチューセッツ インスティテュート オブ テクノロジー Dosage form showing a rapidly dispersing, their use and manufacturing method thereof
WO1999059544A9 (en) * 1998-05-18 2008-02-21 Takeda Chemical Industries Ltd Orally disintegrable tablets
US6284270B1 (en) * 1999-08-04 2001-09-04 Drugtech Corporation Means for creating a mass having structural integrity
EP1301177A2 (en) * 2000-07-10 2003-04-16 Massachusetts Institute Of Technology Method and materials for controlling migration of binder liquid in a powder
KR20090029314A (en) * 2001-06-28 2009-03-20 유씨비 파쉼 소시에떼아노님 Tablet comprising cetirizine and pseudoephedrine
JP4426286B2 (en) * 2001-07-10 2010-03-03 テバ ファーマシューティカル インダストリーズ リミティド Zero order, zero-order - biphasic drug delivery system for the elevation or lowering drug release
JP4845340B2 (en) * 2001-10-29 2011-12-28 マサチューセッツ インスティテュート オブ テクノロジー System and method for uniaxial compression of an article such as a three-dimensional printed dosage forms
WO2003041690A3 (en) * 2001-10-29 2003-08-28 Therics Inc Three-dimensional suspension printing of dosage forms
DE60323482D1 (en) 2002-05-06 2008-10-23 Massachusetts Inst Technology Diffusion controlled dosage form and method of preparation printing by means of three-dimensional
WO2004047793A1 (en) * 2002-11-26 2004-06-10 Alk-Abelló A/S Pharmaceutical allergen product
ES2378452T3 (en) 2004-09-21 2012-04-12 Hypnion, Inc. ? Acid 3- [4- (dibenzo [b, f] [1,4] oxazepine-11-yl) -piperazin-1-yl] propanoic acid -2,2¿dimetil for use in the treatment of sleep disorders
ES2500165T3 (en) 2006-06-29 2014-09-30 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
US7829000B2 (en) * 2005-02-25 2010-11-09 Hewlett-Packard Development Company, L.P. Core-shell solid freeform fabrication
US8187659B2 (en) 2006-05-02 2012-05-29 Jerry Robertson Real Estate Llc Solid medicament dosage form consumption aid
EP3195858A1 (en) * 2010-04-03 2017-07-26 Praful Doshi Medical devices including medicaments and methods of making and using same
US8692001B2 (en) 2010-10-27 2014-04-08 Dynamix Pharmaceuticals Ltd. Sulfonamides for the modulation of PKM2
WO2012106058A3 (en) 2011-01-31 2012-11-08 New Market Pharmaceuticals Animal treatments
US20120302609A1 (en) 2011-05-25 2012-11-29 Dynamix Pharmaceuticals Ltd. Pyrazolines for the Modulation of PKM2
US8937065B2 (en) 2011-06-07 2015-01-20 Clevexel Pharma Compositions and methods for modulating a kinase
US9245061B2 (en) * 2012-04-25 2016-01-26 Shapeways, Inc. Weight-based identification of three dimensional printed parts
CA2872396A1 (en) 2012-05-02 2013-11-07 New Market Pharmaceuticals Pharmaceutical compositions for direct systemic introduction
US9545376B2 (en) 2013-01-23 2017-01-17 Arx, Llc Production of unit dose constructs
US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
CA2906029C (en) * 2013-03-15 2017-09-05 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
CA2906107A1 (en) 2013-03-15 2014-09-18 Aprecia Pharmaceuticals Company Rapidly dispersible dosage form of oxcarbazepine
CA2906172A1 (en) * 2013-03-15 2014-09-18 Aprecia Pharmaceuticals Company Rapidly dispersible dosage form of topiramate
EP3033188A4 (en) 2013-08-16 2017-03-22 The Exone Company Three-dimensional printed metal-casting molds and methods for making the same
EP3086921A4 (en) * 2013-12-23 2017-08-16 The Exone Company Methods and systems for three-dimensional printing utilizing a jetted-particle binder fluid
WO2015100086A4 (en) * 2013-12-23 2015-08-06 The Exone Company Methods and systems for three-dimensional printing utilizing multiple binder fluids
EP3137113A4 (en) * 2014-04-30 2017-03-22 Blaesi Aron H Melt-processed polymeric cellular dosage form
EP3148730A1 (en) 2014-05-29 2017-04-05 The Exone Company Process for making nickel-based superalloy articles by three-dimensional printing
WO2016011098A4 (en) 2014-07-17 2016-05-26 The Exone Company Methods and apparatuses for curing three-dimensional printed articles
KR20170137032A (en) 2014-11-21 2017-12-12 바이오하벤 파마슈티컬 홀딩 컴퍼니 엘티디. Sublingual formulation of riluzole
WO2017158172A1 (en) * 2016-03-18 2017-09-21 Grünenthal GmbH Combination of drugs having different potency

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US4855326A (en) 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
US4990535A (en) * 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
US5206025A (en) 1989-05-24 1993-04-27 Rhone-Poulenc Sante Porous pharmaceutical form and its preparation
FR2647343B1 (en) * 1989-05-24 1994-05-06 Rhone Poulenc Sante New porous pharmaceutical form and its preparation
EP0418596A3 (en) * 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5204055A (en) 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
US5578322A (en) 1990-11-30 1996-11-26 Yamanouchi Pharmaceutical Co., Ltd. Quick release coated preparation
DK0500225T3 (en) 1991-01-31 1996-02-05 Texas Instruments Inc System, method and process for computer-controlled production of three-dimensional objects based on computer data
CA2124686C (en) * 1991-12-20 1998-06-16 Julian B. Lo Porous shaped delivery devices and method of producing thereof
JP2521612B2 (en) * 1992-05-20 1996-08-07 ウエイ・ミン・フアーマシユーテイカル・マニユフアクチヤリング・カンパニー・リミテツド Direct tabletting aids
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
US5380473A (en) 1992-10-23 1995-01-10 Fuisz Technologies Ltd. Process for making shearform matrix
DE4303846A1 (en) * 1993-02-10 1994-08-11 Merck Patent Gmbh A process for preparing an S-ibuprofen tablet containing
US5631023A (en) 1993-07-09 1997-05-20 R.P. Scherer Corporation Method for making freeze dried drug dosage forms
US6176874B1 (en) 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
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JP4563516B2 (en) * 1997-02-20 2010-10-13 マサチューセッツ インスティテュート オブ テクノロジー Dosage form showing a rapidly dispersing, their use and manufacturing method thereof
DE19940944B4 (en) * 1999-08-31 2006-10-12 Grünenthal GmbH Sustained release, oral pharmaceutical forms of administration

Also Published As

Publication number Publication date Type
US9463160B2 (en) 2016-10-11 grant
EP0973507A1 (en) 2000-01-26 application
WO1998036738A1 (en) 1998-08-27 application
JP2009215305A (en) 2009-09-24 application
US20120207929A1 (en) 2012-08-16 application
JP2001512488A (en) 2001-08-21 application
EP0973507B1 (en) 2009-01-21 grant
CA2281473C (en) 2007-01-16 grant
EP0973507A4 (en) 2006-08-23 application
ES2318869T3 (en) 2009-05-01 grant
JP2010120938A (en) 2010-06-03 application
US9114072B2 (en) 2015-08-25 grant
JP4563516B2 (en) 2010-10-13 grant
JP5091910B2 (en) 2012-12-05 grant
US20030133975A1 (en) 2003-07-17 application
DE69840495D1 (en) 2009-03-12 grant
US6471992B1 (en) 2002-10-29 grant

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Legal Events

Date Code Title Description
EEER Examination request