CA2280668C - An improved process for the conversion of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole (tda) to 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (tda sulfone) - Google Patents
An improved process for the conversion of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole (tda) to 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (tda sulfone) Download PDFInfo
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- C07—ORGANIC CHEMISTRY
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- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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Abstract
The present invention provides a process for making thiadiazole sulfones. In particular, the present process is used to make 2--(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole using catalytic oxidation in the presence of a suitable oxidizing agent. The catalyst system used for the oxidation reaction is a mixture of glacial acetic acid and a tungsten catalyst. The tungsten catalyst is preferably selected from the group consisting of sodium tungstate, potassium tunstate, and tungstic acid.
Description
Mo-4853 AN IMPROVED PROCESS FOR THE CONVERSION OF
2-(METHYLTHIO)-5-(TRIFLUOROMETHYL)-1,3,4-THIADIAZOLE (TDA) TO 2-(METHYLSULFONYL)-5-(TRIFLUOROMETHYL)-1,3,4-THIADIAZOLE (TDA SULFONE) TECHNICAL FIELD OF THE INVENTION
The field of the present invention is the synthesis of thiadiazole sulfones. More particularly, the present invention pertains to an improved process for converting 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA) to 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA
sulfone) via a catalytic oxidation.
BACKGROUND OF THE INVENTION
Sulfones have the general structure RR'S02. Sulfones can be produced from a variety of precursors. For example, sulfones can be prepared by (a) oxidizing sulphides, (b) rearranging sulphinate esters, (c) adding sulfonyl halides to alkenes and acetylenes, (d) adding sulphinic acids to polarized bonds, and (e) adding SO2 to polyenes (See, e.g., Durst, T., in Comprehensive Organic Chemistry: Chapter 11.6, Barton and Ollis, Eds., Pergammon Press, Oxford, 1979).
A particular class of sulfones, 2-(alkylsulfonyl)-5-(trifluoro-methyl)-1,3,4-thiadiazoles, are intermediates used in the production of herbicides. A particular sulfone within this class, 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole, has been reported to possess antifungal activity (See, U.S. Patent 3,562,284). According to U.S.
Patent 3,562,284, 2-(substituted sulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazoles can be made by oxidizing a corresponding 2-(substituted thio)-5-(trifluoromethyl)-1,3,4-thiadiazole in the presence of an oxidizing agent such as potassium permanganate, hydrogen peroxide or peroxytrifluoro-acetic acid. Oxidation takes place in an acidic, aqueous medium that includes acetic acid and methylene chloride as a solvent.
Mo4583 - 2 -Methylene chloride is an undesirable solvent from the standpoint of industrial hygiene and handling. Handling is difficult due to its low boiling point (high vapor pressure). In addition, it contaminates aqueous streams. The sulfone product is isolated using crystallization. The reported yield of the sulfone, based on the starting sulfide, is about 65%.
In this known process, the use of acetic acid in the presence of water introduces excess water into the reaction and requires purification of the sulfone using expensive crystallization procedures with resultant low yields. Thus, there continues to be a need in the art for a practical, inexpensive process for preparing thiadiazole sulfones in high yield.
BRIEF SUMMARY OF INVENTION
The present invention provides a process for making 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole comprising oxidizing 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole in a reaction mixture containing glacial acetic acid and a catalytic amount of a tungsten catalyst to form a reaction product. The tungsten catalyst includes any tungsten compound (as opposed to elemental tungsten) which is capable of forming per tungstic acid; or the tungsten catalyst may be tungstic acid itself. Per tungstic acid is the intermediate acid formed when hydrogen peroxide is reacted with tungstic acid. Tungstic acid may be formed by reacting sodium tungstate or potassium tungstate with sulfuric acid. In a preferred embodiment, the tungsten catalyst is selected from the group consisting of sodium tungstate, potassium tungstate, and tungstic acid. A preferred oxidizing agent is hydrogen peroxide. In accordance with this embodiment, the 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is reacted with hydrogen peroxide in the presence of glacial acetic acid and, either sodium tungstate, potassium tungstate, or tungstic acid.
The hydrogen peroxide used in the reaction mixture is preferably an aqueous solution containing from about 30 weight percent to about Mo4583 - 3 -50 weight percent hydrogen peroxide. The hydrogen peroxide is present in a molar excess relative to the 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. Preferably, the molar ratio of hydrogen peroxide to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 2.0:1 to about 3.0:1. Even more preferably, the molar ratio is from about 2.05:1 to about 2.5:1. The glacial acetic acid is present in an amount of from about 0.1 moles to about 0.5 moles of acetic acid per mole of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. More preferably, the molar ratio of glacial acetic acid to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.2:1 to about 0.3:1. In a preferred embodiment, the sodium tungstate is present in an amount of from about 0.001 moles to about 0.025 moles of sodium tungstate per mole of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. More preferably, the molar ratio of sodium tungstate to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.002:1 to about 0.008:1.
In another preferred embodiment, potassium tungstate is present in an amount of from about 0.001 moles to about 0.025 moles of potassium tungstate per mole of 2-(methylthio)-5-(trifluoro-methyl)-1,3,4-thiadiazole. More preferably, the molar ratio of potassium tungstate to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.002:1 to about 0.008:1. In still another preferred embodiment, tungstic acid is present in an amount of from about 0.001 mole to about 0.025 mole of tungstic acid per mole of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. Preferably, the molar ratio of tungstic acid to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.002:1 to about 0.008:1.
Oxidation typically occurs at a temperature of from about 60 C to about 110 C and, preferably at a temperature of from about 70 C to about 100 C.
Mo4583 - 4 -The process of the present invention can include additional steps.
Sulfuric acid can be added to the reaction mixture to acidify the mixture.
Further, water can be removed from the reaction product. The removal of water is preferably accomplished azeotropically. Still further, an embodiment of this invention can include the step of isolating the formed 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole.
A process for making 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole by oxidizing 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole in a reaction mixture containing an activated molybdenum or tungsten catalyst, is known. The activated molybdenum or tungsten catalyst in the invention is molybdic acid or tungstic acid, respectively.
The reaction of the process is carried out in the absence of glacial acetic acid.
A process for making 2-(methyl-sulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole by oxidizing 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole in the presence of a glacial acetic acid catalyst is disclosed in U.S. Patent 5,856,499.
DETAILED DESCRIPTION OF THE INVENTION
The present invention provides a process for producing thiadiazole sulfones. The present process is used to make 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA sulfone) from 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA). TDA sulfone is made using catalytic oxidation of TDA in the presence of a suitable oxidizing agent. The catalysts used for the oxidation reaction are glacial acetic acid and a tungsten catalyst. The tungsten catalyst includes any tungsten compound (as opposed to elemental tungsten) which is capable of forming per tungstic acid; or the tungsten catalyst may be tungstic acid itself. Per tungstic acid is the intermediate acid formed when hydrogen peroxide is reacted with tungstic acid. Tungstic acid may be formed by reacting sodium tungstate or potassium tungstate Mo4583 - 5 -with sulfuric acid. Preferred tungsten catalysts include sodium tungstate, potassium tungstate, and tungstic acid.
The process of the invention includes the step of oxidizing 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA) in a reaction mixture containing glacial acetic acid and a tungsten catalyst, to form a reaction product that contains the TDA sulfone. Oxidation of TDA takes place in the presence of a suitable oxidizing agent. Exemplary such oxidation agents are well known in the art (See, e.g., Durst, T., in Comprehensive Organic Chemistry: Chapter 11.6, Barton and Ollis, Eds., Pergammon Press, Oxford, (1979). A preferred oxidizing agent is hydrogen peroxide (H202). In accordance with this embodiment, TDA is reacted with hydrogen peroxide in the presence of glacial acetic acid and (1) sodium tungstate, or (ii) potassium tungstate, or (iii) tungstic acid. The hydrogen peroxide used in the reaction mixture is preferably an aqueous solution containing from about 30 weight percent to about 50 weight percent hydrogen peroxide. The molar ratio of H202 to TDA is from about 2.0:1 to about 3.0:1 and, preferably, from about 2.05:1 to about 2.5:1. Oxidation conditions are well known in the art. Typically, oxidation is carried out at a temperature of from about 60EC to about 110EC, and preferably at a temperature of from about 70 C to about 100 C.
TDA used in the present process can be obtained from any source. Preferably, the TDA is prepared by a process that provides TDA
in an aprotic, aromatic solvent such as toluene. Especially preferred means for making TDA can be found in the U.S. Patent Applications entitled "A Process for Making 2-(Methylthio)-5-(Trifluoromethyl)-1,3,4-Thiadiazole Using Methyldithiocarbazinate and Trifluoroacetic Acid"
(U.S. Patent 5,905,157), "A Process for Making 2-(Methylthio)-5-(Trifluoromethyl)-1,3,4-Thiadiazole Using Methyldithiocarbazinate with Trifluoroacetic Acid with Selective Removal Mo4583 - 6 -of 2,5-Bis(Methylthio)-1,3,4-Thiadiazole" (U.S. Patent 6,005,114), and "A Process for Preparing 2-(Methylthio)-5-(Trifluoro-methyl)-1,3,4-Thiadiazole Using Methyldithiocarbazinate and a Molar Excess of Trifluoroacetic Acid With Recovery of Trifluoroacetic Acid," (U.S. Patent 5,898,074).
The oxidation of TDA occurs in the presence of a solvent.
Preferably, the solvent is an aprotic, aromatic solvent. Such solvents are well known in the art. Exemplary and preferred such solvents are toluene, xylene, cumene and mesitylene. Toluene is especially preferred. The amount of solvent used can vary over a wide range as readily determined by a skilled artisan. The precise amount of solvent will depend on the particular solvent used. Where toluene is the solvent, it is present in an amount of from about 0.5 mole to about 3.5 moles of toluene per mole of TDA. Preferably, toluene is present in an amount of from about 1.0 mole to about 2.0 moles per mole of TDA and, more preferably in an amount of from about 1.0 mole to about 1.5 moles of toluene per mole of TDA.
TDA is oxidized in a reaction mixture containing glacial acetic acid and a tungsten catalyst preferably selected from the group consisting of sodium tungstate, potassium tungstate, and tungstic acid, to form a reaction product that contains TDA sulfone. Sources of TDA, use of a solvent, oxidation conditions and choice of suitable oxidizing agents are the same as set forth above. The oxidizing agent (e.g., hydrogen peroxide) used in the reaction mixture is preferably present in a molar excess relative to the TDA. Preferably, the molar ratio of oxidizing agent to TDA is from about 2.0:1 to about 3.0:1. Even more preferably, that ratio is from about 2.05:1 to about 2.5:1. The glacial acetic acid and, either the sodium tungstate, the potassium tungstate, or the tungstic acid, are directly added to the reaction mixture. Glacial Mo4583 - 7 -acetic acid is present in an amount of from about 0.1 mole to about 0.5 mole of acetic acid per mole of TDA. Preferably, the molar ratio of glacial acetic acid to TDA is from about 0.2:1 to about 0.3:1. In a preferred embodiment, sodium tungstate is present in an amount of from about 0.001 mole to about 0.025 mole of sodium tungstate per mole of TDA. Preferably, the molar ratio of sodium tungstate to TDA is from about 0.002:1 to about 0.008:1. In another preferred embodiment, potassium tungstate is present in an amount of from about 0.001 mole to about 0.025 mole of potassium tungstate per mole of TDA.
Preferably, the molar ratio of potassium tungstate to TDA is from about 0.002:1 to about 0.008:1. In still another preferred embodiment, tungstic acid is present in an amount of from about 0.001 mole to about 0.025 mole of tungstic acid per mole of TDA. Preferably, the molar ratio of tungstic acid to TDA is from about 0.002:1 to about 0.008:1.
In an embodiment of the present invention, sulfuric acid in an amount less than or equal to about 0.5 mole can be added to the reaction mixture to acidify the mixture. Further, water can be removed from the reaction product. Still further, a process of this invention can include the step of isolating the formed sulfone.
Water removal is preferably accomplished azeotropically. The azeotropic removal of water is readily accomplished in the presence of the solvent, particularly where the solvent is toluene. Because the azeotrope has a lower boiling point than water, heating the reaction product to the boiling point of the solvent effectively removes the water.
Because the oxidation reaction occurs in the range of about 60 C to about 110 C, water is removed during that reaction; no additional step is required.
Mo4583 - 8 -The following Example illustrates a preferred embodiment of the present invention and is not limiting of the specification and claims.
EXAM PLE
Synthesis of TDA Sulfone Using Glacial Acetic Acid and Sodium Tungstate About 1.5 moles of TDA in toluene, about 0.33 mole of glacial acetic acid, about 0.0065 mole of sodium tungstate, and about 0.027 mole of sulfuric acid were charged to a reactor vessel. The reaction mixture was then heated to a temperature of about 80 C to 85 C, and 3.65 moles of 35%
hydrogen peroxide was added over a time period of about 4 hours. The resulting mixture was heated for a period of about 7 hours, and water was azeotropically removed.
The average yield of TDA sulfone was about 99.4% based on the TDA used in the process.
Although the invention has been described in detail in the foregoing for the purpose of illustration, it is to be understood that such detail is solely for that purpose and that variations can be made therein by those skilled in the art without departing from the spirit and scope of the invention except as it may be limited by the claims.
The field of the present invention is the synthesis of thiadiazole sulfones. More particularly, the present invention pertains to an improved process for converting 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA) to 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA
sulfone) via a catalytic oxidation.
BACKGROUND OF THE INVENTION
Sulfones have the general structure RR'S02. Sulfones can be produced from a variety of precursors. For example, sulfones can be prepared by (a) oxidizing sulphides, (b) rearranging sulphinate esters, (c) adding sulfonyl halides to alkenes and acetylenes, (d) adding sulphinic acids to polarized bonds, and (e) adding SO2 to polyenes (See, e.g., Durst, T., in Comprehensive Organic Chemistry: Chapter 11.6, Barton and Ollis, Eds., Pergammon Press, Oxford, 1979).
A particular class of sulfones, 2-(alkylsulfonyl)-5-(trifluoro-methyl)-1,3,4-thiadiazoles, are intermediates used in the production of herbicides. A particular sulfone within this class, 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole, has been reported to possess antifungal activity (See, U.S. Patent 3,562,284). According to U.S.
Patent 3,562,284, 2-(substituted sulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazoles can be made by oxidizing a corresponding 2-(substituted thio)-5-(trifluoromethyl)-1,3,4-thiadiazole in the presence of an oxidizing agent such as potassium permanganate, hydrogen peroxide or peroxytrifluoro-acetic acid. Oxidation takes place in an acidic, aqueous medium that includes acetic acid and methylene chloride as a solvent.
Mo4583 - 2 -Methylene chloride is an undesirable solvent from the standpoint of industrial hygiene and handling. Handling is difficult due to its low boiling point (high vapor pressure). In addition, it contaminates aqueous streams. The sulfone product is isolated using crystallization. The reported yield of the sulfone, based on the starting sulfide, is about 65%.
In this known process, the use of acetic acid in the presence of water introduces excess water into the reaction and requires purification of the sulfone using expensive crystallization procedures with resultant low yields. Thus, there continues to be a need in the art for a practical, inexpensive process for preparing thiadiazole sulfones in high yield.
BRIEF SUMMARY OF INVENTION
The present invention provides a process for making 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole comprising oxidizing 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole in a reaction mixture containing glacial acetic acid and a catalytic amount of a tungsten catalyst to form a reaction product. The tungsten catalyst includes any tungsten compound (as opposed to elemental tungsten) which is capable of forming per tungstic acid; or the tungsten catalyst may be tungstic acid itself. Per tungstic acid is the intermediate acid formed when hydrogen peroxide is reacted with tungstic acid. Tungstic acid may be formed by reacting sodium tungstate or potassium tungstate with sulfuric acid. In a preferred embodiment, the tungsten catalyst is selected from the group consisting of sodium tungstate, potassium tungstate, and tungstic acid. A preferred oxidizing agent is hydrogen peroxide. In accordance with this embodiment, the 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is reacted with hydrogen peroxide in the presence of glacial acetic acid and, either sodium tungstate, potassium tungstate, or tungstic acid.
The hydrogen peroxide used in the reaction mixture is preferably an aqueous solution containing from about 30 weight percent to about Mo4583 - 3 -50 weight percent hydrogen peroxide. The hydrogen peroxide is present in a molar excess relative to the 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. Preferably, the molar ratio of hydrogen peroxide to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 2.0:1 to about 3.0:1. Even more preferably, the molar ratio is from about 2.05:1 to about 2.5:1. The glacial acetic acid is present in an amount of from about 0.1 moles to about 0.5 moles of acetic acid per mole of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. More preferably, the molar ratio of glacial acetic acid to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.2:1 to about 0.3:1. In a preferred embodiment, the sodium tungstate is present in an amount of from about 0.001 moles to about 0.025 moles of sodium tungstate per mole of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. More preferably, the molar ratio of sodium tungstate to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.002:1 to about 0.008:1.
In another preferred embodiment, potassium tungstate is present in an amount of from about 0.001 moles to about 0.025 moles of potassium tungstate per mole of 2-(methylthio)-5-(trifluoro-methyl)-1,3,4-thiadiazole. More preferably, the molar ratio of potassium tungstate to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.002:1 to about 0.008:1. In still another preferred embodiment, tungstic acid is present in an amount of from about 0.001 mole to about 0.025 mole of tungstic acid per mole of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. Preferably, the molar ratio of tungstic acid to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.002:1 to about 0.008:1.
Oxidation typically occurs at a temperature of from about 60 C to about 110 C and, preferably at a temperature of from about 70 C to about 100 C.
Mo4583 - 4 -The process of the present invention can include additional steps.
Sulfuric acid can be added to the reaction mixture to acidify the mixture.
Further, water can be removed from the reaction product. The removal of water is preferably accomplished azeotropically. Still further, an embodiment of this invention can include the step of isolating the formed 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole.
A process for making 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole by oxidizing 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole in a reaction mixture containing an activated molybdenum or tungsten catalyst, is known. The activated molybdenum or tungsten catalyst in the invention is molybdic acid or tungstic acid, respectively.
The reaction of the process is carried out in the absence of glacial acetic acid.
A process for making 2-(methyl-sulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole by oxidizing 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole in the presence of a glacial acetic acid catalyst is disclosed in U.S. Patent 5,856,499.
DETAILED DESCRIPTION OF THE INVENTION
The present invention provides a process for producing thiadiazole sulfones. The present process is used to make 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA sulfone) from 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA). TDA sulfone is made using catalytic oxidation of TDA in the presence of a suitable oxidizing agent. The catalysts used for the oxidation reaction are glacial acetic acid and a tungsten catalyst. The tungsten catalyst includes any tungsten compound (as opposed to elemental tungsten) which is capable of forming per tungstic acid; or the tungsten catalyst may be tungstic acid itself. Per tungstic acid is the intermediate acid formed when hydrogen peroxide is reacted with tungstic acid. Tungstic acid may be formed by reacting sodium tungstate or potassium tungstate Mo4583 - 5 -with sulfuric acid. Preferred tungsten catalysts include sodium tungstate, potassium tungstate, and tungstic acid.
The process of the invention includes the step of oxidizing 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA) in a reaction mixture containing glacial acetic acid and a tungsten catalyst, to form a reaction product that contains the TDA sulfone. Oxidation of TDA takes place in the presence of a suitable oxidizing agent. Exemplary such oxidation agents are well known in the art (See, e.g., Durst, T., in Comprehensive Organic Chemistry: Chapter 11.6, Barton and Ollis, Eds., Pergammon Press, Oxford, (1979). A preferred oxidizing agent is hydrogen peroxide (H202). In accordance with this embodiment, TDA is reacted with hydrogen peroxide in the presence of glacial acetic acid and (1) sodium tungstate, or (ii) potassium tungstate, or (iii) tungstic acid. The hydrogen peroxide used in the reaction mixture is preferably an aqueous solution containing from about 30 weight percent to about 50 weight percent hydrogen peroxide. The molar ratio of H202 to TDA is from about 2.0:1 to about 3.0:1 and, preferably, from about 2.05:1 to about 2.5:1. Oxidation conditions are well known in the art. Typically, oxidation is carried out at a temperature of from about 60EC to about 110EC, and preferably at a temperature of from about 70 C to about 100 C.
TDA used in the present process can be obtained from any source. Preferably, the TDA is prepared by a process that provides TDA
in an aprotic, aromatic solvent such as toluene. Especially preferred means for making TDA can be found in the U.S. Patent Applications entitled "A Process for Making 2-(Methylthio)-5-(Trifluoromethyl)-1,3,4-Thiadiazole Using Methyldithiocarbazinate and Trifluoroacetic Acid"
(U.S. Patent 5,905,157), "A Process for Making 2-(Methylthio)-5-(Trifluoromethyl)-1,3,4-Thiadiazole Using Methyldithiocarbazinate with Trifluoroacetic Acid with Selective Removal Mo4583 - 6 -of 2,5-Bis(Methylthio)-1,3,4-Thiadiazole" (U.S. Patent 6,005,114), and "A Process for Preparing 2-(Methylthio)-5-(Trifluoro-methyl)-1,3,4-Thiadiazole Using Methyldithiocarbazinate and a Molar Excess of Trifluoroacetic Acid With Recovery of Trifluoroacetic Acid," (U.S. Patent 5,898,074).
The oxidation of TDA occurs in the presence of a solvent.
Preferably, the solvent is an aprotic, aromatic solvent. Such solvents are well known in the art. Exemplary and preferred such solvents are toluene, xylene, cumene and mesitylene. Toluene is especially preferred. The amount of solvent used can vary over a wide range as readily determined by a skilled artisan. The precise amount of solvent will depend on the particular solvent used. Where toluene is the solvent, it is present in an amount of from about 0.5 mole to about 3.5 moles of toluene per mole of TDA. Preferably, toluene is present in an amount of from about 1.0 mole to about 2.0 moles per mole of TDA and, more preferably in an amount of from about 1.0 mole to about 1.5 moles of toluene per mole of TDA.
TDA is oxidized in a reaction mixture containing glacial acetic acid and a tungsten catalyst preferably selected from the group consisting of sodium tungstate, potassium tungstate, and tungstic acid, to form a reaction product that contains TDA sulfone. Sources of TDA, use of a solvent, oxidation conditions and choice of suitable oxidizing agents are the same as set forth above. The oxidizing agent (e.g., hydrogen peroxide) used in the reaction mixture is preferably present in a molar excess relative to the TDA. Preferably, the molar ratio of oxidizing agent to TDA is from about 2.0:1 to about 3.0:1. Even more preferably, that ratio is from about 2.05:1 to about 2.5:1. The glacial acetic acid and, either the sodium tungstate, the potassium tungstate, or the tungstic acid, are directly added to the reaction mixture. Glacial Mo4583 - 7 -acetic acid is present in an amount of from about 0.1 mole to about 0.5 mole of acetic acid per mole of TDA. Preferably, the molar ratio of glacial acetic acid to TDA is from about 0.2:1 to about 0.3:1. In a preferred embodiment, sodium tungstate is present in an amount of from about 0.001 mole to about 0.025 mole of sodium tungstate per mole of TDA. Preferably, the molar ratio of sodium tungstate to TDA is from about 0.002:1 to about 0.008:1. In another preferred embodiment, potassium tungstate is present in an amount of from about 0.001 mole to about 0.025 mole of potassium tungstate per mole of TDA.
Preferably, the molar ratio of potassium tungstate to TDA is from about 0.002:1 to about 0.008:1. In still another preferred embodiment, tungstic acid is present in an amount of from about 0.001 mole to about 0.025 mole of tungstic acid per mole of TDA. Preferably, the molar ratio of tungstic acid to TDA is from about 0.002:1 to about 0.008:1.
In an embodiment of the present invention, sulfuric acid in an amount less than or equal to about 0.5 mole can be added to the reaction mixture to acidify the mixture. Further, water can be removed from the reaction product. Still further, a process of this invention can include the step of isolating the formed sulfone.
Water removal is preferably accomplished azeotropically. The azeotropic removal of water is readily accomplished in the presence of the solvent, particularly where the solvent is toluene. Because the azeotrope has a lower boiling point than water, heating the reaction product to the boiling point of the solvent effectively removes the water.
Because the oxidation reaction occurs in the range of about 60 C to about 110 C, water is removed during that reaction; no additional step is required.
Mo4583 - 8 -The following Example illustrates a preferred embodiment of the present invention and is not limiting of the specification and claims.
EXAM PLE
Synthesis of TDA Sulfone Using Glacial Acetic Acid and Sodium Tungstate About 1.5 moles of TDA in toluene, about 0.33 mole of glacial acetic acid, about 0.0065 mole of sodium tungstate, and about 0.027 mole of sulfuric acid were charged to a reactor vessel. The reaction mixture was then heated to a temperature of about 80 C to 85 C, and 3.65 moles of 35%
hydrogen peroxide was added over a time period of about 4 hours. The resulting mixture was heated for a period of about 7 hours, and water was azeotropically removed.
The average yield of TDA sulfone was about 99.4% based on the TDA used in the process.
Although the invention has been described in detail in the foregoing for the purpose of illustration, it is to be understood that such detail is solely for that purpose and that variations can be made therein by those skilled in the art without departing from the spirit and scope of the invention except as it may be limited by the claims.
Claims (22)
1. A process for making 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole comprising oxidizing 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole in a reaction mixture containing an oxidizing agent, glacial acetic acid, and a catalytic amount of a tungsten catalyst which is tungstic acid or which is capable of forming per tungstic acid, to form a reaction product, wherein the molar ratio of glacial acetic acid to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.1:1 to about 0.5:1.
2. The process of Claim 1 wherein the tungsten catalyst is selected from the group consisting of sodium tungstate, potassium tungstate, and tungstic acid.
3. The process of Claim 2 wherein the tungsten catalyst is sodium tungstate.
4. The process of Claim 2 wherein the tungsten catalyst is potassium tungstate.
5. The process of Claim 2 wherein the tungsten catalyst is tungstic acid.
6. The process of Claim 3 wherein the molar ratio of sodium tungstate to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.001:1 to about 0.025:1.
7. The process of Claim 4 wherein the molar ratio of potassium tungstate to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.001:1 to about 0.025:1.
8. The process of Claim 5 wherein the molar ratio of tungstic acid to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.001:1 to about 0.025:1.
9. The process of Claim 1 wherein the oxidizing agent is hydrogen peroxide.
10. The process of Claim 1 wherein the 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is dissolved in an aprotic, aromatic solvent.
11. The process of Claim 10 wherein the solvent is toluene.
12. The process of Claim 11 wherein the molar ratio of toluene to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.5:1 to about 3.5:1.
13. The process of Claim 12 wherein the molar ratio of toluene to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 1:1 to about 1.5:1.
14. The process of Claim 1 wherein oxidation occurs at a temperature of from about 60°C to about 110°C.
15. The process of Claim 14 wherein the temperature is from about 70°C to about 100°C.
16. The process of Claim 9 wherein the molar ratio of hydrogen peroxide to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 2.0:1 to about 3.0:1.
17. The process of the Claim 16 wherein the molar ratio of hydrogen peroxide to 2-(methylthio)-5-(trifluoromethyl)-1,3,4 thiadiazole is from about 2.05:1 to about 2.50:1.
18. The process of Claim 1 wherein the molar ratio of glacial acetic acid to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.2:1 to about 0.3:1.
19. The process of Claim 6 wherein the molar ratio of sodium tungstate to 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole is from about 0.002:1 to about 0.008:1.
20. The process of Claim 1 further comprising azeotropically removing water from the reaction product.
21. The process of Claim 1 further comprising isolating the formed 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole.
22. The process of Claim 1 further comprising the addition of less than or equal to about 0.5 mole of sulfuric acid to the reaction mixture.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/153,920 US6031108A (en) | 1998-09-16 | 1998-09-16 | Process for the preparation of 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA sulfone) |
| US09/153,920 | 1998-09-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2280668A1 CA2280668A1 (en) | 2000-03-16 |
| CA2280668C true CA2280668C (en) | 2008-06-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002280668A Expired - Fee Related CA2280668C (en) | 1998-09-16 | 1999-08-25 | An improved process for the conversion of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole (tda) to 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (tda sulfone) |
Country Status (14)
| Country | Link |
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| US (1) | US6031108A (en) |
| EP (1) | EP0987258B1 (en) |
| JP (1) | JP2000095771A (en) |
| CN (1) | CN1162413C (en) |
| AT (1) | ATE353080T1 (en) |
| BR (1) | BR9904201A (en) |
| CA (1) | CA2280668C (en) |
| DE (1) | DE69935029T2 (en) |
| DK (1) | DK0987258T3 (en) |
| ES (1) | ES2281155T3 (en) |
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| IL (1) | IL131882A (en) |
| TW (1) | TW509684B (en) |
| ZA (1) | ZA995929B (en) |
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| DE10229776A1 (en) * | 2002-07-03 | 2004-01-22 | Bayer Cropscience Ag | Process for the preparation of heterocyclic fluoroalkenyl sulfones |
| CN102311777A (en) * | 2011-08-22 | 2012-01-11 | 浙江工业大学 | Peroxyacetic acid oxidation extraction desulphurization method for gasoline |
| CN106478547B (en) * | 2016-08-30 | 2019-02-01 | 京博农化科技股份有限公司 | A kind of 2- methylsulfonyl -5- Trifluoromethyl-1, the synthetic method of 3,4- thiadiazoles |
| CN106866579B (en) * | 2017-02-23 | 2019-01-04 | 西华大学 | The synthetic method of herbicide flufenacet thiadiazoles intermediate |
| CN106905260B (en) * | 2017-03-02 | 2019-01-11 | 西华大学 | It is used to prepare herbicide flufenacet Intermediate TDA-sulfone method |
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| US3562284A (en) * | 1968-02-05 | 1971-02-09 | American Cyanamid Co | 2-(substituted) sulfonyl-5-trifluoromethyl-1,3,4-thiadiazoles |
| SE417968B (en) * | 1972-10-20 | 1981-04-27 | Fujisawa Pharmaceutical Co | PROCEDURE FOR PENAME DERIVATIVES |
| US4203897A (en) * | 1972-10-20 | 1980-05-20 | Fujisawa Pharmaceutical Company, Limited | Penam derivatives |
| DE2533605A1 (en) * | 1975-07-26 | 1977-02-03 | Bayer Ag | ANTIPARASITE AGENT |
| US4432847A (en) * | 1976-07-29 | 1984-02-21 | Standard Oil Company (Indiana) | Poly sulfoxides from 1,3,4-thiadiazole-2,5-dithiol |
| JPS5748962A (en) * | 1980-09-10 | 1982-03-20 | Nippon Kayaku Co Ltd | Preparation of nitrophenyl-beta-hydroxyethyl-sulfonic acids |
| DE3135367A1 (en) * | 1980-09-10 | 1982-07-08 | Nippon Kayaku K.K., Tokyo | Process for the preparation of nitrophenyl beta -hydroxyethyl sulphide derivatives and nitrophenyl beta -hydroxyethyl sulphone derivatives |
| DE3422861A1 (en) * | 1984-06-20 | 1986-01-02 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING HETEROARYLOXYACETAMIDES |
| DE3722320A1 (en) * | 1987-07-07 | 1989-01-19 | Bayer Ag | MICROBICIDAL AGENTS |
| DE3838432A1 (en) * | 1988-11-12 | 1990-05-17 | Bayer Ag | 2,5-DISUBSTITUTED 1,3,4-THIADIAZOLE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN PEST CONTROL |
| DE4005225A1 (en) * | 1990-02-20 | 1991-08-22 | Bayer Ag | CHLORINE FLUOROMETHYL THIADIAZOLYLOXY ACETIC ACID AMIDE |
| GB9615867D0 (en) * | 1996-07-03 | 1996-09-11 | Merck & Co Inc | Process of preparing phenyl heterocycles useful as cox-2 inhibitors |
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1998
- 1998-09-16 US US09/153,920 patent/US6031108A/en not_active Expired - Lifetime
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1999
- 1999-08-25 CA CA002280668A patent/CA2280668C/en not_active Expired - Fee Related
- 1999-09-06 DK DK99116876T patent/DK0987258T3/en active
- 1999-09-06 ES ES99116876T patent/ES2281155T3/en not_active Expired - Lifetime
- 1999-09-06 DE DE69935029T patent/DE69935029T2/en not_active Expired - Lifetime
- 1999-09-06 EP EP99116876A patent/EP0987258B1/en not_active Expired - Lifetime
- 1999-09-06 AT AT99116876T patent/ATE353080T1/en not_active IP Right Cessation
- 1999-09-08 JP JP11254177A patent/JP2000095771A/en active Pending
- 1999-09-14 IL IL13188299A patent/IL131882A/en not_active IP Right Cessation
- 1999-09-15 ZA ZA9905929A patent/ZA995929B/en unknown
- 1999-09-15 BR BR9904201-0A patent/BR9904201A/en not_active Application Discontinuation
- 1999-09-15 HU HU9903128A patent/HUP9903128A3/en unknown
- 1999-09-16 CN CNB991188802A patent/CN1162413C/en not_active Expired - Lifetime
- 1999-10-05 TW TW088115954A patent/TW509684B/en not_active IP Right Cessation
Also Published As
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| IL131882A0 (en) | 2001-03-19 |
| CA2280668A1 (en) | 2000-03-16 |
| JP2000095771A (en) | 2000-04-04 |
| CN1162413C (en) | 2004-08-18 |
| IL131882A (en) | 2003-04-10 |
| ES2281155T3 (en) | 2007-09-16 |
| DE69935029D1 (en) | 2007-03-22 |
| HU9903128D0 (en) | 1999-11-29 |
| TW509684B (en) | 2002-11-11 |
| EP0987258A1 (en) | 2000-03-22 |
| DE69935029T2 (en) | 2007-07-12 |
| CN1249305A (en) | 2000-04-05 |
| US6031108A (en) | 2000-02-29 |
| ZA995929B (en) | 2000-04-03 |
| HUP9903128A2 (en) | 2000-05-28 |
| HUP9903128A3 (en) | 2000-08-28 |
| ATE353080T1 (en) | 2007-02-15 |
| EP0987258B1 (en) | 2007-01-31 |
| BR9904201A (en) | 2000-08-15 |
| DK0987258T3 (en) | 2007-05-21 |
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