CA2273802A1 - Procede pour la preparation des acides quinolone- et naphthyridonecarboxylique et de leurs esters - Google Patents

Procede pour la preparation des acides quinolone- et naphthyridonecarboxylique et de leurs esters Download PDF

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Publication number
CA2273802A1
CA2273802A1 CA002273802A CA2273802A CA2273802A1 CA 2273802 A1 CA2273802 A1 CA 2273802A1 CA 002273802 A CA002273802 A CA 002273802A CA 2273802 A CA2273802 A CA 2273802A CA 2273802 A1 CA2273802 A1 CA 2273802A1
Authority
CA
Canada
Prior art keywords
group
formula
groups
component selected
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002273802A
Other languages
English (en)
Inventor
Norbert Lui
Hans Panskus
Herbert Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of CA2273802A1 publication Critical patent/CA2273802A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA002273802A 1998-06-12 1999-06-09 Procede pour la preparation des acides quinolone- et naphthyridonecarboxylique et de leurs esters Abandoned CA2273802A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19826050.4 1998-06-12
DE19826050A DE19826050A1 (de) 1998-06-12 1998-06-12 Verfahren zur Herstellung von Chinolon- und Naphthyridoncarbonsäuren und deren Ester

Publications (1)

Publication Number Publication Date
CA2273802A1 true CA2273802A1 (fr) 1999-12-12

Family

ID=7870588

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002273802A Abandoned CA2273802A1 (fr) 1998-06-12 1999-06-09 Procede pour la preparation des acides quinolone- et naphthyridonecarboxylique et de leurs esters

Country Status (12)

Country Link
US (1) US6229017B1 (fr)
EP (1) EP0963977B1 (fr)
JP (1) JP4585634B2 (fr)
KR (1) KR20000006091A (fr)
CN (1) CN1124264C (fr)
CA (1) CA2273802A1 (fr)
CZ (1) CZ211499A3 (fr)
DE (2) DE19826050A1 (fr)
ES (1) ES2199500T3 (fr)
HU (1) HUP9901947A3 (fr)
IL (1) IL130374A0 (fr)
PL (1) PL333646A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003028664A2 (fr) * 2001-10-03 2003-04-10 Teva Pharmaceutical Industries Ltd. Préparation de lévofloxacine et formes à base de cette substance
US7425628B2 (en) * 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
KR100454750B1 (ko) * 2002-06-20 2004-11-03 삼성에스디아이 주식회사 유기 전계 발광 소자용 청색 발광 화합물 및 이를 사용한유기 전계 발광 소자
KR100519158B1 (ko) * 2002-12-21 2005-10-06 주식회사유한양행 퀴놀론 카르복실레이트 유도체의 제조방법
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
CA2954376C (fr) 2006-10-16 2019-06-11 Bionomics Limited Nouveaux composes anxiolytiques
FR2917413B1 (fr) * 2007-06-13 2009-08-21 Sanofi Aventis Sa Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique
CN101838238B (zh) * 2010-04-30 2012-05-23 杭州广林生物医药有限公司 一种喹诺酮主环化合物的合成方法
US9023848B2 (en) 2011-03-02 2015-05-05 Bionomics Limited Small-molecules as therapeutics
WO2012151640A1 (fr) * 2011-05-12 2012-11-15 Bionomics Limited Procédés pour la préparation de naphtyridines
CN103819401B (zh) * 2012-11-19 2016-04-13 浙江中欣氟材股份有限公司 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法
RU2015145134A (ru) * 2013-04-09 2017-05-16 Крессет Биомолекьюлар Дискавери Лтд Местное лечение воспалительных офтальмологических заболеваний
CN104292159B (zh) * 2014-10-10 2016-12-07 浙江同丰医药化工有限公司 一种诺氟沙星、环丙沙星及恩诺沙星的制备方法
CN107163063A (zh) * 2017-06-19 2017-09-15 太仓弘杉环保科技有限公司 一种制备高品质盐酸左氧氟沙星的方法
CN110804064A (zh) * 2019-12-13 2020-02-18 浙江工业大学 一种左氧氟羧酸的合成方法
CN111269131B (zh) * 2020-03-12 2021-12-28 江苏飞宇医药科技股份有限公司 以三正丙胺为吸酸剂制备环丙乙酯胺化物的工艺
CN114716373B (zh) * 2022-04-14 2023-01-10 内蒙古源宏精细化工有限公司 一种加替沙星环合酯的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5051365A (fr) * 1973-09-05 1975-05-08
DE3502935A1 (de) * 1984-09-29 1986-04-10 Bayer Ag, 5090 Leverkusen 3-amino-2-benzoyl-acrylsaeurederivate und ein verfahren zu ihrer herstellung
DE3724466A1 (de) * 1987-07-24 1989-02-02 Bayer Ag Verfahren zur herstellung von chinoloncarbonsaeuren
JP2990903B2 (ja) * 1991-04-09 1999-12-13 宇部興産株式会社 ４−オキソキノリン−３−カルボン酸類の製造方法
DE4342186A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten
PL186737B1 (pl) * 1996-02-23 2004-02-27 Bayer Ag Kwasy 8-cyjano-1-cyklopropylo-7-/2, 8-diazabicyklo [ 4.3.0 ] nonan-8-ylo/-6-fluoro-1,4-dihydro-4-okso-3-chinolinokarboksylowe i ich pochodne, sposób ich wytwarzania, środki medyczne je zawierające i ich zastosowanie do wytwarzania środków medycznychi antybakteryjnych

Also Published As

Publication number Publication date
CZ211499A3 (cs) 1999-12-15
HUP9901947A3 (en) 2001-01-29
JP4585634B2 (ja) 2010-11-24
US6229017B1 (en) 2001-05-08
HU9901947D0 (en) 1999-08-30
HUP9901947A2 (hu) 2000-03-28
CN1124264C (zh) 2003-10-15
IL130374A0 (en) 2000-06-01
CN1239094A (zh) 1999-12-22
EP0963977A1 (fr) 1999-12-15
JP2000026425A (ja) 2000-01-25
ES2199500T3 (es) 2004-02-16
EP0963977B1 (fr) 2003-05-07
KR20000006091A (ko) 2000-01-25
DE59905405D1 (de) 2003-06-12
PL333646A1 (en) 1999-12-20
DE19826050A1 (de) 1999-12-16

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Legal Events

Date Code Title Description
FZDE Discontinued