CA2272822A1 - Polypeptides hvem et leurs utilisations - Google Patents

Polypeptides hvem et leurs utilisations Download PDF

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Publication number
CA2272822A1
CA2272822A1 CA002272822A CA2272822A CA2272822A1 CA 2272822 A1 CA2272822 A1 CA 2272822A1 CA 002272822 A CA002272822 A CA 002272822A CA 2272822 A CA2272822 A CA 2272822A CA 2272822 A1 CA2272822 A1 CA 2272822A1
Authority
CA
Canada
Prior art keywords
hvem
sequence
polypeptide
antibody
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002272822A
Other languages
English (en)
Inventor
Avi J. Ashkenazi
Scot A. Marsters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2272822A1 publication Critical patent/CA2272822A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cette invention se rapporte à de nouveaux polypeptides, appelés HVEM. Elle se rapporte également à des compositions à base de chimères comportant des polypeptides HVEM, à un acide nucléique codant les polypeptides HVEM et à des anticorps dirigés contre les polypeptides HVEM.
CA002272822A 1996-12-12 1997-12-05 Polypeptides hvem et leurs utilisations Abandoned CA2272822A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3270596P 1996-12-12 1996-12-12
US60/032,705 1996-12-12
PCT/US1997/022278 WO1998025967A1 (fr) 1996-12-12 1997-12-05 Polypeptides hvem et leurs utilisations

Publications (1)

Publication Number Publication Date
CA2272822A1 true CA2272822A1 (fr) 1998-06-18

Family

ID=21866390

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002272822A Abandoned CA2272822A1 (fr) 1996-12-12 1997-12-05 Polypeptides hvem et leurs utilisations

Country Status (6)

Country Link
EP (1) EP0948543A1 (fr)
JP (1) JP2001526632A (fr)
AU (1) AU5516898A (fr)
CA (1) CA2272822A1 (fr)
WO (1) WO1998025967A1 (fr)
ZA (1) ZA9711156B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7427492B1 (en) 1995-06-05 2008-09-23 Human Genome Sciences, Inc. Polynucleotides encoding human tumor necrosis factor receptor-like2
US7964190B2 (en) 1996-03-22 2011-06-21 Human Genome Sciences, Inc. Methods and compositions for decreasing T-cell activity
US6635743B1 (en) 1996-03-22 2003-10-21 Human Genome Sciences, Inc. Apoptosis inducing molecule II and methods of use
US6495520B2 (en) 1996-03-22 2002-12-17 Human Genome Sciences, Inc. Apoptosis Inducing Molecule II and methods of use
US6479254B2 (en) 1996-03-22 2002-11-12 Human Genome Sciences, Inc. Apoptosis inducing molecule II
US6998108B1 (en) 1997-07-07 2006-02-14 La Jolla Institute For Allergy And Immunology Antibodies to p30 polypeptides and methods making and using same
US7118742B2 (en) 1997-07-07 2006-10-10 La Jolla Institute For Allergy And Immunology Ligand for herpes simplex virus entry mediator and methods of use
AU5804499A (en) * 1998-09-03 2000-03-27 Millennium Pharmaceuticals, Inc. Novel molecules of the herpes virus-entry-mediator-related protein family and uses thereof
TR200504220T2 (tr) 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
CA2300328A1 (fr) 1999-09-14 2001-03-14 Cardiogene Gentherap. Systeme Ag Modulation de la transcription des genes dans des cellules vasculaires
DE29916160U1 (de) 1999-09-14 2000-03-09 Cardiogene Gentherapeutische Systeme AG, 40699 Erkrath Modulation der Transkription von Genen in vaskulären Zellen
WO2001079496A2 (fr) * 2000-03-13 2001-10-25 La Jolla Institute For Allergy And Immunology Ligand pour mediateur d'entree du virus herpes simplex et procedes de mise en oeuvre
EP1274840B1 (fr) * 2000-04-12 2007-06-20 La Jolla Institute For Allergy And Immunology Ligand pour mediateur d'entree du virus herpes simplex et procedes de mise en oeuvre
WO2003086301A2 (fr) * 2002-04-12 2003-10-23 Human Genome Sciences, Inc. Anticorps se liant specifiquement a tr2
FR2845692A1 (fr) * 2002-10-15 2004-04-16 France Hybrides Procede pour produire un mammifere rendu resistant a une infection par un alpha herpes virus par transgenese germinale ainsi que mammifere obtenu par la mise en oeuvre de ce procede
FR2845693B1 (fr) * 2002-10-15 2005-04-01 France Hybrides Procede pour produire un mammifere rendu resistant a une infection par un alpha herpes virus ainsi que mammifere obtenu par la mise en oeuvre de ce procede et descendant d'un tel mammifere
CA2666934A1 (fr) 2006-10-20 2008-04-24 Biogen Idec Ma Inc. Traitement des troubles de demyelinisation avec un recepteur soluble de la lymphotoxine-beta
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
WO1996003141A1 (fr) * 1994-07-22 1996-02-08 F. Hoffmann-La Roche Ag Compositions pharmaceutiques comprenant une proteine chimere liant le facteur de necrose tumorale
WO1996034095A1 (fr) * 1995-04-27 1996-10-31 Human Genome Sciences, Inc. Recepteurs du facteur de necrose tumorale chez l'homme
US6291207B1 (en) * 1995-07-28 2001-09-18 Northwestern University Herpes virus entry receptor protein

Also Published As

Publication number Publication date
AU5516898A (en) 1998-07-03
WO1998025967A1 (fr) 1998-06-18
ZA9711156B (en) 1999-06-11
EP0948543A1 (fr) 1999-10-13
JP2001526632A (ja) 2001-12-18

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Legal Events

Date Code Title Description
FZDE Discontinued