CA2265508A1 - Bone morphogenetic protein-16 (bmp-16) compositions - Google Patents

Bone morphogenetic protein-16 (bmp-16) compositions

Info

Publication number
CA2265508A1
CA2265508A1 CA 2265508 CA2265508A CA2265508A1 CA 2265508 A1 CA2265508 A1 CA 2265508A1 CA 2265508 CA2265508 CA 2265508 CA 2265508 A CA2265508 A CA 2265508A CA 2265508 A1 CA2265508 A1 CA 2265508A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
proteins
tissue
bmp
disclosed
muscle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2265508
Other languages
French (fr)
Other versions
CA2265508C (en )
Inventor
Anthony J. Celeste
Beth L. Murray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute, Inc.
Anthony J. Celeste
Beth L. Murray
Genetics Institute, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/495Transforming growth factor [TGF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Abstract

Purified BMP-16 proteins and processes for producing them are disclosed. DNA
molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
CA 2265508 1996-09-18 1997-07-09 Bone morphogenetic protein-16 (bmp-16) compositions Expired - Fee Related CA2265508C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US08715202 US5965403A (en) 1996-09-18 1996-09-18 Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
US08/715,202 1996-09-18
PCT/US1997/011954 WO1998012322A1 (en) 1996-09-18 1997-07-09 Bone morphogenetic protein-16 (bmp-16) compositions

Publications (2)

Publication Number Publication Date
CA2265508A1 true true CA2265508A1 (en) 1998-03-26
CA2265508C CA2265508C (en) 2003-11-18

Family

ID=24873057

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2265508 Expired - Fee Related CA2265508C (en) 1996-09-18 1997-07-09 Bone morphogenetic protein-16 (bmp-16) compositions

Country Status (7)

Country Link
US (3) US5965403A (en)
EP (1) EP0941323A1 (en)
JP (1) JP2001500737A (en)
KR (1) KR20000036012A (en)
CA (1) CA2265508C (en)
FI (1) FI990596A (en)
WO (1) WO1998012322A1 (en)

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US8106001B2 (en) * 1996-08-27 2012-01-31 University Of South Florida Diagnostic markers of human female infertility
US5965403A (en) * 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
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US6211157B1 (en) 1998-05-01 2001-04-03 Sulzer Biologics, Inc. Protein mixtures to induce therapeutic angiogenesis
US6992066B2 (en) * 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
US7087577B2 (en) 1998-10-16 2006-08-08 Zimmer Orthobiologies, Inc. Method of promoting natural bypass
EP1181041A2 (en) * 1999-04-30 2002-02-27 Curis, Inc. Morphogen-induced enhancement of fertility
EP1202755A1 (en) * 1999-07-28 2002-05-08 Regeneration Technologies, Inc. Cartilage or bone matrix as a nucleic acid delivery vehicle
CN1331248A (en) * 2000-06-30 2002-01-16 上海博德基因开发有限公司 Polypeptide-human chondral connexin 10.67 and polynucleotide for coding it
US6482936B1 (en) * 2001-04-17 2002-11-19 Pe Corporation (Ny) Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
DK1399023T3 (en) * 2001-06-01 2008-08-18 Wyeth Corp Compositions for systemic administration of sequences encoding bone morphogenesis proteins
US7413753B2 (en) 2001-06-08 2008-08-19 Wyeth Calcium phosphate delivery vehicles for osteoinductive proteins
US7232802B2 (en) * 2001-12-21 2007-06-19 Zimmer Orthobiologics, Inc. Compositions and methods for promoting myocardial and peripheral angiogenesis
US20040265230A1 (en) * 2003-01-06 2004-12-30 Martinez Robert Vincent Compositions and methods for diagnosing and treating colon cancers
WO2004070062A3 (en) * 2003-02-04 2004-11-18 Eugene Brown Compositions and methods for diagnosing and treating cancers
US20050119210A1 (en) * 2003-05-20 2005-06-02 Xiaobing Be Compositions and methods for diagnosing and treating cancers
CN1878565B (en) 2003-09-12 2011-01-12 惠氏公司;埃特克斯公司 Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
DE10361075A1 (en) * 2003-12-22 2005-07-28 Pac Tech - Packaging Technologies Gmbh Method and Vorichtung for drying circuit substrates
EP1571159A1 (en) * 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein of a bone morphogenetic protein and use thereof
WO2005116052A3 (en) * 2004-04-27 2006-06-08 Senyon Choe ANTAGONISM OF TGF-β SUPERFAMILY RECEPTOR SIGNALING
WO2005113585A3 (en) * 2004-05-20 2006-06-08 Acceleron Pharma Inc Modified tgf-beta superfamily polypeptides
WO2005118636A3 (en) * 2004-05-27 2006-06-22 Acceleron Pharma Inc Tgf derepressors and uses related thereto
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US20060166251A1 (en) * 2005-01-26 2006-07-27 Archambault Joanne M Use of sFRPs as markers of BMP activity
JP2008534607A (en) * 2005-03-30 2008-08-28 ワイスWyeth Method for stimulating hair growth by administering Bmp
US20060247790A1 (en) * 2005-04-30 2006-11-02 Mckay William F Shaped osteochondral grafts and methods of using same
JP5368102B2 (en) 2005-11-17 2013-12-18 バイオミメティック セラピューティクス, インコーポレイテッド Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US7659999B2 (en) * 2005-12-23 2010-02-09 Xerox Corporation UIdesign: N-up calculator user interface
ES2443581T3 (en) 2006-02-09 2014-02-19 Biomimetic Therapeutics, Llc Compositions and methods for treating bone
ES2664229T3 (en) 2006-06-30 2018-04-18 Biomimetic Therapeutics, Llc Compositions and Methods of PDGF-biomatrix for treating rotator cuff injuries
US8524265B2 (en) 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
EP2086598B1 (en) 2006-11-03 2015-05-27 BioMimetic Therapeutics, LLC Compositions and methods for arthrodetic procedures
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
EP2259807B1 (en) 2008-02-07 2013-04-24 Biomimetic Therapeutics, Inc. Compositions for distraction osteogenesis
EP2300610A1 (en) * 2008-06-09 2011-03-30 Wyeth LLC Novel bmp-12-related proteins and methods of their manufacture
WO2010030714A8 (en) 2008-09-09 2011-03-10 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US8609127B2 (en) 2009-04-03 2013-12-17 Warsaw Orthopedic, Inc. Medical implant with bioactive material and method of making the medical implant
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
JP6144049B2 (en) 2010-02-22 2017-06-07 バイオミメティック セラピューティクス,リミテッド ライアビリティ カンパニー Platelet-derived growth factor compositions and methods for treating tendinopathy
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
CN105198981A (en) 2010-08-20 2015-12-30 惠氏有限责任公司 Designer osteogenic proteins

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US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5108922A (en) * 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5141905A (en) * 1986-07-01 1992-08-25 Rosen Vicki A Dna sequences encoding bmp-7 proteins
DK0536186T3 (en) * 1990-05-16 2002-05-21 Genetics Inst Bone and cartilage formation-inducing proteins
US5168050A (en) * 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
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DE69432815T2 (en) * 1993-03-19 2003-12-11 Univ Johns Hopkins Med Growth factor-8
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ES2213745T3 (en) * 1993-05-12 2004-09-01 Genetics Institute, Llc BMP11 compositions.
CA2124422A1 (en) * 1993-05-27 1994-11-28 Yukio Fujisawa Heterodimers of tgf-.beta. superfamily
CA2165776A1 (en) * 1993-07-09 1995-01-19 Se-Jin Lee Growth differentiation factor-6
WO1995001802A1 (en) * 1993-07-09 1995-01-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-7
WO1995010539A1 (en) * 1993-10-08 1995-04-20 The Johns Hopkins University School Of Medicine Growth differentiation factor-10
DE69434651T2 (en) * 1993-12-07 2007-03-08 Genetics Institute, Inc., Cambridge BMP-12, BMP-13 and tendon-inducing compositions containing them
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US5914234A (en) * 1994-07-08 1999-06-22 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-11
DK0770089T3 (en) * 1994-07-13 2000-10-23 Univ Johns Hopkins Med Growth differentiation factor-12
US5693779A (en) * 1994-11-08 1997-12-02 The United States Of America As Represented By The Department Of Health And Human Services Production and use of anti-dorsalizing morphogenetic protein
US5965403A (en) * 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)

Also Published As

Publication number Publication date Type
US6623934B2 (en) 2003-09-23 grant
FI990596D0 (en) grant
EP0941323A1 (en) 1999-09-15 application
US20030158379A1 (en) 2003-08-21 application
WO1998012322A1 (en) 1998-03-26 application
US6331612B1 (en) 2001-12-18 grant
US5965403A (en) 1999-10-12 grant
KR20000036012A (en) 2000-06-26 application
FI990596A0 (en) 1999-03-17 application
CA2265508C (en) 2003-11-18 grant
FI990596A (en) 1999-05-03 application
JP2001500737A (en) 2001-01-23 application

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