CA2248186A1 - Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications - Google Patents
Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applicationsInfo
- Publication number
- CA2248186A1 CA2248186A1 CA002248186A CA2248186A CA2248186A1 CA 2248186 A1 CA2248186 A1 CA 2248186A1 CA 002248186 A CA002248186 A CA 002248186A CA 2248186 A CA2248186 A CA 2248186A CA 2248186 A1 CA2248186 A1 CA 2248186A1
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical compositions
- amidinium
- family
- compositions containing
- containing same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000909 amidinium group Chemical group 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention se rapporte à de nouveaux dérivés d'amidinium de formule (I) dans laquelle: R1 représente un dérivé du cholestérol ou un groupement alkyle amino-NR'R'', R2 et R3 représentent indépendamment l'un de l'autre un atome d'hydrogène ou un groupement de formule (II) dans laquelle R4 et R5 représentent indépendamment l'un de l'autre un atome d'hydrogène ou un groupement de formule (III). La présente invention concerne en outre des compositions pharmaceutiques correspondantes utiles notamment en thérapie génique pour le transfert de gènes thérapeutiques dans des cellules.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9602604A FR2745569B1 (fr) | 1996-03-01 | 1996-03-01 | Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications |
FR9602604 | 1996-03-01 | ||
FR9609557 | 1996-07-30 | ||
FR9609557A FR2751972B1 (fr) | 1996-07-30 | 1996-07-30 | Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications |
PCT/FR1997/000364 WO1997031935A1 (fr) | 1996-03-01 | 1997-02-28 | Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2248186A1 true CA2248186A1 (fr) | 1997-09-04 |
CA2248186C CA2248186C (fr) | 2006-09-19 |
Family
ID=37057012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002248186A Expired - Lifetime CA2248186C (fr) | 1996-03-01 | 1997-02-28 | Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2248186C (fr) |
-
1997
- 1997-02-28 CA CA002248186A patent/CA2248186C/fr not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2248186C (fr) | 2006-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20170228 |